GNPAT Variant associated with severe iron overload in HFE hemochromatosis

Hepatology

Volumn 62, Issue 6, 2015, Pages 1917-1918

  Bardou Jacquet, Edouard ^a,b,c   de Tayrac, Marie ^a,b,d   Mosser, Jean ^a,b,d   Deugnier, Yves ^a,b,c  

^a RENNES UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c INSERM   (France)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; HLA ANTIGEN CLASS 1; MEMBRANE PROTEIN;

GENETIC VARIATION; GENETICS; HEMOCHROMATOSIS; HUMAN; IRON OVERLOAD; MALE;

ACYLTRANSFERASES; GENETIC VARIATION; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON OVERLOAD; MALE; MEMBRANE PROTEINS;

EID: 84955185532     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27854     Document Type: Letter

References (2)

1. McLaren CE, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, et al. Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology 2015;62:429-439.
2. de Tayrac M, Roth M, Jouanolle A, Coppin H, le Gac G, Piperno A, et al. Genome-wide association study identifies TF as a significant modifier gene of iron metabolism in HFE hemochromatosis. J Hepatol 2015;62:664-672.