메뉴 건너뛰기




Volumn 4, Issue 1, 2015, Pages

Novel antidotes for target specific oral anticoagulants

Author keywords

[No Author keywords available]

Indexed keywords

ANDEXANET ALFA; ANTICOAGULANT AGENT; ANTIDOTE; APIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; CIRAPARANTAG; DABIGATRAN; EDOXABAN; FONDAPARINUX; IDARUCIZUMAB; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; PROTHROMBIN COMPLEX; RIVAROXABAN; WARFARIN;

EID: 84978024435     PISSN: None     EISSN: 21623619     Source Type: Journal    
DOI: 10.1186/s40164-015-0020-3     Document Type: Review
Times cited : (32)

References (37)
  • 1
    • 0028062665 scopus 로고
    • History of drugs for thrombotic disease. Discovery, development, and directions for the future
    • Mueller RL, Scheidt S. History of drugs for thrombotic disease. Discovery, development, and directions for the future. Circulation. 1994;89(1):432-49.
    • (1994) Circulation. , vol.89 , Issue.1 , pp. 432-449
    • Mueller, R.L.1    Scheidt, S.2
  • 2
    • 77649280047 scopus 로고    scopus 로고
    • The potential benefits of low-molecular-weight heparins in cancer patients
    • Robert F. The potential benefits of low-molecular-weight heparins in cancer patients. J Hematol Oncol. 2010;3:3.
    • (2010) J Hematol Oncol. , vol.3 , pp. 3
    • Robert, F.1
  • 4
    • 84921367759 scopus 로고    scopus 로고
    • Changing practice of anticoagulation: will target-specific anticoagulants replace warfarin?
    • Arepally GM, Ortel TL. Changing practice of anticoagulation: will target-specific anticoagulants replace warfarin? Annu Rev Med. 2015;66:241-53.
    • (2015) Annu Rev Med. , vol.66 , pp. 241-253
    • Arepally, G.M.1    Ortel, T.L.2
  • 5
    • 84937630802 scopus 로고    scopus 로고
    • Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments
    • Mega JL, Simon T. Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments. Lancet. 2015;386(9990):281-91.
    • (2015) Lancet. , vol.386 , Issue.9990 , pp. 281-291
    • Mega, J.L.1    Simon, T.2
  • 6
    • 84885618705 scopus 로고    scopus 로고
    • Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism
    • Buller H, Investigators H-V. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013;369(15):1406-15.
    • (2013) N Engl J Med. , vol.369 , Issue.15 , pp. 1406-1415
    • Buller, H.1    Investigators, H.-V.2
  • 8
    • 84931291673 scopus 로고    scopus 로고
    • Reversal of anticoagulants: an overview of current developments
    • Greinacher A, Thiele T, Selleng K. Reversal of anticoagulants: an overview of current developments. Thromb Haemost. 2015;113(5):931-42.
    • (2015) Thromb Haemost. , vol.113 , Issue.5 , pp. 931-942
    • Greinacher, A.1    Thiele, T.2    Selleng, K.3
  • 9
    • 84897895391 scopus 로고    scopus 로고
    • How I treat target-specific oral anticoagulant-associated bleeding
    • Siegal DM, Garcia DA, Crowther MA. How I treat target-specific oral anticoagulant-associated bleeding. Blood. 2014;123(8):1152-8.
    • (2014) Blood. , vol.123 , Issue.8 , pp. 1152-1158
    • Siegal, D.M.1    Garcia, D.A.2    Crowther, M.A.3
  • 10
    • 84938900144 scopus 로고    scopus 로고
    • Targeted anti-anticoagulants
    • Bauer KA. Targeted anti-anticoagulants. N Engl J Med. 2015;373:569-71.
    • (2015) N Engl J Med. , vol.373 , pp. 569-571
    • Bauer, K.A.1
  • 11
    • 84907202540 scopus 로고    scopus 로고
    • Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials
    • van Es N, Coppens M, Schulman S, Middeldorp S, Büller HR. Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials. Blood. 2014;124(12):1968-75.
    • (2014) Blood. , vol.124 , Issue.12 , pp. 1968-1975
    • Es, N.1    Coppens, M.2    Schulman, S.3    Middeldorp, S.4    Büller, H.R.5
  • 12
    • 84900992940 scopus 로고    scopus 로고
    • Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: the ARISTOTLE Trial (apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation): predictors, characteristics, and clinical outcomes
    • Hylek EM, Held C, Alexander JH, Lopes RD, De Caterina R, Wojdyla DM, et al. Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: the ARISTOTLE Trial (apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation): predictors, characteristics, and clinical outcomes. J Am Coll Cardiol. 2014;63(20):2141-7.
    • (2014) J Am Coll Cardiol. , vol.63 , Issue.20 , pp. 2141-2147
    • Hylek, E.M.1    Held, C.2    Alexander, J.H.3    Lopes, R.D.4    Caterina, R.5    Wojdyla, D.M.6
  • 13
    • 84896117299 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials
    • Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383(9921):955-62.
    • (2014) Lancet. , vol.383 , Issue.9921 , pp. 955-962
    • Ruff, C.T.1    Giugliano, R.P.2    Braunwald, E.3    Hoffman, E.B.4    Deenadayalu, N.5    Ezekowitz, M.D.6
  • 14
    • 84978021375 scopus 로고    scopus 로고
    • Spontaneous, life-threatening hemorrhagic cardiac tamponade secondary to rivaroxaban
    • PMID 26035030.
    • Kham NM, Song M. Spontaneous, life-threatening hemorrhagic cardiac tamponade secondary to rivaroxaban. Am J Ther. 2015;22:PMID 26035030.
    • (2015) Am J Ther. , vol.22
    • Kham, N.M.1    Song, M.2
  • 15
    • 84904047925 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial
    • Halvorsen S, Atar D, Yang H, De Caterina R, Erol C, Garcia D, et al. Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial. Eur Heart J. 2014;35(28):1864-72.
    • (2014) Eur Heart J. , vol.35 , Issue.28 , pp. 1864-1872
    • Halvorsen, S.1    Atar, D.2    Yang, H.3    Caterina, R.4    Erol, C.5    Garcia, D.6
  • 16
    • 84931264466 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation ex vivo: porcine study comparing prothrombin complex concentrates and idarucizumab
    • Honickel M, Treutler S, van Ryn J, Tillmann S, Rossaint R, Grottke O. Reversal of dabigatran anticoagulation ex vivo: porcine study comparing prothrombin complex concentrates and idarucizumab. Thromb Haemost. 2015;113(4):728-40.
    • (2015) Thromb Haemost. , vol.113 , Issue.4 , pp. 728-740
    • Honickel, M.1    Treutler, S.2    Ryn, J.3    Tillmann, S.4    Rossaint, R.5    Grottke, O.6
  • 17
    • 79954456496 scopus 로고    scopus 로고
    • Dabigatran etexilate: a new oral thrombin inhibitor
    • Hankey GJ, Eikelboom JW. Dabigatran etexilate: a new oral thrombin inhibitor. Circulation. 2011;123(13):1436-50.
    • (2011) Circulation. , vol.123 , Issue.13 , pp. 1436-1450
    • Hankey, G.J.1    Eikelboom, J.W.2
  • 19
    • 84920566138 scopus 로고    scopus 로고
    • Risk of bleeding with dabigatran in atrial fibrillation
    • Hernandez I, Baik SH, Piñera A, Zhang Y. Risk of bleeding with dabigatran in atrial fibrillation. JAMA Intern Med. 2015;175(1):18-24.
    • (2015) JAMA Intern Med. , vol.175 , Issue.1 , pp. 18-24
    • Hernandez, I.1    Baik, S.H.2    Piñera, A.3    Zhang, Y.4
  • 20
    • 84857759555 scopus 로고    scopus 로고
    • Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
    • Warkentin TE, Margetts P, Connolly SJ, Lamy A, Ricci C, Eikelboom JW. Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding. Blood. 2012;119(9):2172-4.
    • (2012) Blood. , vol.119 , Issue.9 , pp. 2172-2174
    • Warkentin, T.E.1    Margetts, P.2    Connolly, S.J.3    Lamy, A.4    Ricci, C.5    Eikelboom, J.W.6
  • 21
    • 84930573699 scopus 로고    scopus 로고
    • Management of dabigatran-induced bleeding with continuous venovenous hemodialysis
    • Paul S, Hamouda D, Prashar R, Mbaso C, Khan A, Ali A, et al. Management of dabigatran-induced bleeding with continuous venovenous hemodialysis. Int J Hematol. 2015;101(6):594-7.
    • (2015) Int J Hematol. , vol.101 , Issue.6 , pp. 594-597
    • Paul, S.1    Hamouda, D.2    Prashar, R.3    Mbaso, C.4    Khan, A.5    Ali, A.6
  • 22
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: functional and structural characterization
    • Schiele F, van Ryn J, Canada K, Newsome C, Sepulveda E, Park J, et al. A specific antidote for dabigatran: functional and structural characterization. Blood. 2013;121(18):3554-62.
    • (2013) Blood. , vol.121 , Issue.18 , pp. 3554-3562
    • Schiele, F.1    Ryn, J.2    Canada, K.3    Newsome, C.4    Sepulveda, E.5    Park, J.6
  • 23
    • 84930965307 scopus 로고    scopus 로고
    • A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran
    • Glund S, Moschetti V, Norris S, Stangier J, Schmohl M, van Ryn J, et al. A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran. Thromb Haemost. 2015;113(5):943-51.
    • (2015) Thromb Haemost. , vol.113 , Issue.5 , pp. 943-951
    • Glund, S.1    Moschetti, V.2    Norris, S.3    Stangier, J.4    Schmohl, M.5    Ryn, J.6
  • 24
    • 84947795797 scopus 로고    scopus 로고
    • New Oral Anticoagulants and Their Reversal
    • PMID 25877809.
    • Pinto I, Giri A, Arshad U, Gajra A. New Oral Anticoagulants and Their Reversal. Curr Drug Saf. 2015;10:PMID 25877809.
    • (2015) Curr Drug Saf. , vol.10
    • Pinto, I.1    Giri, A.2    Arshad, U.3    Gajra, A.4
  • 25
    • 84869183192 scopus 로고    scopus 로고
    • New oral anticoagulants in the ED setting: a review
    • Pollack CV. New oral anticoagulants in the ED setting: a review. Am J Emerg Med. 2012;30(9):2046-54.
    • (2012) Am J Emerg Med. , vol.30 , Issue.9 , pp. 2046-2054
    • Pollack, C.V.1
  • 26
    • 84969567323 scopus 로고    scopus 로고
    • Coagulation assessment with the new generation of oral anticoagulants
    • Pollack CV. Coagulation assessment with the new generation of oral anticoagulants. Emerg Med J. 2015;32. doi: 10.1136/emermed-2015-204891 .
    • (2015) Emerg Med J. , pp. 32
    • Pollack, C.V.1
  • 27
    • 84934759814 scopus 로고    scopus 로고
    • Design and rationale for RE-VERSE AD: a phase 3 study of idarucizumab, a specific reversal agent for dabigatran
    • Pollack CV, Reilly PA, Bernstein R, Dubiel R, Eikelboom J, Glund S, et al. Design and rationale for RE-VERSE AD: a phase 3 study of idarucizumab, a specific reversal agent for dabigatran. Thromb Haemost. 2015;114(1):198-205.
    • (2015) Thromb Haemost. , vol.114 , Issue.1 , pp. 198-205
    • Pollack, C.V.1    Reilly, P.A.2    Bernstein, R.3    Dubiel, R.4    Eikelboom, J.5    Glund, S.6
  • 29
    • 84905747093 scopus 로고    scopus 로고
    • Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry
    • Beyer-Westendorf J, Förster K, Pannach S, Ebertz F, Gelbricht V, Thieme C, et al. Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry. Blood. 2014;124(6):955-62.
    • (2014) Blood. , vol.124 , Issue.6 , pp. 955-962
    • Beyer-Westendorf, J.1    Förster, K.2    Pannach, S.3    Ebertz, F.4    Gelbricht, V.5    Thieme, C.6
  • 31
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
    • Lu G, DeGuzman FR, Hollenbach SJ, Karbarz MJ, Abe K, Lee G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013;19(4):446-51.
    • (2013) Nat Med. , vol.19 , Issue.4 , pp. 446-451
    • Lu, G.1    DeGuzman, F.R.2    Hollenbach, S.J.3    Karbarz, M.J.4    Abe, K.5    Lee, G.6
  • 32
    • 84977617316 scopus 로고    scopus 로고
    • A phase 2 randomized, double-blind, placebo-controlled trial of PRT064445, a novel, universal antidote for direct and indirect factor Xa inhibitors
    • AS20.1.
    • Crowther M KM, Lorenz T, Mathur V, Lu G, Hutchaleelaha A, et al. A phase 2 randomized, double-blind, placebo-controlled trial of PRT064445, a novel, universal antidote for direct and indirect factor Xa inhibitors. J Thromb Haemost. 2013;11(Suppl 2): AS20.1.
    • (2013) J Thromb Haemost. , vol.11
    • Crowther, M.K.M.1    Lorenz, T.2    Mathur, V.3    Lu, G.4    Hutchaleelaha, A.5
  • 33
    • 84922313320 scopus 로고    scopus 로고
    • Reversal of enoxaparin-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for direct and indirect FXa inhibitors-a phase 2 randomized, double-blind, placebo- controlled trial
    • abstract
    • Crowther M LG, Lu G, Conley PB, Castillo J, Hollenbach S, et al. Reversal of enoxaparin-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for direct and indirect FXa inhibitors-a phase 2 randomized, double-blind, placebo- controlled trial. J Thromb Haemost. 2014;12(Suppl 1): COA01 (abstract).
    • (2014) J Thromb Haemost. , vol.12
    • Crowther, M.L.G.1    Lu, G.2    Conley, P.B.3    Castillo, J.4    Hollenbach, S.5
  • 34
    • 84922272270 scopus 로고    scopus 로고
    • Sustained reversal of apixaban anticoagulation with andexanet alfa using a bolus plus infusion regimen in a phase 2 placebo controlled trial
    • (abstract).
    • Crowther M LG, Conley P, Hollenbach S, Castillo J, Lawrence, J, et al. Sustained reversal of apixaban anticoagulation with andexanet alfa using a bolus plus infusion regimen in a phase 2 placebo controlled trial. Eur Heart J 2014;35(Suppl.1): P738 (abstract).
    • (2014) Eur Heart J , vol.35 , pp. P738
    • Crowther, M.L.G.1    Conley, P.2    Hollenbach, S.3    Castillo, J.4    Lawrence, J.5
  • 35
    • 84896638883 scopus 로고    scopus 로고
    • A phase 2 randomized, double blind, placebo-controlled trial demonstrating reversal of rivaroxaban-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for Fxa inhibitors
    • Crowther MMV, Kitt M, Lu G, Conley PB, Hollenbach S, et al. A phase 2 randomized, double blind, placebo-controlled trial demonstrating reversal of rivaroxaban-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for Fxa inhibitors. Blood. 2013;122(21):3636.
    • (2013) Blood. , vol.122 , Issue.21 , pp. 3636
    • Crowther, M.M.V.1    Kitt, M.2    Lu, G.3    Conley, P.B.4    Hollenbach, S.5
  • 36
    • 84904750357 scopus 로고    scopus 로고
    • PER977: a synthetic small molecule which reverses over-dosage and bleeding by the new oral anticoagulants
    • Bakhru S, Laulicht B, Jiang X, Chen L, Pan D, Grosso M, et al. PER977: a synthetic small molecule which reverses over-dosage and bleeding by the new oral anticoagulants. Ciuculation. 2013;128:A18809.
    • (2013) Ciuculation. , vol.128 , pp. A18809
    • Bakhru, S.1    Laulicht, B.2    Jiang, X.3    Chen, L.4    Pan, D.5    Grosso, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.