Alterations of p53 and Bcl-2 protein expression in the recurrent laryngeal and pharyngeal squamous cell carcinoma

American Journal of Otolaryngology - Head and Neck Medicine and Surgery

Volumn 32, Issue 3, 2011, Pages 210-214

  Rashad, Usama M ^a,b   Hussein, Mahmoud R ^a   Algizawy, Samy M ^a  

^a Assiut University Faculty of Medicine   (Egypt)

^b KING FAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; MALE; MUCOSA CELL; PHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT CANCER; SQUAMOUS CELL CARCINOMA; TUMOR BIOPSY; UPREGULATION;

ADULT; AGED; BIOPSY, NEEDLE; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INCIDENCE; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PHARYNGEAL NEOPLASMS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RISK ASSESSMENT; SAMPLING STUDIES; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79955521920     PISSN: 01960709     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjoto.2010.01.012     Document Type: Article

References (13)

1. Condon L.T., Ashman J.N., and Ell S.R. Overexpression of Bcl-2 in squamous cell carcinoma of the larynx: a marker of radioresistance Int J Cancer 100 2002 472 475
2. Sanz-Ortega J., Valor C., and Saez M.C. 3p21, 5q21, 9p21 and 17p13 allelic deletions accumulate in the dysplastic spectrum of laryngeal carcinogenesis and precede malignant transformation Histol Histopathol 18 2003 1053 1057 (Pubitemid 37265008)
3. Hussein M.R., Haemel A.K., and Wood G.S. p53-related pathways and the molecular pathogenesis of melanoma Eur J Cancer Prev 12 2003 93 100 (Pubitemid 36543422)
4. Erdamar B., Keles N., and Kaur A. Expression of the cyclin-kinase inhibitors p21(WAF1) and p27(Kip1) and the p53 tumor suppressor genes in adult-onset laryngeal papillomas Eur Arch Otorhinolaryngol 259 2002 516 520 (Pubitemid 35352108)
5. Assimakopoulos D., Kolettas E., and Zagorianakou N. Prognostic significance of p53 in the cancer of the larynx Anticancer Res 20 2000 3555 3564
6. Chen W.L., Guo X.F., and Quan C.S. The expression and significance of Bcl-2 and Bax in each phase of the cell cycle in laryngeal carcinoma Zhonghua Er Bi Yan Hou Ke Za Zhi 39 2004 157 161
7. Megha T., Ferrari F., and Benvenuto A. p53 mutation in breast cancer. Correlation with cell kinetics and cell of origin J Clin Pathol 55 2002 461 466 (Pubitemid 34620784)
8. Hussein M.R., Sun M., and Roggero E. Loss of heterozygosity, microsatellite instability, and mismatch repair protein alterations in the radial growth phase of cutaneous malignant melanomas Mol Carcinog 34 2002 35 44 (Pubitemid 34461655)
9. Chan W.Y., Cheung K.K., and Schorge J.O. Bcl-2 and p53 protein expression, apoptosis, and p53 mutation in human epithelial ovarian cancers Am J Pathol 156 2000 409 417 (Pubitemid 30643795)
10. Wikonkal N.M., Berg R.J., and van Haselen C.W. Bcl-2 vs p53 protein expression and apoptotic rate in human nonmelanoma skin cancers Arch Dermatol 133 1997 599 602 (Pubitemid 27214969)
11. Hardisson D. Molecular pathogenesis of head and neck squamous cell carcinoma D Eur Arch Otorhinolaryngol 260 2003 502 508 (Pubitemid 37363578)
12. Anwar K., Nakakuki K., and Imai H. Over-expression of p53 protein in human laryngeal carcinoma Int J Cancer 53 1993 952 956 (Pubitemid 23119542)
13. Lo Muzio L., Mignoga M.D., and Pannone G. Expression of Bcl-2 in oral squamous cell carcinoma: an immunohistochemical study of 90 cases with clinico-pathological correlations Oncol Rep 10 2003 285 291