GNPAT variant is not associated with severe iron overload in Irish C282Y homozygotes

Hepatology

Volumn 63, Issue 6, 2016, Pages 2055-2056

  Ryan, Eleanor ^a   Russell, Jennifer ^a   Ryan, John D ^b   Crowe, John ^a   Stewart, Stephen ^a  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON;

ALCOHOL CONSUMPTION; DISEASE SEVERITY; FERRITIN BLOOD LEVEL; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GNPAT GENE; HEMOCHROMATOSIS; HOMOZYGOTE; HUMAN; IRISH (CITIZEN); IRON OVERLOAD; LETTER; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84978252414     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28258     Document Type: Letter

References (3)

1. McLaren CE, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, et al. Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology 2015;62:429-439.
2. Bardou-Jacquet E, de Tayrac M, Mosser J, Deugnier Y. GNPAT variant associated with severe iron overload in HFE hemochromatosis. Hepatology 2015;62:1917-1918.
3. De Tayrac M, Roth M-P, Jouanolle A-M, Coppin H, le Gac G, Piperno A, et al. Genome-wide association study identifies TF as a significant modifier of iron metabolism in HFE hemochromatosis. J Hepatol 2015;62:664-672.