Validation of NICE diagnostic guidance for rule out of myocardial infarction using high-sensitivity troponin tests

Heart

Volumn 102, Issue 16, 2016, Pages 1279-1286

  Parsonage, W A ^a   Mueller, C ^b   Greenslade, J H ^a   Wildi, K ^b   Pickering, J ^c   Than, M ^c   Aldous, S ^c   Boeddinghaus, J ^b   Hammett, C J ^a   Hawkins, T ^a   Nestelberger, T ^b   Reichlin, T ^b   Reidt, S ^b   Rubin Gimenez, M ^b   Tate, J R ^a   Twerenbold, R ^b   Ungerer, J P ^a   Cullen, L ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH SENSITIVITY TROPONIN; TROPONIN; TROPONIN I; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; TROPONIN T;

ACUTE HEART INFARCTION; ADULT; AGED; ALGORITHM; ARTICLE; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; EMERGENCY WARD; FEMALE; HEART DEATH; HEART INFARCTION; HUMAN; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; OBSERVATIONAL STUDY; PRACTICE GUIDELINE; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TERTIARY CARE CENTER; THORAX PAIN; VALIDATION STUDY; ADOLESCENT; ANGINA PECTORIS; BLOOD; CARDIOLOGY SERVICE; COMPLICATION; DECISION SUPPORT SYSTEM; HOSPITAL EMERGENCY SERVICE; MIDDLE AGED; MULTICENTER STUDY; MYOCARDIAL INFARCTION; NEW ZEALAND; PREDICTIVE VALUE; PROGNOSIS; QUEENSLAND; REPRODUCIBILITY; STANDARDS; SWITZERLAND; TIME FACTOR; UPREGULATION; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; ANGINA PECTORIS; BIOMARKERS; CARDIOLOGY SERVICE, HOSPITAL; DECISION SUPPORT TECHNIQUES; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NEW ZEALAND; PRACTICE GUIDELINES AS TOPIC; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; QUEENSLAND; REPRODUCIBILITY OF RESULTS; SWITZERLAND; TERTIARY CARE CENTERS; TIME FACTORS; TROPONIN I; TROPONIN T; UP-REGULATION; YOUNG ADULT;

EID: 84979025655     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2016-309270     Document Type: Article

References (30)

1. Bhuiya F, Pitts SR, McCaig LF. Emergency department visits for chest pain and abdominal pain: United States, 1999-2008. NCHS data brief. Hyattsville, MD, USA: U.S. Department of Health and Human Services Centers for Disease Control and Prevention NCfHS, 2010:1-8.
2. Than M, Cullen L, Aldous S, et al. A 2-hour accelerated Diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial. J Am Coll Cardiol 2012;59:2091-8.
3. Thygesen K, Alpert JS, Jaffe AS, et al. Third Universal Definition of Myocardial Infarction. Circulation 2012;126:2020-35.
4. Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin (CG95) National Institute for Health and Clinical Excellence, 2010.
5. Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;64:e139-228.
6. Apple FS. A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem 2009;55:1303-6.
7. Bandstein N, Ljung R, Johansson M, et al. Undetectable high-sensitivity cardiac troponin t level in the emergency department and risk of myocardial infarction. J Am Coll Cardiol 2014;63:2569-78.
8. Shah AS, Anand A, Sandoval Y, et al. High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study. Lancet 2015;386:2481-8.
9. Myocardial infarction (acute): Early rule out using high-sensitivity troponin tests (Elecsys Troponin T high-sensitive, ARCHITECT STAT High Sensitive Troponin-I and AccuTnI+3 assays)(DG15). National Institute for Health and Care Excellence, 2014.
10. George T, Ashover S, Cullen L, et al. Introduction of an accelerated diagnostic protocol in the assessment of emergency department patients with possible acute coronary syndrome: the Nambour Short Low-Intermediate Chest pain project. Emerg Med Australas 2013;25:340-4.
11. Reichlin T, Schindler C, Drexler B, et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch Intern Med 2012;172:1211-18.
12. Reichlin T, Hochholzer W, Bassetti S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009;361:858-67.
13. Aroney CN, Aylward P, Kelly A, et al. Guidelines for the management of acute coronary syndromes. Med J Aust 2006;184(8 Suppl):S1-29.
14. Cullen L, Than M, Brown AF, et al. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas 2010;22:35-55.
15. Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2011;32:2999-3054.
16. Zamora J, Abraira V, Muriel A, et al. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol 2006;6:31.
17. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. Br Med J 2003;327:557-60.
18. Wildi K, Gimenez MR, Twerenbold R, et al. Misdiagnosis of Myocardial Infarction Related to Limitations of the Current Regulatory Approach to Define Clinical Decision Values for Cardiac Troponin. Circulation 2015;131:2032-40.
19. Than M, Herbert M, Flaws D, et al. What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the Emergency Department?: A clinical survey. Int J Cardiol 2013;166:752-4.
20. Boeddinghaus J, Reichlin T, Cullen L, et al. Two-Hour Algorithm for Triage Toward Rule-Out and Rule-In of Acute Myocardial Infarction by Use of High-Sensitivity Cardiac Troponin I. Clin Chem 2016;62:494-504.
21. Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 2016;37:267-315.
22. Update: Elecsys® cardiac troponin T-high sensitive assay. Roche Diagnostics; 2012. Report Number IM12-014.
23. Apple FS, Jaffe AS. Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware. Clin Chem 2012;58:1599-600.
24. Hoeller R, Rubini Giménez M, Reichlin T, et al. Normal presenting levels of high-sensitivity troponin and myocardial infarction. Heart 2013;99:1567-72.
25. Aldous SJ, Florkowski CM, Crozier IG, et al. Comparison of high sensitivity and contemporary troponin assays for the early detection of acute myocardial infarction in the emergency department. Ann Clin Biochem 2011;48(Pt 3):241-8.
26. Aldous SJ, Richards M, Cullen L, et al. Diagnostic and prognostic utility of early measurement with high-sensitivity troponin T assay in patients presenting with chest pain. CMAJ 2012;184:E260-8.
27. Body R, Carley S, McDowell G, et al. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol 2011;58:1332-9.
28. Christ M, Popp S, Pohlmann H, et al. Implementation of high sensitivity cardiac troponin T measurement in the emergency department. Am J Med 2010;123:1134-42.
29. Reiter M, Twerenbold R, Reichlin T, et al. Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays. Eur Heart J 2011;32:1379-89.
30. Parsonage WA, Tate JR, Greenslade JH, et al. Effect of recalibration of the hs-TnT assay on diagnostic performance. Clin Chem Lab Med 2014;52:e25-27.