Reducing unnecessary antibiotic use in the neonatal intensive care unit (SCOUT): a prospective interrupted time-series study

The Lancet Infectious Diseases

Volumn 16, Issue 10, 2016, Pages 1178-1184

  Cantey, Joseph B ^a   Wozniak, Phillip S ^a   Pruszynski, Jessica E ^b   Sánchez, Pablo J ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; GENTAMICIN; OXACILLIN; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; ARTICLE; CHILD DEATH; DRUG INDICATION; DRUG MONITORING; DRUG SAFETY; FEMALE; GESTATION PERIOD; HUMAN; INFANT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MICROBIAL COLONIZATION; MULTIDRUG RESISTANCE; NECROTIZING ENTEROCOLITIS; NEONATAL INTENSIVE CARE UNIT; NEWBORN SEPSIS; OBSERVATIONAL STUDY; PNEUMONIA; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK REDUCTION; TIME SERIES ANALYSIS; TREATMENT OUTCOME; ADULT; ADVERSE EFFECTS; ANTIBIOTIC RESISTANCE; INAPPROPRIATE PRESCRIBING; MICROBIOLOGY; NEWBORN; PREMATURITY; SEPSIS; TEXAS;

ADULT; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; INAPPROPRIATE PRESCRIBING; INFANT, NEWBORN; INFANT, PREMATURE; INTENSIVE CARE UNITS, NEONATAL; LENGTH OF STAY; MALE; PROSPECTIVE STUDIES; SEPSIS; TEXAS;

EID: 84979284146     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(16)30205-5     Document Type: Article

References (30)

1. 1 Clark, RH, Bloom, BT, Spitzer, AR, Gerstmann, DR, Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 117 (2006), 1979–1987.
2. 2 Schulman, J, Dimand, RJ, Lee, HC, Duenas, GV, Bennett, MV, Gould, JB, Neonatal intensive care unit antibiotic use. Pediatrics 135 (2015), 826–833.
3. 3 Tsai, MH, Chu, SM, Hsu, JF, et al. Risk factors and outcomes for multidrug-resistant Gram-negative bacteremia in the NICU. Pediatrics 133 (2014), e322–e329.
4. 4 Cotten, CM, McDonald, S, Stoll, B, et al. The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics 118 (2006), 717–722.
5. 5 Cotten, CM, Taylor, S, Stoll, B, et al. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics 123 (2009), 58–66.
6. 6 Kuppala, VS, Meinzen-Derr, J, Morrow, AL, Schibler, KR, Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr 159 (2011), 720–725.
7. 7 Saiman, L, Ludington, E, Dawson, JD, et al. Risk factors for candida species colonization of neonatal intensive care unit patients. Pediatr Infect Dis J 20 (2001), 1119–1124.
8. 8 Alexander, VN, Northrup, V, Bizzarro, MJ, Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis. J Pediatr 159 (2011), 392–397.
9. 9 Novitsky, A, Tuttle, D, Locke, RG, Saiman, L, Mackley, A, Paul, DA, Prolonged early antibiotic use and bronchopulmonary dysplasia in very low birth weight infants. Am J Perinatol 32 (2015), 43–48.
10. 10 Lapin, B, Piorkowski, J, Ownby, D, et al. The relationship of early-life antibiotic use with asthma in at-risk children. J Allergy Clin Immunol 134 (2014), 728–729.
11. 11 Saari, A, Virta, LJ, Sankilampi, U, Dunkel, L, Saxen, H, Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life. Pediatrics 135 (2015), 617–626.
12. 12 Teo, SM, Mok, D, Pham, K, et al. The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development. Cell Host Microbe 17 (2015), 704–715.
13. 13 Cantey, JB, Patel, SJ, Antimicrobial stewardship in the NICU. Infect Dis Clin North Am 28 (2014), 247–261.
14. 14 Dellit, TH, Owens, RC, McGowan, JE Jr, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 44 (2007), 159–177.
15. 15 Patel, SJ, Oshodi, A, Prasad, P, et al. Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12 Step Campaign to Prevent Antimicrobial Resistance. Pediatr Infect Dis J 28 (2009), 1047–1051.
16. 16 Wendel, GD Jr, Leveno, KJ, Sanchez, PJ, Jackson, GL, McIntire, DD, Siegel, JD, Prevention of neonatal group B streptococcal disease: a combined intrapartum and neonatal protocol. Am J Obstet Gynecol 186 (2002), 618–626.
17. 17 Ibrahim, OM, Polk, RE, Antimicrobial use metrics and benchmarking to improve stewardship outcomes: methodology, opportunities, and challenges. Infect Dis Clin North Am 28 (2014), 195–214.
18. 18 Parry, G, Tucker, J, Tarnow-Mordi, W, CRIB II: an update of the clinical risk index for babies score. Lancet 361 (2003), 1789–1791.
19. 19 Cantey, JB, Wozniak, PS, Sanchez, PJ, Prospective surveillance of antibiotic use in the neonatal intensive care unit: results from the SCOUT study. Pediatr Infect Dis J 34 (2014), 267–272.
20. 20 Engle, WD, Jackson, GL, Sendelbach, D, et al. Neonatal pneumonia: comparison of 4 vs 7 days of antibiotic therapy in term and near-term infants. J Perinatol 20 (2000), 421–426.
21. 21 Stoll, BJ, Hansen, N, Fanaroff, AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110 (2002), 285–291.
22. 22 Bekhof, J, Reitsma, JB, Kok, JH, Van Straaten, IH, Clinical signs to identify late-onset sepsis in preterm infants. Eur J Pediatr 172 (2013), 501–508.
23. 23 Weintraub, AS, Cadet, CT, Perez, R, DeLorenzo, E, Holzman, IR, Stroustrup, A, Antibiotic use in newborns with transient tachypnea of the newborn. Neonatology 103 (2013), 235–240.
24. 24 Shani, L, Weitzman, D, Melamed, R, Zmora, E, Marks, K, Risk factors for early sepsis in very low birth weight neonates with respiratory distress syndrome. Acta Paediatrica 97 (2008), 12–15.
25. 25 Ronchi, A, Michelow, IC, Chapin, KC, et al. Viral respiratory tract infections in the neonatal intensive care unit: the VIRIoN-I study. J Pediatr 165 (2014), 690–696.
26. 26 Cordero, L, Ayers, LW, Duration of empiric antibiotics for suspected early-onset sepsis in extremely low birth weight infants. Infect Control Hosp Epidemiol 24 (2003), 662–666.
27. 27 Geerlings, SE, Hulscher, M, Prins, JM, Appropriate use of antibiotics shortens length of hospital stay. Ned Tijdschr Geneeskd, 158, 2014, A7288 (in Dutch).
28. 28 Szymczak, JE, Feemster, KA, Zaoutis, TE, Gerber, JS, Pediatrician perceptions of an outpatient antimicrobial stewardship intervention. Infect Control Hosp Epidemiol 35:suppl 3 (2014), S69–S78.
29. 29 Gerber, JS, Prasad, PA, Fiks, AG, et al. Durability of benefits of an outpatient antimicrobial stewardship intervention after discontinuation of audit and feedback. JAMA 312 (2014), 2569–2570.
30. 30 Shipp, KD, Chiang, T, Karasick, S, Quick, K, Nguyen, ST, Cantey, JB, Antibiotic stewardship challenges in a referral neonatal intensive care unit. Am J Perinatol 33 (2015), 518–524.