Proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist

New England Journal of Medicine

Volumn 375, Issue 3, 2016, Pages 240-246

  Kühnen, Peter ^a   Clément, Karine ^c   Wiegand, Susanna ^a   Blankenstein, Oliver ^a   Gottesdiener, Keith ^d   Martini, Lea L ^c   Mai, Knut ^a,b   Blume Peytavi, Ulrike ^a   Grüters, Annette ^a   Krude, Heiko ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b BERLIN INSTITUTE OF HEALTH   (Germany)

^c INSERM   (France)

^d Rhythm Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GONADORELIN; HYDROCORTISONE; INSULIN; LEPTIN; PROOPIOMELANOCORTIN; SETMELANOTIDE; ALPHA INTERMEDIN; BIM-22493; MC4R PROTEIN, HUMAN; MELANOCORTIN 4 RECEPTOR;

ADRENAL INSUFFICIENCY; ADULT; ARTICLE; BLOOD PRESSURE MONITORING; BODY MASS; CASE REPORT; CLINICAL TRIAL; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GENE; GENE MUTATION; GLUCOSE BLOOD LEVEL; GONADORELIN TEST; HAIR COLOR; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERPHAGIA; INDIRECT CALORIMETRY; INJECTION SITE INDURATION; INJECTION SITE PAIN; INSULIN RESISTANCE; LIVER FAILURE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; POMC GENE; PRIORITY JOURNAL; PROOPIOMELANOCORTIN DEFICIENCY; PROTEIN BLOOD LEVEL; PUBERTY; QUALITY OF LIFE; SIDE EFFECT; SKIN COLOR; WEIGHT REDUCTION; XEROSTOMIA; YOUNG ADULT; AGONISTS; ANALOGS AND DERIVATIVES; BLOOD PRESSURE; DEFICIENCY; GENETICS; METABOLISM, INBORN ERRORS; PHASE 2 CLINICAL TRIAL; PILOT STUDY;

ADULT; ALPHA-MSH; BLOOD PRESSURE; FEMALE; HUMANS; HYPERPHAGIA; METABOLISM, INBORN ERRORS; OBESITY; PHENOTYPE; PILOT PROJECTS; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 4; YOUNG ADULT;

EID: 84979666715     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1512693     Document Type: Article

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