메뉴 건너뛰기




Volumn 5-12, Issue , 2008, Pages 443-469

Issues of Large-Scale Plasmid DNA Manufacturing

Author keywords

Eukaryotic cells; Immunogenic; Specifications; Stability; Therapeutic

Indexed keywords


EID: 84978760315     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527620999.ch20d     Document Type: Chapter
Times cited : (8)

References (83)
  • 1
    • 84978740455 scopus 로고    scopus 로고
    • Anonymous, Stuttgart: Deutscher Apotheker Verlag; Eschborn: Govi-Verlag-Pharmazeu-tischer Verlag GmbH
    • Anonymous (1998), Europäisches Arzneibuch, Nachtrag 1998. Stuttgart: Deutscher Apotheker Verlag; Eschborn: Govi-Verlag-Pharmazeu-tischer Verlag GmbH.
    • (1998) Europäisches Arzneibuch, Nachtrag 1998
  • 4
    • 84978637787 scopus 로고
    • Biotechnology product validation, Part 8: Chromatography media and column qualification
    • BARRY, A. R., CHOJNACKI, R. (1995), Biotechnology product validation, Part 8: Chromatography media and column qualification, Pharm. Tech-nol. Eur. 6, 32-38.
    • (1995) Pharm. Tech-nol. Eur , vol.6 , pp. 32-38
    • Barry, A.R.1    Chojnacki, R.2
  • 5
    • 0028501007 scopus 로고
    • Gene transfer with synthetic cationic amphiphiles: Prospects for gene therapy
    • BEHR, J. P. (1994), Gene transfer with synthetic cationic amphiphiles: Prospects for gene therapy, Bioconj. Chem. 5, 382-389.
    • (1994) Bioconj. Chem , vol.5 , pp. 382-389
    • Behr, J.P.1
  • 6
    • 0018800089 scopus 로고
    • A rapid alkaline extraction procedure for screening recombinant plasmid DNA
    • BIRNBOIM, H. C, DOLY, J. (1979), A rapid alkaline extraction procedure for screening recombinant plasmid DNA, Nucleic Acids Res. 7, 1513-1523.
    • (1979) Nucleic Acids Res , vol.7 , pp. 1513-1523
    • Birnboim, H.C.1    Doly, J.2
  • 7
    • 0028387979 scopus 로고
    • Gene therapy for cystic fibrosis in humans by liposome-me-diated DNA transfer: U.K. regulatory process and production of resources
    • CAPLEN, N. J., GAO, X., HAYES, P., ELASWARA-PU, R., FISHER, G. et al. (1994), Gene therapy for cystic fibrosis in humans by liposome-me-diated DNA transfer: U.K. regulatory process and production of resources, Gene Ther. 1, 139-147.
    • (1994) Gene Ther , vol.1 , pp. 139-147
    • Caplen, N.J.1    Gao, X.2    Hayes, P.3    Elaswara-Pu, R.4    Fisher, G.5
  • 10
    • 0003861194 scopus 로고
    • Rockville, MD: Center for Drug Evaluation and Research, FDA, Division of Manufacturing and Product Quality (HFD-320)
    • CDER (1987), Guidelines on General Principles of Process Validation, Rockville, MD: Center for Drug Evaluation and Research, FDA, Division of Manufacturing and Product Quality (HFD-320), .
    • (1987) Guidelines on General Principles of Process Validation
  • 11
    • 84970093341 scopus 로고
    • Current Good Manufacturing Practice in Manufacturing, Processing, Packaging, or Holding of Drugs; General
    • Title, Part
    • CFR-21 (1991), Current Good Manufacturing Practice in Manufacturing, Processing, Packaging, or Holding of Drugs; General, Code of Federal Regulations, Title 21, Part 210.
    • (1991) Code of Federal Regulations , vol.21 , pp. 210
  • 12
    • 0026666888 scopus 로고
    • Large-scale purification of plasmid DNA by fast protein liquid chromatography using a Hi-load Q sepharose column
    • CHANDRA, G., PATEL, P., KOST, T. A., GRAY, J. G. (1992), Large-scale purification of plasmid DNA by fast protein liquid chromatography using a Hi-load Q sepharose column, Anal. Bio-chem. 203, 169-172.
    • (1992) Anal. Bio-chem , vol.203 , pp. 169-172
    • Chandra, G.1    Patel, P.2    Kost, T.A.3    Gray, J.G.4
  • 13
    • 0004703076 scopus 로고
    • A history of validation in the United States: Part I
    • CHAPMAN, K. G. (1991), A history of validation in the United States: Part I, Pharm. Technol. 15, 82-96.
    • (1991) Pharm. Technol , vol.15 , pp. 82-96
    • Chapman, K.G.1
  • 14
    • 0030934349 scopus 로고    scopus 로고
    • Automated fed-batch fermentation with feed-back controls based on dissolved oxygen (DO) and pH for production of DNA vaccines
    • CHEN, W., GRAHAM, C, CICCARELLI, R. B. (1997), Automated fed-batch fermentation with feed-back controls based on dissolved oxygen (DO) and pH for production of DNA vaccines, J. Ind. Microbiol. Biotechnol. 18, 43-48.
    • (1997) J. Ind. Microbiol. Biotechnol , vol.18 , pp. 43-48
    • Chen, W.1    Graham, C.2    Ciccarelli, R.B.3
  • 15
    • 84978713855 scopus 로고    scopus 로고
    • Gene therapy in Germany and in Europe: Regulatory issues
    • in press
    • CICHUTEK, K., KRAMER, I. (in press), Gene therapy in Germany and in Europe: Regulatory issues, Qual. Assur. J.
    • Qual. Assur. J
    • Cichutek, K.1    Kramer, I.2
  • 16
    • 84978713856 scopus 로고
    • Process for producing endotoxin-free or endotoxin-poor nucleic acids and/or oligonucleotides for gene therapy
    • COLPAN, M., SCHORR, I., MORITZ, P. (1995), Process for producing endotoxin-free or endotoxin-poor nucleic acids and/or oligonucleotides for gene therapy, WO 95/21177.
    • (1995) WO 95/21177
    • Colpan, M.1    Schorr, I.2    Moritz, P.3
  • 17
    • 0028466386 scopus 로고
    • Lipopolysaccaride is a frequent contamination of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus
    • COTTEN, M., BAKER, A., SALTIK, M., WAGNER, E., BUSCHLE, M. (1994), Lipopolysaccaride is a frequent contamination of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus, Gene Ther. 1, 239-246.
    • (1994) Gene Ther , vol.1 , pp. 239-246
    • Cotten, M.1    Baker, A.2    Saltik, M.3    Wagner, E.4    Buschle, M.5
  • 18
    • 0029762187 scopus 로고    scopus 로고
    • A systematic approach to screening ion-exchange chromatography media for process development
    • DASARTHY, Y., RAMBERG, M., ANDERSSON, M. (1996), A systematic approach to screening ion-exchange chromatography media for process development, Biopharm 9, 42-45.
    • (1996) Biopharm , vol.9 , pp. 42-45
    • Dasarthy, Y.1    Ramberg, M.2    Andersson, M.3
  • 20
    • 84978708149 scopus 로고
    • Master production batch records
    • DESAIN, C (1991), Master production batch records, Biopharm 4, 20-24.
    • (1991) Biopharm , vol.4 , pp. 20-24
    • Desain, C.1
  • 23
    • 0023447252 scopus 로고
    • Lipofectin: A highly efficient, lipid-mediated DNA transfec-tion procedure
    • FELGNER, P. L., GADEK, T. R., HOLM, M., ROMAN, R., CAHN, H. W. et al. (1987), Lipofectin: A highly efficient, lipid-mediated DNA transfec-tion procedure, Proc. Natl. Acad. Sci. USA 84, 7413-7417.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7413-7417
    • Felgner, P.L.1    Gadek, T.R.2    Holm, M.3    Roman, R.4    Cahn, H.W.5
  • 24
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • GRAHAM, F. L., VAN DER EB, A. L. (1973), A new technique for the assay of infectivity of human adenovirus 5 DNA, Virology 52, 456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van Der Eb, A.L.2
  • 25
  • 26
    • 0031802584 scopus 로고    scopus 로고
    • Genetic vaccines: Strategies for optimization
    • GREGORIADIS, G. (1998), Genetic vaccines: Strategies for optimization, Pharm. Res. 15, 661-670.
    • (1998) Pharm. Res , vol.15 , pp. 661-670
    • Gregoriadis, G.1
  • 28
    • 0018547791 scopus 로고
    • Bacterial plasmids: Autonomous replication and vehicles for gene cloning
    • HELINSKI, D. (1979), Bacterial plasmids: Autonomous replication and vehicles for gene cloning, CRC Crit. Rev. Biochem. 7, 83-101.
    • (1979) CRC Crit. Rev. Biochem , vol.7 , pp. 83-101
    • Helinski, D.1
  • 30
    • 0019877072 scopus 로고
    • Rapid and efficient cosmid cloning
    • ISH-HOROWICS, D., BURKE, I. F. (1981), Rapid and efficient cosmid cloning, Nucleic Acids Res. 9, 2989-2998.
    • (1981) Nucleic Acids Res , vol.9 , pp. 2989-2998
    • Ish-Horowics, D.1    Burke, I.F.2
  • 31
    • 0029005997 scopus 로고
    • Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease
    • ISNER, I. M., WALSH, I., SYMES, A., PIECZEK, A., TAKESHITA, S. et al. (1995), Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease, Circulation 91, 2687-2692.
    • (1995) Circulation , vol.91 , pp. 2687-2692
    • Isner, I.M.1    Walsh, I.2    Symes, A.3    Pieczek, A.4    Takeshita, S.5
  • 32
    • 0030656956 scopus 로고    scopus 로고
    • Testing the genetic stability of recombinant DNA cell banks
    • KITTLE, I. D., PIMENTEL, B. I. (1997), Testing the genetic stability of recombinant DNA cell banks, Biopharm 10, 30-35.
    • (1997) Biopharm , vol.10 , pp. 30-35
    • Kittle, I.D.1    Pimentel, B.I.2
  • 33
    • 0029239706 scopus 로고
    • Simple fed-batch technique for high cell density cultivation of Escherichia coli
    • KORZ, D. I., RINAS, U., HELLMUTH, K, SANDERS, E. A., DECKWER, W.-D. (1995), Simple fed-batch technique for high cell density cultivation of Escherichia coli, J. Biotechnol. 39, 59-65.
    • (1995) J. Biotechnol , vol.39 , pp. 59-65
    • Korz, D.I.1    Rinas, U.2    Hellmuth, K.3    Sanders, E.A.4    Deckwer, W.-D.5
  • 34
    • 0029932729 scopus 로고    scopus 로고
    • Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA
    • KRIEG, A. M. (1996), Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA, Trends Microbiol. 4,11-11.
    • (1996) Trends Microbiol , vol.4 , pp. 11-11
    • Krieg, A.M.1
  • 35
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • KRIEG, A. M., Yi, A.-K, MATSON, S., WALD-SCHMIDT, T. J., BISHOP, G. A. et al. (1995), CpG motifs in bacterial DNA trigger direct B-cell activation, Nature 374, 546-549.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1    Yi, A.-K.2    Matson, S.3    Wald-Schmidt, T.J.4    Bishop, G.A.5
  • 36
    • 84978702460 scopus 로고    scopus 로고
    • Process for preparing purified nucleic acid and the use thereof
    • KUHNE, W. (1997), Process for preparing purified nucleic acid and the use thereof, WO 97/29113.
    • (1997) WO 97/29113
    • Kuhne, W.1
  • 37
    • 0029796205 scopus 로고    scopus 로고
    • High-yield production of pBR322-derived plasmids intended for human gene therapy by employing a temperature-controllable point mutation
    • LAHIJANI, R., HULLEY, G., SORIANO, G., HORM, N. A., MARQUET, M. (1996), High-yield production of pBR322-derived plasmids intended for human gene therapy by employing a temperature-controllable point mutation, Hum. Gene Ther. 7, 1971-1980.
    • (1996) Hum. Gene Ther , vol.7 , pp. 1971-1980
    • Lahijani, R.1    Hulley, G.2    Soriano, G.3    Horm, N.A.4    Marquet, M.5
  • 38
    • 0032518355 scopus 로고    scopus 로고
    • In vivo induction of specific cytotoxic T lymphocytes in mice and rhesus macaques immunized with DNA vector encoding an HIV epitope fused with hepatitis B surface antigen
    • LE BORGNE, S., MANCINI, M., LE GRAND, R., SCHLEEF, M., DORMONT, D. et al. (1998), In vivo induction of specific cytotoxic T lymphocytes in mice and rhesus macaques immunized with DNA vector encoding an HIV epitope fused with hepatitis B surface antigen, Virology 240, 304-315.
    • (1998) Virology , vol.240 , pp. 304-315
    • Le Borgne, S.1    Mancini, M.2    Le Grand, R.3    Schleef, M.4    Dormont, D.5
  • 39
    • 84978637061 scopus 로고
    • Environmental requirements for clean rooms
    • LEE, J. Y. (1989), Environmental requirements for clean rooms, Biopharm 2,42-t5.
    • (1989) Biopharm , vol.2 , pp. 42-t5
    • Lee, J.Y.1
  • 40
    • 84978782100 scopus 로고    scopus 로고
    • A method for large-scale plasmid purification
    • LEE, A. L., SAGAR, S. (1996), A method for large-scale plasmid purification, WO96/36706.
    • (1996) WO96/36706
    • Lee, A.L.1    Sagar, S.2
  • 41
    • 0029084640 scopus 로고
    • DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid
    • MAJOR, M. E., VITVITSKI, L., MINK, M. A., SCHLEEF, M., WHALEN, R. G. et al. (1995), DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid, J. Virol. 69, 5798-5805.
    • (1995) J. Virol , vol.69 , pp. 5798-5805
    • Major, M.E.1    Vitvitski, L.2    Mink, M.A.3    Schleef, M.4    Whalen, R.G.5
  • 43
    • 0001875768 scopus 로고
    • Process development for the manufacture of plasmid DNA vectors for use in gene therapy
    • MARQUET, M., HORN, N, MEEK, J. (1995b), Process development for the manufacture of plasmid DNA vectors for use in gene therapy, Biopharm 8, 26-37.
    • (1995) Biopharm , vol.8 , pp. 26-37
    • Marquet, M.1    Horn, N.2    Meek, J.3
  • 44
    • 0345452827 scopus 로고    scopus 로고
    • Regulatory and standardization issues for DNA and vectored vaccines
    • MEAGER, A., ROBERTSON, I. S. (1998), Regulatory and standardization issues for DNA and vectored vaccines, Curr. Res. Mol. Ther. 1, 262-265.
    • (1998) Curr. Res. Mol. Ther , vol.1 , pp. 262-265
    • Meager, A.1    Robertson, I.S.2
  • 45
    • 0031745917 scopus 로고    scopus 로고
    • Outsourcing biopharmaceu-tical manufacturing operations
    • MESSING, S. H. (1998), Outsourcing biopharmaceu-tical manufacturing operations, Biopharm 11, 28-30.
    • (1998) Biopharm , vol.11 , pp. 28-30
    • Messing, S.H.1
  • 46
    • 84978672227 scopus 로고    scopus 로고
    • Criteria for the design of cleanrooms in biotechnology
    • METZNER, B. (1997), Criteria for the design of cleanrooms in biotechnology, Swiss Pharma 19, 5-8.
    • (1997) Swiss Pharma , vol.19 , pp. 5-8
    • Metzner, B.1
  • 47
    • 0029051321 scopus 로고
    • DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans
    • MICHEL, M.-L., DAVIS, H. L., SCHLEEF, M., MAN-CINI, M., TIOLLAIS, P., WHALEN, R. G. (1995), DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans, Proc. Natl. Acad. Sci. USA 92, 5307-5311.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5307-5311
    • Michel, M.-L.1    Davis, H.L.2    Schleef, M.3    Man-Cini, M.4    Tiollais, P.5    Whalen, R.G.6
  • 48
    • 0023079312 scopus 로고
    • Endotoxins and disease mechanism
    • MORRISON, D. C, RYAN, J. L. (1987), Endotoxins and disease mechanism, Annu. Rev. Med. 38, 417-432.
    • (1987) Annu. Rev. Med , vol.38 , pp. 417-432
    • Morrison, D.C.1    Ryan, J.L.2
  • 49
    • 0008512899 scopus 로고
    • Validation of fermentation processes
    • NAGLAK, T. L., KEITH, M. G., OMSTEAD, D. R. (1994), Validation of fermentation processes, Biopharm 7, 28-36.
    • (1994) Biopharm , vol.7 , pp. 28-36
    • Naglak, T.L.1    Keith, M.G.2    Omstead, D.R.3
  • 51
    • 0020339802 scopus 로고
    • Gene transfer into mouse lyoma cells by electroporation in high electric fields
    • NEUMANN, E., SCHAEFER-RIDDER, M., WANG, Y., HOFSCHNEIDER, P. H. (1982), Gene transfer into mouse lyoma cells by electroporation in high electric fields, EMBO J. 7, 841-845.
    • (1982) EMBO J , vol.7 , pp. 841-845
    • Neumann, E.1    Schaefer-Ridder, M.2    Wang, Y.3    Hofschneider, P.H.4
  • 52
    • 84978782107 scopus 로고    scopus 로고
    • Product recovery and purification
    • ORR, T. (1998), Product recovery and purification, Gen. Eng. News 18,No. 5.
    • (1998) Gen. Eng. News , vol.18 , pp. 5
    • Orr, T.1
  • 53
    • 0031936845 scopus 로고    scopus 로고
    • Therapeutic delivery issues in gene therapy, Part 1: Vectors
    • PARASRAMPURIA, D. A., HUNT, C. A. (1998), Therapeutic delivery issues in gene therapy, Part 1: Vectors, Biopharm 11, 38-45.
    • (1998) Biopharm , vol.11 , pp. 38-45
    • Parasrampuria, D.A.1    Hunt, C.A.2
  • 54
    • 0027997082 scopus 로고
    • Safety considerations for nucleic acid vaccines
    • ROBERTSON, L. S. (1994), Safety considerations for nucleic acid vaccines, Vaccine 12, 1526-1528.
    • (1994) Vaccine , vol.12 , pp. 1526-1528
    • Robertson, L.S.1
  • 55
    • 0029765477 scopus 로고    scopus 로고
    • Environmental monitoring considerations for biological manufacturing
    • ROSCIOLI, N. A., RENSHAW, C. A., GILBERT, A. A., KERRY, C. F., PROBST, P. G. (1996), Environmental monitoring considerations for biological manufacturing, Biopharm 9, 32-40.
    • (1996) Biopharm , vol.9 , pp. 32-40
    • Roscioli, N.A.1    Renshaw, C.A.2    Gilbert, A.A.3    Kerry, C.F.4    Probst, P.G.5
  • 57
    • 8944253295 scopus 로고    scopus 로고
    • Immunstimulatory DNA sequences necessary for effective intradermal gene immunization
    • SATO, Y., ROMAN, M., TIGHE, H., LEE, D., CORR, M. et al. (1996), Immunstimulatory DNA sequences necessary for effective intradermal gene immunization, Science 273, 352-354.
    • (1996) Science , vol.273 , pp. 352-354
    • Sato, Y.1    Roman, M.2    Tighe, H.3    Lee, D.4    Corr, M.5
  • 59
    • 0012005174 scopus 로고    scopus 로고
    • How to produce nucleic acids for human gene therapy and genetic vaccination under full cGMP pharmaceutical manufacturing conditions
    • SCHLEEF, M., MORTIZ, P., SCHORR, I. (1996), How to produce nucleic acids for human gene therapy and genetic vaccination under full cGMP pharmaceutical manufacturing conditions, Eur. J. Pharm. Sci. 4,S25.
    • (1996) Eur. J. Pharm. Sci , vol.4 , pp. S25
    • Schleef, M.1    Mortiz, P.2    Schorr, I.3
  • 60
    • 0030595040 scopus 로고    scopus 로고
    • Rapid determination of plasmid copy number
    • SCHMIDT, T., FRIEHS, K, FLASCHEL, E. (1996), Rapid determination of plasmid copy number, J. Biotechnol. 49, 219-229.
    • (1996) J. Biotechnol , vol.49 , pp. 219-229
    • Schmidt, T.1    Friehs, K.2    Flaschel, E.3
  • 61
    • 0029552250 scopus 로고
    • Plasmid DNA for human gene therapy and DNA vaccines
    • SCHORR, J., MORITZ, P., SEDDON, T, SCHLEEF, M. (1995), Plasmid DNA for human gene therapy and DNA vaccines, N. Y. Acad. Sci. 772, 271-273.
    • (1995) N. Y. Acad. Sci , vol.772 , pp. 271-273
    • Schorr, J.1    Moritz, P.2    Seddon, T.3    Schleef, M.4
  • 62
    • 84978659391 scopus 로고
    • Principles of genetic engineering for Escherichia coli
    • (PÜHLER, A., Ed.), Weinheim: VCH
    • SCHWAB, H. (1993), Principles of genetic engineering for Escherichia coli, in: Genetic Engineering of Microorganisms (PÜHLER, A., Ed.), pp. 1-54. Weinheim: VCH.
    • (1993) Genetic Engineering of Microorganisms , pp. 1-54
    • Schwab, H.1
  • 63
    • 84978637943 scopus 로고
    • Biotechnology product validation, Part 7: Validation of chromatography resin useful life
    • SEELY, R. L., WIGHT, H. D., FRY, H. H., RUDGE, S. R., SLAFF, G. F. (1994), Biotechnology product validation, Part 7: Validation of chromatography resin useful life, Pharm. Technol. Eur. 6, 32-38.
    • (1994) Pharm. Technol. Eur , vol.6 , pp. 32-38
    • Seely, R.L.1    Wight, H.D.2    Fry, H.H.3    Rudge, S.R.4    Slaff, G.F.5
  • 64
    • 0030754104 scopus 로고    scopus 로고
    • Workshop on the control and standardization of nucleic acid vaccines
    • SMITH, H. A., GOLDENTHAL, K. L., VOGEL, F. R., RABINOVICH, R., AGUADO, T. (1997), Workshop on the control and standardization of nucleic acid vaccines, Vaccine 15, 931-933.
    • (1997) Vaccine , vol.15 , pp. 931-933
    • Smith, H.A.1    Goldenthal, K.L.2    Vogel, F.R.3    Rabinovich, R.4    Aguado, T.5
  • 65
    • 0029939446 scopus 로고    scopus 로고
    • Establishing cell banks under current good manufacturing practices
    • STEUR, A., OSTROVE, I. M. (1996), Establishing cell banks under current good manufacturing practices, Biopharm 9, 40-44.
    • (1996) Biopharm , vol.9 , pp. 40-44
    • Steur, A.1    Ostrove, I.M.2
  • 67
    • 0030293017 scopus 로고    scopus 로고
    • In vitro gene delivery by degraded po-lyamidoamine dendrimers
    • TANG, M. X., REDEMANN, C. T., SZOKA, F. C. (1996), In vitro gene delivery by degraded po-lyamidoamine dendrimers, Bioconj. Chem. 7, 703-714.
    • (1996) Bioconj. Chem , vol.7 , pp. 703-714
    • Tang, M.X.1    Redemann, C.T.2    Szoka, F.C.3
  • 68
    • 0013942666 scopus 로고
    • Molecular biology, nucleic acids, and the future of medicine
    • TATUM, E. L. (1966), Molecular biology, nucleic acids, and the future of medicine, Perspect. Biol. Med. 10, 19-32.
    • (1966) Perspect. Biol. Med , vol.10 , pp. 19-32
    • Tatum, E.L.1
  • 70
    • 0031043783 scopus 로고    scopus 로고
    • The processing of a plasmid-based gene from E. coli. Primary recovery by filtration
    • THEODOSSIOU, I., COLLINS, I. J., WARD, J. M., THOMAS, O. R. T., DUNNILL, P. (1997), The processing of a plasmid-based gene from E. coli. Primary recovery by filtration, Bioprocess Eng. 16, 175-183.
    • (1997) Bioprocess Eng , vol.16 , pp. 175-183
    • Theodossiou, I.1    Collins, I.J.2    Ward, J.M.3    Thomas, O.R.T.4    Dunnill, P.5
  • 71
    • 84978714941 scopus 로고    scopus 로고
    • Methods of enhancing the recovery of plasmid genes from neutralized cell lysate
    • in press
    • THEODOSSIOU, I., THOMAS, O. R. T, DUNNILL, P. (in press), Methods of enhancing the recovery of plasmid genes from neutralized cell lysate, Bioprocess Eng.
    • Bioprocess Eng
    • Theodossiou, I.1    Thomas, O.R.T.2    Dunnill, P.3
  • 72
    • 0029749996 scopus 로고    scopus 로고
    • Designing an initial gene therapy manufacturing facility
    • TOLBERT, W. R., MERCHANT, B., TAYLOR, J. A., PERGOLIZZI, R. G. (1996), Designing an initial gene therapy manufacturing facility, Biopharm 9, 32-40.
    • (1996) Biopharm , vol.9 , pp. 32-40
    • Tolbert, W.R.1    Merchant, B.2    Taylor, J.A.3    Pergolizzi, R.G.4
  • 73
    • 0030755365 scopus 로고    scopus 로고
    • DNA supercoiling and bacterial adaption: Thermotol-erance and thermoresistance
    • TSE-DINH, Y.-C, Qi, H., MENZEL, R. (1997), DNA supercoiling and bacterial adaption: Thermotol-erance and thermoresistance, Trends Microbiol. 5, 323-326.
    • (1997) Trends Microbiol , vol.5 , pp. 323-326
    • Tse-Dinh, Y.-C.1    Qi, H.2    Menzel, R.3
  • 74
    • 84978660751 scopus 로고
    • Rockville, MD: United States Pharmacopoeia Convention, Inc
    • TJSP23 (1995), The United States Pharmacopoeia, 23. Rockville, MD: United States Pharmacopoeia Convention, Inc.
    • (1995) The United States Pharmacopoeia , pp. 23
  • 76
    • 0023153002 scopus 로고
    • Activation of human serum complement by bacterial lipopolysaccarides: Structural requirements for antibody independent activation of the classic and alternative pathways
    • VUKAJLOVICH, S. W., HOFFMAN, J., MORRISON, D. (1987), Activation of human serum complement by bacterial lipopolysaccarides: Structural requirements for antibody independent activation of the classic and alternative pathways, Mol. Immunol. 24, 319-331.
    • (1987) Mol. Immunol , vol.24 , pp. 319-331
    • Vukajlovich, S.W.1    Hoffman, J.2    Morrison, D.3
  • 77
    • 0028972307 scopus 로고
    • Effects of lipopolysaccharide on trans-fection efficiency in eukaryotic cells
    • WEBER, M., MOLLER, K., WELZECK, M., SCHORR, J. (1995), Effects of lipopolysaccharide on trans-fection efficiency in eukaryotic cells, Biotech-niques 19, 930-940.
    • (1995) Biotech-niques , vol.19 , pp. 930-940
    • Weber, M.1    Moller, K.2    Welzeck, M.3    Schorr, J.4
  • 79
    • 0028991824 scopus 로고
    • Bacterial lipopolysaccaride copurifies with plasmid DNA: Implications for animal models and human gene therapy
    • WICKS, I. P., HOWELL, M. L., HANCOCK, T., KOH-SAKA, H., OLEE, T, CARSON, D. A. (1995), Bacterial lipopolysaccaride copurifies with plasmid DNA: Implications for animal models and human gene therapy, Hum. Gene Ther. 6, 317-323.
    • (1995) Hum. Gene Ther , vol.6 , pp. 317-323
    • Wicks, I.P.1    Howell, M.L.2    Hancock, T.3    Koh-Saka, H.4    Olee, T.5    Carson, D.A.6
  • 80
    • 0030895171 scopus 로고    scopus 로고
    • Effect of pH and ionic strength on the spectrophotometric assessment of nucleic acid purification
    • WILFINGER, W. W., MACKEY, K., CHOMCZYNSKI, P. (1997), Effect of pH and ionic strength on the spectrophotometric assessment of nucleic acid purification, Biotechniques 22, 474-181.
    • (1997) Biotechniques , vol.22 , pp. 474-181
    • Wilfinger, W.W.1    Mackey, K.2    Chomczynski, P.3
  • 82
    • 0030979103 scopus 로고    scopus 로고
    • Efficient purification of plasmid DNA for gene transfer using triple-helix affinity chromatography
    • WILS, P., ESCRIOU, V., WARNERY, A., LACROIX, F., LAGNEAUX, D. et al. (1997), Efficient purification of plasmid DNA for gene transfer using triple-helix affinity chromatography, Gene Ther. 4, 323-330.
    • (1997) Gene Ther , vol.4 , pp. 323-330
    • Wils, P.1    Escriou, V.2    Warnery, A.3    Lacroix, F.4    Lagneaux, D.5
  • 83
    • 0025938020 scopus 로고
    • Conditions affecting direct gene transfer into rodent muscle in vivo
    • WOLFF, J. A., WILLIAMS, P., ACSADI, G., IIAO, S., IANI, A., CHONG, W. (1991), Conditions affecting direct gene transfer into rodent muscle in vivo, Biotechniques 11, 474-185.
    • (1991) Biotechniques , vol.11 , pp. 474-185
    • Wolff, J.A.1    Williams, P.2    Acsadi, G.3    Iiao, S.4    Iani, A.5    Chong, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.