Poly(amino carbonate urethane)-based biodegradable, temperature and pH-sensitive injectable hydrogels for sustained human growth hormone delivery

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Phan, V H Giang ^a   Thambi, Thavasyappan ^a   Duong, Huu Thuy Trang ^a   Lee, Doo Sung ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; DRUG CARRIER; HUMAN GROWTH HORMONE; MACROGOL; POLYURETHAN;

ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG RELEASE; DRUG STABILITY; HUMAN; HYDROGEL; MALE; MATERIALS TESTING; PH; PHASE TRANSITION; RAT; SYNTHESIS; TEMPERATURE;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL LINE; CELL SURVIVAL; DRUG CARRIERS; DRUG LIBERATION; DRUG STABILITY; HUMAN GROWTH HORMONE; HUMANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; MALE; MATERIALS TESTING; PHASE TRANSITION; POLYETHYLENE GLYCOLS; POLYURETHANES; RATS; TEMPERATURE;

EID: 84979577998     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep29978     Document Type: Article

References (46)

1. Walsh, G. Biopharmaceutical benchmarks 2014. Nat. Biotech. 32, 992-1000 (2014).
2. Leader, B., Baca, Q. J., Golan, D. E. Protein therapeutics: a summary and pharmacological classification. Nat. Rev. Drug Discov. 7, 21-39 (2008).
3. Fu, K., Klibanov, A. M., Langer, R. Protein stability in controlled-release systems. Nat. Biotech. 18, 24-25 (2000).
4. Amet, N., Wang, W., Shen, W.-C. Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats. J. Control. Release 141, 177-182 (2010).
5. Lee, H. J. et al. In Vivo Characterization of Sustained-Release Formulations of Human Growth Hormone. J. Pharmacol. Exp. Ther. 281, 1431-1439 (1997).
6. Webster, R. et al. PEGylation of somatropin (recombinant human growth hormone): Impact on its clearance in humans. Xenobiotica 38, 1340-1351 (2008).
7. Cai, Y., Xu, M., Yuan, M., Liu, Z., Yuan, W. Developments in human growth hormone preparations: sustained-release, prolonged half-life, novel injection devices, and alternative delivery routes. Int. J. Nanomedicine 9, 3527-3538 (2014).
8. Johnson, O. L. et al. A month-long effect from a single injection of microencapsulated human growth hormone. Nat. Med. 2, 795-799 (1996).
9. Sivasubramanian, M. et al. Cyclodextrin-Based Nanocomplexes for Sustained Delivery of Human Growth Hormone. J. Nanosci. Nanotechnol. 13, 7306-7311 (2013).
10. Choi, W. I., Kim, M., Tae, G., Kim, Y. H. Sustained Release of Human Growth Hormone from Heparin-Based Hydrogel. Biomacromolecules 9, 1698-1704 (2008).
11. da Silva Freitas, D., Mero, A., Pasut, G. Chemical and Enzymatic Site Specific PEGylation of hGH. Bioconjug. Chem. 24, 456-463 (2013).
12. Govardhan, C. et al. Novel Long-Acting Crystal Formulation of Human Growth Hormone. Pharm. Res. 22, 1461-1470 (2005).
13. Sivasubramanian, M. et al. Thiolated Glycol Chitosan Bearing -Cyclodextrin for Sustained Delivery of PEGylated Human Growth Hormone. J. Biomater. Sci. Polym. Ed. 23, 1995-2005 (2012).
14. Kang, J. et al. Development of Recombinant Human Growth Hormone (rhGH) sustained-release microspheres by a low temperature aqueous phase/aqueous phase emulsion method. Eur. J. Pharm. Sci. 62, 141-147 (2014).
15. Vermonden, T., Censi, R., Hennink, W. E. Hydrogels for Protein Delivery. Chem. Rev. 112, 2853-2888 (2012).
16. Li, Y., Rodrigues, J., Tomas, H. Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chem. Soc. Rev. 41, 2193-2221 (2012).
17. Webber, M. J., Appel, E. A., Meijer, E. W., Langer, R. Supramolecular biomaterials. Nat. Mater. 15, 13-26 (2016).
18. Bae, K. H., Wang, L.-S., Kurisawa, M. Injectable biodegradable hydrogels: progress and challenges. J. Mater. Chem. B 1, 5371-5388 (2013).
19. Joo, M. K., Park, M. H., Choi, B. G., Jeong, B. Reverse thermogelling biodegradable polymer aqueous solutions. J. Mater. Chem. 19, 5891-5905 (2009).
20. Phan, V. H. G. et al. Pancreatic cancer therapy using an injectable nanobiohybrid hydrogel. RSC Adv. 6, 41644-41655 (2016).
21. Yang, J.-A., Yeom, J., Hwang, B. W., Hoffman, A. S., Hahn, S. K. In situ-forming injectable hydrogels for regenerative medicine. Prog. Polym. Sci. 39, 1973-1986 (2014).
22. Purcell, B. P. et al. Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition. Nat. Mater. 13, 653-661 (2014).
23. Singh, N. K., Lee, D. S. In situ gelling pH-and temperature-sensitive biodegradable block copolymer hydrogels for drug delivery. J. Control. Release 193, 214-227 (2014).
24. Pyun, D. G., Choi, H. J., Yoon, H. S., Thambi, T., Lee, D. S. Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds: Synthesis, characterization, in vitro and in vivo studies. Colloids Surf. B 135, 699-706 (2015).
25. Pyun, D. G. et al. Evaluation of AgHAP-containing polyurethane foam dressing for wound healing: synthesis, characterization, in vitro and in vivo studies. J. Mater. Chem. B 3, 7752-7763 (2015).
26. Kloxin, A. M., Kasko, A. M., Salinas, C. N., Anseth, K. S. Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties. Science 324, 59-63 (2009).
27. Nishimura, T. et al. A light sensitive self-assembled nanogel as a tecton for protein patterning materials. Chem. Commun. 52, 1222-1225 (2016).
28. Sim, H. J., Thambi, T., Lee, D. S. Heparin-based temperature-sensitive injectable hydrogels for protein delivery. J. Mater. Chem. B 3, 8892-8901 (2015).
29. Huynh, C. T., Kang, S. W., Li, Y., Kim, B. S., Lee, D. S. Controlled release of human growth hormone from a biodegradable pH/temperature-sensitive hydrogel system. Soft Matter 7, 8984-8990 (2011).
30. Singh, N. K., Nguyen, Q. V., Kim, B. S., Lee, D. S. Nanostructure controlled sustained delivery of human growth hormone using injectable, biodegradable, pH/temperature responsive nanobiohybrid hydrogel. Nanoscale 7, 3043-3054 (2015).
31. Thambi, T., Park, J. H., Lee, D. S. Stimuli-responsive polymersomes for cancer therapy. Biomater. Sci. 4, 55-69 (2016).
32. Qu, Y. et al. A biodegradable thermo-responsive hybrid hydrogel: therapeutic applications in preventing the post-operative recurrence of breast cancer. NPG Asia Mater. 7, e207 (2015).
33. Hoare, T. R., Kohane, D. S. Hydrogels in drug delivery: Progress and challenges. Polymer 49, 1993-2007 (2008).
34. Chung, H. J., Lee, Y., Park, T. G. Thermo-sensitive and biodegradable hydrogels based on stereocomplexed Pluronic multi-block copolymers for controlled protein delivery. J. Control. Release 127, 22-30 (2008).
35. Park, M.-R. et al. Cationic and thermosensitive protamine conjugated gels for enhancing sustained human growth hormone delivery. Biomaterials 31, 1349-1359 (2010).
36. Fukushima, K. Poly(trimethylene carbonate)-based polymers engineered for biodegradable functional biomaterials. Biomater. Sci. 4, 9-24 (2016).
37. Chen, W. et al. Advanced drug and gene delivery systems based on functional biodegradable polycarbonates and copolymers. J. Control. Release 190, 398-414 (2014).
38. Kim, S. Y. et al. Reverse Thermal Gelling PEG PTMC Diblock Copolymer Aqueous Solution. Macromolecules 40, 5519-5525 (2007).
39. Pascual, A. et al. Broad-Spectrum Antimicrobial Polycarbonate Hydrogels with Fast Degradability. Biomacromolecules 16, 1169-1178 (2015).
40. Rodell, C. B. et al. Shear-Thinning Supramolecular Hydrogels with Secondary Autonomous Covalent Crosslinking to Modulate Viscoelastic Properties In Vivo. Adv. Funct. Mater. 25, 636-644 (2015).
41. Peysselon, F., Ricard-Blum, S. Heparin-protein interactions: From affinity and kinetics to biological roles. Application to an interaction network regulating angiogenesis. Matrix Biol. 35, 73-81 (2014).
42. Sakiyama-Elbert, S. E., Hubbell, J. A. Development of fibrin derivatives for controlled release of heparin-binding growth factors. J. Control. Release 65, 389-402 (2000).
43. Shinde, U. P., Moon, H. J., Ko, D. Y., Jung, B. K., Jeong, B. Control of rhGH Release Profile from PEG-PAF Thermogel. Biomacromolecules 16, 1461-1469 (2015).
44. Park, M.-R., Seo, B.-B., Song, S.-C. Dual ionic interaction system based on polyelectrolyte complex and ionic, injectable, and thermosensitive hydrogel for sustained release of human growth hormone. Biomaterials 34, 1327-1336 (2013).
45. Kim, D. H. et al. Enhancing neurogenesis and angiogenesis with target delivery of stromal cell derived factor-1 using a dual ionic pH-sensitive copolymer. Biomaterials 61, 115-125 (2015).
46. Thambi, T., Son, S., Lee, D. S., Park, J. H. Poly(ethylene glycol)-b-poly(lysine) copolymer bearing nitroaromatics for hypoxiasensitive drug delivery. Acta Biomater. 29, 261-270 (2016).