PT-141: A melanocortin agonist for the treatment of sexual dysfunction

Annals of the New York Academy of Sciences

Volumn 994, Issue , 2003, Pages 96-102

  Molinoff, P B ^a   Shadiack, A M ^a   Earle, D ^a   Diamond, L E ^a   Quon, C Y ^a  

^a Palatin Technologies   (United States)

Author keywords

Erectile dysfunction; Melanocortin agonist; Melanocortin receptors

Indexed keywords

ALPHA INTERMEDIN DERIVATIVE; HORMONE RECEPTOR AFFECTING AGENT; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR STIMULATING AGENT; N ACETYLNORLEUCYLASPARTYLHISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE 2,7 CYCLIC AMIDE; PHOSPHODIESTERASE INHIBITOR; PROTEIN FOS; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANIMAL TISSUE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORPUS CAVERNOSUM; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG RESPONSE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NORMAL HUMAN; ONCOGENE C FOS; PENIS ERECTION; PRIAPISM; PSEUDORABIES HERPETOVIRUS; RANDOMIZED CONTROLLED TRIAL; RAT; SEXUAL DYSFUNCTION;

ANIMALIA; PRIMATES; SUID HERPESVIRUS 1;

EID: 0037713325     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb03167.x     Document Type: Conference Paper

References (6)

1. O'DONAHUE, T.L. & D.M. DORSA. 1982. The opiomelanotropinergic neuronal and endocrine systems. Peptides 3: 353-395.
2. ARGIOLAS, A. & M.R. MELIS. 1995. Neuromodulation of penile erection. In Progress in Neurobiology. G.A. Kerkut & J.W. Phillis, Eds.: 235-255. Pergamon Press. London.
3. WESSELLS, H., K. FUCIARELLI, J. HANSEN, et al. 1998. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J. Urol. 160: 389-393.
4. GANTZ, I., H. MIWA, Y. KONDA, et al. 1993. Molecular cloning expression and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 268: 15174-15179.
5. LINDBLOM, J., H.B. SCHIOTH, A. LARSSON, et al. 1998. Autoradiographic discrimination of melanocortin receptors indicate that the MC3 subtype dominates in the medial rat brain. Brain Res. 810: 161-171.
6. KLOTZ, T., A. SACHSE, A. HEIDRICH, et al. 2001. Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: a RigiScan and pharmacokinetic study. World J. Urol. 19: 32-39.