Simvastatin Therapy in the Acute Stage of Traumatic Brain Injury Attenuates Brain Trauma-Induced Depression-Like Behavior in Rats by Reducing Neuroinflammation in the Hippocampus

Neurocritical Care

Volumn 26, Issue 1, 2017, Pages 122-132

  Lim, Sher Wei ^a,b,d   Shiue, Yow Ling ^a   Liao, Jen Chieh ^b   Wee, Hsiao Yue ^b   Wang, Che Chuan ^b,c   Chio, Chung Ching ^b   Chang, Chin Hung ^b   Hu, Chiao Ya ^b   Kuo, Jinn Rung ^b,c  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d Min Hwei College of Health Care Management   (Taiwan)

Author keywords

Depression like behavior; Fluid percussion injury; Forced swim; Hippocampus; Maximal angle; Microglia; Simvastatin; Tumor necrosis factor alpha

Indexed keywords

CASPASE 3; GLIAL FIBRILLARY ACIDIC PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN; SIMVASTATIN; TUMOR NECROSIS FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEPRESSION; DRUG DOSE COMPARISON; FORCED SWIM TEST; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; IMMOBILITY; IMMUNOFLUORESCENCE TEST; MALE; MICROGLIA; MOTOR PERFORMANCE; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; TRAUMATIC BRAIN INJURY; TUNEL ASSAY; ACUTE DISEASE; ANIMAL; BRAIN INJURIES, TRAUMATIC; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ACUTE DISEASE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN INJURIES, TRAUMATIC; DEPRESSION; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 84978152269     PISSN: 15416933     EISSN: 15560961     Source Type: Journal    
DOI: 10.1007/s12028-016-0290-6     Document Type: Article

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