CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T cell accumulation in the heart and lungs

Hypertension

Volumn 68, Issue 3, 2016, Pages 688-696

  Wang, Huan ^a   Kwak, Dongmin ^a   Fassett, John ^c   Hou, Lei ^d   Xu, Xin ^a   Burbach, Brandon J ^b   Thenappan, Thenappan ^a   Xu, Yawei ^d   Ge, Jun Bo ^d   Shimizu, Yoji ^b   Bache, Robert J ^a   Chen, Yingjie ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF GRAZ   (Austria)

^d TONGJI UNIVERSITY   (China)

Author keywords

congestive heart failure; heart; inflammation; leukocytes; lung; T cell activation

Indexed keywords

ABATACEPT; CD28 ANTIGEN; CD3 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; B7 ANTIGEN; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HEART WEIGHT; KNOCKOUT MOUSE; LUNG WEIGHT; MALE; MOUSE; MYOCARDITIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DEFICIENCY; T LYMPHOCYTE ACTIVATION; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; HEART FAILURE; IMMUNOLOGY; METABOLISM; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SYSTOLE; T LYMPHOCYTE;

ABATACEPT; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD28; B7 ANTIGENS; CYTOKINES; DISEASE MODELS, ANIMAL; HEART FAILURE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PNEUMONIA; RANDOM ALLOCATION; STATISTICS, NONPARAMETRIC; SYSTOLE; T-LYMPHOCYTES;

EID: 84978698576     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.116.07579     Document Type: Article

References (27)

1. Diwan A, Tran T, Misra A, Mann DL, Inflammatory mediators and the failing heart: a translational approach. Curr Mol Med 2003 3 161 182
2. Wang H, Xu X, Fassett J, Kwak D, Liu X, Hu X, Falls TJ, Bell JC, Li H, Bitterman P, Bache RJ, Chen Y, Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure. Circulation 2014 129 1397 1406. doi: 10.1161/CIRCULATIONAHA.113.002209
3. El-Menyar AA, Cytokines and myocardial dysfunction: state of the art. J Card Fail 2008 14 61 74. doi: 10.1016/j.cardfail.2007.09.006
4. Rossi MA, Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens 1998 16 1031 1041
5. Weber KT, Jalil JE, Janicki JS, Pick R, Myocardial collagen remodeling in pressure overload hypertrophy A case for interstitial heart disease. Am J Hypertens 1989 2 12 pt 1 931 940
6. Pereda D, García-Alvarez A, Sánchez-Quintana D, Nuño M, Fernández-Friera L, Fernández-Jiménez R, García-Ruíz JM, Sandoval E, Aguero J, Castellá M, Hajjar RJ, Fuster V, Ibáñez B, Swine model of chronic postcapillary pulmonary hypertension with right ventricular remodeling: long-Term characterization by cardiac catheterization, magnetic resonance, and pathology. J Cardiovasc Transl Res 2014 7 494 506. doi: 10.1007/s12265-014-9564-6
7. Wagenvoort CA, Lung biopsy findings in secondary pulmonary hypertension. Heart Lung 1986 15 429 450
8. Chen Y, Guo H, Xu D, Xu X, Wang H, Hu X, Lu Z, Kwak D, Xu Y, Gunther R, Huo Y, Weir EK, Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: heart failure causes severe lung disease. Hypertension 2012 59 1170 1178. doi: 10.1161/HYPERTENSIONAHA.111.186072
9. Wang H, Hou L, Kwak D, Fassett J, Xu X, Chen A, Chen W, Blazar BR, Xu Y, Hall JL, Ge JB, Bache RJ, Chen Y, Increasing regulatory T cells with interleukin-2 and interleukin-2 antibody complexes attenuates lung inflammation and heart failure progression. Hypertension 2016 68 114 122
10. Larsen CP, Knechtle SJ, Adams A, Pearson T, Kirk AD, A new look at blockade of T-cell costimulation: a therapeutic strategy for long-Term maintenance immunosuppression. Am J Transplant 2006 6 5 pt 1 876 883. doi: 10.1111/j.1600-6143.2006.01259.x
11. June CH, Bluestone JA, Nadler LM, Thompson CB, The B7 and CD28 receptor families. Immunol Today 1994 15 321 331. doi: 10.1016/0167-5699(94)90080-9
12. Laroumanie F, Douin-Echinard V, Pozzo J, Lairez O, Tortosa F, Vinel C, Delage C, Calise D, Dutaur M, Parini A, Pizzinat N, CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload. Circulation 2014 129 2111 2124. doi: 10.1161/CIRCULATIONAHA.113.007101
13. Nevers T, Salvador AM, Grodecki-Pena A, Knapp A, Velázquez F, Aronovitz M, Kapur NK, Karas RH, Blanton RM, Alcaide P, Left ventricular T-cell recruitment contributes to the pathogenesis of heart failure. Circ Heart Fail 2015 8 776 787. doi: 10.1161/CIRCHEARTFAILURE.115.002225
14. Lowe JB, Glycosylation in the control of selectin counter-receptor structure and function. Immunol Rev 2002 186 19 36
15. Tietz W, Allemand Y, Borges E, von Laer D, Hallmann R, Vestweber D, Hamann A, CD4+ T cells migrate into inflamed skin only if they express ligands for E-And P-selectin. J Immunol 1998 161 963 970
16. Dandel M, Wallukat G, Englert A, Hetzer R, Immunoadsorption therapy for dilated cardiomyopathy and pulmonary arterial hypertension. Atheroscler Suppl 2013 14 203 211. doi: 10.1016/j.atherosclerosissup.2012.10.029
17. Kirabo A, Fontana V, de Faria AP, DC isoketal-modified proteins activate T cells and promote hypertension. J Clin Invest 2014 124 4642 4656. doi: 10.1172/JCI74084
18. Wu J, Saleh MA, Kirabo A, Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest 2016 126 50 67. doi: 10.1172/JCI80761
19. Frieler RA, Mortensen RM, Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling. Circulation 2015 131 1019 1030. doi: 10.1161/CIRCULATIONAHA.114.008788
20. Kondo S, Kooshesh F, Wang B, Fujisawa H, Sauder DN, Contribution of the CD28 molecule to allergic and irritant-induced skin reactions in CD28-/-mice. J Immunol 1996 157 4822 4829
21. Haspot F, Séveno C, Dugast AS, Coulon F, Renaudin K, Usal C, Hill M, Anegon I, Heslan M, Josien R, Brouard S, Soulillou JP, Vanhove B, Anti-CD28 antibody-induced kidney allograft tolerance related to tryptophan degradation and TCR class II B7 regulatory cells. Am J Transplant 2005 5 2339 2348. doi: 10.1111/j.1600-6143.2005.01018.x
22. Liu D, Krummey SM, Badell IR, Wagener M, Schneeweis LA, Stetsko DK, Suchard SJ, Nadler SG, Ford ML, 2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses. J Exp Med 2014 211 297 311. doi: 10.1084/jem.20130902
23. Szot GL, Zhou P, Sharpe AH, He G, Kim O, Newell KA, Bluestone JA, Thistlethwaite JR Jr, Absence of host B7 expression is sufficient for long-Term murine vascularized heart allograft survival. Transplantation 2000 69 904 909
24. Bîrsan T, Hausen B, Higgins JP, Hubble RW, Klupp J, Stalder M, Celniker A, Friedrich S, O'Hara RM, Morris RE, Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys. Transplantation 2003 75 2106 2113. doi: 10.1097/01.TP.0000066806.10029.7A
25. Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ, Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation 2010 122 2529 2537. doi: 10.1161/CIRCULATIONAHA.109.930446
26. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG, Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 2007 204 2449 2460. doi: 10.1084/jem.20070657
27. Gross JA, Callas E, Allison JP, Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol 1992 149 380 388