Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor α agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, on experimental traumatic brain injury

Journal of Pharmacology and Experimental Therapeutics

Volumn 326, Issue 3, 2008, Pages 966-974

  Xiao, Ru Chen ^a   Besson, Valerie C ^a,b   Beziaud, Tiphaine ^a   Plotkine, Michel ^a   Marchand Leroux, Catherine ^a  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FENOFIBRATE; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; SIMVASTATIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; CONTROLLED STUDY; DOSE RESPONSE; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENTIATION; HISTOPATHOLOGY; MALE; MOTOR COORDINATION; NEUROPROTECTION; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; TRAUMATIC BRAIN INJURY; AGONISTS; ANIMAL; BRAIN INJURIES; COMPARATIVE STUDY; DISEASE MODEL; DRUG COMBINATION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FENOFIBRATE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; PPAR ALPHA; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 53849118824     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.140368     Document Type: Article

References (41)

1. Athyros VG, Papageorgiou AA, Athyrou VV, Demitriadis DS, and Kontopoulos AG (2002) Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia. Diabetes Care 25:1198-1202.
2. Bareyre F, Wahl F, McIntosh TK, and Stutzmann JM (1997) Time course of cerebral oedema after traumatic brain injury in rats: effects of riluzole and mannitol. J Neurotrauma 14:839-849.
3. Besson VC, Croci N, Boulu RG, Plotkine M, and Marchand-Verrecchia C (2003) Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat. Brain Res 989:58-66.
4. Besson VC, Chen XR, Plotkine M, and Marchand-Verrecchia C (2005) Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, exerts neuroprotective effects in traumatic brain injury. Neurosci Lett 388:7-12.
5. Bordet R, Ouk T, Petrault O, Gelé P, Gautier S, Laprais M, Deplanque D, Duriez P, Staels B, Fruchart JC, et al. (2006) PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases. Biochem Soc Trans 34:1341-1346.
6. Bramlett HM and Dietrich WD (2004) Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J Cereb Blood Flow Metab 24:133-150.
7. Chen SF, Hung TH, Chen CC, Lin KH, Huang YN, Tsai HC, and Wang JY (2007a) Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury. Life Sci 81:288-298.
8. Chen XR, Besson VC, Palmier B, Garcia Y, Plotkine M, and Marchand-Leroux C (2007b) Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury. J Neurotrauma 24:1119-1131.
9. Davidson MH, Armani A, McKenney JM, and Jacobson TA (2007) Safety considerations with fibrate therapy. Am J Cardiol 99:3C-18C.
10. Fruchart JC, Duriez P, and Staels B (1999) Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 10:245-257.
11. Golanov EV and Reis DJ (1995) Contribution of cerebral edema to the neuronal salvage elicited by stimulation of cerebellar fastigial nucleus after occlusion of the middle cerebral artery in rat. J Cereb Blood Flow Metab 15:172-174.
12. Greenwood J and Mason JC (2007) Statins and the vascular endothelial inflammatory response. Trends Immunol 28:88-98.
13. Inoue I, Goto S, Mizotani K, Awata T, Mastunaga T, Kawai S, Nakajima T, Hokari S, Komoda T, and Katayama S (2000) Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of mRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in primary endothelial cells. Life Sci 67:863-876.
14. Inoue I, Itoh F, Aoyagi S, Tazawa S, Kusama H, Akahane M, Mastunaga T, Hayashi K, Awata T, Komoda T, et al. (2002) Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NF-kappa B. Biochem Biophys Res Commun 290:131-139.
15. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
16. Koh KK, Ahn JY, Jin DK, Han SH, Kim HS, Choi IS, Ahn TH, Shin EK, and Jeong EM (2004) Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia. Int J Cardiol 97:239-244.
17. Koh KK, Quon MJ, Han SH, Chung WJ, Ahn JY, Seo YH, Choi IS, and Shin EK (2005) Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia. J Am Coll Cardiol 45:1649-1653.
18. Koh KK, Quon MJ, Rosenson RS, Chung WJ, and Han SH (2008) Vascular and metabolic effects of treatment of combined hyperlipidemia: focus on statins and fibrates. Int J Cardiol 124:149-159.
19. Landrier JF, Thomas C, Grober J, Duez H, Percevault F, Souidi M, Linard C, Staels B, and Besnard P (2004) Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent. J Biol Chem 279:45512-45518.
20. Law M and Rudnicka AR (2006) Statin safety: a systematic review. Am J Cardiol 97:52C-60C.
21. Liao JK and Laufs U (2005) Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45:89-118.
22. Lu D, Goussev A, Chen J, Pannu P, Li Y, Mahmood A, and Chopp M (2004) Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury. J Neurotrauma 21:21-32.
23. Lu D, Qu C, Goussev A, Jiang H, Lu C, Schallert T, Mahmood A, Chen J, Li Y, and Chopp M (2007) Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma 24:1132-1146.
24. Martin G, Duez H, Blanquart C, Berezowski V, Poulain P, Fruchart JC, Najib-Fruchart J, Glineur C, and Staels B (2001) Statin-induced inhibition of the Rhosignaling pathway activates PPARalpha and induces HDL apoA-I. J Clin Invest 107:1423-1432.
25. Millerot-Serrurot E, Chausset A, Mossiat C, Prigent-Tessier A, Bertrand N, Garnier P, Beley A, and Marie C (2007) Effect of early decrease in the lesion size on late brain tissue loss, synaptophysin expression and functionality after a focal brain lesion in rats. Neurochem Int 50:328-335.
26. Moinard C, Neveux N, Royo N, Genthon C, Marchand-Verrecchia C, Plotkine M, and Cynober L (2005) Characterization of the alteration of nutritional state in brain injury induced by fluid percussion in rats. Intensive Care Med 31:281-288.
27. Musial J, Undas A, Gajewski P, Jankowski M, Sydor W, and Szczeklik A (2001) Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia. Int J Cardiol 77:247-253.
28. Pannu R, Barbosa E, Singh AK, and Singh I (2005) Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats. J Neurosci Res 79:340-350.
29. Paumelle R, Blanquart C, Briand O, Barbier O, Duhem C, Woerly G, Percevault F, Fruchart JC, Dombrowicz D, Glineur C, et al. (2006) Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway. Circ Res 98:361-369.
30. Penn R, Williams RX 3rd, Guha-Ray DK, Sawyers WG, Braun SL, and Rains KT (2006) An open-label, crossover study of the pharmacokinetics of insoluble drug delivery-microparticle fenofibrate in combination with atorvastatin, simvastatin, and extended-release niacin in healthy volunteers. Clin Ther 28:45-54.
31. Qu C, Lu D, Goussev A, Schallert T, Mahmood A, and Chopp M (2005) Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury. J Neurosurg 103:695-701.
32. Ray SK, Dixon CE, and Banik NL (2002) Molecular mechanisms in the pathogenesis of traumatic brain injury. Histol Histopathol 17:1137-1152.
33. Shabanzadeh AP, Shuiab A, and Wang CX (2005) Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke. Brain Res 1042:1-5.
34. Staels B, Koenig W, Habib A, Merval R, Lebret M, Torra IP, Delerive P, Fadel A, Chinetti G, Fruchart JC, et al. (1998) Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. Nature 393: 790-793.
35. StepieńK, Tomaszewski M, and Czuczwar SJ (2005) Neuroprotective properties of statins. Pharmacol Rep 57:561-569.
36. Unterberg AW, Stover J, Kress B, and Kiening KL (2004) Edema and brain trauma. Neuroscience 129:1021-1029.
37. Vega GL, Ma PT, Cater NB, Filipchuk N, Meguro S, Garcia-Garcia AB, and Grundy SM (2003) Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome. Am J Cardiol 91:956-960.
38. Wagner AK, Postal BA, Darrah SD, Chen X, and Khan AS (2007) Deficits in novelty exploration after controlled cortical impact. J Neurotrauma 24:1308-1320.
39. Wang H, Lynch JR, Song P, Yang HJ, Yates RB, Mace B, Warner DS, Guyton JR, and Laskowitz DT (2007) Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol 206:59-69.
40. Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, et al. (2007) Statins activate peroxisome proliferator-activated receptor γ through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. Circ Res 100:1442-1451.
41. Zapolska-Downar D, Siennicka A, Kaczmarczyk M, Kolodziej B, and Naruszewicz M (2004) Simvastatin modulates TNFalpha-induced adhesion molecules expression in human endothelial cells. Life Sci 75:1287-1302.