메뉴 건너뛰기




Volumn 17, Issue 9, 2016, Pages

Relapsed Glioblastoma: Treatment Strategies for Initial and Subsequent Recurrences

Author keywords

Chemotherapy; Radiotherapy; Recurrent glioblastoma; Surgery; Treatment

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CARMUSTINE; CEDIRANIB; ENZASTAURIN; ERLOTINIB; FOTEMUSTINE; GALUNISERTIB; GRANULOCYTE COLONY STIMULATING FACTOR; IPILIMUMAB; IRINOTECAN; LOMUSTINE; NIVOLUMAB; PEMBROLIZUMAB; PLACEBO; RINDOPEPIMUT; TEMOZOLOMIDE; TRIACYLGLYCEROL LIPASE;

EID: 84979527797     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-016-0422-4     Document Type: Review
Times cited : (50)

References (49)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • COI: 1:CAS:528:DC%2BD2MXit1Wksbk%3D, PID: 15758009
    • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–96.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3    Weller, M.4    Fisher, B.5    Taphoorn, M.J.6
  • 2
    • 34447285771 scopus 로고    scopus 로고
    • Prognostic factors for survival in adult patients with recurrent glioma enrolled onto the new approaches to brain tumor therapy CNS consortium phase I and II clinical trials
    • PID: 17577040
    • Carson KA, Grossman SA, Fisher JD, Shaw EG. Prognostic factors for survival in adult patients with recurrent glioma enrolled onto the new approaches to brain tumor therapy CNS consortium phase I and II clinical trials. J Clin Oncol. 2007;25(18):2601–6.
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 2601-2606
    • Carson, K.A.1    Grossman, S.A.2    Fisher, J.D.3    Shaw, E.G.4
  • 3
    • 75849127029 scopus 로고    scopus 로고
    • Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma
    • COI: 1:CAS:528:DC%2BC3cXotFKitbo%3D, PID: 20150383
    • Wu W, Lamborn KR, Buckner JC, Novotny PJ, Chang SM, O’Fallon JR, et al. Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma. Neuro-Oncology. 2010;12(2):164–72. doi:10.1093/neuonc/nop019.
    • (2010) Neuro-Oncology , vol.12 , Issue.2 , pp. 164-172
    • Wu, W.1    Lamborn, K.R.2    Buckner, J.C.3    Novotny, P.J.4    Chang, S.M.5    O’Fallon, J.R.6
  • 4
    • 84860430771 scopus 로고    scopus 로고
    • New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: a pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials
    • PID: 22464345, These three studies analized the role of prognostic factors in large series of GBM recurrent patients
    • Gorlia T, Stupp R, Brandes AA, Rampling RR, Fumoleau P, Dittrich C, et al. New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: a pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials. Eur J Cancer. 2012;48(8):1176–84. doi:10.1016/j.ejca.2012.02.004.These three studies analized the role of prognostic factors in large series of GBM recurrent patients
    • (2012) Eur J Cancer , vol.48 , Issue.8 , pp. 1176-1184
    • Gorlia, T.1    Stupp, R.2    Brandes, A.A.3    Rampling, R.R.4    Fumoleau, P.5    Dittrich, C.6
  • 5
    • 0034871451 scopus 로고    scopus 로고
    • A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival
    • COI: 1:STN:280:DC%2BD38%2FlsFGitA%3D%3D, PID: 11780887
    • Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001;95(2):190–8.
    • (2001) J Neurosurg , vol.95 , Issue.2 , pp. 190-198
    • Lacroix, M.1    Abi-Said, D.2    Fourney, D.R.3    Gokaslan, Z.L.4    Shi, W.5    DeMonte, F.6
  • 6
    • 79960001570 scopus 로고    scopus 로고
    • An extent of resection threshold for newly diagnosed glioblastomas
    • PID: 21417701
    • Sanai N, Polley MY, McDermott MW, Parsa AT, Berger MS. An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg. 2011;115(1):3–8. doi:10.3171/2011.2.JNS10998.
    • (2011) J Neurosurg , vol.115 , Issue.1 , pp. 3-8
    • Sanai, N.1    Polley, M.Y.2    McDermott, M.W.3    Parsa, A.T.4    Berger, M.S.5
  • 7
    • 0038188507 scopus 로고    scopus 로고
    • Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project
    • PID: 12816260
    • Chang SM, Parney IF, McDermott M, Barker 2nd FG, Schmidt MH, Huang W, et al. Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project. J Neurosurg. 2003;98(6):1175–81. doi:10.3171/jns.2003.98.6.1175.
    • (2003) J Neurosurg , vol.98 , Issue.6 , pp. 1175-1181
    • Chang, S.M.1    Parney, I.F.2    McDermott, M.3    Barker, F.G.4    Schmidt, M.H.5    Huang, W.6
  • 9
    • 84880655281 scopus 로고    scopus 로고
    • A practical scoring system to determine whether to proceed with surgical resection in recurrent glioblastoma
    • PID: 23800677
    • Park CK, Kim JH, Nam DH, Kim CY, Chung SB, Kim YH, et al. A practical scoring system to determine whether to proceed with surgical resection in recurrent glioblastoma. Neuro-Oncology. 2013;15(8):1096–101. doi:10.1093/neuonc/not069.
    • (2013) Neuro-Oncology , vol.15 , Issue.8 , pp. 1096-1101
    • Park, C.K.1    Kim, J.H.2    Nam, D.H.3    Kim, C.Y.4    Chung, S.B.5    Kim, Y.H.6
  • 10
    • 84899450186 scopus 로고    scopus 로고
    • Survival effect of first- and second-line treatments for patients with primary glioblastoma: a cohort study from a prospective registry, 1997-2010
    • PID: 24463354
    • Nava F, Tramacere I, Fittipaldo A, Bruzzone MG, Dimeco F, Fariselli L, et al. Survival effect of first- and second-line treatments for patients with primary glioblastoma: a cohort study from a prospective registry, 1997-2010. Neuro-Oncology. 2014;16(5):719–27. doi:10.1093/neuonc/not316.
    • (2014) Neuro-Oncology , vol.16 , Issue.5 , pp. 719-727
    • Nava, F.1    Tramacere, I.2    Fittipaldo, A.3    Bruzzone, M.G.4    Dimeco, F.5    Fariselli, L.6
  • 11
    • 84961918899 scopus 로고    scopus 로고
    • Patient outcomes following second surgery for recurrent glioblastoma
    • COI: 1:CAS:528:DC%2BC28Xks1ejsrY%3D, PID: 26880307, This study conducted in a large series of GBM patients reoperated at recurrence demonstrated that extent of resection and MGMT methylation status were correlated with survival
    • Brandes AA, Bartolotti M, Tosoni A, Poggi R, Bartolini S, Paccapelo A, et al. Patient outcomes following second surgery for recurrent glioblastoma. Future Oncol. 2016;12(8):1039–44. doi:10.2217/fon.16.9.This study conducted in a large series of GBM patients reoperated at recurrence demonstrated that extent of resection and MGMT methylation status were correlated with survival
    • (2016) Future Oncol , vol.12 , Issue.8 , pp. 1039-1044
    • Brandes, A.A.1    Bartolotti, M.2    Tosoni, A.3    Poggi, R.4    Bartolini, S.5    Paccapelo, A.6
  • 12
    • 84960426654 scopus 로고    scopus 로고
    • Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection
    • PID: 26243790
    • Ringel F, Pape H, Sabel M, Krex D, Bock HC, Misch M, et al. Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection. Neuro-Oncology. 2016;18(1):96–104. doi:10.1093/neuonc/nov145.
    • (2016) Neuro-Oncology , vol.18 , Issue.1 , pp. 96-104
    • Ringel, F.1    Pape, H.2    Sabel, M.3    Krex, D.4    Bock, H.C.5    Misch, M.6
  • 13
    • 80755159093 scopus 로고    scopus 로고
    • Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma?
    • PID: 21813511
    • Clarke JL, Ennis MM, Yung WK, Chang SM, Wen PY, Cloughesy TF, et al. Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma? Neuro-Oncology. 2011;13(10):1118–24. doi:10.1093/neuonc/nor110.
    • (2011) Neuro-Oncology , vol.13 , Issue.10 , pp. 1118-1124
    • Clarke, J.L.1    Ennis, M.M.2    Yung, W.K.3    Chang, S.M.4    Wen, P.Y.5    Cloughesy, T.F.6
  • 14
    • 84924376838 scopus 로고    scopus 로고
    • Reoperation for recurrent high-grade glioma: a current perspective of the literature
    • PID: 24991712, discussion 8-9
    • Hervey-Jumper SL, Berger MS. Reoperation for recurrent high-grade glioma: a current perspective of the literature. Neurosurgery. 2014;75(5):491–9. doi:10.1227/NEU.0000000000000486.discussion 8-9
    • (2014) Neurosurgery , vol.75 , Issue.5 , pp. 491-499
    • Hervey-Jumper, S.L.1    Berger, M.S.2
  • 15
    • 84966589269 scopus 로고    scopus 로고
    • Complete resection of contrast-enhancing tumor volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial
    • PID: 26823503, The study demonstrated that complete resection was associated with improved survival in GBM reoperated patients
    • Suchorska B, Weller M, Tabatabai G, Senft C, Hau P, Sabel MC, et al. Complete resection of contrast-enhancing tumor volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial. Neuro-Oncology. 2016;18(4):549–56. doi:10.1093/neuonc/nov326.The study demonstrated that complete resection was associated with improved survival in GBM reoperated patients
    • (2016) Neuro-Oncology , vol.18 , Issue.4 , pp. 549-556
    • Suchorska, B.1    Weller, M.2    Tabatabai, G.3    Senft, C.4    Hau, P.5    Sabel, M.C.6
  • 17
    • 77949891455 scopus 로고    scopus 로고
    • Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
    • COI: 1:CAS:528:DC%2BC3cXktF2ltb4%3D, PID: 20124186
    • Wick W, Puduvalli VK, Chamberlain MC, van den Bent MJ, Carpentier AF, Cher LM, et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol. 2010;28(7):1168–74. doi:10.1200/JCO.2009.23.2595.
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1168-1174
    • Wick, W.1    Puduvalli, V.K.2    Chamberlain, M.C.3    van den Bent, M.J.4    Carpentier, A.F.5    Cher, L.M.6
  • 18
    • 84982131467 scopus 로고    scopus 로고
    • A phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
    • Brandes AA, Carpentier AF, Kesari S, Sepulveda-Sanchez JM, Wheeler HR, Chinot O, et al. A phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma. Neuro-Oncology. 2016. doi:10.1093/neuonc/now009.
    • (2016) Neuro-Oncology
    • Brandes, A.A.1    Carpentier, A.F.2    Kesari, S.3    Sepulveda-Sanchez, J.M.4    Wheeler, H.R.5    Chinot, O.6
  • 19
    • 84887116872 scopus 로고    scopus 로고
    • Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
    • COI: 1:CAS:528:DC%2BC3sXhs1ahur7O, PID: 23940216
    • Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol. 2013;31(26):3212–8. doi:10.1200/JCO.2012.47.2464.
    • (2013) J Clin Oncol , vol.31 , Issue.26 , pp. 3212-3218
    • Batchelor, T.T.1    Mulholland, P.2    Neyns, B.3    Nabors, L.B.4    Campone, M.5    Wick, A.6
  • 20
    • 84904913239 scopus 로고    scopus 로고
    • Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial
    • COI: 1:CAS:528:DC%2BC2cXhtFGltr%2FL, PID: 25035291
    • Taal W, Oosterkamp HM, Walenkamp AM, Dubbink HJ, Beerepoot LV, Hanse MC, et al. Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial. Lancet Oncol. 2014;15(9):943–53. doi:10.1016/S1470-2045(14)70314-6.
    • (2014) Lancet Oncol , vol.15 , Issue.9 , pp. 943-953
    • Taal, W.1    Oosterkamp, H.M.2    Walenkamp, A.M.3    Dubbink, H.J.4    Beerepoot, L.V.5    Hanse, M.C.6
  • 21
    • 68149169111 scopus 로고    scopus 로고
    • Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    • COI: 1:CAS:528:DC%2BD1MXptFCks7k%3D, PID: 19169684
    • Brandes AA, Tosoni A, Franceschi E, Blatt V, Santoro A, Faedi M, et al. Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Cancer Chemother Pharmacol. 2009;64(4):769–75. doi:10.1007/s00280-009-0926-8.
    • (2009) Cancer Chemother Pharmacol , vol.64 , Issue.4 , pp. 769-775
    • Brandes, A.A.1    Tosoni, A.2    Franceschi, E.3    Blatt, V.4    Santoro, A.5    Faedi, M.6
  • 22
    • 84985912308 scopus 로고    scopus 로고
    • AVAREG: a phase 2, randomized, noncomparative study of fotemustine or bevacizumab for patients with recurrent glioblastoma
    • Brandes AA, Finocchiaro G, Zagonel V, Reni M, Caserta C, Fabi A, et al. AVAREG: a phase 2, randomized, noncomparative study of fotemustine or bevacizumab for patients with recurrent glioblastoma. Neuro-Oncology. 2016. doi:10.1093/neuonc/now035.
    • (2016) Neuro-Oncology
    • Brandes, A.A.1    Finocchiaro, G.2    Zagonel, V.3    Reni, M.4    Caserta, C.5    Fabi, A.6
  • 23
    • 84906991854 scopus 로고    scopus 로고
    • Are we done with dose-intense temozolomide in recurrent glioblastoma?
    • PID: 25063550, This review evaluated the role of intensified temozolomide schedules in recurrent GBM
    • van den Bent MJ, Taal W. Are we done with dose-intense temozolomide in recurrent glioblastoma? Neuro-Oncology. 2014;16(9):1161–3. doi:10.1093/neuonc/nou157.This review evaluated the role of intensified temozolomide schedules in recurrent GBM
    • (2014) Neuro-Oncology , vol.16 , Issue.9 , pp. 1161-1163
    • van den Bent, M.J.1    Taal, W.2
  • 24
    • 84937939301 scopus 로고    scopus 로고
    • MGMT promoter methylation is a strong prognostic biomarker for benefit from dose-intensified temozolomide rechallenge in progressive glioblastoma: the DIRECTOR trial
    • COI: 1:CAS:528:DC%2BC2MXnvFaqsr0%3D, PID: 25655102, This study provides the evidence for temozolomide rechallange in MGMT methylated patients in recurrence after temozolomide interruption
    • Weller M, Tabatabai G, Kastner B, Felsberg J, Steinbach JP, Wick A, et al. MGMT promoter methylation is a strong prognostic biomarker for benefit from dose-intensified temozolomide rechallenge in progressive glioblastoma: the DIRECTOR trial. Clin Cancer Res. 2015;21(9):2057–64. doi:10.1158/1078-0432.CCR-14-2737.This study provides the evidence for temozolomide rechallange in MGMT methylated patients in recurrence after temozolomide interruption
    • (2015) Clin Cancer Res , vol.21 , Issue.9 , pp. 2057-2064
    • Weller, M.1    Tabatabai, G.2    Kastner, B.3    Felsberg, J.4    Steinbach, J.P.5    Wick, A.6
  • 25
    • 84911097954 scopus 로고    scopus 로고
    • Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges
    • PID: 25342602
    • Reardon DA, Wen PY, Mellinghoff IK. Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges. Neuro-Oncology. 2014;16(Suppl 8):viii7–13. doi:10.1093/neuonc/nou232.
    • (2014) Neuro-Oncology , vol.16 , pp. viii7-vii13
    • Reardon, D.A.1    Wen, P.Y.2    Mellinghoff, I.K.3
  • 26
    • 62449150719 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
    • PID: 19204207
    • van den Bent MJ, Brandes AA, Rampling R, Kouwenhoven MC, Kros JM, Carpentier AF, et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol. 2009;27(8):1268–74. doi:10.1200/JCO.2008.17.5984.
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1268-1274
    • van den Bent, M.J.1    Brandes, A.A.2    Rampling, R.3    Kouwenhoven, M.C.4    Kros, J.M.5    Carpentier, A.F.6
  • 27
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • COI: 1:CAS:528:DC%2BD2sXhvF2htr8%3D, PID: 17317837
    • Vredenburgh JJ, Desjardins A, Herndon 2nd JE, Dowell JM, Reardon DA, Quinn JA, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res. 2007;13(4):1253–9.
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1253-1259
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon, J.E.3    Dowell, J.M.4    Reardon, D.A.5    Quinn, J.A.6
  • 28
    • 36049037819 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    • COI: 1:CAS:528:DC%2BD2sXhtlCgsLjF, PID: 17947719
    • Vredenburgh JJ, Desjardins A, Herndon 2nd JE, Marcello J, Reardon DA, Quinn JA, et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol. 2007;25(30):4722–9. doi:10.1200/JCO.2007.12.2440.
    • (2007) J Clin Oncol , vol.25 , Issue.30 , pp. 4722-4729
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon, J.E.3    Marcello, J.4    Reardon, D.A.5    Quinn, J.A.6
  • 29
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • COI: 1:CAS:528:DC%2BD1MXjsVCjs7o%3D, PID: 19114704
    • Kreisl TN, Kim L, Moore K, Duic P, Royce C, Stroud I, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 2009;27(5):740–5.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3    Duic, P.4    Royce, C.5    Stroud, I.6
  • 30
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • COI: 1:CAS:528:DC%2BD1MXhtlGgtbbM, PID: 19720927
    • Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009;27(28):4733–40. doi:10.1200/JCO.2008.19.8721.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3    Mikkelsen, T.4    Schiff, D.5    Abrey, L.E.6
  • 31
    • 84925372706 scopus 로고    scopus 로고
    • Bevacizumab and glioblastoma: scientific review, newly reported updates, and ongoing controversies
    • COI: 1:CAS:528:DC%2BC2MXkvFCls7o%3D, PID: 25263092
    • Field KM, Jordan JT, Wen PY, Rosenthal MA, Reardon DA. Bevacizumab and glioblastoma: scientific review, newly reported updates, and ongoing controversies. Cancer. 2015;121(7):997–1007. doi:10.1002/cncr.28935.
    • (2015) Cancer , vol.121 , Issue.7 , pp. 997-1007
    • Field, K.M.1    Jordan, J.T.2    Wen, P.Y.3    Rosenthal, M.A.4    Reardon, D.A.5
  • 32
    • 84979554307 scopus 로고    scopus 로고
    • Phase III trial exploring the combination of bevacizumab and lomustine in patients with first recurrence of glioblastoma: the EORTC 26101 trial
    • Wick W, Brandes A, Gorlia T, Bendszus M, Sahm F, Taal W et al phase III study randomized recurrent GBM patients to bevacizumab in combination with CCNU or CCNU alone demonstrating a significant increase in PFS not translating in a survival advantage
    • Wick W, Brandes A, Gorlia T, Bendszus M, Sahm F, Taal W et al. Phase III trial exploring the combination of bevacizumab and lomustine in patients with first recurrence of glioblastoma: the EORTC 26101 trial. Neuro Oncol. 2015;(17). This phase III study randomized recurrent GBM patients to bevacizumab in combination with CCNU or CCNU alone demonstrating a significant increase in PFS not translating in a survival advantage.
    • (2015) Neuro Oncol.
  • 33
    • 84898714738 scopus 로고    scopus 로고
    • Bevacizumab for the treatment of high-grade glioma: an update after phase III trials
    • COI: 1:CAS:528:DC%2BC2cXlvFSrsL0%3D, PID: 24655021
    • Khasraw M, Ameratunga M, Grommes C. Bevacizumab for the treatment of high-grade glioma: an update after phase III trials. Expert Opin Biol Ther. 2014;14(5):729–40. doi:10.1517/14712598.2014.898060.
    • (2014) Expert Opin Biol Ther , vol.14 , Issue.5 , pp. 729-740
    • Khasraw, M.1    Ameratunga, M.2    Grommes, C.3
  • 34
    • 84925632920 scopus 로고    scopus 로고
    • Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma
    • COI: 1:CAS:528:DC%2BC2MXntFentrs%3D, PID: 25713439
    • Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, et al. Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma. J Clin Oncol. 2015;33(10):1197–213. doi:10.1200/JCO.2014.55.9575.
    • (2015) J Clin Oncol , vol.33 , Issue.10 , pp. 1197-1213
    • Lu-Emerson, C.1    Duda, D.G.2    Emblem, K.E.3    Taylor, J.W.4    Gerstner, E.R.5    Loeffler, J.S.6
  • 35
    • 84901006041 scopus 로고    scopus 로고
    • Deferred use of bevacizumab for recurrent glioblastoma is not associated with diminished efficacy
    • PID: 25155359
    • Piccioni DE, Lai A. Deferred use of bevacizumab for recurrent glioblastoma is not associated with diminished efficacy. Neuro-Oncology. 2014;16(10):1427–8. doi:10.1093/neuonc/nou214.
    • (2014) Neuro-Oncology , vol.16 , Issue.10 , pp. 1427-1428
    • Piccioni, D.E.1    Lai, A.2
  • 36
    • 84924620037 scopus 로고    scopus 로고
    • Impact of bevacizumab administered dose on overall survival of patients with progressive glioblastoma
    • COI: 1:CAS:528:DC%2BC2MXhtVCru7s%3D
    • Levin VA, Mendelssohn ND, Chan J, Stovall MC, Peak SJ, Yee JL, et al. Impact of bevacizumab administered dose on overall survival of patients with progressive glioblastoma. J Neuro-Oncol. 2015;122(1):145–50. doi:10.1007/s11060-014-1693-x.
    • (2015) J Neuro-Oncol , vol.122 , Issue.1 , pp. 145-150
    • Levin, V.A.1    Mendelssohn, N.D.2    Chan, J.3    Stovall, M.C.4    Peak, S.J.5    Yee, J.L.6
  • 37
    • 79953876016 scopus 로고    scopus 로고
    • Bevacizumab for recurrent glioblastoma multiforme: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3MXmtl2isbY%3D
    • Wong ET, Gautam S, Malchow C, Lun M, Pan E, Brem S. Bevacizumab for recurrent glioblastoma multiforme: a meta-analysis. J Natl Compr Cancer Netw. 2011;9(4):403–7.
    • (2011) J Natl Compr Cancer Netw , vol.9 , Issue.4 , pp. 403-407
    • Wong, E.T.1    Gautam, S.2    Malchow, C.3    Lun, M.4    Pan, E.5    Brem, S.6
  • 39
    • 85050577350 scopus 로고    scopus 로고
    • The role of bevacizumab in recurrent glioblastoma: new insights from randomized trials
    • COI: 1:CAS:528:DC%2BC2MXntlSqurw%3D, PID: 25906382
    • Franceschi E, Brandes AA. The role of bevacizumab in recurrent glioblastoma: new insights from randomized trials. CNS Oncol. 2015;4(3):117–9. doi:10.2217/cns.15.7.
    • (2015) CNS Oncol , vol.4 , Issue.3 , pp. 117-119
    • Franceschi, E.1    Brandes, A.A.2
  • 40
    • 84941359544 scopus 로고    scopus 로고
    • Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: retrospective analysis of the AVAglio trial
    • COI: 1:CAS:528:DC%2BC28XkvFSltrY%3D, PID: 26124478
    • Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, et al. Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: retrospective analysis of the AVAglio trial. J Clin Oncol. 2015;33(25):2735–44. doi:10.1200/JCO.2015.61.5005.
    • (2015) J Clin Oncol , vol.33 , Issue.25 , pp. 2735-2744
    • Sandmann, T.1    Bourgon, R.2    Garcia, J.3    Li, C.4    Cloughesy, T.5    Chinot, O.L.6
  • 41
    • 84979545389 scopus 로고    scopus 로고
    • Molecular predictors of outcome and response to bevacizumab (BEV) based on analysis of RTOG 0825, a phase III randomized trial comparing chemoradiation with or without BEV in patients with newly diagnosed glioblastoma (GBM)
    • Sulman EP, Won M, Blumenthal A, Vogelbaum M, Colman H, Jenkins RB et al
    • Sulman EP, Won M, Blumenthal A, Vogelbaum M, Colman H, Jenkins RB et al. Molecular predictors of outcome and response to bevacizumab (BEV) based on analysis of RTOG 0825, a phase III randomized trial comparing chemoradiation with or without BEV in patients with newly diagnosed glioblastoma (GBM) J Clin Oncol. 2013;31:suppl;abstr.
    • (2013) J Clin Oncol.
  • 42
    • 84958191343 scopus 로고    scopus 로고
    • Identification of patients with recurrent glioblastoma who may benefit from combined bevacizumab and CCNU therapy: a report from the BELOB trial
    • COI: 1:CAS:528:DC%2BC28XhslSgsbk%3D, PID: 26762204
    • Erdem-Eraslan L, van den Bent MJ, Hoogstrate Y, Naz-Khan H, Stubbs A, van der Spek P, et al. Identification of patients with recurrent glioblastoma who may benefit from combined bevacizumab and CCNU therapy: a report from the BELOB trial. Cancer Res. 2016;76(3):525–34. doi:10.1158/0008-5472.CAN-15-0776.
    • (2016) Cancer Res , vol.76 , Issue.3 , pp. 525-534
    • Erdem-Eraslan, L.1    van den Bent, M.J.2    Hoogstrate, Y.3    Naz-Khan, H.4    Stubbs, A.5    van der Spek, P.6
  • 43
    • 84916936048 scopus 로고    scopus 로고
    • Immunotherapy for primary brain tumors: no longer a matter of privilege
    • COI: 1:CAS:528:DC%2BC2cXhvFGgs7nF, PID: 25398845
    • Fecci PE, Heimberger AB, Sampson JH. Immunotherapy for primary brain tumors: no longer a matter of privilege. Clin Cancer Res. 2014;20(22):5620–9. doi:10.1158/1078-0432.CCR-14-0832.
    • (2014) Clin Cancer Res , vol.20 , Issue.22 , pp. 5620-5629
    • Fecci, P.E.1    Heimberger, A.B.2    Sampson, J.H.3
  • 44
    • 84947509509 scopus 로고    scopus 로고
    • Preliminary safety and activity of nivolumab and its combination with ipilimumab in recurrent glioblastoma (GBM): CHECKMATE-143
    • Sampson J, Vlahovic G, Sahebjam S, Omuro A, Baehring J, Hafler D, et al. Preliminary safety and activity of nivolumab and its combination with ipilimumab in recurrent glioblastoma (GBM): CHECKMATE-143. J Clin Oncol. 2015;33(No 15_suppl (May 20 Supplement)):3010.
    • (2015) J Clin Oncol , vol.33 , pp. 3010
    • Sampson, J.1    Vlahovic, G.2    Sahebjam, S.3    Omuro, A.4    Baehring, J.5    Hafler, D.6
  • 45
    • 85016924184 scopus 로고    scopus 로고
    • Vaccination strategies for neuro-oncology
    • PID: 26516221
    • Sampson JH, Mitchell DA. Vaccination strategies for neuro-oncology. Neuro-Oncology. 2015;17(Suppl 7):vii15–25. doi:10.1093/neuonc/nov159.
    • (2015) Neuro-Oncology , vol.17 , pp. vii15-vii25
    • Sampson, J.H.1    Mitchell, D.A.2
  • 46
    • 84966335010 scopus 로고    scopus 로고
    • ReACT: long-term survival from a randomized phase ii study of rindopepimut (CDX-110) plus bevacizumab in relapsed glioblastoma
    • Reardon D, Desjardins A, Schuster J, Tran D, Fink KL, Nabors BL, et al. ReACT: long-term survival from a randomized phase ii study of rindopepimut (CDX-110) plus bevacizumab in relapsed glioblastoma. Neuro-Oncology. 2015;17:v107–12.
    • (2015) Neuro-Oncology , vol.17 , pp. v107-v112
    • Reardon, D.1    Desjardins, A.2    Schuster, J.3    Tran, D.4    Fink, K.L.5    Nabors, B.L.6
  • 47
    • 84871951211 scopus 로고    scopus 로고
    • Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein
    • COI: 1:CAS:528:DC%2BC3sXktFGgtw%3D%3D, PID: 22872572
    • Crane CA, Han SJ, Ahn B, Oehlke J, Kivett V, Fedoroff A, et al. Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein. Clin Cancer Res. 2013;19(1):205–14. doi:10.1158/1078-0432.CCR-11-3358.
    • (2013) Clin Cancer Res , vol.19 , Issue.1 , pp. 205-214
    • Crane, C.A.1    Han, S.J.2    Ahn, B.3    Oehlke, J.4    Kivett, V.5    Fedoroff, A.6
  • 48
    • 84899411363 scopus 로고    scopus 로고
    • Heat shock protein peptide complex-96 (HSPPC-96) vaccination for recurrent glioblastoma: a phase II, single arm trial
    • PID: 24729070
    • Bloch O, Parsa AT. Heat shock protein peptide complex-96 (HSPPC-96) vaccination for recurrent glioblastoma: a phase II, single arm trial. Neuro-Oncology. 2014;16(5):758–9. doi:10.1093/neuonc/nou054.
    • (2014) Neuro-Oncology , vol.16 , Issue.5 , pp. 758-759
    • Bloch, O.1    Parsa, A.T.2
  • 49
    • 84945130835 scopus 로고    scopus 로고
    • Carboplatin and etoposide in heavily pretreated patients with progressive high-grade glioma
    • COI: 1:CAS:528:DC%2BC2MXhslylu7nN, PID: 26496463
    • Tonder M, Weller M, Eisele G, Roth P. Carboplatin and etoposide in heavily pretreated patients with progressive high-grade glioma. Chemotherapy. 2014;60(5–6):375–8. doi:10.1159/000440678.
    • (2014) Chemotherapy , vol.60 , Issue.5-6 , pp. 375-378
    • Tonder, M.1    Weller, M.2    Eisele, G.3    Roth, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.