-
1
-
-
19644379014
-
The burden of atopic dermatitis: Impact on the patient, family, and society
-
Carroll CL, Balkrishnan R, Feldman SR, et al. The burden of atopic dermatitis: impact on the patient, family, and society. Pediatr Dermatol. 2005;22:192-199.
-
(2005)
Pediatr Dermatol
, vol.22
, pp. 192-199
-
-
Carroll, C.L.1
Balkrishnan, R.2
Feldman, S.R.3
-
2
-
-
37749025593
-
Atopic dermatitis
-
Bieber T. Atopic dermatitis. N Engl J Med. 2008;358:1483-1494.
-
(2008)
N Engl J Med
, vol.358
, pp. 1483-1494
-
-
Bieber, T.1
-
3
-
-
84939937146
-
New pathogenic and therapeutic paradigms in atopic dermatitis
-
Malajian D, Guttman-Yassky E. New pathogenic and therapeutic paradigms in atopic dermatitis. Cytokine. 2015;73:311-318.
-
(2015)
Cytokine
, vol.73
, pp. 311-318
-
-
Malajian, D.1
Guttman-Yassky, E.2
-
4
-
-
84922352134
-
The translational revolution and use of biologics in patients with inflammatory skin diseases
-
Noda S, Krueger JG, Guttman-Yassky E. The translational revolution and use of biologics in patients with inflammatory skin diseases. J Allergy Clin Immunol. 2015;135:324-336.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 324-336
-
-
Noda, S.1
Krueger, J.G.2
Guttman-Yassky, E.3
-
5
-
-
84904049668
-
Skin barrier and immune dysregulation in atopic dermatitis: An evolving story with important clinical implications
-
Czarnowicki T, Krueger JG, Guttman-Yassky E. Skin barrier and immune dysregulation in atopic dermatitis: an evolving story with important clinical implications. J Allergy Clin Immunol Pract. 2014;2:371-379.
-
(2014)
J Allergy Clin Immunol Pract
, vol.2
, pp. 371-379
-
-
Czarnowicki, T.1
Krueger, J.G.2
Guttman-Yassky, E.3
-
8
-
-
84903303598
-
Guidelines of care for the management of atopic dermatitis: Section 2. Management and treatment of atopic dermatitis with topical therapies
-
Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71:116-132.
-
(2014)
J Am Acad Dermatol
, vol.71
, pp. 116-132
-
-
Eichenfield, L.F.1
Tom, W.L.2
Berger, T.G.3
-
9
-
-
63149123045
-
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis
-
Akama T, Baker SJ, Zhang YK, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009;19:2129-2132.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 2129-2132
-
-
Akama, T.1
Baker, S.J.2
Zhang, Y.K.3
-
10
-
-
84901193124
-
A review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology
-
Moustafa F, Feldman SR. A review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology. Dermatol Online J. 2014;20:22608.
-
(2014)
Dermatol Online J
, vol.20
, pp. 22608
-
-
Moustafa, F.1
Feldman, S.R.2
-
11
-
-
84919632880
-
Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells
-
Tan Y, Watkins AA, Freeman BB, et al. Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. J Immunol. 2015;194:101-112.
-
(2015)
J Immunol
, vol.194
, pp. 101-112
-
-
Tan, Y.1
Watkins, A.A.2
Freeman, B.B.3
-
12
-
-
70350708143
-
Phosphodiesterase 3 and 4 negatively regulate receptor activator of nuclear factor-kappaB ligand-mediated osteoclast formation by prostaglandin E2
-
Noh AL, Yang M, Lee JM, et al. Phosphodiesterase 3 and 4 negatively regulate receptor activator of nuclear factor-kappaB ligand-mediated osteoclast formation by prostaglandin E2. Biol Pharm Bull. 2009;32:1844-1848.
-
(2009)
Biol Pharm Bull
, vol.32
, pp. 1844-1848
-
-
Noh, A.L.1
Yang, M.2
Lee, J.M.3
-
13
-
-
4644223413
-
Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes
-
Jimenez JL, Iniguez MA, Munoz-Fernandez MA, Fresno M. Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes. Cell Signal. 2004;16:1363-1373.
-
(2004)
Cell Signal
, vol.16
, pp. 1363-1373
-
-
Jimenez, J.L.1
Iniguez, M.A.2
Munoz-Fernandez, M.A.3
Fresno, M.4
-
14
-
-
84866611020
-
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center
-
Freund YR, Akama T, Alley MR, et al. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012;586:3410-3414.
-
(2012)
FEBS Lett
, vol.586
, pp. 3410-3414
-
-
Freund, Y.R.1
Akama, T.2
Alley, M.R.3
-
15
-
-
70449368604
-
AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis
-
Nazarian R, Weinberg JM. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009;10:1236-1242.
-
(2009)
Curr Opin Investig Drugs
, vol.10
, pp. 1236-1242
-
-
Nazarian, R.1
Weinberg, J.M.2
-
16
-
-
84878996237
-
New insights into atopic dermatitis: Role of skin barrier and immune dysregulation
-
Leung DY. New insights into atopic dermatitis: role of skin barrier and immune dysregulation. Allergol Int. 2013;62:151-161.
-
(2013)
Allergol Int
, vol.62
, pp. 151-161
-
-
Leung, D.Y.1
-
17
-
-
84908095090
-
Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches
-
Leung DY, Guttman-Yassky E. Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. J Allergy Clin Immunol. 2014;134:769-779.
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 769-779
-
-
Leung, D.Y.1
Guttman-Yassky, E.2
-
18
-
-
84870294267
-
Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
-
Gittler JK, Shemer A, Suarez-Farinas M, et al. Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol. 2012;130:1344-1354.
-
(2012)
J Allergy Clin Immunol
, vol.130
, pp. 1344-1354
-
-
Gittler, J.K.1
Shemer, A.2
Suarez-Farinas, M.3
-
19
-
-
34247889972
-
Therapeutic benefit of PDE4 inhibitors in inflammatory diseases
-
Dastidar SG, Rajagopal D, Ray A. Therapeutic benefit of PDE4 inhibitors in inflammatory diseases. Curr Opin Investig Drugs. 2007;8:364-372.
-
(2007)
Curr Opin Investig Drugs
, vol.8
, pp. 364-372
-
-
Dastidar, S.G.1
Rajagopal, D.2
Ray, A.3
-
20
-
-
33947687574
-
Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis
-
Baumer W, Hoppmann J, Rundfeldt C, Kietzmann M. Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis. Inflamm Allergy Drug Targets. 2007;6:17-26.
-
(2007)
Inflamm Allergy Drug Targets
, vol.6
, pp. 17-26
-
-
Baumer, W.1
Hoppmann, J.2
Rundfeldt, C.3
Kietzmann, M.4
-
21
-
-
0027155666
-
Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate- Phosphodiesterase activity and is reversible by phosphodiesterase inhibition
-
Chan SC, Li SH, Hanifin JM. Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate- phosphodiesterase activity and is reversible by phosphodiesterase inhibition. J Invest Dermatol. 1993;100:681-684.
-
(1993)
J Invest Dermatol
, vol.100
, pp. 681-684
-
-
Chan, S.C.1
Li, S.H.2
Hanifin, J.M.3
-
22
-
-
0029147508
-
Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis
-
Hanifin JM, Chan SC. Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis. J Invest Dermatol. 1995;105:84S-88S.
-
(1995)
J Invest Dermatol
, vol.105
, pp. 84S-88S
-
-
Hanifin, J.M.1
Chan, S.C.2
-
23
-
-
0030056483
-
Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis
-
Hanifin JM, Chan SC, Cheng JB, et al. Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. J Invest Dermatol. 1996;107:51-56.
-
(1996)
J Invest Dermatol
, vol.107
, pp. 51-56
-
-
Hanifin, J.M.1
Chan, S.C.2
Cheng, J.B.3
-
24
-
-
84858636270
-
A phase 2, open-label, investigator-initiated study to evaluate the safety and efficacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis
-
Volf EM, Au SC, Dumont N, et al. A phase 2, open-label, investigator-initiated study to evaluate the safety and efficacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis. J Drugs Dermatol. 2012;11:341-346.
-
(2012)
J Drugs Dermatol
, vol.11
, pp. 341-346
-
-
Volf, E.M.1
Au, S.C.2
Dumont, N.3
-
25
-
-
77952192978
-
Is PDE4 too difficult a drug target?
-
Higgs G. Is PDE4 too difficult a drug target? Curr Opin Investig Drugs. 2010;11:495-498.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 495-498
-
-
Higgs, G.1
-
26
-
-
84937880965
-
Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)
-
Papp K, Reich K, Leonardi CL, et al. Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1). J Am Acad Dermatol. 2015;73:37-49.
-
(2015)
J Am Acad Dermatol
, vol.73
, pp. 37-49
-
-
Papp, K.1
Reich, K.2
Leonardi, C.L.3
-
27
-
-
84899981396
-
Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor
-
Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor. Ann Rheum Dis. 2014;73:1020-1026.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 1020-1026
-
-
Kavanaugh, A.1
Mease, P.J.2
Gomez-Reino, J.J.3
-
28
-
-
84924250308
-
Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): A multicentre randomised controlled trial
-
Martinez FJ, Calverley PM, Goehring UM, et al. Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet. 2015;385:857-866.
-
(2015)
Lancet
, vol.385
, pp. 857-866
-
-
Martinez, F.J.1
Calverley, P.M.2
Goehring, U.M.3
-
29
-
-
84894482680
-
From the test tube to the teatment room: Fundamentals of boron-containing compounds and their relevance to dermatology
-
Del Rosso JQ, Plattner JJ. From the test tube to the teatment room: fundamentals of boron-containing compounds and their relevance to dermatology. J Clin Aesthet Dermatol. 2014;7:13-21.
-
(2014)
J Clin Aesthet Dermatol
, vol.7
, pp. 13-21
-
-
Del Rosso, J.Q.1
Plattner, J.J.2
-
31
-
-
84878910411
-
An assessment of the genetic toxicology of novel boron-containing therapeutic agents
-
Ciaravino V, Plattner J, Chanda S. An assessment of the genetic toxicology of novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013;54:338-346.
-
(2013)
Environ Mol Mutagen
, vol.54
, pp. 338-346
-
-
Ciaravino, V.1
Plattner, J.2
Chanda, S.3
-
32
-
-
85029003365
-
Maximal use systemic exposure (MUSE) study evaluating AN2728 topical ointment, 2%, a boron-based small molecule for the treatment of mild-to-moderate atopic dermatitis in children 2 to 17 years of age [poster]
-
September 10-13 Copenhagen Denmark
-
Kircik L, Call R, Tschen E, et al. Maximal use systemic exposure (MUSE) study evaluating AN2728 topical ointment, 2%, a boron-based small molecule for the treatment of mild-to-moderate atopic dermatitis in children 2 to 17 years of age [poster]. Presented at the Annual Meeting of the European Society for Dermatological Research, September 10-13, 2014, Copenhagen, Denmark.
-
(2014)
Annual Meeting of The European Society for Dermatological Research
-
-
Kircik, L.1
Call, R.2
Tschen, E.3
-
33
-
-
84988472794
-
A phase 2, randomized, controlled, dose-ranging study evaluating AN2728 topical ointment, 0.5% and 2% in adolescents with mild to moderate atopic dermatitis
-
Stein Gold LF, Spelman L, Spellman MC, et al. A phase 2, randomized, controlled, dose-ranging study evaluating AN2728 topical ointment, 0.5% and 2% in adolescents with mild to moderate atopic dermatitis. J Drugs Dermatol. 2015;14:1394-1399.
-
(2015)
J Drugs Dermatol
, vol.14
, pp. 1394-1399
-
-
Stein Gold, L.F.1
Spelman, L.2
Spellman, M.C.3
-
34
-
-
84978926390
-
AN2728 topical ointment, 2% in adults with atopic dermatitis: A phase 2a, vehicle-controlled, proof-of-concept study
-
Murrell DF, Gebauer K, Spelman L, Zane LT. AN2728 topical ointment, 2% in adults with atopic dermatitis: a phase 2a, vehicle-controlled, proof-of-concept study. J Drugs Dermatol. 2015;14:1108-1112.
-
(2015)
J Drugs Dermatol
, vol.14
, pp. 1108-1112
-
-
Murrell, D.F.1
Gebauer, K.2
Spelman, L.3
Zane, L.T.4
-
35
-
-
85028966296
-
Safety, pharmacokinetics and efficacy of AN2728 ointment, 2% in a phase 2 study of adolescents with mild-to-moderate atopic dermatitis [poster
-
May 8-11 Edinburgh Scotland
-
Zane LT, Tom WL, Chanda S, Liu L, Van Syoc M. Safety, pharmacokinetics and efficacy of AN2728 ointment, 2% in a phase 2 study of adolescents with mild-to-moderate atopic dermatitis [poster]. Presented at the International Investigative Dermatology Meeting, May 8-11, 2013, Edinburgh, Scotland.
-
(2013)
International Investigative Dermatology Meeting
-
-
Zane, L.T.1
Tom, W.L.2
Chanda, S.3
Liu, L.4
Van Syoc, M.5
|