메뉴 건너뛰기




Volumn 34, Issue 34, 2016, Pages 4025-4031

Virus-like particle-based vaccine against coxsackievirus A6 protects mice against lethal infections

Author keywords

Coxsackievirus A6; Hand, foot, and mouth disease; Vaccine; Virus like particle

Indexed keywords

PROTEIN 3CD; PROTEIN P1; PROTEIN VP1; PROTEIN VP3; RECOMBINANT VACCINE; UNCLASSIFIED DRUG; VIRUS LIKE PARTICLE VACCINE; ANTISERUM; CAPSID PROTEIN; VIRUS ANTIBODY; VIRUS VACCINE;

EID: 84979283009     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2016.06.028     Document Type: Article
Times cited : (22)

References (41)
  • 1
    • 84906960592 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease: identifying and managing an acute viral syndrome
    • [1] Repass, G.L., Palmer, W.C., Stancampiano, F.F., Hand, foot, and mouth disease: identifying and managing an acute viral syndrome. Cleve Clin J Med 81 (2014), 537–543.
    • (2014) Cleve Clin J Med , vol.81 , pp. 537-543
    • Repass, G.L.1    Palmer, W.C.2    Stancampiano, F.F.3
  • 2
    • 77954931134 scopus 로고    scopus 로고
    • Human enterovirus 71 and hand, foot and mouth disease
    • [2] Wong, S.S., Yip, C.C., Lau, S.K., Yuen, K.Y., Human enterovirus 71 and hand, foot and mouth disease. Epidemiol Infect 138 (2010), 1071–1089.
    • (2010) Epidemiol Infect , vol.138 , pp. 1071-1089
    • Wong, S.S.1    Yip, C.C.2    Lau, S.K.3    Yuen, K.Y.4
  • 3
    • 78649635618 scopus 로고    scopus 로고
    • The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains
    • [3] Wu, Y., Yeo, A., Phoon, M.C., Tan, E.L., Poh, C.L., Quak, S.H., et al. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis 14 (2010), e1076–e1081.
    • (2010) Int J Infect Dis , vol.14 , pp. e1076-e1081
    • Wu, Y.1    Yeo, A.2    Phoon, M.C.3    Tan, E.L.4    Poh, C.L.5    Quak, S.H.6
  • 4
    • 84896492664 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease in China, 2008–12: an epidemiological study
    • [4] Xing, W., Liao, Q., Viboud, C., Zhang, J., Sun, J., Wu, J.T., et al. Hand, foot, and mouth disease in China, 2008–12: an epidemiological study. Lancet Infect Dis 14 (2014), 308–318.
    • (2014) Lancet Infect Dis , vol.14 , pp. 308-318
    • Xing, W.1    Liao, Q.2    Viboud, C.3    Zhang, J.4    Sun, J.5    Wu, J.T.6
  • 5
    • 84939209670 scopus 로고    scopus 로고
    • Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide
    • [5] Bian, L., Wang, Y., Yao, X., Mao, Q., Xu, M., Liang, Z., Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. Expert Rev Anti Infect Ther 13 (2015), 1061–1071.
    • (2015) Expert Rev Anti Infect Ther , vol.13 , pp. 1061-1071
    • Bian, L.1    Wang, Y.2    Yao, X.3    Mao, Q.4    Xu, M.5    Liang, Z.6
  • 6
    • 84905009449 scopus 로고    scopus 로고
    • Hand, foot and mouth disease in Guangdong, China, in 2013: new trends in the continuing epidemic
    • [6] Lu, J., Zeng, H., Zheng, H., Yi, L., Guo, X., Liu, L., et al. Hand, foot and mouth disease in Guangdong, China, in 2013: new trends in the continuing epidemic. Clin Microbiol Infect 20 (2014), O442–O445.
    • (2014) Clin Microbiol Infect , vol.20 , pp. O442-O445
    • Lu, J.1    Zeng, H.2    Zheng, H.3    Yi, L.4    Guo, X.5    Liu, L.6
  • 7
    • 84925493453 scopus 로고    scopus 로고
    • Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013
    • [7] Tan, X.J., Li, L., Zhang, B.M., Jorba, J., Su, X., Ji, T.J., et al. Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013. Arch Virol 160 (2015), 1097–1104.
    • (2015) Arch Virol , vol.160 , pp. 1097-1104
    • Tan, X.J.1    Li, L.2    Zhang, B.M.3    Jorba, J.4    Su, X.5    Ji, T.J.6
  • 8
    • 84862025486 scopus 로고    scopus 로고
    • Notes from the field: severe hand, foot, and mouth disease associated with coxsackievirus A6 – Alabama, Connecticut, California, and Nevada, vol. 61, November 2011–February 2012. MMWR Morb Mortal Wkly Rep; 2012. p. 213–4.
    • [8] Notes from the field: severe hand, foot, and mouth disease associated with coxsackievirus A6 – Alabama, Connecticut, California, and Nevada, vol. 61, November 2011–February 2012. MMWR Morb Mortal Wkly Rep; 2012. p. 213–4.
    • (2012) , pp. 213-4
  • 9
    • 84859923573 scopus 로고    scopus 로고
    • Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study
    • [9] Mirand, A., Henquell, C., Archimbaud, C., Ughetto, S., Antona, D., Bailly, J.L., et al. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin Microbiol Infect 18 (2012), E110–E118.
    • (2012) Clin Microbiol Infect , vol.18 , pp. E110-E118
    • Mirand, A.1    Henquell, C.2    Archimbaud, C.3    Ughetto, S.4    Antona, D.5    Bailly, J.L.6
  • 10
    • 77950595652 scopus 로고    scopus 로고
    • Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland
    • [10] Blomqvist, S., Klemola, P., Kaijalainen, S., Paananen, A., Simonen, M.L., Vuorinen, T., et al. Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J Clin Virol 48 (2010), 49–54.
    • (2010) J Clin Virol , vol.48 , pp. 49-54
    • Blomqvist, S.1    Klemola, P.2    Kaijalainen, S.3    Paananen, A.4    Simonen, M.L.5    Vuorinen, T.6
  • 11
    • 84939605352 scopus 로고    scopus 로고
    • Fourteen types of co-circulating recombinant enterovirus were associated with hand, foot, and mouth disease in children from Wenzhou, China
    • [11] Guo, W.P., Lin, X.D., Chen, Y.P., Liu, Q., Wang, W., Wang, C.Q., et al. Fourteen types of co-circulating recombinant enterovirus were associated with hand, foot, and mouth disease in children from Wenzhou, China. J Clin Virol 70 (2015), 29–38.
    • (2015) J Clin Virol , vol.70 , pp. 29-38
    • Guo, W.P.1    Lin, X.D.2    Chen, Y.P.3    Liu, Q.4    Wang, W.5    Wang, C.Q.6
  • 12
    • 84930170326 scopus 로고    scopus 로고
    • Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity
    • [12] Gaunt, E., Harvala, H., Osterback, R., Sreenu, V.B., Thomson, E., Waris, M., et al. Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity. J Gen Virol 96 (2015), 1067–1079.
    • (2015) J Gen Virol , vol.96 , pp. 1067-1079
    • Gaunt, E.1    Harvala, H.2    Osterback, R.3    Sreenu, V.B.4    Thomson, E.5    Waris, M.6
  • 13
    • 84934779769 scopus 로고    scopus 로고
    • A novel recombinant lineage's contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012–2013
    • [13] Feng, X., Guan, W., Guo, Y., Yu, H., Zhang, X., Cheng, R., et al. A novel recombinant lineage's contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012–2013. Sci Rep, 5, 2015, 11700.
    • (2015) Sci Rep , vol.5 , pp. 11700
    • Feng, X.1    Guan, W.2    Guo, Y.3    Yu, H.4    Zhang, X.5    Cheng, R.6
  • 14
    • 84886554467 scopus 로고    scopus 로고
    • Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6- and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China
    • [14] He, Y.Q., Chen, L., Xu, W.B., Yang, H., Wang, H.Z., Zong, W.P., et al. Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6- and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China. J Clin Microbiol 51 (2013), 3560–3566.
    • (2013) J Clin Microbiol , vol.51 , pp. 3560-3566
    • He, Y.Q.1    Chen, L.2    Xu, W.B.3    Yang, H.4    Wang, H.Z.5    Zong, W.P.6
  • 15
    • 84927742058 scopus 로고    scopus 로고
    • Phylogenetic analysis of the major causative agents of hand, foot and mouth disease in Suzhou city, Jiangsu province, China, in 2012–2013
    • [15] Zhang, C., Zhu, R., Yang, Y., Chi, Y.D., Yin, J.Y., Tang, X.Y., et al. Phylogenetic analysis of the major causative agents of hand, foot and mouth disease in Suzhou city, Jiangsu province, China, in 2012–2013. Emerg Microb Inf, 2015, 4.
    • (2015) Emerg Microb Inf , pp. 4
    • Zhang, C.1    Zhu, R.2    Yang, Y.3    Chi, Y.D.4    Yin, J.Y.5    Tang, X.Y.6
  • 16
    • 84884235020 scopus 로고    scopus 로고
    • Coxsackievirus A6 and hand, foot and mouth disease: three case reports of familial child-to-immunocompetent adult transmission and a literature review
    • [16] Kaminska, K., Martinetti, G., Lucchini, R., Kaya, G., Mainetti, C., Coxsackievirus A6 and hand, foot and mouth disease: three case reports of familial child-to-immunocompetent adult transmission and a literature review. Case Rep Dermatol 5 (2013), 203–209.
    • (2013) Case Rep Dermatol , vol.5 , pp. 203-209
    • Kaminska, K.1    Martinetti, G.2    Lucchini, R.3    Kaya, G.4    Mainetti, C.5
  • 17
    • 84897030989 scopus 로고    scopus 로고
    • Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014
    • [17] Sinclair, C., Gaunt, E., Simmonds, P., Broomfield, D., Nwafor, N., Wellington, L., et al. Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014. Euro Surveill, 19, 2014, 20745.
    • (2014) Euro Surveill , vol.19 , pp. 20745
    • Sinclair, C.1    Gaunt, E.2    Simmonds, P.3    Broomfield, D.4    Nwafor, N.5    Wellington, L.6
  • 18
    • 79959573078 scopus 로고    scopus 로고
    • Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009
    • [18] Lo, S.H., Huang, Y.C., Huang, C.G., Tsao, K.C., Li, W.C., Hsieh, Y.C., et al. Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009. J Microbiol Immunol Infect 44 (2011), 252–257.
    • (2011) J Microbiol Immunol Infect , vol.44 , pp. 252-257
    • Lo, S.H.1    Huang, Y.C.2    Huang, C.G.3    Tsao, K.C.4    Li, W.C.5    Hsieh, Y.C.6
  • 19
    • 83355161454 scopus 로고    scopus 로고
    • An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010
    • [19] Wei, S.H., Huang, Y.P., Liu, M.C., Tsou, T.P., Lin, H.C., Lin, T.L., et al. An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010. BMC Infect Dis, 11, 2011, 346.
    • (2011) BMC Infect Dis , vol.11 , pp. 346
    • Wei, S.H.1    Huang, Y.P.2    Liu, M.C.3    Tsou, T.P.4    Lin, H.C.5    Lin, T.L.6
  • 20
    • 84910116068 scopus 로고    scopus 로고
    • Epididymitis caused by coxsackievirus A6 in association with hand, foot, and mouth disease
    • [20] Vuorinen, T., Osterback, R., Kuisma, J., Ylipalosaari, P., Epididymitis caused by coxsackievirus A6 in association with hand, foot, and mouth disease. J Clin Microbiol 52 (2014), 4412–4413.
    • (2014) J Clin Microbiol , vol.52 , pp. 4412-4413
    • Vuorinen, T.1    Osterback, R.2    Kuisma, J.3    Ylipalosaari, P.4
  • 21
    • 33747077515 scopus 로고    scopus 로고
    • Molecular typing of enteroviruses associated with viral meningitis in Cyprus, 2000–2002
    • [21] Richter, J., Koptides, D., Tryfonos, C., Christodoulou, C., Molecular typing of enteroviruses associated with viral meningitis in Cyprus, 2000–2002. J Med Microbiol 55 (2006), 1035–1041.
    • (2006) J Med Microbiol , vol.55 , pp. 1035-1041
    • Richter, J.1    Koptides, D.2    Tryfonos, C.3    Christodoulou, C.4
  • 23
    • 0016727690 scopus 로고
    • Propagation and isolation of group A coxsackieviruses in RD cells
    • [23] Schmidt, N.J., Ho, H.H., Lennette, E.H., Propagation and isolation of group A coxsackieviruses in RD cells. J Clin Microbiol 2 (1975), 183–185.
    • (1975) J Clin Microbiol , vol.2 , pp. 183-185
    • Schmidt, N.J.1    Ho, H.H.2    Lennette, E.H.3
  • 24
    • 0019435009 scopus 로고
    • Use of guinea pig embryo cell cultures for isolation and propagation of group A coxsackieviruses
    • [24] Landry, M.L., Madore, H.P., Fong, C.K., Hsiung, G.D., Use of guinea pig embryo cell cultures for isolation and propagation of group A coxsackieviruses. J Clin Microbiol 13 (1981), 588–593.
    • (1981) J Clin Microbiol , vol.13 , pp. 588-593
    • Landry, M.L.1    Madore, H.P.2    Fong, C.K.3    Hsiung, G.D.4
  • 25
    • 84947441773 scopus 로고    scopus 로고
    • Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice
    • [25] Yang, L., Li, S., Liu, Y., Hou, W., Lin, Q., Zhao, H., et al. Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice. Virus Res 210 (2015), 165–168.
    • (2015) Virus Res , vol.210 , pp. 165-168
    • Yang, L.1    Li, S.2    Liu, Y.3    Hou, W.4    Lin, Q.5    Zhao, H.6
  • 26
    • 84874332378 scopus 로고    scopus 로고
    • Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre- and post-attachment steps
    • [26] Ku, Z., Ye, X., Huang, X., Cai, Y., Liu, Q., Li, Y., et al. Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre- and post-attachment steps. PLoS ONE, 8, 2013, e57601.
    • (2013) PLoS ONE , vol.8 , pp. e57601
    • Ku, Z.1    Ye, X.2    Huang, X.3    Cai, Y.4    Liu, Q.5    Li, Y.6
  • 27
    • 84949685281 scopus 로고    scopus 로고
    • Single neutralizing monoclonal antibodies targeting the VP1 GH loop of enterovirus 71 inhibit both virus attachment and internalization during viral entry
    • [27] Ku, Z., Ye, X., Shi, J., Wang, X., Liu, Q., Huang, Z., Single neutralizing monoclonal antibodies targeting the VP1 GH loop of enterovirus 71 inhibit both virus attachment and internalization during viral entry. J Virol 89 (2015), 12084–12095.
    • (2015) J Virol , vol.89 , pp. 12084-12095
    • Ku, Z.1    Ye, X.2    Shi, J.3    Wang, X.4    Liu, Q.5    Huang, Z.6
  • 28
    • 79952184229 scopus 로고    scopus 로고
    • Detection, characterization and quantitation of coxsackievirus A16 using polyclonal antibodies against recombinant capsid subunit proteins
    • [28] Liu, Q.W., Ku, Z.Q., Cai, Y.C., Sun, B., Leng, Q.B., Huang, Z., Detection, characterization and quantitation of coxsackievirus A16 using polyclonal antibodies against recombinant capsid subunit proteins. J Virol Methods 173 (2011), 115–120.
    • (2011) J Virol Methods , vol.173 , pp. 115-120
    • Liu, Q.W.1    Ku, Z.Q.2    Cai, Y.C.3    Sun, B.4    Leng, Q.B.5    Huang, Z.6
  • 29
    • 84867482187 scopus 로고    scopus 로고
    • A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge
    • [29] Liu, Q., Yan, K., Feng, Y., Huang, X., Ku, Z., Cai, Y., et al. A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge. Vaccine 30 (2012), 6642–6648.
    • (2012) Vaccine , vol.30 , pp. 6642-6648
    • Liu, Q.1    Yan, K.2    Feng, Y.3    Huang, X.4    Ku, Z.5    Cai, Y.6
  • 30
    • 84890876293 scopus 로고    scopus 로고
    • Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms
    • [30] Ye, X., Ku, Z., Liu, Q., Wang, X., Shi, J., Zhang, Y., et al. Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms. J Virol 88 (2014), 72–81.
    • (2014) J Virol , vol.88 , pp. 72-81
    • Ye, X.1    Ku, Z.2    Liu, Q.3    Wang, X.4    Shi, J.5    Zhang, Y.6
  • 31
    • 84903819994 scopus 로고    scopus 로고
    • A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice
    • [31] Ku, Z., Liu, Q., Ye, X., Cai, Y., Wang, X., Shi, J., et al. A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice. Vaccine 32 (2014), 4296–4303.
    • (2014) Vaccine , vol.32 , pp. 4296-4303
    • Ku, Z.1    Liu, Q.2    Ye, X.3    Cai, Y.4    Wang, X.5    Shi, J.6
  • 32
    • 40849137446 scopus 로고    scopus 로고
    • Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge
    • [32] Chung, Y.C., Ho, M.S., Wu, J.C., Chen, W.J., Huang, J.H., Chou, S.T., et al. Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge. Vaccine 26 (2008), 1855–1862.
    • (2008) Vaccine , vol.26 , pp. 1855-1862
    • Chung, Y.C.1    Ho, M.S.2    Wu, J.C.3    Chen, W.J.4    Huang, J.H.5    Chou, S.T.6
  • 33
    • 33645050114 scopus 로고    scopus 로고
    • Expression, purification and characterization of enterovirus-71 virus-like particles
    • [33] Chung, Y.C., Huang, J.H., Lai, C.W., Sheng, H.C., Shih, S.R., Ho, M.S., et al. Expression, purification and characterization of enterovirus-71 virus-like particles. World J Gastroenterol 12 (2006), 921–927.
    • (2006) World J Gastroenterol , vol.12 , pp. 921-927
    • Chung, Y.C.1    Huang, J.H.2    Lai, C.W.3    Sheng, H.C.4    Shih, S.R.5    Ho, M.S.6
  • 34
    • 84899837750 scopus 로고    scopus 로고
    • Cryo-electron microscopy study of insect cell-Expressed enterovirus 71 and coxsackievirus A16 virus-like particles provides a structural basis for vaccine development
    • [34] Gong, M.Q., Zhu, H.T., Zhou, J., Yang, C.T., Feng, J., Huang, X.J., et al. Cryo-electron microscopy study of insect cell-Expressed enterovirus 71 and coxsackievirus A16 virus-like particles provides a structural basis for vaccine development. J Virol 88 (2014), 6444–6452.
    • (2014) J Virol , vol.88 , pp. 6444-6452
    • Gong, M.Q.1    Zhu, H.T.2    Zhou, J.3    Yang, C.T.4    Feng, J.5    Huang, X.J.6
  • 35
    • 84957438394 scopus 로고    scopus 로고
    • Characterizing enterovirus 71 and coxsackievirus A16 virus-like particles production in insect cells
    • [35] Somasundaram, B., Chang, C., Fan, Y.Y., Lim, P.Y., Cardosa, J., Lua, L., Characterizing enterovirus 71 and coxsackievirus A16 virus-like particles production in insect cells. Methods 95 (2016), 38–45.
    • (2016) Methods , vol.95 , pp. 38-45
    • Somasundaram, B.1    Chang, C.2    Fan, Y.Y.3    Lim, P.Y.4    Cardosa, J.5    Lua, L.6
  • 36
  • 37
    • 84907974648 scopus 로고    scopus 로고
    • Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases
    • [37] Liu, C.C., Chow, Y.H., Chong, P., Klein, M., Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases. Vaccine 32 (2014), 6177–6182.
    • (2014) Vaccine , vol.32 , pp. 6177-6182
    • Liu, C.C.1    Chow, Y.H.2    Chong, P.3    Klein, M.4
  • 38
    • 84963947307 scopus 로고    scopus 로고
    • Is a multivalent hand, foot, and mouth disease vaccine feasible?
    • [38] Klein, M., Chong, P., Is a multivalent hand, foot, and mouth disease vaccine feasible?. Hum Vacc Immunother 11 (2015), 2688–2704.
    • (2015) Hum Vacc Immunother , vol.11 , pp. 2688-2704
    • Klein, M.1    Chong, P.2
  • 39
    • 84921599753 scopus 로고    scopus 로고
    • Towards broadly protective polyvalent vaccines against hand, foot and mouth disease
    • [39] Liu, Q., Tong, X., Huang, Z., Towards broadly protective polyvalent vaccines against hand, foot and mouth disease. Microbes Infect 17 (2015), 155–162.
    • (2015) Microbes Infect , vol.17 , pp. 155-162
    • Liu, Q.1    Tong, X.2    Huang, Z.3
  • 40
    • 84898437031 scopus 로고    scopus 로고
    • A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses
    • [40] Cai, Y., Ku, Z., Liu, Q., Leng, Q., Huang, Z., A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses. Vaccine 32 (2014), 2406–2412.
    • (2014) Vaccine , vol.32 , pp. 2406-2412
    • Cai, Y.1    Ku, Z.2    Liu, Q.3    Leng, Q.4    Huang, Z.5
  • 41
    • 84921383706 scopus 로고    scopus 로고
    • Evaluation of monovalent and bivalent vaccines against lethal enterovirus 71 and coxsackievirus A16 infection in newborn mice
    • [41] Sun, S., Jiang, L., Liang, Z., Mao, Q., Su, W., Zhang, H., et al. Evaluation of monovalent and bivalent vaccines against lethal enterovirus 71 and coxsackievirus A16 infection in newborn mice. Hum Vacc Immunother 10 (2014), 2885–2895.
    • (2014) Hum Vacc Immunother , vol.10 , pp. 2885-2895
    • Sun, S.1    Jiang, L.2    Liang, Z.3    Mao, Q.4    Su, W.5    Zhang, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.