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Volumn 9, Issue , 2016, Pages 4265-4275

Theaflavins suppress tumor growth and metastasis via the blockage of the STAT3 pathway in hepatocellular carcinoma

Author keywords

Hepatocellular carcinoma; STAT3; Theaflavins; Tumor growth; Tumor metastasis

Indexed keywords

CASPASE 3; CASPASE 9; CASPASE INHIBITOR; GELATINASE A; GELATINASE B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; STAT3 PROTEIN; SURVIVIN; THEAFLAVIN;

EID: 84978697997     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S102858     Document Type: Article
Times cited : (16)

References (31)
  • 1
    • 84944392238 scopus 로고    scopus 로고
    • Hepatocellular carcinoma from epidemiology to prevention: Translating knowledge into practice
    • Singal AG, El-Serag HB. Hepatocellular carcinoma from epidemiology to prevention: translating knowledge into practice. Clin Gastroenterol Hepatol. 2015;13(12):2140-2151.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , Issue.12 , pp. 2140-2151
    • Singal, A.G.1    El-Serag, H.B.2
  • 2
    • 7044274454 scopus 로고    scopus 로고
    • Genome-scale profiling of gene expression in hepatocellular carcinoma: Classification, survival prediction, and identification of therapeutic targets
    • Lee JS, Thorgeirsson SS. Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets. Gastroenterology. 2004;127(5 Suppl 1):S51-S55.
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. S51-S55
    • Lee, J.S.1    Thorgeirsson, S.S.2
  • 3
    • 33644913732 scopus 로고    scopus 로고
    • Molecular prognostication of liver cancer: End of the beginning
    • Thorgeirsson SS, Lee JS, Grisham JW. Molecular prognostication of liver cancer: end of the beginning. J Hepatol. 2006;44(4):798-805.
    • (2006) J Hepatol , vol.44 , Issue.4 , pp. 798-805
    • Thorgeirsson, S.S.1    Lee, J.S.2    Grisham, J.W.3
  • 5
    • 11144311139 scopus 로고    scopus 로고
    • Lessons from natural molecules
    • Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004;432(7019):829-837.
    • (2004) Nature , vol.432 , Issue.7019 , pp. 829-837
    • Clardy, J.1    Walsh, C.2
  • 6
    • 0035543019 scopus 로고    scopus 로고
    • Two types of oxidative dimerization of the black tea polyphenol theaflavin
    • Tanaka T, Inoue K, Betsumiya Y, Mine C, Kouno I. Two types of oxidative dimerization of the black tea polyphenol theaflavin. J Agric Food Chem. 2001;49(12):5785-5789.
    • (2001) J Agric Food Chem , vol.49 , Issue.12 , pp. 5785-5789
    • Tanaka, T.1    Inoue, K.2    Betsumiya, Y.3    Mine, C.4    Kouno, I.5
  • 7
    • 0034856072 scopus 로고    scopus 로고
    • Theaflavins in black tea and catechins in green tea are equally effective antioxidants
    • Leung LK, Su Y, Chen R, Zhang Z, Huang Y, Chen ZY. Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J Nutr. 2001;131(9):2248-2251.
    • (2001) J Nutr , vol.131 , Issue.9 , pp. 2248-2251
    • Leung, L.K.1    Su, Y.2    Chen, R.3    Zhang, Z.4    Huang, Y.5    Chen, Z.Y.6
  • 8
    • 0030876013 scopus 로고    scopus 로고
    • Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate
    • Hasaniya N, Youn K, Xu M, Hernaez J, Dashwood R. Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate. Jpn J Cancer Res. 1997;88(6):553-558.
    • (1997) Jpn J Cancer Res , vol.88 , Issue.6 , pp. 553-558
    • Hasaniya, N.1    Youn, K.2    Xu, M.3    Hernaez, J.4    Dashwood, R.5
  • 9
    • 0028179642 scopus 로고
    • Antioxidative and antimutagenic effects of theaflavins from black tea
    • Shiraki M, Hara Y, Osawa T, Kumon H, Nakayama T, Kawakishi S. Antioxidative and antimutagenic effects of theaflavins from black tea. Mutat Res. 1994;323(1-2):29-34.
    • (1994) Mutat Res , vol.323 , Issue.1-2 , pp. 29-34
    • Shiraki, M.1    Hara, Y.2    Osawa, T.3    Kumon, H.4    Nakayama, T.5    Kawakishi, S.6
  • 10
    • 77649207635 scopus 로고    scopus 로고
    • Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells
    • Lahiry L, Saha B, Chakraborty J, et al. Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. Carcinogenesis. 2010;31(2):259-268.
    • (2010) Carcinogenesis , vol.31 , Issue.2 , pp. 259-268
    • Lahiry, L.1    Saha, B.2    Chakraborty, J.3
  • 11
    • 71549169241 scopus 로고    scopus 로고
    • Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk
    • Adhikary A, Mohanty S, Lahiry L, Hossain DM, Chakraborty S, Das T. Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk. FEBS Lett. 2010;584(1):7-14.
    • (2010) FEBS Lett , vol.584 , Issue.1 , pp. 7-14
    • Adhikary, A.1    Mohanty, S.2    Lahiry, L.3    Hossain, D.M.4    Chakraborty, S.5    Das, T.6
  • 12
    • 35348983446 scopus 로고    scopus 로고
    • Theaflavins induce G2/M arrest by modulating expression of p21waf1/cip1, cdc25C and cyclin B in human prostate carcinoma PC-3 cells
    • Prasad S, Kaur J, Roy P, Kalra N, Shukla Y. Theaflavins induce G2/M arrest by modulating expression of p21waf1/cip1, cdc25C and cyclin B in human prostate carcinoma PC-3 cells. Life Sci. 2007;81(17-18):1323-1331.
    • (2007) Life Sci , vol.81 , Issue.17-18 , pp. 1323-1331
    • Prasad, S.1    Kaur, J.2    Roy, P.3    Kalra, N.4    Shukla, Y.5
  • 13
    • 84879616328 scopus 로고    scopus 로고
    • Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction
    • Sun S, Pan S, Miao A, et al. Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction. Oncol Rep. 2013;30(2):763-772.
    • (2013) Oncol Rep , vol.30 , Issue.2 , pp. 763-772
    • Sun, S.1    Pan, S.2    Miao, A.3
  • 14
    • 77952210300 scopus 로고    scopus 로고
    • Black tea polyphenol (Theaflavin) downregulates MMP-2 in human melanoma cell line A375 by involving multiple regulatory molecules
    • Sil H, Sen T, Moulik S, Chatterjee A. Black tea polyphenol (theaflavin) downregulates MMP-2 in human melanoma cell line A375 by involving multiple regulatory molecules. J Environ Pathol Toxicol Oncol. 2010;29(1):55-68.
    • (2010) J Environ Pathol Toxicol Oncol , vol.29 , Issue.1 , pp. 55-68
    • Sil, H.1    Sen, T.2    Moulik, S.3    Chatterjee, A.4
  • 15
    • 44149090471 scopus 로고    scopus 로고
    • Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis
    • Lahiry L, Saha B, Chakraborty J, et al. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis. 2008;13(6):771-781.
    • (2008) Apoptosis , vol.13 , Issue.6 , pp. 771-781
    • Lahiry, L.1    Saha, B.2    Chakraborty, J.3
  • 16
    • 84931096811 scopus 로고    scopus 로고
    • Protective effect of theaflavin-enriched black tea extracts against dimethylnitrosamine-induced liver fibrosis in rats
    • Weerawatanakorn M, Lee YL, Tsai CY, et al. Protective effect of theaflavin-enriched black tea extracts against dimethylnitrosamine-induced liver fibrosis in rats. Food Funct. 2015;6(6):1832-1840.
    • (2015) Food Funct , vol.6 , Issue.6 , pp. 1832-1840
    • Weerawatanakorn, M.1    Lee, Y.L.2    Tsai, C.Y.3
  • 18
    • 84957612113 scopus 로고    scopus 로고
    • Targeting transcription factor STAT3 for cancer prevention and therapy
    • Chai EZ, Shanmugam MK, Arfuso F, et al. Targeting transcription factor STAT3 for cancer prevention and therapy. Pharmacol Ther. 2016;162:86-97.
    • (2016) Pharmacol Ther , vol.162 , pp. 86-97
    • Chai, E.Z.1    Shanmugam, M.K.2    Arfuso, F.3
  • 19
    • 0034660463 scopus 로고    scopus 로고
    • Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
    • Schuringa JJ, Wierenga AT, Kruijer W, Vellenga E. Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. Blood. 2000;95(12):3765-3770.
    • (2000) Blood , vol.95 , Issue.12 , pp. 3765-3770
    • Schuringa, J.J.1    Wierenga, A.T.2    Kruijer, W.3    Vellenga, E.4
  • 20
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264(5155):95-98.
    • (1994) Science , vol.264 , Issue.5155 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 21
    • 0029991793 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation
    • Hemmann U, Gerhartz C, Heesel B, et al. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation. J Biol Chem. 1996;271(22):12999-13007.
    • (1996) J Biol Chem , vol.271 , Issue.22 , pp. 12999-13007
    • Hemmann, U.1    Gerhartz, C.2    Heesel, B.3
  • 22
    • 84951574260 scopus 로고    scopus 로고
    • A STAT inhibitor patent review: Progress since 2011
    • Lai PS, Rosa DA, Magdy Ali A, et al. A STAT inhibitor patent review: progress since 2011. Expert Opin Ther Pat. 2015;25(12):1397-1421.
    • (2015) Expert Opin Ther Pat , vol.25 , Issue.12 , pp. 1397-1421
    • Lai, P.S.1    Rosa, D.A.2    Magdy Ali, A.3
  • 23
    • 84881257821 scopus 로고    scopus 로고
    • Critical analysis of the potential for targeting STAT3 in human malignancy
    • Peyser ND, Grandis JR. Critical analysis of the potential for targeting STAT3 in human malignancy. Onco Targets Ther. 2013;6:999-1010.
    • (2013) Onco Targets Ther , vol.6 , pp. 999-1010
    • Peyser, N.D.1    Grandis, J.R.2
  • 24
    • 84873908235 scopus 로고    scopus 로고
    • Potential use of STAT3 inhibitors in targeted prostate cancer therapy: Future prospects
    • Shodeinde AL, Barton BE. Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects. Onco Targets Ther. 2012;5:119-125.
    • (2012) Onco Targets Ther , vol.5 , pp. 119-125
    • Shodeinde, A.L.1    Barton, B.E.2
  • 25
    • 84929629270 scopus 로고    scopus 로고
    • LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy
    • Zuo M, Li C, Lin J, Javle M. LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy. Oncotarget. 2015;6(13):10940-10949.
    • (2015) Oncotarget , vol.6 , Issue.13 , pp. 10940-10949
    • Zuo, M.1    Li, C.2    Lin, J.3    Javle, M.4
  • 26
    • 84885105794 scopus 로고    scopus 로고
    • Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
    • Subramaniam A, Shanmugam MK, Ong TH, et al. Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. Br J Pharmacol. 2013;170(4):807-821.
    • (2013) Br J Pharmacol , vol.170 , Issue.4 , pp. 807-821
    • Subramaniam, A.1    Shanmugam, M.K.2    Ong, T.H.3
  • 27
    • 79954459349 scopus 로고    scopus 로고
    • γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
    • Rajendran P, Li F, Manu KA, et al. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. Br J Pharmacol. 2011;163(2):283-298.
    • (2011) Br J Pharmacol , vol.163 , Issue.2 , pp. 283-298
    • Rajendran, P.1    Li, F.2    Manu, K.A.3
  • 28
    • 79955839265 scopus 로고    scopus 로고
    • XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells
    • Liu Y, Liu A, Xu Z, et al. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis. 2011;16(5):502-510.
    • (2011) Apoptosis , vol.16 , Issue.5 , pp. 502-510
    • Liu, Y.1    Liu, A.2    Xu, Z.3
  • 29
    • 0036717295 scopus 로고    scopus 로고
    • Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
    • Yoshida T, Hanada T, Tokuhisa T, et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med. 2002;196(5):641-653.
    • (2002) J Exp Med , vol.196 , Issue.5 , pp. 641-653
    • Yoshida, T.1    Hanada, T.2    Tokuhisa, T.3
  • 30
    • 84868693885 scopus 로고    scopus 로고
    • Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
    • Subramaniam A, Shanmugam MK, Perumal E, et al. Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. Biochim Biophys Acta. 2013;1835(1):46-60.
    • (2013) Biochim Biophys Acta , vol.1835 , Issue.1 , pp. 46-60
    • Subramaniam, A.1    Shanmugam, M.K.2    Perumal, E.3
  • 31
    • 70349606667 scopus 로고    scopus 로고
    • Role of oxidation-triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells
    • Bhattacharya U, Halder B, Mukhopadhyay S, Giri AK. Role of oxidation-triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells. Cancer Sci. 2009;100(10):1971-1978.
    • (2009) Cancer Sci , vol.100 , Issue.10 , pp. 1971-1978
    • Bhattacharya, U.1    Halder, B.2    Mukhopadhyay, S.3    Giri, A.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.