Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 10, 2016, Pages 2475-2480

  Sturdivant, Jill M ^a   Royalty, Susan M ^a   Lin, Cheng Wen ^a   Moore, Lori A ^a   Yingling, Jeffrey D ^a   Laethem, Carmen L ^a   Sherman, Bryan ^a   Heintzelman, Geoffrey R ^a   Kopczynski, Casey C ^a   Delong, Mitchell A ^a  

^a and Durham   (United States)

Author keywords

InChIKey OURRXQUGYQRVML UHFFFAOYSA N

Indexed keywords

2 CARBOXYLBENZAMIDE DERIVATIVE; 2,4 DIMETHYLBENZOATE; 4 CHLOROPHENYL DERIVATIVE; 4 HYDROXYL PHENYL DERIVATIVE; 4 HYDROXYLMETHYL PHENYL; 4 METHYL PHENYL DERIVATIVE; ALPHA ARYL ALPHA AMINO ISOQUINOLINE DERIVATIVE; ALPHA ARYL BETA AMINO ISOQUINOLINE DERIVATIVE; ALPHA ARYL GAMMA AMINO ISOQUINOLINE DERIVATIVE; BENZOIC ACID; BETA NAPHTHYL DERIVATIVE; HYDROXYMETHYL ISOPROPYL; ISOQUINOLINE AMIDE DERIVATIVE; ISOQUINOLINE DERIVATIVE; METHYL 2 (4 HYDROXYPHENYL)ACETATE DERIVATIVE; METHYL 2 [4 (HYDROXYMETHYL)PHENYL]ACETATE DERIVATIVE; N (BROMOMRTHYL)PHTHALIMIDE DERIVATIVE; N TERT BUTYLOXYCARBONYL AMINO ISOQUINOLINE AMIDE DERIVATIVE; NETARSUDIL; PHENYLACETIC ACID; RHO KINASE; RHO KINASE INHIBITOR; SNJ 1656; TER BUTYL ESTER; TERT BUTYLOXYCARBONY BENZYL ALCOHOL DERIVATIVE; TERT BUTYLOXYCARBONY PHENOL DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEROSUDIL; AR-13324; BENZOIC ACID DERIVATIVE; BETA ALANINE; NORADRENALIN TRANSPORTER; PROTEIN KINASE INHIBITOR; ROCK2 PROTEIN, HUMAN; SEROTONIN TRANSPORTER; SLC6A2 PROTEIN, HUMAN; SLC6A4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL ANALYSIS; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; INTRAOCULAR PRESSURE; NONHUMAN; OPEN ANGLE GLAUCOMA; RABBIT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; LEPORIDAE; METABOLISM; PRECLINICAL STUDY; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRABECULAR MESHWORK;

ANIMALS; BENZOATES; BETA-ALANINE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; MOLECULAR STRUCTURE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROTEIN KINASE INHIBITORS; RABBITS; RHO-ASSOCIATED KINASES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRABECULAR MESHWORK;

EID: 84978328533     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.03.104     Document Type: Article

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