NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

Free Radical Biology and Medicine

Volumn 97, Issue , 2016, Pages 556-567

  Di Marco, Elyse ^a,b   Gray, Stephen P ^a,b   Kennedy, Kit ^a   Szyndralewiez, Cedric ^c   Lyle, Alicia N ^d   Lassègue, Bernard ^d   Griendling, Kathy K ^d   Cooper, Mark E ^a   Schmidt, Harald H H W ^e   Jandeleit Dahm, Karin A M ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c GENKYOTEX SA   (Switzerland)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Atherosclerosis; Diabetes; NOX4; Vascular smooth muscle cell

Indexed keywords

2 (2 CHLOROPHENYL) 4 [3 (DIMETHYLAMINO)PHENYL] 5 METHYL 1H PYRAZOLO[4,3 C]PYRIDINE 3,6(2H,5H) DIONE; ALPHA ACTIN; CALPONIN; COLLAGEN TYPE 1; FIBRONECTIN; GLUCOSE; HYDROGEN PEROXIDE; KI 67 ANTIGEN; MESSENGER RNA; OSTEOPONTIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; SUPEROXIDE; TRANSGELIN; BECAPLERMIN; NOX1 PROTEIN, MOUSE; NOX4 PROTEIN, MOUSE; PLATELET DERIVED GROWTH FACTOR B;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL ISOLATION; CELL PROLIFERATION; CHEMOLUMINESCENCE; COMPARATIVE STUDY; CONTROLLED STUDY; EX VIVO STUDY; EXTRACELLULAR MATRIX; FIBROSIS; GENE DELETION; GENE EXPRESSION; HYPERGLYCEMIA; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; 129 MOUSE; ANIMAL; AORTA; C57BL MOUSE; CELL CULTURE; COMPLICATION; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; ATHEROSCLEROSIS; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; FIBROSIS; MALE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE 1; NADPH OXIDASE 4; OSTEOPONTIN; PROTO-ONCOGENE PROTEINS C-SIS; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 84979650344     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.07.013     Document Type: Article

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