Clinical efficacy of therapy with recombinant human interferon α1b in Hand, Foot, and Mouth Disease with enterovirus 71 infection

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Huang, Xueyong ^a   Zhang, Xi ^b   Wang, Fang ^c   Wei, Haiyan ^a   Ma, Hong ^a   Sui, Meili ^d   Lu, Jie ^d   Wang, Huaili ^e   Dumler, J Stephen ^f   Sheng, Guangyao ^e   Xu, Bianli Xu ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b Children s Hospital of Kaifeng City   (China)

^c ZHENGZHOU CHILDREN S HOSPITAL   (China)

^d ZHENGZHOU UNIVERSITY   (China)

^e THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ALPHA INTERFERON; RECOMBINANT HUMAN INTERFERON ALPHA1B; UNCLASSIFIED DRUG; ALPHA INTERFERON; RECOMBINANT PROTEIN;

ABSENCE OF SIDE EFFECTS; AEROSOL; ARTICLE; CHILD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ENTEROVIRUS 71; FEMALE; HAND FOOT AND MOUTH DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL MUCOSAL DISEASE; RANDOMIZED CONTROLLED TRIAL; VIRAL CLEARANCE; VIRUS LOAD; CHINA; DRUG EFFECTS; ENTEROVIRUS A; ENTEROVIRUS INFECTIONS; GENETICS; HAND, FOOT AND MOUTH DISEASE; INFANT; PATHOGENICITY; PATHOLOGY; PRESCHOOL CHILD; TREATMENT OUTCOME; VIROLOGY;

CHILD, PRESCHOOL; CHINA; DOUBLE-BLIND METHOD; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; FEMALE; HAND, FOOT AND MOUTH DISEASE; HUMANS; INFANT; INTERFERON-ALPHA; MALE; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 84978745046     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148907     Document Type: Article

References (20)

1. Xu M, Su L, Cao L, Zhong H, Dong N, Xu J. Enterovirus genotypes causing hand foot and mouth disease in Shanghai, China: a molecular epidemiological analysis. BMC Infect Dis. 2013; 13: 489. doi: 10. 1186/1471-2334-13-489 PMID: 24148902
2. Tan X, Huang X, Zhu S, Chen H, Yu Q, Wang H, et al. The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008. PLoS One. 2011; 6 (9): e25662. doi: 10.1371/journal.pone.0025662 PMID: 21980521
3. Huang X, Wei H, Wu S, Du Y, Liu L, Su J, et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013. Sci Rep. 2015; 5:8904. doi: 10.1038/srep08904 PMID: 25754970
4. Kadurugamuwa JL, Shaheen E. Inactivation of human enterovirus 71 and coxsackie virus A16 and hand, foot, and mouth disease. Am J Infect Control. 2011; 39(9):788-789. doi: 10.1016/j.ajic.2011.01. 015 PMID: 21565426
5. Zhang Y, Tan X, Cui A, Mao N, Xu S, Zhu Z, et al. Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years. PLoS One. 2013; 8(2):e56341. doi: 10.1371/journal.pone.0056341 PMID: 23441179
6. Tee KK, Lam TT, Chan YF, Bible JM, Kamarulzaman A, Tong CY, et al. Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene. J Virol. 2010; 84(7):3339-3350. doi: 10.1128/JVI.01019-09 PMID: 20089660
7. Urin V, Levin D, Sharma N, Harari D, Schreiber G. Fine Tuning of a Type 1 Interferon Antagonist. PLoS One. 2015; 10(7):e0130797. doi: 10.1371/journal.pone.0130797 PMID: 26158644
8. Ioannidis I, Ye F, McNally B, Willette M, Flano E. Toll-like receptor expression and induction of type I and type III interferons in primary airway epithelial cells. J Virol. 2013; 87(6):3261-3270. doi: 10.1128/ JVI.01956-12 PMID: 23302870
9. Masci P, Olencki T, Wood L, Rybicki L, Jacobs B, Williams B, et al. Gene modulatory effects, pharmacokinetics, and clinical tolerance of interferon-alpha1b: a second member of the interferon-alpha family. Clin Pharmacol Ther. 2007; 81(3):354-361. PMID: 17339865
10. Zheng Y, Zhao L, Wu T, Guo S, Chen Y, Zhou T. Efficacy of consensus interferon in treatment of HbeAg-positive chronic hepatitis B: a multicentre, randomized controlled trial. Virol J. 2009; 6:99. doi: 10.1186/1743-422X-6-99 PMID: 19586556
11. Stegmann KA, Björkström NK, Ciesek S, Lunemann S, Jaroszewicz J, Wiegand J, et al. Interferon α-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCVinfected and uninfected hepatoma cells via DNAX accessory molecule-1. J Infect Dis. 2012; 205 (9):1351-1362. doi: 10.1093/infdis/jis210 PMID: 22457290
12. Sun W, Yang L, Jia YY, Qiao Y, Wen AD. Tolerance and Safety Study of Aerosol Inhalation of Recombinant Human Interferon α1b in Children with Viral Pneumonia. China Pharmacy. 2011; 22(14): 1277-1280.
13. Liu X, Lu J, He ML, Li Z, Zhang B, Zhou LH, et al. Antitumor effects of interferon-alpha on cell growth and metastasis in human nasopharyngeal carcinoma. Curr Cancer Drug Targets. 2012; 12(5):561-570. PMID: 22414012
14. Huang XY, Kang K, Xu YL, Wei HY, Li XL, Ma H, et al. Etiology surveillance of hand-foot-mouth disease in Henan province between 2008 and 2011. Chin J Prev Med. 2012; 46(10):883-887.
15. Yu HJ, Xu BL, Huang XY, Wei HY, Li XL, Du YH. Construction and primary application on a TaqMan PCR detection method for detection of enterovirus 71. Modern Preventive Medicine. 2010; 37(8): 1517-1523.
16. Ding X, Nie K, Shi L, Zhang Y, Guan L, Zhang D, et al. Improved detection limit in rapid detection of human enterovirus 71 and coxsackievirus A16 by a novel reverse transcription-isothermal multiple-selfmatching-initiated amplification assay. J Clin Microbiol. 2014; 52(6):1862-1870. doi: 10.1128/JCM. 03298-13 PMID: 24648558
17. Bible JM, Pantelidis P, Chan PK, Tong CY. Genetic evolution of enterovirus 71: epidemiological and pathological implications. Rev Med Virol. 2007; 17(6):371-379. PMID: 17487831
18. Xu LJ, Jiang T, Zhang FJ, Han JF, Liu J, Zhao H, et al. Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection. PLoS One. 2013; 8(7):e65948. doi: 10. 1371/journal.pone.0065948 PMID: 23861741
19. Cao HJ, Liu ZL, Steinmann P, Mu YJ, Luo H, Liu JP. Chinese herbal medicines for treatment of hand, foot and mouth disease: A systematic review of randomized clinical trials. European Journal of Integrative Medicine. 2012; 4: 85-111.
20. Ryu WS, Kang B, Hong J, Hwang S, Kim J, Cheon DS. Clinical and etiological characteristics of enterovirus 71-related diseases during a recent 2-year period in Korea. J Clin Microbiol. 2010; 48(7):2490-2494. doi: 10.1128/JCM.02369-09 PMID: 20463159