Prevalence of anaemia and the relationship between haemoglobin concentration and CD4 count in HIV positive children on highly active antiretroviral therapy (HAART) in Lagos, Nigeria

Current Pediatric Research

Volumn 20, Issue 1-2, 2016, Pages 29-36

  Ahumareze, Regina Esiovwa ^a   Rankin, Jean ^a   David, Agatha ^b   Wapmuk, Agatha ^b   Disu, Elizabeth ^c   Balogun, Yetunde ^c   Adetunji, Adebukola ^b   Macarthur, Ewan ^a   Amoo, Olufemi ^b  

^a UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

^b NIGERIAN INSTITUTE OF MEDICAL RESEARCH   (Nigeria)

^c LAGOS STATE UNIVERSITY TEACHING HOSPITAL   (Nigeria)

Author keywords

Anaemia; CD4 count; Haemoglobin; HIV; Nigeria

Indexed keywords

ANTIRETROVIRUS AGENT; HEMOGLOBIN; MULTIVITAMIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANEMIA; ARTICLE; CD4 LYMPHOCYTE COUNT; CHILD; DISEASE ASSOCIATION; FEMALE; HEALTH STATUS; HEMOGLOBIN DETERMINATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; NIGERIA; OUTPATIENT; PREDICTION; PRESCHOOL CHILD; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCHOOL CHILD; TREATMENT DURATION;

EID: 84979025804     PISSN: 09719032     EISSN: 09761691     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Obirikorang C, Yeboah F A. ‘Blood haemoglobin measurement as a predictive indicator for the progression of HIV/AIDS in resource-limited setting’. Journal of Biomedical Science 2009; 16: 102.
2. Buskin S E, Sullivan PS. ‘Anemia and its treatment and outcomes in persons infected with human immunodeficiency virus’. Transfusion 2004; 44: 826–832.
3. Volberding P. ‘The Impact of Anemia on Quality of Life in Human Immunodeficiency Virus–Infected Patients’. The Journal of Infectious Diseases 2002; 185: S110–S114.
4. Umar I, Hassan-Hanga F, Ibrahim M. ‘Prevalence of anaemia in paediatric patients with HIV infection in Kano’. Nigerian Journal of Paediatrics 2015; 42:103–106.
5. Meidani M, Rezaei F, Maracy M, et al. Prevalence, severity, and related factors of anemia in HIV/AIDS patients’. J Res Med Sci. 2012; 17: 138–142.
6. Erhabor O, Ejele O, Nwauche C et al. ‘Some haematological parameters in Human Immunodeficiency Virus (HIV) infected Africans: the Nigerian perspective’. Nigerian Journal of Medicine 2005; 14.
7. Volberding P., Levine AM, Dieterich D, et al. ‘Anemia in HIV Infection: Clinical Impact and Evidence-Based Management Strategies’. Clinical Infectious Diseases 2004; 38:1454–1463.
8. Nandlal V, Moodley D, Grobler A, et al. ‘Anaemia in pregnancy is associated with advanced HIV disease’. PloS one 2014; 9.
9. Wills T, Nadler J, Somboonwit C, et al. ‘Anemia prevalence and associated risk factors in a single-center ambulatory HIV clinical cohort’. AIDS Read. 2004; 14: 305–313.
10. Bain BJ. ‘Pathogenesis and pathophysiology of anemia in HIV infection’. Current Opinion in Hematology 1999; 6: 89.
11. Sullivan PS, Hanson DL, Chu S, et al. ‘Epidemiology of Anemia in Human Immunodeficiency Virus (HIV)-Infected Persons: Results From the Multistate Adult and Adolescent Spectrum of HIV Disease Surveillance Project’. Blood 1998; 91: 301–308.
12. Munyazesa E, Emile I, Mutimura E, et al. ‘Assessment of haematological parameters in HIV-infected and uninfected Rwandan women: a cross-sectional study’. BMJ Open 2012; 2: e001600–e001600.
13. Maciejewski J, Weichold F, Young N. ‘HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha’. J Immunol 1994; 153: 4303–4310.
14. Belperio PS, Rhew DC. ‘Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: a systematic review of the literature’. The American Journal of Medicine 2004; 116:27–43.
15. Mocroft A, Kirk O, Barton SE, et al. ‘Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe’. AIDS 1999; 13: 943–950.
16. Anastos K, Shi Q, French A, et al. ‘Total lymphocyte count, haemoglobin, and delayed-type hypersensitivity as predictors of death and AIDS illness in HIV-1-infected women receiving highly active antiretroviral therapy’. Journal of acquired immune deficiency syndromes 2004; 35.
17. Nacoulma E, Some Y, Tieno H, et al. ‘Haematological parameters evolution during the antiretroviral therapy of HIV infected patients in Burkina-Faso’. Bull Soc Pathol Exot 2007; 100: 271–274.
18. Berhane K, Karim R, Cohen MH, et al. ‘Impact of Highly Active Antiretroviral Therapy on Anemia and Relationship between Anemia and Survival in a Large Cohort of HIV-Infected Women’. JAIDS Journal of Acquired Immune Deficiency Syndromes 2004 37: 1245–1252.
19. Kibaru EG, Nduati R, Wamalwa D, et al. ‘Impact of highly active antiretroviral therapy on hematological indices among HIV-1 infected children at Kenyatta national Hospital-Kenya: Retrospective study’. AIDS Res Therapy 2015; 12.
20. Teklemariam Z, Mitiku H, Mesfin F. ‘Prevalence of anemia and nutritional status among HIV-positive children receiving antiretroviral therapy in Harar, eastern Ethiopa’. HIV/AIDS 2015; 5:191–196.
21. Mihiretie H, Taye B, Tsegaye A. ‘Magnitude of anemia and associated factors among pediatric HIV/AIDS patients attending Zewditu memorial hospital ART Clinic, Addis Ababa, Ethiopia’. Anemia 2015.
22. WHO. Worldwide prevalence of anaemia 1993–2005.WHO Global Database on Anaemia 2008.
23. Levine A, Berhane K, Masri-Lavine L, et al. ‘Prevalence and correlates of anemia in a large cohort of HIV-infected women: Women’s interagency HIV study’. Journal of acquired immune deficiency syndromes 2001; 26: 28–35.
24. Osazuwa F, Ayo OM. ‘Contribution of malnutrition and malaria to anemia in children in rural communities of Edo state, Nigeria’. N Am J Med Sci 2010; 2.
25. Thakur N, Chandra J, Pemde H et al. ‘Anemia in severe acute malnutrition’. Nutrition 2014; 4.
26. Semba RD, Shah N, Vlahov D. ‘Improvement of anemia among HIV-Infected injection drug users receiving highly active antiretroviral therapy. JAIDS 2001; 26: 315–319.
27. Huang SS, Barbour JD, Deeks SG, et al. ‘Reversal of human immunodeficiency virus type 1-Associated Hematosuppression by effective Antiretroviral therapy’. Clinical Infectious Diseases 2000; 30: 504–510.
28. Isgrò A, Mezzaroma I, Aiuti A, et al. ‘Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy’. AIDS research and human retroviruses 2000; 16: 1471–1479.
29. Sloand E, Maciejewski J, Kumar P, et al, ‘Protease inhibitors stimulate hematopoiesis and decrease apoptosis and ICE expression in CD34(+) cells’. Blood 2000; 96: 2735–2739.
30. Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children. Guidelines for the use of Antiretroviral agents in pediatric HIV infection 2011.
31. WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity 2011.
32. WHO. Interim WHO clinical staging of HIV/AIDS and HIV/AIDS case definitions for surveillance: African Region 2005.
33. Tesfaye Z, Enawgaw B. ‘Prevalence of anemia before and after initiation of highly active antiretroviral therapy among HIV positive patients in northwest Ethiopia: A retrospective study’. BMC Research Notes 2014; 7: 745.
34. De Santis GC, Brunetta DM, Vilar FC, et al. ‘Hematological abnormalities in HIV-infected patients’. International Journal of Infectious Diseases 2011; 15: e808–e811.
35. Mata-Marín JA, Martínez-Martínez RE, Gaytán-Martínez JE, et al. ‘Risk factors and correlates for anemia in HIV treatment-naïve infected patients: A cross-sectional analytical study’. BMC Research Notes 2010; 3: 230.
36. Renner L, Dicko F, Kouéta F, et al. ‘Anaemia and zidovudinecontaining antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric west African database to evaluate AIDS’. Journal of the International AIDS Society 2013; 17.
37. Abebe M, Alemseged F. ‘Hematologic abormalities among children on Haart, in Jimma university specialized hospital, southwestern ethiopia’. Ethiopian Journal of Health Sciences 2009; 19.
38. Jaganath D, Walker SA, Ssali F, et al. ‘HIV-Associated anemia after 96 weeks on therapy: Determinants across age ranges in Uganda and Zimbabwe’. AIDS Res Hum Retroviruses 2014; 30: 523–530.
39. Ughasoro MD, Emodi IJ, Okafor HU, et al. ‘Prevalence of moderate and severe Anaemia in children under 5 in university of Nigeria teaching hospital Enugu, southeast Nigeria’. Pediatric Research 2011; 70:489–489.
40. Noland GS, Graves PM, Sallau A, et al. ‘Malaria prevalence, anemia and baseline intervention coverage prior to mass net distributions in Abia and plateau states, Nigeria’. BMC Infect Dis 2014; 14.
41. Giganti MJ, Limbada M, Mwango A, et al. ‘Six-month hemoglobin concentration and its association with subsequent mortality among adults on antiretroviral therapy in Lusaka, Zambia’. J Acquir Immune Defic Syndr 2012; 61.
42. Johannessen A, Naman E, Gundersen SG, et al. ‘Antiretroviral treatment reverses HIV-associated anemia in rural Tanzania’. BMC Infectious Diseases 2011; 11: 190.
43. Masaisa F, Gahutu JB, Mukiibi J, et al. ‘Anemia in human immunodeficiency Virus–Infected and uninfected women in Rwanda’. Am J Trop Med Hyg 2011; 84.
44. Agarwal D, Chakravarty J, Chaube L, et al. ‘High incidence of zidovudine induced anaemia in HIV infected patients in eastern India’. The Indian journal of medical research 2010; 132.
45. Moyle G, Sawyer W, Law M, et al. ‘Changes in hematologic parameters and efficacy of thymidine analogue-based, highly active antiretroviral therapy: A meta-analysis of six prospective, randomized, comparative studies’. Clinical therapeutics 2004; 1.
46. Koduri P, Parekh S. ‘Zidovudine-related anemia with reticulocytosis’. Annals of hematology 2003; 3.
47. Shen Y, Wang Z, Lu H, et al. ‘Prevalence of anemia among adults with newly diagnosed HIV/AIDS in china’. PLoS One 2013; 8.
48. Emuchay C, Okeniyi S, Okeniyi J. ‘Correlation between total lymphocyte count, hemoglobin, hematocrit and CD4 count in HIV patients in Nigeria’. PJBS 2014; 4.
49. Pande A, Bhattacharyya M, Pain S, et al. ‘Anemia in Antiretroviral Naïve HIV/AIDS Patients: A Study from Eastern India’. Online Journal of Health & Allied Sciences 2012; 10.
50. Sen S, Vyas A, Sanghi S, et al. ‘Correlation of CD4+ T cell count with total lymphocyte count, haemoglobin and erythrocyte sedimentation rate levels in human immunodeficiency virus type-1 disease’. Medical Journal Armed Forces India 2011; 67:15–20.
51. Alavi S, Ahmadi F, Farhadi M. ‘Correlation between total Lymphocyte count, hemoglobin, Hematocrit and CD4 count in HIV/AIDS patients’. Acta Medica Iranica 2009; 47:1–4.
52. Smith C, Sabin C, Lampe F, et al. ‘The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapy’. AIDS 2003; 7.
53. Hunt P, Deeks S, Rodriguez B, et al. ‘Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy’. AIDS 2003; 13.
54. Olawumi H, Olatunji P, Salami A, et al. ‘Effect of highly active antiretroviral therapy on CD4 count and weight in AIDS patients seen at the UITH, Ilorin’. Nigerian journal of clinical practice 2009; 4.
55. Sarcletti M, Quirchmair G, Weiss G, et al. ‘Increase of haemoglobin levels by anti-retroviral therapy is associated with a decrease in immune activation’. European journal of haematology 2003; 1.
56. Ezeonwu B, Ikefuna A, Oguonu T, et al. ‘Prevalence of hematological abnormalities and malnutrition in HIV-infected under five children in Enugu’. Nigerian journal of clinical practice 2014; 3.
57. Fuchs D, Zangerle R, Artner-Dworzak E, et al. ‘Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection’. European journal of haematology 1993; 2.
58. Silva E, Grotto H, Vilela M. ‘Clinical aspects and complete blood counts in children exposed to HIV-1: Comparison between infected patients and seroreverters’. Jornal de pediatria 2001; 6.
59. Spacek L, Griswold M, Quinn T, et al. ‘Total lymphocyte count and hemoglobin combined in an algorithm to initiate the use of highly active antiretroviral therapy in resourcelimited settings’. AIDS 2003; 9.
60. WHO. Treatment and care 2015.
61. AIDS. Overview of HIV treatments 2015.
62. Grinsztejn B, Hosseinipour MC, Ribaudo HJ, et al. ‘Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial’. Lancet Infect Dis 2014; 14.
63. Osazuwa F, Ayo OM, Imade P. ‘A significant association between intestinal helminth infection and anaemia burden in children in rural communities of Edo state, Nigeria’. N Am J Med Sci 2011; 3: 30–34.
64. Ekwochi U, Osuorah D, Odetunde O, et al. ‘Prevalence of iron deficiency anaemia in anaemic under-5 children in Enugu south east Nigeria’. Nigerian Journal of Paediatrics 2014; 41:129.
65. Wilhan EB. ‘Total lymphocyte count and hemoglobin combined to predict CD4 lymphocyte counts of less than 200 cells/mm(3) in HIV/AIDS’. Acta medica Indonesiana 2008; 40: 59–62.