Prolonged early antibiotic use and bronchopulmonary dysplasia in very low birth weight infants

American Journal of Perinatology

Volumn 32, Issue 1, 2015, Pages 43-48

  Novitsky, Alexandra ^a   Tuttle, Deborah ^b   Locke, Robert G ^b   Saiman, Lisa ^c   Mackley, Amy ^b   Paul, David A ^b  

^a The Chester County Hospital   (United States)

^b CHRISTIANA CARE HEALTH SYSTEM   (United States)

^c Columbia University ^*  (United States)

Author keywords

antibiotics; bronchopulmonary dysplasia; endotracheal tube cultures

Indexed keywords

AMPICILLIN; ANTIINFECTIVE AGENT; GENTAMICIN; VANCOMYCIN;

ARTIFICIAL VENTILATION; BACTERIUM; BRONCHOPULMONARY DYSPLASIA; CASE CONTROL STUDY; COHORT ANALYSIS; DEVICES; ENDOTRACHEAL INTUBATION; FEMALE; HUMAN; ISOLATION AND PURIFICATION; MALE; NEWBORN; PREMATURITY; RETROSPECTIVE STUDY; RISK FACTOR; SEPSIS; TIME; VERY LOW BIRTH WEIGHT;

AMPICILLIN; ANTI-BACTERIAL AGENTS; BACTERIA; BRONCHOPULMONARY DYSPLASIA; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENTAMICINS; HUMANS; INFANT, EXTREMELY PREMATURE; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; INTUBATION, INTRATRACHEAL; MALE; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; TIME FACTORS; VANCOMYCIN;

EID: 84899467338     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0034-1373844     Document Type: Article

References (18)

1. Horbar J. D., Carpenter J. H., Badger G. J., et al. Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009. Pediatrics: 2012; 129 6 1019 1026
2. Schmidt B., Asztalos E. V., Roberts R. S., Robertson C. M., Sauve R. S., Whitfield M. F.; Trial of Indomethacin Prophylaxis in Preterms (TIPP) Investigators. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. JAMA: 2003; 289 9 1124 1129
3. Sanchez-Solis M., Garcia-Marcos L., Bosch-Gimenez V., Pérez-Fernandez V., Pastor-Vivero M. D., Mondéjar-Lopez P. Lung function among infants born preterm, with or without bronchopulmonary dysplasia. Pediatr Pulmonol: 2012; 47 7 674 681
4. Laughon M. M., Langer J. C., Bose C. L., et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants. Am J Respir Crit Care Med: 2011; 183 12 1715 1722
5. Paul D. A., Zook K., Mackley A., Locke R. G. Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants. J Perinatol: 2010; 30 1 58 62
6. Kramer B. W. Antenatal inflammation and lung injury: prenatal origin of neonatal disease. J Perinatol: 2008; 28 01 S21 S27
7. Ballard J. L., Khoury J. C., Wedig K., Wang L., Eilers-Walsman B. L., Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr: 1991; 119 3 417 423
8. Richardson D. K., Gray J. E., McCormick M. C., Workman K., Goldmann D. A. Score for neonatal acute physiology: a physiologic severity index for neonatal intensive care. Pediatrics: 1993; 91 3 617 623
9. Bell M. J., Ternberg J. L., Feigin R. D., et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg: 1978; 187 1 1 7
10. Kuppala V. S., Meinzen-Derr J., Morrow A. L., Schibler K. R. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr: 2011; 159 5 720 725
11. Stephens B. E., Tucker R., Vohr B. R. Special health care needs of infants born at the limits of viability. Pediatrics: 2010; 125 6 1152 1158
12. Cotten C. M., Taylor S., Stoll B., et al. NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics: 2009; 123 1 58 66
13. Spiliopoulou A., Dimitriou G., Jelastopulu E., Giannakopoulos I., Anastassiou E. D., Christofidou M. Neonatal intensive care unit candidemia: epidemiology, risk factors, outcome, and critical review of published case series. Mycopathologia: 2012; 173 4 219 228
14. Wright A. J., Unger S., Coleman B. L., Lam P. P., McGeer A. J. Maternal antibiotic exposure and risk of antibiotic resistance in neonatal early-onset sepsis: a case-cohort study. Pediatr Infect Dis J: 2012; 31 11 1206 1208
15. Clark R. H., Bloom B. T., Spitzer A. R., Gerstmann D. R. Empiric use of ampicillin and cefotaxime, compared with ampicillin and gentamicin, for neonates at risk for sepsis is associated with an increased risk of neonatal death. Pediatrics: 2006; 117 1 67 74
16. Le J., Nguyen T., Okamoto M., McKamy S., Lieberman J. M. Impact of empiric antibiotic use on development of infections caused by extended-spectrum beta-lactamase bacteria in a neonatal intensive care unit. Pediatr Infect Dis J: 2008; 27 4 314 318
17. Folsgaard N. V., Schjorring S., Chawes B. L., et al. Pathogenic bacteria colonizing the airways in asymptomatic neonates stimulates topical inflammatory mediator release. Am J Respir Crit Care Med: 2013; 187 6 589 595
18. Walsh M. C., Yao Q., Gettner P., et al. National Institute of Child Health and Human Development Neonatal Research Network. Impact of a physiologic definition on bronchopulmonary dysplasia rates. Pediatrics: 2004; 114 5 1305 1311