Rapamycin normalizes serum leptin by alleviating obesity and reducing leptin synthesis in aged rats

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 71, Issue 7, 2016, Pages 891-899

  Scarpace, Philip J ^a   Matheny, Michael ^a   Strehler, Kevin Y E ^a   Toklu, Hale Zerrin ^a   Kirichenko, Nataliya ^a   Carter, Christy S ^a   Morgan, Drake ^a   Tümer, Nihal ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Leptin synthesis; mTORC1; Rapamycin

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; LEPTIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

AGING; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; DOSE RESPONSE; DRUG EFFECTS; GLUCOSE METABOLISM DISORDERS; METABOLISM; OBESITY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ADIPOSITY; AGING; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE METABOLISM DISORDERS; IMMUNOSUPPRESSIVE AGENTS; LEPTIN; MULTIPROTEIN COMPLEXES; OBESITY; RATS; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; TREATMENT OUTCOME;

EID: 84979299148     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu230     Document Type: Article

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