Risk factors and outcomes for multidrug-resistant Gram-negative bacteremia in the NICU

Pediatrics

Volumn 133, Issue 2, 2014, Pages

  Tsai, Ming Horng ^a,b,c   Chu, Shih Ming ^a,b   Hsu, Jen Fu ^a,b   Lien, Reyin ^a,b   Huang, Hsuan Rong ^a,b   Chiang, Ming Chou ^a,b   Fu, Ren Huei ^a,b   Lee, Chiang Wen ^c   Huang, Yhu Chering ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Bacteremia; Extended spectrum lactamase producing bacteria; Gram negative bacilli; Mortality; Nosocomial infection

Indexed keywords

BACTEREMIA; EXTENDED-SPECTRUM Β-LACTAMASE-PRODUCING BACTERIA; GRAM-NEGATIVE BACILLI; MORTALITY; NOSOCOMIAL INFECTION;

BACTEREMIA; CARBAPENEMS; COHORT STUDIES; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; MALE; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME;

EID: 84893246856     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2013-1248     Document Type: Article

References (38)

1. Atif ML, Sadaoui F, Bezzaoucha A, et al. Prolongation of hospital stay and additional costs due to nosocomial bloodstream infection in an Algerian neonatal care unit. Infect Control Hosp Epidemiol. 2008;29(11):1066-1070
2. Schlapbach LJ, Aebischer M, Adams M, et al Swiss Neonatal Network and Follow-Up Group. Impact of sepsis on neurodevelopmental outcome in a Swiss National Cohort of extremely premature infants. Pediatrics. 2011;128(2). Available at: www.pediatrics.org/cgi/content/full/128/2/e348
3. Cohen-Wolkowiez M, Moran C, Benjamin DK, et al. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J. 2009; 28(12):1052-1056
4. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B. Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics. 2002;109(1):34-39
5. Gordon A, Isaacs D. Late onset neonatal Gram-negative bacillary infection in Australia and New Zealand: 1992-2002. Pediatr Infect Dis J. 2006;25(1):25-29
6. Apisarnthanarak A, Holzmann-Pazgal G, Hamvas A, Olsen MA, Fraser VJ. Antimicrobial use and the influence of inadequate empiric antimicrobial therapy on the outcomes of nosocomial bloodstream infections in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2004;25(9):735-741
7. Foglia EE, Fraser VJ, Elward AM. Effect of nosocomial infections due to antibiotic-resistant organisms on length of stay and mortality in the pediatric intensive care unit. Infect Control Hosp Epidemiol. 2007;28 (3):299-306
8. Anderson B, Nicholas S, Sprague B, Campos J, Short B, Singh N. Molecular and descriptive epidemiology of multidrug-resistant Enterobacteriaceae in hospitalized infants. Infect Control Hosp Epidemiol. 2008;29(3): 250-255
9. Toltzis P, Dul MJ, Hoyen C, et al. Molecular epidemiology of antibiotic-resistant gram-negative bacilli in a neonatal intensive care unit during a nonoutbreak period. Pediatrics. 2001;108(5):1143-1148
10. Mammina C, Di Carlo P, Cipolla D, et al. Surveillance of multidrug-resistant gram-negative bacilli in a neonatal intensive care unit: prominent role of cross transmission. Am J Infect Control. 2007;35(4): 222-230
11. Toltzis P, Dul MJ, Hoyen C, et al. The effect of antibiotic rotation on colonization with antibiotic-resistant bacilli in a neonatal intensive care unit. Pediatrics. 2002;110(4): 707-711
12. Maragakis LL, Winkler A, Tucker MG, et al. Outbreak of multidrug-resistant Serratia marcescens infection in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2008;29(5):418-423
13. Güngör S, Ozen M, Akinci A, Durmaz R. A Chryseobacterium meningosepticum outbreak in a neonatal ward. Infect Control Hosp Epidemiol. 2003;24(8):613-617
14. Gray JE, Richardson DK, McCormick MC, Workman-Daniels K, Goldmann DA. Neonatal therapeutic intervention scoring system: a therapy-based severity-of-illness index. Pediatrics. 1992;90(4):561-567
15. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309-332
16. Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drugresistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3): 268-281
17. Sutter D, Stagliano D, Braun L, et al. Polymicrobial bloodstream infection in pediatric patients: risk factors, microbiology, and antimicrobial management. Pediatr Infect Dis J. 2008;27(5):400-405
18. Taeusch HW, Ballard RA, Gleason CA. Avery's Diseases of the Newborn. 8th ed. Philadelphia, PA: Elsevier Saunders; 2006
19. Kermorvant-Duchemin E, Laborie S, Rabilloud M, Lapillonne A, Claris O. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med. 2008;9(2):186-191
20. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twenty-second Informational Supplement M100-S22. Wayne, PA: Clinical and Laboratory Standards Institute; 2012
21. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk Susceptibility Tests: Approved Standard - Tenth Informational Supplement M02-A10. Wayne, PA: Clinical and Laboratory Standards Institute; 2009
22. Chia JH, Chu C, Su LH, et al. Development of a multiplex PCR and SHV melting-curve mutation detection system for detection of some SHV and CTX-M beta-lactamases of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae in Taiwan. J Clin Microbiol. 2005;43(9):4486-4491
23. Shu JC, Chia JH, Kuo AJ, Su LH, Wu TL. A 7-year surveillance for ESBL-producing Escherichia coli and Klebsiella pneumoniae at a university hospital in Taiwan: the increase of CTX-M-15 in the ICU. Epidemiol Infect. 2010;138(2):253-263
24. Singh N, Patel KM, Léger MM, et al. Risk of resistant infections with Enterobacteriaceae in hospitalized neonates. Pediatr Infect Dis J. 2002;21(11):1029-1033
25. Huang Y, Zhuang S, Du M. Risk factors of nosocomial infection with extended-spectrum beta-lactamase-producing bacteria in a neonatal intensive care unit in China. Infection. 2007;35(5):339-345
26. Litzow JM, Gill CJ, Mantaring JB, et al. High frequency of multidrug-resistant gram-negative rods in 2 neonatal intensive care units in the Philippines. Infect Control Hosp Epidemiol. 2009;30(6):543-549
27. Linkin DR, Fishman NO, Patel JB, Merrill JD, Lautenbach E. Risk factors for extendedspectrum beta-lactamase-producing Enterobacteriaceae in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2004;25 (9):781-783
28. Le J, Nguyen T, Okamoto M, McKamy S, Lieberman JM. Impact of empiric antibiotic use on development of infections caused by extended-spectrum beta-lactamase bacteria in a neonatal intensive care unit. Pediatr Infect Dis J. 2008;27(4):314-318
29. Kritsotakis EI, Tsioutis C, Roumbelaki M, Christidou A, Gikas A. Antibiotic use and the risk of carbapenem-resistant extendedspectrum-b- lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: results of a double case-control study. J Antimicrob Chemother. 2011;66(6):1383-1391
30. Gudiol C, Tubau F, Calatayud L, et al. Bacteraemia due to multidrug-resistant Gramnegative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother. 2011;66 (3):657-663
31. Peralta G, Sánchez MB, Garrido JC, et al. Impact of antibiotic resistance and of adequate empirical antibiotic treatment in the prognosis of patients with Escherichia coli bacteraemia. J Antimicrob Chemother. 2007;60(4):855-863
32. Schwaber MJ, Carmeli Y. Mortality and delay in effective therapy associated with extended-spectrum b-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis. J Antimicrob Chemother. 2007;60(5):913-920
33. Kang CI, Kim SH, Park WB, et al. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother. 2005;49(2):760-766
34. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B; Israel Neonatal Network. Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. Clin Infect Dis. 2005;40(2):218-224
35. Lee J, Pai H, Kim YK, et al. Control of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a children's hospital by changing antimicrobial agent usage policy. J Antimicrob Chemother. 2007;60(3):629-637
36. Velasco C, Rodríguez-Baño J, García L, et al. Eradication of an extensive outbreak in a neonatal unit caused by two sequential Klebsiella pneumoniae clones harbouring related plasmids encoding an extendedspectrum beta-lactamase. J Hosp Infect. 2009;73(2):157-163
37. Paterson DL. Impact of antibiotic resistance in gram-negative bacilli on empirical and definitive antibiotic therapy. Clin Infect Dis. 2008;47(suppl 1):S14-S20
38. Bagattini M, Crivaro V, Di Popolo A, et al. Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit. J Antimicrob Chemother. 2006;57(5):979-982