Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 7, 2016, Pages 1660-1663

  Feng, Yun ^a   Yang, Dazhang ^a   Chen, Hongbo ^b   Cheng, Wenli ^a   Wang, Lixia ^b   Sun, Hongxia ^b   Tang, Yalin ^b  

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^b INSTITUTE OF CHEMISTRY   (China)

Author keywords

Bcl 2 gene; G quadruplex; P1 promoter; Pyridostatin analog; Transcription

Indexed keywords

ANTINEOPLASTIC AGENT; DOUBLE STRANDED DNA; GUANINE QUADRUPLEX; LUCIFERASE; PROTEIN BCL 2; PROTEIN INHIBITOR; PYRIDOSTATIN; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; DNA; PICOLINIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; HEP 2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LARYNX SQUAMOUS CELL CARCINOMA; LUCIFERASE ASSAY; PROTEIN EXPRESSION; THERMOSTABILITY; TRANSCRIPTION INITIATION; CARCINOMA, SQUAMOUS CELL; CHEMISTRY; DOWN REGULATION; DRUG EFFECTS; GENETICS; LARYNGEAL NEOPLASMS; LARYNX; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

AMINOQUINOLINES; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DNA; DOWN-REGULATION; G-QUADRUPLEXES; HUMANS; LARYNGEAL NEOPLASMS; LARYNX; PICOLINIC ACIDS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSCRIPTIONAL ACTIVATION;

EID: 84979026168     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.02.065     Document Type: Article

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