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Volumn 101, Issue 7, 2016, Pages 2937-2944

Stable intraprostatic dihydrotestosterone in healthy medically castrate men treated with exogenous testosterone

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANOLONE; GONADORELIN ANTAGONIST; PLACEBO; TESTOSTERONE; ACYLINE; GONADORELIN; OLIGOPEPTIDE;

EID: 84978401137     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2016-1483     Document Type: Article
Times cited : (23)

References (40)
  • 1
    • 8844263744 scopus 로고    scopus 로고
    • Risks of testosterone replacement therapy in ageing men
    • Tan RS, Salazar JA. Risks of testosterone replacement therapy in ageing men. Expert Opin Drug Saf. 2004;3(6):599-606.
    • (2004) Expert Opin Drug Saf. , vol.3 , Issue.6 , pp. 599-606
    • Tan, R.S.1    Salazar, J.A.2
  • 2
    • 33646400728 scopus 로고    scopus 로고
    • Fundamental aspects of hypogonadism in the aging male
    • Matsumoto AM. Fundamental aspects of hypogonadism in the aging male. Rev Urol. 2003;5(suppl 1):S3-S10.
    • (2003) Rev Urol. , vol.5 , pp. S3-S10
    • Matsumoto, A.M.1
  • 4
    • 70349254624 scopus 로고    scopus 로고
    • Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: The Tromsø Study
    • Vikan T, Schirmer H, Njølstad I, Svartberg J. Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study. Eur J Endocrinol. 2009; 161(3):435-442.
    • (2009) Eur J Endocrinol. , vol.161 , Issue.3 , pp. 435-442
    • Vikan, T.1    Schirmer, H.2    Njølstad, I.3    Svartberg, J.4
  • 5
    • 77950323382 scopus 로고    scopus 로고
    • Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men
    • Vikan T, Schirmer H, Njølstad I, Svartberg J. Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men. Eur J Endocrinol. 2010;162(4):747-754.
    • (2010) Eur J Endocrinol. , vol.162 , Issue.4 , pp. 747-754
    • Vikan, T.1    Schirmer, H.2    Njølstad, I.3    Svartberg, J.4
  • 6
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    • Harman SM, Metter EJ, Tobin JD, et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86(2):724-731.
    • (2001) J Clin Endocrinol Metab. , vol.86 , Issue.2 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3
  • 7
    • 0036170745 scopus 로고    scopus 로고
    • Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts Male Aging Study
    • Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 2002;87(2):589-598.
    • (2002) J Clin Endocrinol Metab. , vol.87 , Issue.2 , pp. 589-598
    • Feldman, H.A.1    Longcope, C.2    Derby, C.A.3
  • 8
    • 0033307232 scopus 로고    scopus 로고
    • Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age
    • Snyder PJ, Peachey H, Hannoush P, et al. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab. 1999;84(8):2647-2653.
    • (1999) J Clin Endocrinol Metab. , vol.84 , Issue.8 , pp. 2647-2653
    • Snyder, P.J.1    Peachey, H.2    Hannoush, P.3
  • 9
    • 2442543161 scopus 로고    scopus 로고
    • Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hy-pogonadal men
    • Wang C, Cunningham G, Dobs A, et al. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hy-pogonadal men. J Clin Endocrinol Metab. 2004;89(5):2085-2098.
    • (2004) J Clin Endocrinol Metab. , vol.89 , Issue.5 , pp. 2085-2098
    • Wang, C.1    Cunningham, G.2    Dobs, A.3
  • 10
    • 79956271879 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)
    • Jones TH, Arver S, Behre HM, et al. Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study). Diabetes Care. 2011;34(4):828-837.
    • (2011) Diabetes Care. , vol.34 , Issue.4 , pp. 828-837
    • Jones, T.H.1    Arver, S.2    Behre, H.M.3
  • 11
    • 84959036202 scopus 로고    scopus 로고
    • Effects of testosterone treatment in older men
    • Snyder PJ, Bhasin S, Cunningham GR, et al. Effects of testosterone treatment in older men. N Engl J Med. 2016;374(7):611-624.
    • (2016) N Engl J Med. , vol.374 , Issue.7 , pp. 611-624
    • Snyder, P.J.1    Bhasin, S.2    Cunningham, G.R.3
  • 13
    • 84856770496 scopus 로고    scopus 로고
    • Androgen deprivation therapy as primary treatment for prostate cancer
    • Cannata DH, Kirschenbaum A, Levine AC. Androgen deprivation therapy as primary treatment for prostate cancer. J Clin Endocrinol Metab. 2012;97(2):360-365.
    • (2012) J Clin Endocrinol Metab. , vol.97 , Issue.2 , pp. 360-365
    • Cannata, D.H.1    Kirschenbaum, A.2    Levine, A.C.3
  • 14
    • 0028358995 scopus 로고
    • Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal controls
    • Behre HM, Bohmeyer J, Nieschlag E. Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal controls. Clin Endocrinol (Oxf). 1994;40(3):341-349.
    • (1994) Clin Endocrinol (Oxf). , vol.40 , Issue.3 , pp. 341-349
    • Behre, H.M.1    Bohmeyer, J.2    Nieschlag, E.3
  • 15
    • 67349282280 scopus 로고    scopus 로고
    • Testosterone and prostate cancer: Revisiting old paradigms
    • Isbarn H, Pinthus JH, Marks LS, et al. Testosterone and prostate cancer: revisiting old paradigms. Eur Urol. 2009;56(1):48-56.
    • (2009) Eur Urol. , vol.56 , Issue.1 , pp. 48-56
    • Isbarn, H.1    Pinthus, J.H.2    Marks, L.S.3
  • 16
    • 33845329200 scopus 로고    scopus 로고
    • Prevalence of prostate cancer among hypogonadal men with prostate-specific antigen levels of 4.0 ng/mL or less
    • Morgentaler A, Rhoden EL. Prevalence of prostate cancer among hypogonadal men with prostate-specific antigen levels of 4.0 ng/mL or less. Urology. 2006;68(6):1263-1267.
    • (2006) Urology. , vol.68 , Issue.6 , pp. 1263-1267
    • Morgentaler, A.1    Rhoden, E.L.2
  • 17
    • 39149084101 scopus 로고    scopus 로고
    • Endogenous sexhormones and prostate cancer: A collaborative analysis of 18 prospective studies
    • Endogenous Hormones and Prostate Cancer Collaborative Group, Roddam AW, Allen NE, Appleby P, et al. Endogenous sexhormones and prostate cancer: a collaborative analysis of 18 prospective studies. J Natl Cancer Inst. 2008;100(3):170-183.
    • (2008) J Natl Cancer Inst. , vol.100 , Issue.3 , pp. 170-183
    • Roddam, A.W.1    Allen, N.E.2    Appleby, P.3
  • 18
    • 85028161077 scopus 로고    scopus 로고
    • Incidence of prostate cancer in hypogonadal men receiving testosterone therapy: Observations from 5-year median followup of 3 registries
    • Haider A, Zitzmann M, Doros G, Isbarn H, Hammerer P, Yassin A. Incidence of prostate cancer in hypogonadal men receiving testosterone therapy: observations from 5-year median followup of 3 registries. J Urol. 2015;193(1):80-86.
    • (2015) J Urol. , vol.193 , Issue.1 , pp. 80-86
    • Haider, A.1    Zitzmann, M.2    Doros, G.3    Isbarn, H.4    Hammerer, P.5    Yassin, A.6
  • 19
    • 84901189874 scopus 로고    scopus 로고
    • The effect of testosterone replacement therapy on prostate cancer: A systematic review and meta-analysis
    • Cui Y, Zong H, Yan H, Zhang Y. The effect of testosterone replacement therapy on prostate cancer: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2014;17(2):132-143.
    • (2014) Prostate Cancer Prostatic Dis. , vol.17 , Issue.2 , pp. 132-143
    • Cui, Y.1    Zong, H.2    Yan, H.3    Zhang, Y.4
  • 20
    • 0035658551 scopus 로고    scopus 로고
    • Testosterone dose-response relationshipsinhealthy young men
    • Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationshipsinhealthy young men. Am J Physiol Endocrinol Metab. 2001;281(6):E1172-E1181.
    • (2001) Am J Physiol Endocrinol Metab. , vol.281 , Issue.6 , pp. E1172-E1181
    • Bhasin, S.1    Woodhouse, L.2    Casaburi, R.3
  • 21
    • 84883699325 scopus 로고    scopus 로고
    • Gonadal steroids and body composition, strength, and sexual function in men
    • Finkelstein JS, Lee H, Burnett-Bowie SA, et al. Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med. 2013;369(11):1011-1022.
    • (2013) N Engl J Med. , vol.369 , Issue.11 , pp. 1011-1022
    • Finkelstein, J.S.1    Lee, H.2    Burnett-Bowie, S.A.3
  • 22
    • 33749550602 scopus 로고    scopus 로고
    • Persistent intraprostatic androgen concentrations after medical castration in healthy men
    • Page ST, Lin DW, Mostaghel EA, et al. Persistent intraprostatic androgen concentrations after medical castration in healthy men. J Clin Endocrinol Metab. 2006;91(10):3850-3856.
    • (2006) J Clin Endocrinol Metab. , vol.91 , Issue.10 , pp. 3850-3856
    • Page, S.T.1    Lin, D.W.2    Mostaghel, E.A.3
  • 23
    • 84864808462 scopus 로고    scopus 로고
    • Impact of male hormonal contraception on prostate androgens and androgen action in healthy men: A randomized, controlled trial
    • Mostaghel EA, Lin DW, Amory JK, et al. Impact of male hormonal contraception on prostate androgens and androgen action in healthy men: a randomized, controlled trial. J Clin Endocrinol Metab. 2012; 97(8):2809-2817.
    • (2012) J Clin Endocrinol Metab. , vol.97 , Issue.8 , pp. 2809-2817
    • Mostaghel, E.A.1    Lin, D.W.2    Amory, J.K.3
  • 24
    • 79951714359 scopus 로고    scopus 로고
    • Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: A ran-domized-controlled trial
    • Page ST, Lin DW, Mostaghel EA, et al. Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a ran-domized-controlled trial. J Clin Endocrinol Metab. 2011;96(2): 430-437.
    • (2011) J Clin Endocrinol Metab. , vol.96 , Issue.2 , pp. 430-437
    • Page, S.T.1    Lin, D.W.2    Mostaghel, E.A.3
  • 25
    • 0015921748 scopus 로고
    • Androgens and erythropoiesis
    • Shahidi NT. Androgens and erythropoiesis. N Engl J Med. 1973; 289(2):72-80.
    • (1973) N Engl J Med. , vol.289 , Issue.2 , pp. 72-80
    • Shahidi, N.T.1
  • 26
    • 0026591918 scopus 로고
    • The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association
    • discussion 1564
    • Barry MJ, Fowler FJ Jr, O'Leary MP, et al. The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol. 1992;148(5):1549-1557; discussion 1564.
    • (1992) J Urol. , vol.148 , Issue.5 , pp. 1549-1557
    • Barry, M.J.1    Fowler, F.J.2    O'Leary, M.P.3
  • 27
    • 0028838399 scopus 로고
    • A brief male sexual function inventory for urology
    • O'Leary MP, Fowler FJ, Lenderking WR, et al. A brief male sexual function inventory for urology. Urology. 1995;46(5):697-706.
    • (1995) Urology. , vol.46 , Issue.5 , pp. 697-706
    • O'Leary, M.P.1    Fowler, F.J.2    Lenderking, W.R.3
  • 28
    • 84897018817 scopus 로고    scopus 로고
    • Targeted androgen pathway suppression in localized prostate cancer: A pilot study
    • Mostaghel EA, Nelson PS, Lange P, et al. Targeted androgen pathway suppression in localized prostate cancer: a pilot study. J Clin Oncol. 2014;32(3):229-237.
    • (2014) J Clin Oncol. , vol.32 , Issue.3 , pp. 229-237
    • Mostaghel, E.A.1    Nelson, P.S.2    Lange, P.3
  • 29
    • 77955348221 scopus 로고    scopus 로고
    • Dose-dependent increase in intra-testicular testosterone by very low-dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency
    • Roth MY, Page ST, Lin K, et al. Dose-dependent increase in intra-testicular testosterone by very low-dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency. J Clin Endocrinol Metab. 2010;95(8):3806-3813.
    • (2010) J Clin Endocrinol Metab. , vol.95 , Issue.8 , pp. 3806-3813
    • Roth, M.Y.1    Page, S.T.2    Lin, K.3
  • 30
    • 0020417830 scopus 로고
    • Calculation of free and bound fractions of testosterone and estradiol-17 β to human plasma proteins at body temperature
    • Södergård R, Bäckström T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 β to human plasma proteins at body temperature. J Steroid Biochem. 1982;16(6):801-810.
    • (1982) J Steroid Biochem. , vol.16 , Issue.6 , pp. 801-810
    • Södergård, R.1    Bäckström, T.2    Shanbhag, V.3    Carstensen, H.4
  • 31
    • 84941671156 scopus 로고    scopus 로고
    • Serum testosterone (T) level variability in T gel-treated older hypogonadal men: Treatment monitoring implications
    • Swerdloff RS, Pak Y, Wang C, et al. Serum testosterone (T) level variability in T gel-treated older hypogonadal men: treatment monitoring implications. J Clin Endocrinol Metab. 2015;100(9):3280-3287.
    • (2015) J Clin Endocrinol Metab. , vol.100 , Issue.9 , pp. 3280-3287
    • Swerdloff, R.S.1    Pak, Y.2    Wang, C.3
  • 32
    • 33750978404 scopus 로고    scopus 로고
    • Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: A randomized controlled trial
    • Marks LS, Mazer NA, Mostaghel E, et al. Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial. JAMA. 2006;296(19): 2351-2361.
    • (2006) JAMA. , vol.296 , Issue.19 , pp. 2351-2361
    • Marks, L.S.1    Mazer, N.A.2    Mostaghel, E.3
  • 33
    • 0842311632 scopus 로고    scopus 로고
    • The androgen axis in recurrent prostate cancer
    • Mohler JL, Gregory CW, Ford OH 3rd, et al. The androgen axis in recurrent prostate cancer. Clin Cancer Res. 2004;10(2):440-448.
    • (2004) Clin Cancer Res. , vol.10 , Issue.2 , pp. 440-448
    • Mohler, J.L.1    Gregory, C.W.2    Ford, O.H.3
  • 34
    • 34250331066 scopus 로고    scopus 로고
    • Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
    • Mostaghel EA, Page ST, Lin DW, et al. Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007;67(10):5033-5041.
    • (2007) Cancer Res. , vol.67 , Issue.10 , pp. 5033-5041
    • Mostaghel, E.A.1    Page, S.T.2    Lin, D.W.3
  • 35
    • 79958287449 scopus 로고    scopus 로고
    • Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy
    • Page ST, Hirano L, Gilchriest J, et al. Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy. J Urol. 2011;186(1):191-197.
    • (2011) J Urol. , vol.186 , Issue.1 , pp. 191-197
    • Page, S.T.1    Hirano, L.2    Gilchriest, J.3
  • 36
    • 57649176913 scopus 로고    scopus 로고
    • Shifting the paradigm of testosterone and prostate cancer: The saturation model and the limits of andro-gen-dependent growth
    • Morgentaler A, Traish AM. Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of andro-gen-dependent growth. Eur Urol. 2009;55(2):310-320.
    • (2009) Eur Urol. , vol.55 , Issue.2 , pp. 310-320
    • Morgentaler, A.1    Traish, A.M.2
  • 37
    • 0014154355 scopus 로고
    • Response of men with advanced prostatic carcinoma to exogenous administration of testosterone
    • Prout GR Jr, Brewer WR. Response of men with advanced prostatic carcinoma to exogenous administration of testosterone. Cancer. 1967;20(11):1871-1878.
    • (1967) Cancer. , vol.20 , Issue.11 , pp. 1871-1878
    • Prout, G.R.1    Brewer, W.R.2
  • 39
    • 77954394453 scopus 로고    scopus 로고
    • Clinical review 1: Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis
    • Fernández-Balsells MM, Murad MH, Lane M, et al. Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2010;95(6): 2560-2575.
    • (2010) J Clin Endocrinol Metab. , vol.95 , Issue.6 , pp. 2560-2575
    • Fernández-Balsells, M.M.1    Murad, M.H.2    Lane, M.3
  • 40
    • 20044388344 scopus 로고    scopus 로고
    • Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    • Bhasin S, Woodhouse L, Casaburi R, et al. Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab. 2005; 90(2):678-688.
    • (2005) J Clin Endocrinol Metab. , vol.90 , Issue.2 , pp. 678-688
    • Bhasin, S.1    Woodhouse, L.2    Casaburi, R.3


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