Histoplasmosis-induced hemophagocytic syndrome: A case series and review of the literature

Open Forum Infectious Diseases

Volumn 2, Issue 2, 2015, Pages

  Townsend, Jennifer Leigh ^a   Shanbhag, Satish ^a   Hancock, John ^b   Bowman, Kathryn ^b   Nijhawan, Ank E ^c  

^a JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c PARKLAND HEALTH AND HOSPITAL SYSTEM   (United States)

Author keywords

Disseminated histoplasmosis; Hemophagocytic syndrome; HIV

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; FERRITIN; IMMUNOGLOBULIN; INTERLEUKIN 2 RECEPTOR; ITRACONAZOLE; PREDNISONE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AJELLOMYCES CAPSULATUS; ARTICLE; CARDIOMEGALY; CLINICAL ARTICLE; DEATH; DISEASE ASSOCIATION; FEMALE; FEVER; HEMOPHAGOCYTIC SYNDROME; HISTOPLASMOSIS; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LUNG EDEMA; LYMPHADENOPATHY; MALE; MIDDLE AGED; PNEUMOTHORAX; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPLENOMEGALY; TREATMENT DURATION;

EID: 84978328471     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofv055     Document Type: Article

References (43)

1. Rouphael NG, Talati NJ, Vaughan C, et al. Infections associated with haemophagocytic syndrome. Lancet Infect Dis 2007; 7:814-22.
2. Filipovich AH. The expanding spectrum of hemophagocytic lymphohistiocytosis. Curr Opin Allergy Clin Immunol 2011; 11:512-6.
3. Henter JI, Horne A, Arico M, et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007; 48:124-31.
4. Tseng YT, Sheng WH, Lin BH, et al. Causes, clinical symptoms, and outcomes of infectious diseases associated with hemophagocytic lymphohistiocytosis in Taiwanese adults. J Microbiol Immunol Infect 2011; 44:191-7.
5. Chandrakasan S, Filipovich AH. Hemophagocytic lymphohistiocytosis: advances in pathophysiology, diagnosis, and treatment. J Pediatr 2013; 163:1253-9.
6. Meeths M, Chiang SC, Lofstedt A, et al. Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity. Exp Cell Res 2014; 325:10-7.
7. Tincati C, Basilissi M, Sinigaglia E, et al. Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment. PloS One 2014; 9:e110287.
8. Parasa VR, Selvaraj A, Sikhamani R, Raja A. Interleukins 15 and 12 in combination expand the selective loss of natural killer T cells in HIV infection in vitro. Clin Exp Med 2014; 15:205-13.
9. Naluyima P, Eller MA, Laeyendecker O, et al. Impaired natural killer cell responses are associated with loss of the highly activated NKG2A(+) CD57(+)CD56(dim) subset in HIV-1 subtype D infection in Uganda. AIDS 2014; 28:1273-8.
10. Merino AM, Dugast AS, Wilson CM, et al. KIR2DS4 promotes HIV-1 pathogenesis: new evidence from analyses of immunogenetic data and natural killer cell function. PloS One 2014; 9:e99353.
11. Dillon SM, Lee EJ, Bramante JM, et al. The natural killer cell interferongamma response to bacteria is diminished in untreated HIV-1 infection and defects persist despite viral suppression. J Acquir Immune Defic Syndr 2014; 65:259-67.
12. Majluf-Cruz AS, Hurtado Monroy R, Souto-Meirino C, et al. [Hemophagocytic syndrome associated with histoplasmosis in the acquired immunodeficiency syndrome: description of 3 cases and review of the literature]. Sangre (Barc) 1993; 38:51-5.
13. Keller FG, Kurtzberg J. Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. Am J Pediatr Hematol Oncol 1994; 16:368-71.
14. Koduri PR, Carandang G, DeMarais P, Patel AR. Hyperferritinemia in reactive hemophagocytic syndrome report of four adult cases. Am J Hematol 1995; 49:247-9.
15. Koduri PR, Chundi V, DeMarais P, et al. Reactive hemophagocytic syndrome: a new presentation of disseminated histoplasmosis in patients with AIDS. Clin Infect Dis 1995; 21:1463-5.
16. Chemlal K, Andrieu-Bautru V, Couvelard A. Hemophagocytic syndrome during Histoplasma capsulatum infection. Haematologica 1997; 82:726.
17. Kumar N, Jain S, Singh ZN. Disseminated histoplasmosis with reactive hemophagocytosis: aspiration cytology findings in two cases. Diagn Cytopathol 2000; 23:422-4.
18. Rao RD, Morice WG, Phyliky RL. Hemophagocytosis in a patient with chronic lymphocytic leukemia and histoplasmosis. Mayo Clin Proc 2002; 77:287-90.
19. Masri K, Mahon N, Rosario A, et al. Reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a heart transplant recipient. J Heart Lung Transplant 2003; 22:487-91.
20. Gil-Brusola A, Peman J, Santos M, et al. Disseminated histoplasmosis with hemophagocytic syndrome in a patient with AIDS: description of one case and review of the Spanish literature. Rev Iberoam Micol 2007; 24:312-6.
21. Guiot HM, Bertran-Pasarell J, Tormos LM, et al. Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: the role of the real-time polymerase chain reaction in the diagnosis and successful treatment with amphotericin B lipid complex. Diagn Microbiol Infect Dis 2007; 57:429-33.
22. Sanchez A, Celaya AK, Victorio A. Histoplasmosis-associated hemophagocytic syndrome: a case report. AIDS Read 2007; 17:496-9.
23. Wang Z, Duarte AG, Schnadig VJ. Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis: an unusual case diagnosed at autopsy. South Med J 2007; 100:208-11.
24. Phillips J, Staszewski H, Garrison M. Successful treatment of secondary hemophagocytic lymphohistiocytosis in a patient with disseminated histoplasmosis. Hematology 2008; 13:282-5.
25. De Lavaissiere M, Manceron V, Bouree P, et al. Reconstitution inflammatory syndrome related to histoplasmosis, with a hemophagocytic syndrome in HIV infection. J Infect 2009; 58:245-7.
26. Lo MM, Mo JQ, Dixon BP, Czech KA. Disseminated histoplasmosis associated with hemophagocytic lymphohistiocytosis in kidney transplant recipients. Am J Transplant 2010; 10:687-91.
27. van Koeveringe MP, Brouwer RE. Histoplasma capsulatum reactivation with haemophagocytic syndrome in a patient with chronic lymphocytic leukaemia. Neth J Med 2010; 68:418-21.
28. Vaid N, Patel P. A case of haemophagocytic syndrome in HIVassociated disseminated histoplasmosis. Acute Med 2011; 10:142-4.
29. Chandra H, Chandra S, Sharma A. Histoplasmosis on bone marrow aspirate cytological examination associated with hemophagocytosis and pancytopenia in an AIDS patient. Korean J Hematol 2012; 47:77-9.
30. Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 2007; 45:807-25.
31. Centers for Disease Control and Prevention. Texas-2013 State Health Profile. State Health Profiles 2013; P. 1-2. Available at: http://www.cdc.gov/nchhstp/stateprofiles/pdf/Texas_profile.pdf. Accessed 30 October, 2014.
32. Prevention CfDCa. Sources of Histoplasmosis: Where does Histoplasma live? 2014. Available at: http://www.cdc.gov/fungal/diseases/histoplasmosis/causes.html. Accessed 30 October, 2014.
33. Nieto-Rios JF, Aristizabal-Alzate A, Ocampo C, et al. Disseminated histoplasmosis and haemophagocytic syndrome in two kidney transplant patients. Nefrologia 2012; 32:683-4.
34. Naranbhai V, Altfeld M, Abdool Karim Q, et al. Natural killer cell function in women at high risk for HIV acquisition: insights from a microbicide trial. AIDS 2012; 26:1745-53.
35. Adachi E, Koibuchi T, Imai K, et al. Hemophagocytic syndrome in an acute human immunodeficiency virus infection. Intern Med 2013; 52:629-32.
36. National Institutes of Health. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. AIDSInfo 2015. Available at: http://aidsinfo.nih.gov/guidelines/html/4/adultand-adolescent-oi-prevention-and-treatment-guidelines/0. Accessed 10 October, 2014.
37. Schulert GS, Grom AA. Pathogenesis of macrophage activation syndrome and potential for cytokine-directed therapies. Annu Rev Med 2015; 66:145-59.
38. Guo X, Chen N, Wang TY, et al. [Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis: report of four childhood cases]. Zhonghua Er Ke Za Zhi 2011; 49:550-3.
39. Thoden J, Rieg S, VenhoffN, et al. Fatal hemophagocytic syndrome in a patient with a previously well-controlled asymptomatic HIV infection after EBV reactivation. J Infect 2012; 64:110-2.
40. Safdar SM, Rehman JU, Samman EM, Bahabri NM. Fatal hemophagocytic syndrome as a manifestation of immune reconstitution syndrome in a patient with acquired immunodeficiency syndrome. Saudi Med J 2013; 34:861-4.
41. Patel KK, Patel AK, Sarda P, et al. Immune reconstitution visceral leishmaniasis presented as hemophagocytic syndrome in a patient with AIDS from a nonendemic area: a case report. J Int Assoc Physicians AIDS Care 2009; 8:217-20.
42. Cuttelod M, Pascual A, Baur Chaubert AS, et al. Hemophagocytic syndrome after highly active antiretroviral therapy initiation: a lifethreatening event related to immune restoration inflammatory syndrome? AIDS 2008; 22:549-51.
43. Kanitez M, Kapmaz M, Alpay N, et al. Hemophagocytic syndrome associated with immune reconstitution inflammatory syndrome in a patient with AIDS related Burkitt's leukemia/lymphoma. Case Report Med 2014; 2014:308081.