Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice

Virus Research

Volumn 210, Issue , 2015, Pages 165-168

  Yang, Lisheng ^a   Li, Shuxuan ^a   Liu, Yajing ^a   Hou, Wangheng ^a   Lin, Qiaona ^a   Zhao, Huan ^a   Xu, Longfa ^a   He, Delei ^a   Ye, Xiangzhong ^b   Zhu, Hua ^c   Cheng, Tong ^a   Xia, Ningshao ^a  

^a XIAMEN UNIVERSITY   (China)

^b Beijing Wantai Biological Pharmacy Enterprise Co Ltd   (China)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Animal model; Coxsackievirus A6; Enterovirus; HFMD; Infectious clone

Indexed keywords

PLASMID VECTOR; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; COXSACKIE VIRUS INFECTION; COXSACKIEVIRUS A6; CYTOPATHOGENIC EFFECT; ENTEROVIRUS; GENETIC TRANSFECTION; MOLECULAR CLONING; MOUSE; NEWBORN; NONHUMAN; PHYLOGENETIC TREE; PHYLOGENY; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; VIRUS GENOME; VIRUS PARTICLE; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; CLUSTER ANALYSIS; DISEASE MODEL; DNA SEQUENCE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; NUCLEIC ACID AMPLIFICATION; PATHOGENICITY; PATHOLOGY; PLASMID; REVERSE GENETICS; SEQUENCE HOMOLOGY; TAIWAN; ULTRASTRUCTURE; VIRION; VIROLOGY; VIRULENCE;

ANIMALS; ANIMALS, NEWBORN; CLONING, MOLECULAR; CLUSTER ANALYSIS; COXSACKIEVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; ENTEROVIRUS; GENOME, VIRAL; HUMANS; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PHYLOGENY; PLASMIDS; REVERSE GENETICS; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY; TAIWAN; VIRION; VIRULENCE;

EID: 84947441773     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2015.08.002     Document Type: Article

References (23)

1. Arita M., Shimizu H., Nagata N., Ami Y., Suzaki Y., Sata T., Iwasaki T., Miyamura T. Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys. J. Gen. Virol. 2005, 86(5):1391-1401.
2. Blomqvist S., Klemola P., Kaijalainen S., Paananen A., Simonen M.-L., Vuorinen T., Roivainen M. Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J. Clin. Virol. 2010, 48(1):49-54.
3. Chen K.-T., Chang H.-L., Wang S.-T., Cheng Y.-T., Yang J.-Y. Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. Pediatrics 2007, 120(2):e244-e252.
4. Chen P., Song Z., Qi Y., Feng X., Xu N., Sun Y., Wu X., Yao X., Mao Q., Li X., Dong W., Wan X., Huang N., Shen X., Liang Z., Li W. Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2. J. Biol. Chem. 2012, 287(9):6406-6420.
5. Chong P., Guo M.-S., Lin F.H.-Y., Hsiao K.-N., Weng S.-Y., Chou A.-H., Wang J.-R., Hsieh S.-Y., Su I.-J., Liu C.-C. Immunological and biochemical characterization of coxsackie virus A16 viral particles. PLoS One 2012, 7(11):e49973.
6. Cordey S., Petty T.J., Schibler M., Martinez Y., Gerlach D., van Belle S., Turin L., Zdobnov E., Kaiser L., Tapparel C. Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection. PLoS Pathog. 2012, 8(7):e1002826.
7. Feder H.M., Bennett N., Modlin J.F. Atypical hand, foot, and mouth disease: a vesiculobullous eruption caused by Coxsackie virus A6. Lancet Infect. Dis. 2014, 14(1):83-86.
8. Gibson D.G., Young L., Chuang R.-Y., Venter J.C., Hutchison C.A., Smith H.O. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 2009, 6(5):343-345.
9. Guimbao J., Rodrigo P., Alberto M., Omenaca M. 2010. Onychomadesis outbreak linked to hand, foot, and mouth disease, Spain, July 2008. Euro Surveill. 2010, 15(37):1.
10. Hou W., Yang L., Li S., Yu H., Xu L., He D., Chen M., He S., Ye X., Que Y., Shih J.W., Cheng T., Xia N. Construction and characterization of an infectious cDNA clone of Echovirus 25. Virus Res. 2015, 205(0):41-44.
11. Kung Y.-H., Huang S.-W., Kuo P.-H., Kiang D., Ho M.-S., Liu C.-C., Yu C.-K., Su I.-J., Wang J.-R. Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase. Virology 2010, 396(1):1-9.
12. Liu F., Liu Q., Cai Y., Leng Q., Huang Z. Construction and characterization of an infectious clone of coxsackievirus A16. Virol. J. 2011, 8(1):534-541.
13. Lu Q.-B., Zhang X.-A., Wo Y., Xu H.-M., Li X.-J., Wang X.-J., Ding S.-J., Chen X.-D., He C., Liu L.-J. Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009-2011. PloS one 2012, 7(12):e52073.
14. McMinn P., Stratov I., Nagarajan L., Davis S. Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia. Clin. Infect. Dis. 2001, 32(2):236-242.
15. Meng T., Kolpe A.B., Kiener T.K., Chow V.T., Kwang J. Display of VP1 on the surface of baculovirus and its immunogenicity against heterologous human enterovirus 71 strains in mice. PLoS One 2011, 6(7):e21757.
16. Ramirez-Fort M.K., Downing C., Doan H.Q., Benoist F., Oberste M.S., Khan F., Tyring S.K. Coxsackievirus A6 associated hand, foot and mouth disease in adults: clinical presentation and review of the literature. J. Clin. Virol. 2014, 60(4):381-386.
17. Sadeghipour S., Bek E.J., McMinn P.C. Ribavirin-resistant mutants of human enterovirus 71 express a high replication fidelity phenotype during growth in cell culture. J. Virol. 2013, 87(3):1759-1769.
18. Shih S.-R., Chiang C., Chen T.-C., Wu C.-N., Hsu J.T.-A., Lee J.-C., Hwang M.-J., Li M.-L., Chen G.-W., Ho M.-S. Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities. J. Biomed. Sci. 2004, 11(2):239-248.
19. Tang W.-F., Yang S.-Y., Wu B.-W., Jheng J.-R., Chen Y.-L., Shih C.-H., Lin K.-H., Lai H.-C., Tang P., Horng J.-T. Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. J. Biol. Chem. 2007, 282(8):5888-5898.
20. Wang G., Cao R.Y., Chen R., Mo L., Han J.F., Wang X., Xu X., Jiang T., Deng Y.Q., Lyu K., Zhu S.Y., Qin E.D., Tang R., Qin C.F. Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions. Proc. Natl. Acad. Sci. U. S. A. 2013, 7619-7624.
21. Wang X., Peng W., Ren J., Hu Z., Xu J., Lou Z., Li X., Yin W., Shen X., Porta C. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat. Struct. Mol. Biol. 2012, 19(4):424-429.
22. Wei S.-H., Huang Y.-P., Liu M.-C., Tsou T.-P., Lin H.-C., Lin T.-L., Tsai C.-Y., Chao Y.-N., Chang L.-Y., Hsu C.-M. An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010. BMC Infect. Dis. 2011, 11(1):346.
23. Yamayoshi S., Yamashita Y., Li J., Hanagata N., Minowa T., Takemura T., Koike S. Scavenger receptor B2 is a cellular receptor for enterovirus 71. Nat. Med. 2009, 15(7):798-801.