Neutrophil Fluorescence: A New Indicator of Cell Activation during Septic Shock-Induced Disseminated Intravascular Coagulation

Critical Care Medicine

Volumn 44, Issue 11, 2016, Pages e1132-e1136

  Stiel, Laure ^a,b   Delabranche, Xavier ^a,b   Galoisy, Anne Cécile ^c   Severac, François ^d   Toti, Florence ^b   Mauvieux, Laurent ^b,c   Meziani, Ferhat ^a,b   Boisramé Helms, Julie ^a,b  

^a HÔPITAL CIVIL   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c HÔPITAL DE HAUTEPIERRE   (France)

^d UNIVERSITY HOSPITAL OF STRASBOURG   (France)

Author keywords

disseminated intravascular coagulation; fluorescence; microparticles; neutrophils; septic shock

Indexed keywords

CD66B ANTIGEN; LEUKOCYTE ANTIGEN; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; VPM CHLORIDE;

ADULT; ARTICLE; ASSAY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; FLOW CYTOMETRY; FLUORESCENT LIGHTING; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE MICROPARTICLE; MAJOR CLINICAL STUDY; NEUTROPHIL COUNT; NEUTROPHIL SIDE FLUORESCENCE LIGHT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTHROMBINASE ASSAY; SENSITIVITY AND SPECIFICITY; SEPTIC SHOCK; CELL COUNT; COMPLICATION; DISSEMINATED INTRAVASCULAR COAGULATION; FLUORESCENCE; INTENSIVE CARE UNIT; NEUTROPHIL; PHYSIOLOGY;

CELL COUNT; DISSEMINATED INTRAVASCULAR COAGULATION; FLOW CYTOMETRY; FLUORESCENCE; HUMANS; INDOLES; INTENSIVE CARE UNITS; NEUTROPHIL ACTIVATION; NEUTROPHILS; PROSPECTIVE STUDIES; SHOCK, SEPTIC;

EID: 84978975200     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001851     Document Type: Article

References (9)

1. Fourrier F: Severe sepsis, coagulation, and fibrinolysis: Dead end or one way? Crit Care Med 2012; 40:2704-2708
2. Gando S, Iba T, Eguchi Y, et al; Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DiC) Study Group: A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria. Crit Care Med 2006; 34:625-631
3. Taylor FB Jr, Toh CH, Hoots WK, et al; Scientific Subcommittee on Disseminated Intravascular Coagulation (DiC) of the International Society on Thrombosis and Haemostasis (ISTH): Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001; 86:1327-1330
4. Delabranche X, Quenot JP, Lavigne T, et al; on behalf to the Clinical Research in Intensive Care and Sepsis Network: Early detection of disseminated intravascular coagulation during septic shock: A multicentre prospective study. Crit Care Med 2016 Jun 17. [Epub ahead of print]
5. Chung S, Kim JE, Park S, et al: Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: In vitro effect of thrombin on monocyte CD163 shedding. Thromb Res 2011; 127:450-456
6. Engelmann B, Massberg S: Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol 2013; 13:34-45
7. Zonneveld R, Molema G, Plotz FB: Analyzing neutrophil morphology, mechanics, and motility in sepsis: Options and challenges for novel bedside technologies. Crit Care Med 2016; 44:218-228
8. Matsumoto H: The technology of reagents in the automated hematology analyzers Sysmex XE-2100™-Red fluorescence technology. Sysmex J Int 1999; 9:179-185
9. Park SH, Park CJ, Lee BR, et al: Sepsis affects most routine and cell population data (CPD) obtained using the Sysmex XN-2000 blood cell analyzer: Neutrophil-related CPD NE-SFL and NE-WY provide useful information for detecting sepsis. Int J Lab Hematol 2015; 37:190-198