메뉴 건너뛰기




Volumn 151, Issue 2, 2016, Pages 324-337.e12

Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma

Author keywords

Kinase Inhibitor; Liver Cancer; RalGAPs; Sleeping Beauty

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HEPATITIS B SURFACE ANTIGEN; SHORT HAIRPIN RNA; SORAFENIB; RAL PROTEIN;

EID: 84978544533     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.04.040     Document Type: Article
Times cited : (27)

References (33)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
    • 1 Ferlay, J., Soerjomataram, I., Dikshit, R., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136 (2015), E359–E386.
    • (2015) Int J Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3
  • 2
    • 84879925475 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma: consider the population
    • 2 Mittal, S., El-Serag, H.B., Epidemiology of hepatocellular carcinoma: consider the population. J Clin Gastroenterol 47:Suppl (2013), S2–S6.
    • (2013) J Clin Gastroenterol , vol.47 , pp. S2-S6
    • Mittal, S.1    El-Serag, H.B.2
  • 3
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • 3 Llovet, J.M., Ricci, S., Mazzaferro, V., et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359 (2008), 378–390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 4
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • 4 International Cancer Genome Consortium, Hudson, T.J., Anderson, W., et al. International network of cancer genome projects. Nature 464 (2010), 993–998.
    • (2010) Nature , vol.464 , pp. 993-998
    • Hudson, T.J.1    Anderson, W.2
  • 5
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • 5 Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487 (2012), 330–337.
    • (2012) Nature , vol.487 , pp. 330-337
  • 6
    • 84922551107 scopus 로고    scopus 로고
    • Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
    • 6 Totoki, Y., Tatsuno, K., Covington, K.R., et al. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat Genet 46 (2014), 1267–1273.
    • (2014) Nat Genet , vol.46 , pp. 1267-1273
    • Totoki, Y.1    Tatsuno, K.2    Covington, K.R.3
  • 7
    • 84892833777 scopus 로고    scopus 로고
    • Discovery and saturation analysis of cancer genes across 21 tumour types
    • 7 Lawrence, M.S., Stojanov, P., Mermel, C.H., et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505 (2014), 495–501.
    • (2014) Nature , vol.505 , pp. 495-501
    • Lawrence, M.S.1    Stojanov, P.2    Mermel, C.H.3
  • 8
    • 84891372971 scopus 로고    scopus 로고
    • Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model
    • 8 Bard-Chapeau, E.A., Nguyen, A.T., Rust, A.G., et al. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nat Genet 46 (2014), 24–32.
    • (2014) Nat Genet , vol.46 , pp. 24-32
    • Bard-Chapeau, E.A.1    Nguyen, A.T.2    Rust, A.G.3
  • 9
    • 70350227239 scopus 로고    scopus 로고
    • A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice
    • 9 Dupuy, A.J., Rogers, L.M., Kim, J., et al. A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res 69 (2009), 8150–8156.
    • (2009) Cancer Res , vol.69 , pp. 8150-8156
    • Dupuy, A.J.1    Rogers, L.M.2    Kim, J.3
  • 10
    • 79751488721 scopus 로고    scopus 로고
    • Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system
    • 10 Thoolen, B., Maronpot, R.R., Harada, T., et al. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol Pathol 38 (2010), 5S–81S.
    • (2010) Toxicol Pathol , vol.38 , pp. 5S-81S
    • Thoolen, B.1    Maronpot, R.R.2    Harada, T.3
  • 11
    • 84862976633 scopus 로고    scopus 로고
    • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
    • 11 Fujimoto, A., Totoki, Y., Abe, T., et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet 44 (2012), 760–764.
    • (2012) Nat Genet , vol.44 , pp. 760-764
    • Fujimoto, A.1    Totoki, Y.2    Abe, T.3
  • 12
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • 12 Guichard, C., Amaddeo, G., Imbeaud, S., et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet 44 (2012), 694–698.
    • (2012) Nat Genet , vol.44 , pp. 694-698
    • Guichard, C.1    Amaddeo, G.2    Imbeaud, S.3
  • 13
    • 84866868120 scopus 로고    scopus 로고
    • Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma
    • 13 Huang, J., Deng, Q., Wang, Q., et al. Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat Genet 44 (2012), 1117–1121.
    • (2012) Nat Genet , vol.44 , pp. 1117-1121
    • Huang, J.1    Deng, Q.2    Wang, Q.3
  • 14
    • 80052271807 scopus 로고    scopus 로고
    • Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
    • 14 Li, M., Zhao, H., Zhang, X., et al. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet 43 (2011), 828–829.
    • (2011) Nat Genet , vol.43 , pp. 828-829
    • Li, M.1    Zhao, H.2    Zhang, X.3
  • 15
    • 0024818649 scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
    • 15 Chisari, F.V., Klopchin, K., Moriyama, T., et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59 (1989), 1145–1156.
    • (1989) Cell , vol.59 , pp. 1145-1156
    • Chisari, F.V.1    Klopchin, K.2    Moriyama, T.3
  • 16
    • 77957132245 scopus 로고    scopus 로고
    • Harnessing transposons for cancer gene discovery
    • 16 Copeland, N.G., Jenkins, N.A., Harnessing transposons for cancer gene discovery. Nat Rev Cancer 10 (2010), 696–706.
    • (2010) Nat Rev Cancer , vol.10 , pp. 696-706
    • Copeland, N.G.1    Jenkins, N.A.2
  • 17
    • 1542515338 scopus 로고    scopus 로고
    • A census of human cancer genes
    • 17 Futreal, P.A., Coin, L., Marshall, M., et al. A census of human cancer genes. Nat Rev Cancer 4 (2004), 177–183.
    • (2004) Nat Rev Cancer , vol.4 , pp. 177-183
    • Futreal, P.A.1    Coin, L.2    Marshall, M.3
  • 18
    • 84929501731 scopus 로고    scopus 로고
    • The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications
    • 18 Delire, B., Starkel, P., The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications. Eur J Clin Invest 45 (2015), 609–623.
    • (2015) Eur J Clin Invest , vol.45 , pp. 609-623
    • Delire, B.1    Starkel, P.2
  • 19
    • 56349121125 scopus 로고    scopus 로고
    • An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
    • 19 Zender, L., Xue, W., Zuber, J., et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135 (2008), 852–864.
    • (2008) Cell , vol.135 , pp. 852-864
    • Zender, L.1    Xue, W.2    Zuber, J.3
  • 20
    • 77956628160 scopus 로고    scopus 로고
    • Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
    • 20 Zhang, H., Zhai, Y., Hu, Z., et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet 42 (2010), 755–758.
    • (2010) Nat Genet , vol.42 , pp. 755-758
    • Zhang, H.1    Zhai, Y.2    Hu, Z.3
  • 21
    • 84937838755 scopus 로고    scopus 로고
    • ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis
    • 21 Jin, S., Chen, J., Chen, L., et al. ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis. Proc Natl Acad Sci U S A 112 (2015), 9088–9093.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 9088-9093
    • Jin, S.1    Chen, J.2    Chen, L.3
  • 22
    • 84874112967 scopus 로고    scopus 로고
    • Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer
    • 22 Saito, R., Shirakawa, R., Nishiyama, H., et al. Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene 32 (2013), 894–902.
    • (2013) Oncogene , vol.32 , pp. 894-902
    • Saito, R.1    Shirakawa, R.2    Nishiyama, H.3
  • 23
    • 0037102428 scopus 로고    scopus 로고
    • Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
    • 23 Nakau, M., Miyoshi, H., Seldin, M.F., et al. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res 62 (2002), 4549–4553.
    • (2002) Cancer Res , vol.62 , pp. 4549-4553
    • Nakau, M.1    Miyoshi, H.2    Seldin, M.F.3
  • 24
    • 84878251843 scopus 로고    scopus 로고
    • Neuroblastoma: developmental biology, cancer genomics and immunotherapy
    • 24 Cheung, N.K., Dyer, M.A., Neuroblastoma: developmental biology, cancer genomics and immunotherapy. Nat Rev Cancer 13 (2013), 397–411.
    • (2013) Nat Rev Cancer , vol.13 , pp. 397-411
    • Cheung, N.K.1    Dyer, M.A.2
  • 25
    • 33645741210 scopus 로고    scopus 로고
    • 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis
    • 25 Oh, J.J., Razfar, A., Delgado, I., et al. 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. Cancer Res 66 (2006), 3419–3427.
    • (2006) Cancer Res , vol.66 , pp. 3419-3427
    • Oh, J.J.1    Razfar, A.2    Delgado, I.3
  • 26
    • 84887415078 scopus 로고    scopus 로고
    • Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups
    • 26 Genovesi, L.A., Ng, C.G., Davis, M.J., et al. Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups. Proc Natl Acad Sci U S A 110 (2013), E4325–E4334.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E4325-E4334
    • Genovesi, L.A.1    Ng, C.G.2    Davis, M.J.3
  • 27
    • 0024602144 scopus 로고
    • Tumor cell proliferation kinetics and tumor growth rate
    • 27 Tubiana, M., Tumor cell proliferation kinetics and tumor growth rate. Acta Oncol 28 (1989), 113–121.
    • (1989) Acta Oncol , vol.28 , pp. 113-121
    • Tubiana, M.1
  • 28
    • 84907494105 scopus 로고    scopus 로고
    • Ral small GTPase signaling and oncogenesis: more than just 15 minutes of fame
    • 28 Gentry, L.R., Martin, T.D., Reiner, D.J., et al. Ral small GTPase signaling and oncogenesis: more than just 15 minutes of fame. Biochim Biophys Acta 1843 (2014), 2976–2988.
    • (2014) Biochim Biophys Acta , vol.1843 , pp. 2976-2988
    • Gentry, L.R.1    Martin, T.D.2    Reiner, D.J.3
  • 29
    • 84911479371 scopus 로고    scopus 로고
    • Discovery and characterization of small molecules that target the GTPase Ral
    • 29 Yan, C., Liu, D., Li, L., et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature 515 (2014), 443–447.
    • (2014) Nature , vol.515 , pp. 443-447
    • Yan, C.1    Liu, D.2    Li, L.3
  • 30
    • 84921270388 scopus 로고    scopus 로고
    • Targeting RAS-ERK signalling in cancer: promises and challenges
    • 30 Samatar, A.A., Poulikakos, P.I., Targeting RAS-ERK signalling in cancer: promises and challenges. Nat Rev Drug Discov 13 (2014), 928–942.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 928-942
    • Samatar, A.A.1    Poulikakos, P.I.2
  • 31
    • 84876878661 scopus 로고    scopus 로고
    • Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis
    • 31 Riordan, J.D., Keng, V.W., Tschida, B.R., et al. Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. PLoS Genet, 9, 2013, e1003441.
    • (2013) PLoS Genet , vol.9 , pp. e1003441
    • Riordan, J.D.1    Keng, V.W.2    Tschida, B.R.3
  • 32
    • 0141742293 scopus 로고    scopus 로고
    • PANTHER: a library of protein families and subfamilies indexed by function
    • 32 Thomas, P.D., Campbell, M.J., Kejariwal, A., et al. PANTHER: a library of protein families and subfamilies indexed by function. Genome Res 13 (2003), 2129–2141.
    • (2003) Genome Res , vol.13 , pp. 2129-2141
    • Thomas, P.D.1    Campbell, M.J.2    Kejariwal, A.3
  • 33
    • 84903818917 scopus 로고    scopus 로고
    • A role for Ral GTPase-activating protein subunit beta in mitotic regulation
    • 33 Personnic, N., Lakisic, G., Gouin, E., et al. A role for Ral GTPase-activating protein subunit beta in mitotic regulation. FEBS J 281 (2014), 2977–2989.
    • (2014) FEBS J , vol.281 , pp. 2977-2989
    • Personnic, N.1    Lakisic, G.2    Gouin, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.