Differential expression of PCSK9 modulates infection, inflammation, and coagulation in a murine model of sepsis

Shock

Volumn 46, Issue 6, 2016, Pages 672-680

  Dwivedi, Dhruva J ^a,b   Grin, Peter M ^a,b   Khan, Momina ^a,b   Prat, Annik ^c   Zhou, Ji ^a,b   Fox Robichaud, Alison E ^a,b   Seidah, Nabil G ^c   Liaw, Patricia C ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Bacteria; bacterial dissemination; cytokines; histopathology; morbidity; pathogen; proprotein convertase subtilisin kexin type 9; sepsis

Indexed keywords

ALANINE AMINOTRANSFERASE; CELL DNA; CREATININE; INTERLEUKIN 10; INTERLEUKIN 6; MYELOPEROXIDASE; PROPROTEIN CONVERTASE 9; PROTEIN C; THROMBIN ANTITHROMBIN COMPLEX; PCSK9 PROTEIN, MOUSE; PEROXIDASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL LOAD; BLOOD; BLOOD CLOTTING; BODY FLUID; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CECUM; CONTROLLED STUDY; CORE TEMPERATURE; CREATININE BLOOD LEVEL; CYANOSIS; DYSPNEA; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; INFECTION; KIDNEY; KIDNEY DISEASE; LIGATION; LIVER; LIVER DISEASE; LUNG; MALE; MOUSE; NONHUMAN; PERITONEAL CAVITY; PLASMA; PNEUMONIA; PROTEIN BLOOD LEVEL; PUNCTURE; SCORING SYSTEM; SHAM PROCEDURE; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; DISEASE MODEL; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SEPSIS;

ALANINE TRANSAMINASE; ANIMALS; BLOOD COAGULATION; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; KIDNEY; LIVER; LUNG; MALE; MICE; MICE, KNOCKOUT; PEROXIDASE; PROPROTEIN CONVERTASE 9; PROTEIN C; SEPSIS;

EID: 84978128476     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000682     Document Type: Article

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