Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity

Respiratory Research

Volumn 15, Issue 1, 2014, Pages

  Perotin, Jeanne Marie ^a   Adam, Damien ^a   Vella Boucaud, Juliette ^a   Delepine, Gonzague ^a   Sandu, Sebastian ^a   Jonvel, Anne Carole ^b   Prevost, Alain ^c   Berthiot, Gérard ^b   Pison, Christophe ^d   Lebargy, François ^a   Birembaut, Philippe ^a   Coraux, Christelle ^a   Deslee, Gaëtan ^a  

^a REIMS UNIVERSITY HOSPITAL   (France)

^b Hospital   (France)

^c INSTITUT JEAN GODINOT   (France)

^d UNIV GRENOBLE ALPES   (France)

Author keywords

Airway epithelium; Bronchial cells; Bronchiolar cells; Cell proliferation; COPD; Wound repair

Indexed keywords

GELATINASE A; GELATINASE B; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; AUTACOID; CYTOKINE; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN;

AIRWAY OBSTRUCTION; AIRWAY REMODELING; ARTICLE; BRONCHUS MUCOSA; CELL HYPERPLASIA; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; EMPHYSEMA; KIDNEY CANCER; LUNG CANCER; LUNG FUNCTION TEST; LUNG TRANSPLANTATION; PROSPECTIVE STUDY; RESPIRATORY EPITHELIUM; WOUND CLOSURE; WOUND HEALING; AGED; BRONCHUS; CELL CULTURE; EPITHELIUM CELL; FEMALE; HUMAN; IMMUNOLOGY; LUNG EMPHYSEMA; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TIME FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AIRWAY REMODELING; BRONCHI; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; SEVERITY OF ILLNESS INDEX; TIME FACTORS; WOUND HEALING;

EID: 84978087367     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-014-0151-9     Document Type: Article

References (24)

1. Nussbaumer-Ochsner Y, Rabe KF: Systemic manifestations of COPD. Chest. 2011, 139: 165-173. 10.1378/chest.10-1252.
2. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2014. [], [ http://www.goldcopd.org/ ]
3. Halpin DM, Miravittles M: Chronic obstructive pulmonary disease: the disease and its burden to society. Proc Am Thorac Soc. 2006, 3: 619-623. 10.1513/pats.200603-093SS.
4. Grainge CL, Davies DE: Epithelial injury and repair in airways diseases. Chest. 2013, 144: 1906-1912. 10.1378/chest.12-1944.
5. Hirota N, Martin JG: Mechanisms of airway remodeling. Chest. 2013, 144: 1026-1032. 10.1378/chest.12-3073.
6. Ganesan S, Sajjan US: Repair and remodeling of airway epithelium after injury in chronic obstructive pulmonary disease. Curr Respir Care Rep. 2013, 2: 145-154. 10.1007/s13665-013-0052-2.
7. Washko GR, Criner GJ, Mohsenifar Z, Sciurba FC, Sharafkhaneh A, Make BJ, Hoffman EA, Reilly JJ: Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanics. COPD. 2008, 5: 177-186. 10.1080/15412550802093025.
8. Trinh NT, Bardou O, Privé A, Maillé E, Adam D, Lingée S, Ferraro P, Desrosiers MY, Coraux C, Brochiero E: Improvement of defective cystic fibrosis airway epithelial wound repair after CFTR rescue. Eur Respir J. 2012, 40: 1390-1400. 10.1183/09031936.00221711.
9. Bals R, Beisswenger C, Blouquit S, Chinet T: Isolation and air-liquid interface culture of human large airway and bronchiolar epithelial cells. J Cyst Fibros. 2004, 3: 49-51. 10.1016/j.jcf.2004.05.010.
10. Lapperre TS, Sont JK, van Schadewijk A, Gosman MM, Postma DS, Bajema IM, Timens W, Mauad T, Hiemstra PS: Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study. Respir Res. 2007, 8: 85-10.1186/1465-9921-8-85.
11. Zhou F, Onizawa S, Nagai A, Aoshiba K: Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury. Respir Res. 2011, 12: 78-10.1186/1465-9921-12-78.
12. Allen-Gipson DS, Zimmerman MC, Zhang H, Castellanos G, O'Malley JK, Alvarez-Ramirez H, Kharbanda K, Sisson JH, Wyatt TA: Smoke extract impairs adenosine wound healing: implications of smoke-generated reactive oxygen species. Am J Respir Cell Mol Biol. 2013, 48: 665-673. 10.1165/rcmb.2011-0273OC.
13. Herfs M, Hubert P, Poirrier AL, Vandevenne P, Renoux V, Habraken Y, Cataldo D, Boniver J, Delvenne P: Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy. Am J Respir Cell Mol Biol. 2012, 47: 67-79. 10.1165/rcmb.2011-0353OC.
14. Elkington PT, Friedland JS: Matrix metalloproteinases in destructive pulmonary pathology. Thorax. 2006, 61: 259-266. 10.1136/thx.2005.051979.
15. Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM: The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med. 2011, 183: 876-884. 10.1164/rccm.201005-0718OC.
16. Buisson AC, Zahm JM, Polette M, Pierrot D, Bellon G, Puchelle E, Birembaut P, Tournier JM: Gelatinase B is involved in the in vitro wound repair of human respiratory epithelium. J Cell Physiol. 1996, 166: 413-426. 10.1002/(SICI)1097-4652(199602)166:2<413::AID-JCP20>3.0.CO;2-A.
17. Legrand C, Gilles C, Zahm JM, Polette M, Buisson AC, Kaplan H, Birembaut P, Tournier JM: Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling. J Cell Biol. 1999, 146: 517-529. 10.1083/jcb.146.2.517.
18. Baraldo S, Bazzan E, Zanin ME, Turato G, Garbisa S, Maestrelli P, Papi A, Miniati M, Fabbri LM, Zuin R, Saetta M: Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression. Chest. 2007, 132: 1733-1740. 10.1378/chest.06-2819.
19. Crosby LM, Waters CM: Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol. 2010, 298: L715-L731. 10.1152/ajplung.00361.2009.
20. White SR, Martin LD, Abe MK, Marroquin BA, Stern R, Fu X: Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2009, 297: L164-L173. 10.1152/ajplung.90453.2008.
21. Lesur O, Brisebois M, Thibodeau A, Chagnon F, Lane D, Fullop T: Role of IFN-gamma and IL-2 in rat lung epithelial cell migration and apoptosis after oxidant injury. Am J Physiol Lung Cell Mol Physiol. 2004, 286: L4-L14. 10.1152/ajplung.00367.2002.
22. Sharma G, Hanania NA, Shim YM: The aging immune system and its relationship to the development of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009, 6: 573-580. 10.1513/pats.200904-022RM.
23. McDonough JE, Yuan R, Suzuki M, Seyednejad N, Elliott WM, Sanchez PG, Wright AC, Gefter WB, Litzky L, Coxson HO, Paré PD, Sin DD, Pierce RA, Woods JC, McWilliams AM, Mayo JR, Lam SC, Cooper JD, Hogg JC: Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med. 2011, 365: 1567-1575. 10.1056/NEJMoa1106955.
24. Hogg JC, McDonough JE, Suzuki M: Small airway obstruction in COPD: new insights based on micro-CT imaging and MRI imaging. Chest. 2013, 143: 1436-1443. 10.1378/chest.12-1766.