Structural optimization and structure-functional selectivity relationship studies of G protein-biased EP2 receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 10, 2016, Pages 2446-2449

  Ogawa, Seiji ^a   Watanabe, Toshihide ^a   Moriyuki, Kazumi ^a   Goto, Yoshikazu ^a   Yamane, Shinsaku ^a   Watanabe, Akio ^a   Tsuboi, Kazuma ^a   Kinoshita, Atsushi ^a   Okada, Takuya ^a   Takeda, Hiroyuki ^a   Tani, Kousuke ^a   Maruyama, Toru ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Agonist; Biased ligand; EP2; Prostaglandin; Structure functional selectivity relationship

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; PROSTAGLANDIN E RECEPTOR 2 AGONIST; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN; OLIGOPEPTIDE; PROSTAGLANDIN E RECEPTOR 2; PTGER2 PROTEIN, HUMAN; SARCOSINE-ARGINYL-VALYL-TYROSYL-ISOLEUCYL-HISTIDYL-PROLYL-ALANINE;

ARTICLE; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG SYNTHESIS; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN FUNCTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; AGONISTS; CHEMISTRY; DRUG SCREENING; HUMAN; PROCEDURES;

DRUG SCREENING ASSAYS, ANTITUMOR; GTP-BINDING PROTEINS; HUMANS; OLIGOPEPTIDES; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84978328256     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.03.110     Document Type: Article

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