Bacterial survival and distribution during buffy coat platelet production

Vox Sanguinis

Volumn 111, Issue 4, 2016, Pages 333-340

  Taha, M ^a   Kalab, M ^b   Yi, Q L ^a   Maurer, E ^c   Jenkins, C ^a   Schubert, P ^a   Ramirez Arcos, S ^a  

^a CANADIAN BLOOD SERVICES   (Canada)

^b AGRICULTURE AND AGRI FOOD CANADA   (Canada)

^c LightIntegra Technology Inc   (Canada)

Author keywords

bacterial contamination in platelets; buffy coat platelets; platelet production

Indexed keywords

ENDOTOXIN; PADGEM PROTEIN; THROMBOCYTE CONCENTRATE; SELP PROTEIN, HUMAN;

ARTICLE; BACTERIAL CLEARANCE; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIUM ADHERENCE; BACTERIUM CONTAMINATION; BLOOD BUFFY COAT; BLOOD STORAGE; CONTROLLED STUDY; ESCHERICHIA COLI; HUMAN; IN VITRO STUDY; INOCULATION; KLEBSIELLA PNEUMONIAE; NONHUMAN; NORMAL HUMAN; PHOTON CORRELATION SPECTROSCOPY; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITY CONTROL PROCEDURES; STAPHYLOCOCCUS EPIDERMIDIS; BLOOD SAFETY; FLOW CYTOMETRY; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; PHYSIOLOGY; SERRATIA MARCESCENS; THROMBOCYTE; THROMBOCYTE RICH PLASMA; THROMBOCYTOPHERESIS;

BLOOD BUFFY COAT; BLOOD PLATELETS; BLOOD SAFETY; ESCHERICHIA COLI; FLOW CYTOMETRY; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL VIABILITY; P-SELECTIN; PLATELET-RICH PLASMA; PLATELETPHERESIS; SERRATIA MARCESCENS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 84978686259     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12427     Document Type: Article

References (34)

1. Hong H, Xiao W, Lazarus HM, et al.: Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance. Blood 2016; 127:496–502
2. Kou Y, Pagotto F, Hannach B, et al.: Fatal false-negative transfusion infection involving a buffy coat platelet pool contaminated with biofilm-positive Staphylococcus epidermidis: a case report. Transfusion 2015; 55:2384–2389
3. Fatalities Reported to FDA Following Blood Collection and Transfusion. Annual Summary for Fiscal Year 2014. [Cited March 23, 2016]. Available from http://www.fda.gov/downloads/BiologicsBloodVaccines/SafetyAvailability/ReportaProblem/TransfusionDonationFatalities/UCM459461.pdf
4. Benjamin RJ, McDonald CP: The international experience of bacterial screen testing of platelet components with an automated microbial detection system: a need for consensus testing and reporting guidelines. Transfus Med Rev 2014; 28:61–71
5. Jenkins C, Ramírez-Arcos S, Goldman M, et al.: Bacterial contamination in platelets: incremental improvements drive down but do not eliminate risk. Transfusion 2011; 51:2555–2565
6. Macauley A, Chandrasekar A, Geddis G, et al.: Operational feasibility of routine bacterial monitoring of platelets. Transfus Med 2003; 13:189–195
7. Larsen CP, Ezligini F, Hermansen NO, et al.: Six years’ experience of using the BacT/ALERT system to screen all platelet concentrates, and additional testing of outdated platelet concentrates to estimate the frequency of false-negative results. Vox Sang 2005; 88:93–97
8. Pearce S, Rowe GP, Field SP: Screening of platelets for bacterial contamination at the Welsh Blood Service. Transfus Med 2011; 21:25–32
9. Benjamin RJ, Wagner SJ: The residual risk of sepsis: modeling the effect of concentration on bacterial detection in two-bottle culture systems and an estimation of false-negative culture rates. Transfusion 2007; 47:1381–1389
10. Greco-Stewart VS, Brown EE, Parr C, et al.: Serratia marcescens strains implicated in adverse transfusion reactions form biofilms in platelet concentrates and demonstrate reduced detection by automated culture. Vox Sang 2012; 102:212–220
11. Graul A, Heiden M, Gräf K, et al.: Hämovigilanz in Deutschland-Berichte an das Paul-Ehrlich-Institut über Verdachtsfälle von Transfusionsreaktionen im Beobachtungszeitraum Januar 1995 bis Dezember 2002. Transfus Med Hemotherapy 2003; 30:232–238
12. Levin E, Culibrk B, Gyöngyössy-Issa MIC, et al.: Implementation of buffy coat platelet component production: comparison to platelet-rich plasma platelet production. Transfusion 2008; 48:2331–2337
13. Mastronardi C, Yang L, Halpenny M, et al.: Evaluation of the sterility testing process of hematopoietic stem cells at Canadian Blood Services. Transfusion 2012; 52:1778–1784
14. Labrie A, Marshall A, Bedi H, et al.: Characterization of platelet concentrates using dynamic light scattering. Transfus Med Hemotherapy 2013; 40:93–100
15. Jacobs MR, Good CE, Lazarus HM, et al.: Relationship between bacterial load, species virulence, and transfusion reaction with transfusion of bacterially contaminated platelets. Clin Infect Dis 2008; 46:1214–1220
16. Mohr H, Bayer A, Gravemann U, et al.: Elimination and multiplication of bacteria during preparation and storage of buffy coat-derived platelet concentrates. Transfusion 2006; 46:949–955
17. Summers C, Rankin SM, Condliffe AM, et al.: Neutrophil kinetics in health and disease. Trends Immunol 2010; 31:318–324
18. Bashir S, Stanworth S, Massey E, et al.: Neutrophil function is preserved in a pooled granulocyte component prepared from whole blood donations. Br J Haematol 2008; 140:701–711
19. Joiner KA, Brown EJ, Frank MM: Complement and Bacteria: chemistry and Biology in Host Defense. Annu Rev Immunol 1984; 2:461–492
20. Taylor PW: Bactericidal and bacteriolytic activity of serum against gram-negative bacteria. Microbiol Rev 1983; 47:46–83
21. Weiser JN, Gotschlich EC: Outer membrane protein A (OmpA) contributes to serum resistance and pathogenicity of Escherichia coli K-1. Infect Immun 1991; 59:2252–2258
22. Cortés G, Borrell N, de Astorza B, et al.: Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia. Infect Immun 2002; 70:2583–2590
23. Cheung GYC, Rigby K, Wang R, et al.: Staphylococcus epidermidis Strategies to Avoid Killing by Human Neutrophils. PLoS Pathog 2010; 6:e1001133
24. Kristian SA, Birkenstock TA, Sauder U, et al.: Biofilm formation induces C3a release and protects Staphylococcus epidermidis from IgG and complement deposition and from neutrophil-dependent killing. J Infect Dis 2008; 197:1028–1035
25. De Korte D, Marcelis JH, Soeterboek Am: Determination of the degree of bacterial contamination of whole-blood collections using an automated microbe-detection system. Transfusion 2001; 41:815–818
26. Dzik W: Use of leukodepletion filters for the removal of bacteria. Immunol Invest 1995; 24:95–115
27. Buchholz DH, Aubuchon JP, Snyder EL, et al.: Effects of white cell reduction on the resistance of blood components to bacterial multiplication. Transfusion 1994; 34:852–857
28. Holden F, Foley M, Devin G, et al.: Coagulase-negative staphylococcal contamination of whole blood and its components: the effects of WBC reduction. Transfusion 2000; 40:1508–1513
29. Bravo M, Shaz BH, Kamel H, et al.: Detection of bacterial contamination in apheresis platelets: is apheresis technology a factor? Transfusion 2015; 55:2113–2122
30. Damgaard C, Magnussen K, Enevold C, et al.: Viable bacteria associated with red blood cells and plasma in freshly drawn blood donations. PLoS ONE 2015; 10:e0120826
31. Greco CA, Zhang JG, Kalab M, et al.: Effect of platelet additive solution on bacterial dynamics and their influence on platelet quality in stored platelet concentrates. Transfusion 2010; 50:2344–2352
32. Keil SD, Hovenga N, Gilmour D, et al.: Treatment of platelet products with riboflavin and UV light: effectiveness against high titer bacterial contamination. J Vis Exp JoVE 2015; 102:52820
33. Schmidt M, Hourfar MK, Sireis W, et al.: Evaluation of the effectiveness of a pathogen inactivation technology against clinically relevant transfusion-transmitted bacterial strains. Transfusion 2015; 55:2104–2112
34. Kwon SY, Kim IS, Bae JE, et al.: Pathogen inactivation efficacy of Mirasol PRT System and Intercept Blood System for non-leucoreduced platelet-rich plasma-derived platelets suspended in plasma. Vox Sang 2014; 107:254–260