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Volumn 386, Issue 9990, 2015, Pages 281-291

Pharmacology of antithrombotic drugs: An assessment of oral antiplatelet and anticoagulant treatments

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; ANTIVITAMIN K; APIXABAN; ATOPAXAR; CLOPIDOGREL; DABIGATRAN; EDOXABAN; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; RIVAROXABAN; TICAGRELOR; VORAPAXAR; WARFARIN; CYTOCHROME P450; PURINERGIC P2Y RECEPTOR ANTAGONIST;

EID: 84937630802     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(15)60243-4     Document Type: Review
Times cited : (219)

References (119)
  • 1
    • 50449098285 scopus 로고    scopus 로고
    • Mechanisms of thrombus formation
    • B Furie, BC Furie Mechanisms of thrombus formation N Engl J Med 359 2008 938 949
    • (2008) N Engl J Med , vol.359 , pp. 938-949
    • Furie, B.1    Furie, B.C.2
  • 2
    • 84921578013 scopus 로고    scopus 로고
    • Novel antiplatelet agents in acute coronary syndrome
    • F Franchi, DJ Angiolillo Novel antiplatelet agents in acute coronary syndrome Nat Rev Cardiol 12 2015 30 47
    • (2015) Nat Rev Cardiol , vol.12 , pp. 30-47
    • Franchi, F.1    Angiolillo, D.J.2
  • 3
    • 30444454823 scopus 로고    scopus 로고
    • Antiplatelet drugs
    • G Born, C Patrono Antiplatelet drugs Br J Pharmacol 147 suppl 1 2006 S241 S251
    • (2006) Br J Pharmacol , vol.147 , pp. S241-S251
    • Born, G.1    Patrono, C.2
  • 4
    • 0016748441 scopus 로고
    • Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
    • M Hamberg, J Svensson, B Samuelsson Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides Proc Natl Acad Sci USA 72 1975 2994 2998
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 2994-2998
    • Hamberg, M.1    Svensson, J.2    Samuelsson, B.3
  • 5
    • 0029056992 scopus 로고
    • The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase
    • PJ Loll, D Picot, RM Garavito The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase Nat Struct Biol 2 1995 637 643
    • (1995) Nat Struct Biol , vol.2 , pp. 637-643
    • Loll, P.J.1    Picot, D.2    Garavito, R.M.3
  • 7
    • 0029610453 scopus 로고
    • Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers
    • IH Benedek, AS Joshi, HJ Pieniaszek, SY King, DM Kornhauser Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers J Clin Pharmacol 35 1995 1181 1186
    • (1995) J Clin Pharmacol , vol.35 , pp. 1181-1186
    • Benedek, I.H.1    Joshi, A.S.2    Pieniaszek, H.J.3    King, S.Y.4    Kornhauser, D.M.5
  • 8
    • 84866732231 scopus 로고    scopus 로고
    • ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
    • PG Steg, SK James, D Atar the Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC) ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation Eur Heart J 33 2012 2569 2619
    • (2012) Eur Heart J , vol.33 , pp. 2569-2619
    • Steg, P.G.1    James, S.K.2    Atar, D.3
  • 9
    • 84872710874 scopus 로고    scopus 로고
    • 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: Executive summary: A report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines
    • the Society for Cardiovascular Angiography and Interventions
    • PT O'Gara, FG Kushner, DD Ascheim the American College of Emergency Physicians the Society for Cardiovascular Angiography and Interventions 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines J Am Coll Cardiol 61 2013 485 510
    • (2013) J Am Coll Cardiol , vol.61 , pp. 485-510
    • O'Gara, P.T.1    Kushner, F.G.2    Ascheim, D.D.3
  • 10
    • 77956290748 scopus 로고    scopus 로고
    • Dose comparisons of clopidogrel and aspirin in acute coronary syndromes
    • SR Mehta, JP Bassand, S Chrolavicius the CURRENT-OASIS 7 Investigators Dose comparisons of clopidogrel and aspirin in acute coronary syndromes N Engl J Med 363 2010 930 942
    • (2010) N Engl J Med , vol.363 , pp. 930-942
    • Mehta, S.R.1    Bassand, J.P.2    Chrolavicius, S.3
  • 12
    • 2042504400 scopus 로고    scopus 로고
    • Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its relation to metabolic control
    • C Watala, J Golanski, J Pluta et al. Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its relation to metabolic control Thromb Res 113 2004 101 113
    • (2004) Thromb Res , vol.113 , pp. 101-113
    • Watala, C.1    Golanski, J.2    Pluta, J.3
  • 13
    • 33845748629 scopus 로고    scopus 로고
    • Drug insight: Aspirin resistance - Fact or fashion?
    • C Patrono, B Rocca Drug insight: aspirin resistance - fact or fashion? Nat Clin Pract Cardiovasc Med 4 2007 42 50
    • (2007) Nat Clin Pract Cardiovasc Med , vol.4 , pp. 42-50
    • Patrono, C.1    Rocca, B.2
  • 14
    • 84863430537 scopus 로고    scopus 로고
    • The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes
    • B Rocca, F Santilli, D Pitocco et al. The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes J Thromb Haemost 10 2012 1220 1230
    • (2012) J Thromb Haemost , vol.10 , pp. 1220-1230
    • Rocca, B.1    Santilli, F.2    Pitocco, D.3
  • 15
    • 79959318812 scopus 로고    scopus 로고
    • Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease
    • D Capodanno, A Patel, K Dharmashankar et al. Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease Circ Cardiovasc Interv 4 2011 180 187
    • (2011) Circ Cardiovasc Interv , vol.4 , pp. 180-187
    • Capodanno, D.1    Patel, A.2    Dharmashankar, K.3
  • 16
    • 0028332937 scopus 로고
    • Ticlopidine and subcutaneous heparin as an alternative regimen following coronary stenting
    • P Barragan, J Sainsous, M Silvestri et al. Ticlopidine and subcutaneous heparin as an alternative regimen following coronary stenting Cathet Cardiovasc Diagn 32 1994 133 138
    • (1994) Cathet Cardiovasc Diagn , vol.32 , pp. 133-138
    • Barragan, P.1    Sainsous, J.2    Silvestri, M.3
  • 17
    • 0029792473 scopus 로고    scopus 로고
    • Combined antiplatelet therapy with ticlopidine and aspirin. A simplified approach to intracoronary stent management
    • JM Lablanche, EP McFadden, JL Bonnet et al. Combined antiplatelet therapy with ticlopidine and aspirin. A simplified approach to intracoronary stent management Eur Heart J 17 1996 1373 1380
    • (1996) Eur Heart J , vol.17 , pp. 1373-1380
    • Lablanche, J.M.1    McFadden, E.P.2    Bonnet, J.L.3
  • 18
    • 10144234792 scopus 로고    scopus 로고
    • Intracoronary stent implantation without ultrasound guidance and with replacement of conventional anticoagulation by antiplatelet therapy. 30-day clinical outcome of the French Multicenter Registry
    • GJ Karrillon, MC Morice, E Benveniste et al. Intracoronary stent implantation without ultrasound guidance and with replacement of conventional anticoagulation by antiplatelet therapy. 30-day clinical outcome of the French Multicenter Registry Circulation 94 1996 1519 1527
    • (1996) Circulation , vol.94 , pp. 1519-1527
    • Karrillon, G.J.1    Morice, M.C.2    Benveniste, E.3
  • 19
    • 7844220998 scopus 로고    scopus 로고
    • Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study
    • ME Bertrand, V Legrand, J Boland et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study Circulation 98 1998 1597 1603
    • (1998) Circulation , vol.98 , pp. 1597-1603
    • Bertrand, M.E.1    Legrand, V.2    Boland, J.3
  • 21
    • 0034622539 scopus 로고    scopus 로고
    • Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: The clopidogrel aspirin stent international cooperative study (CLASSICS)
    • ME Bertrand, HJ Rupprecht, P Urban, AH Gershlick the CLASSICS Investigators Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study (CLASSICS) Circulation 102 2000 624 629
    • (2000) Circulation , vol.102 , pp. 624-629
    • Bertrand, M.E.1    Rupprecht, H.J.2    Urban, P.3    Gershlick, A.H.4
  • 22
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • S Yusuf, F Zhao, SR Mehta, S Chrolavicius, G Tognoni, KK Fox the Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation N Engl J Med 345 2001 494 502
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 23
    • 84864577575 scopus 로고    scopus 로고
    • The story of clopidogrel and its predecessor, ticlopidine: Could these major antiplatelet and antithrombotic drugs be discovered and developed today?
    • JP Maffrand The story of clopidogrel and its predecessor, ticlopidine: Could these major antiplatelet and antithrombotic drugs be discovered and developed today? C R Chim 15 2012 737 743
    • (2012) C R Chim , vol.15 , pp. 737-743
    • Maffrand, J.P.1
  • 24
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • SD Wiviott, E Braunwald, CH McCabe the TRITON-TIMI 38 Investigators Prasugrel versus clopidogrel in patients with acute coronary syndromes N Engl J Med 357 2007 2001 2015
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 25
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • L Wallentin, RC Becker, A Budaj the PLATO Investigators Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 361 2009 1045 1057
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 26
    • 84883710340 scopus 로고    scopus 로고
    • Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes
    • G Montalescot, L Bolognese, D Dudek the ACCOAST Investigators Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes N Engl J Med 369 2013 999 1010
    • (2013) N Engl J Med , vol.369 , pp. 999-1010
    • Montalescot, G.1    Bolognese, L.2    Dudek, D.3
  • 27
    • 84907048411 scopus 로고    scopus 로고
    • Prehospital ticagrelor in ST-segment elevation myocardial infarction
    • G Montalescot, AW van't Hof Prehospital ticagrelor in ST-segment elevation myocardial infarction N Engl J Med 371 2014 2337 2339
    • (2014) N Engl J Med , vol.371 , pp. 2337-2339
    • Montalescot, G.1    Van'T Hof, A.W.2
  • 28
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • DL Bhatt, KA Fox, W Hacke the CHARISMA Investigators Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events N Engl J Med 354 2006 1706 1717
    • (2006) N Engl J Med , vol.354 , pp. 1706-1717
    • Bhatt, D.L.1    Fox, K.A.2    Hacke, W.3
  • 29
    • 84918772240 scopus 로고    scopus 로고
    • Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents
    • L Mauri, DJ Kereiakes, RW Yeh the DAPT Study Investigators Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents N Engl J Med 371 2014 2155 2166
    • (2014) N Engl J Med , vol.371 , pp. 2155-2166
    • Mauri, L.1    Kereiakes, D.J.2    Yeh, R.W.3
  • 30
    • 84897104036 scopus 로고    scopus 로고
    • Design and rationale for the prevention of cardiovascular events in patients with prior heart attack using ticagrelor compared to placebo on a background of aspirin-thrombolysis in myocardial infarction 54 (PEGASUS-TIMI 54) trial
    • e5.
    • MP Bonaca, DL Bhatt, E Braunwald et al. Design and rationale for the prevention of cardiovascular events in patients with prior heart attack using ticagrelor compared to placebo on a background of aspirin-thrombolysis in myocardial infarction 54 (PEGASUS-TIMI 54) trial Am Heart J 167 2014 437 444 e5.
    • (2014) Am Heart J , vol.167 , pp. 437-444
    • Bonaca, M.P.1    Bhatt, D.L.2    Braunwald, E.3
  • 31
    • 0033678468 scopus 로고    scopus 로고
    • Identification and biological activity of the active metabolite of clopidogrel
    • P Savi, JM Pereillo, MF Uzabiaga et al. Identification and biological activity of the active metabolite of clopidogrel Thromb Haemost 84 2000 891 896
    • (2000) Thromb Haemost , vol.84 , pp. 891-896
    • Savi, P.1    Pereillo, J.M.2    Uzabiaga, M.F.3
  • 32
    • 33645105318 scopus 로고    scopus 로고
    • Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450
    • JL Rehmel, JA Eckstein, NA Farid et al. Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450 Drug Metab Dispos 34 2006 600 607
    • (2006) Drug Metab Dispos , vol.34 , pp. 600-607
    • Rehmel, J.L.1    Eckstein, J.A.2    Farid, N.A.3
  • 33
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • M Kazui, Y Nishiya, T Ishizuka et al. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite Drug Metab Dispos 38 2010 92 99
    • (2010) Drug Metab Dispos , vol.38 , pp. 92-99
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3
  • 34
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation
    • e9-16.
    • JT Brandt, CD Payne, SD Wiviott et al. A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation Am Heart J 153 2007 66 e9-16.
    • (2007) Am Heart J , vol.153 , pp. 66
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3
  • 35
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • L Wallentin, C Varenhorst, S James et al. Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease Eur Heart J 29 2008 21 30
    • (2008) Eur Heart J , vol.29 , pp. 21-30
    • Wallentin, L.1    Varenhorst, C.2    James, S.3
  • 36
    • 84867177857 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel for acute coronary syndromes without revascularization
    • MT Roe, PW Armstrong, KA Fox the TRILOGY ACS Investigators Prasugrel versus clopidogrel for acute coronary syndromes without revascularization N Engl J Med 367 2012 1297 1309
    • (2012) N Engl J Med , vol.367 , pp. 1297-1309
    • Roe, M.T.1    Armstrong, P.W.2    Fox, K.A.3
  • 37
    • 84923285247 scopus 로고    scopus 로고
    • Prasugrel plus aspirin beyond 12 months is associated with improved outcomes after taxus liberté paclitaxel-eluting coronary stent placement
    • KN Garratt, WD Weaver, RG Jenkins et al. Prasugrel plus aspirin beyond 12 months is associated with improved outcomes after taxus liberté paclitaxel-eluting coronary stent placement Circulation 131 2015 62 73
    • (2015) Circulation , vol.131 , pp. 62-73
    • Garratt, K.N.1    Weaver, W.D.2    Jenkins, R.G.3
  • 38
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • JS Hulot, A Bura, E Villard et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects Blood 108 2006 2244 2247
    • (2006) Blood , vol.108 , pp. 2244-2247
    • Hulot, J.S.1    Bura, A.2    Villard, E.3
  • 39
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • T Simon, C Verstuyft, M Mary-Krause the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators Genetic determinants of response to clopidogrel and cardiovascular events N Engl J Med 360 2009 363 375
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 40
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • J-P Collet, J-S Hulot, A Pena et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study Lancet 373 2009 309 317
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.-P.1    Hulot, J.-S.2    Pena, A.3
  • 41
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • JL Mega, T Simon, JP Collet et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis JAMA 304 2010 1821 1830
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 42
    • 79960603688 scopus 로고    scopus 로고
    • Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects
    • T Simon, DL Bhatt, L Bergougnan et al. Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects Clin Pharmacol Ther 90 2011 287 295
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 287-295
    • Simon, T.1    Bhatt, D.L.2    Bergougnan, L.3
  • 43
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19∗17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • D Sibbing, W Koch, D Gebhard et al. Cytochrome 2C19∗17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement Circulation 121 2010 512 518
    • (2010) Circulation , vol.121 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3
  • 44
    • 84860538806 scopus 로고    scopus 로고
    • Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): A prospective, randomised, proof-of-concept trial
    • JD Roberts, GA Wells, MR Le May et al. Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial Lancet 379 2012 1705 1711
    • (2012) Lancet , vol.379 , pp. 1705-1711
    • Roberts, J.D.1    Wells, G.A.2    Le May, M.R.3
  • 45
    • 84903134076 scopus 로고    scopus 로고
    • CYP2C19 genotype-guided antiplatelet therapy in ST-segment elevation myocardial infarction patients-Rationale and design of the Patient Outcome after primary PCI (POPular) Genetics study
    • TO Bergmeijer, PW Janssen, JC Schipper et al. CYP2C19 genotype-guided antiplatelet therapy in ST-segment elevation myocardial infarction patients-Rationale and design of the Patient Outcome after primary PCI (POPular) Genetics study Am Heart J 168 2014 16 22
    • (2014) Am Heart J , vol.168 , pp. 16-22
    • Bergmeijer, T.O.1    Janssen, P.W.2    Schipper, J.C.3
  • 47
    • 27744516843 scopus 로고    scopus 로고
    • Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-CHOICE (intracoronary stenting and antithrombotic regimen: Choose between 3 high oral doses for immediate clopidogrel effect) trial
    • N von Beckerath, D Taubert, G Pogatsa-Murray, E Schömig, A Kastrati, A Schömig Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (intracoronary stenting and antithrombotic regimen: choose between 3 high oral doses for immediate clopidogrel effect) trial Circulation 112 2005 2946 2950
    • (2005) Circulation , vol.112 , pp. 2946-2950
    • Von Beckerath, N.1    Taubert, D.2    Pogatsa-Murray, G.3    Schömig, E.4    Kastrati, A.5    Schömig, A.6
  • 48
    • 17744376570 scopus 로고    scopus 로고
    • Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: Results from the ARMYDA-2 (antiplatelet therapy for reduction of myocardial damage during angioplasty) study
    • G Patti, G Colonna, V Pasceri, LL Pepe, A Montinaro, G Di Sciascio Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (antiplatelet therapy for reduction of myocardial damage during angioplasty) study Circulation 111 2005 2099 2106
    • (2005) Circulation , vol.111 , pp. 2099-2106
    • Patti, G.1    Colonna, G.2    Pasceri, V.3    Pepe, L.L.4    Montinaro, A.5    Di Sciascio, G.6
  • 49
    • 33747874088 scopus 로고    scopus 로고
    • A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: The ALBION (assessment of the best loading dose of clopidogrel to blunt platelet activation, inflammation and ongoing necrosis) trial
    • G Montalescot, G Sideris, C Meuleman the ALBION Trial Investigators A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (assessment of the best loading dose of clopidogrel to blunt platelet activation, inflammation and ongoing necrosis) trial J Am Coll Cardiol 48 2006 931 938
    • (2006) J Am Coll Cardiol , vol.48 , pp. 931-938
    • Montalescot, G.1    Sideris, G.2    Meuleman, C.3
  • 50
    • 79955116606 scopus 로고    scopus 로고
    • High doses of clopidogrel to overcome genetic resistance: The randomized crossover CLOVIS-2 (clopidogrel and response variability investigation study 2)
    • JP Collet, JS Hulot, G Anzaha the CLOVIS-2 Investigators High doses of clopidogrel to overcome genetic resistance: the randomized crossover CLOVIS-2 (clopidogrel and response variability investigation study 2) JACC Cardiovasc Interv 4 2011 392 402
    • (2011) JACC Cardiovasc Interv , vol.4 , pp. 392-402
    • Collet, J.P.1    Hulot, J.S.2    Anzaha, G.3
  • 51
    • 78650517232 scopus 로고    scopus 로고
    • Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: Randomized, placebo-controlled, crossover comparison studies
    • DJ Angiolillo, CM Gibson, S Cheng et al. Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies Clin Pharmacol Ther 89 2011 65 74
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 65-74
    • Angiolillo, D.J.1    Gibson, C.M.2    Cheng, S.3
  • 52
    • 84856078255 scopus 로고    scopus 로고
    • Antiplatelet therapy and proton pump inhibition: Clinician update
    • GV Moukarbel, DL Bhatt Antiplatelet therapy and proton pump inhibition: clinician update Circulation 125 2012 375 380
    • (2012) Circulation , vol.125 , pp. 375-380
    • Moukarbel, G.V.1    Bhatt, D.L.2
  • 53
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomised trials
    • ML O'Donoghue, E Braunwald, EM Antman et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials Lancet 374 2009 989 997
    • (2009) Lancet , vol.374 , pp. 989-997
    • O'Donoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 54
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without omeprazole in coronary artery disease
    • DL Bhatt, BL Cryer, CF Contant the COGENT Investigators Clopidogrel with or without omeprazole in coronary artery disease N Engl J Med 363 2010 1909 1917
    • (2010) N Engl J Med , vol.363 , pp. 1909-1917
    • Bhatt, D.L.1    Cryer, B.L.2    Contant, C.F.3
  • 55
    • 84857992585 scopus 로고    scopus 로고
    • Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor: Insights from the platelet inhibition and patient outcomes trial
    • SG Goodman, R Clare, KS Pieper the Platelet Inhibition and Patient Outcomes Trial Investigators Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor: insights from the platelet inhibition and patient outcomes trial Circulation 125 2012 978 986
    • (2012) Circulation , vol.125 , pp. 978-986
    • Goodman, S.G.1    Clare, R.2    Pieper, K.S.3
  • 56
    • 79951677465 scopus 로고    scopus 로고
    • Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: Results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry
    • T Simon, PG Steg, M Gilard et al. Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry Circulation 123 2011 474 482
    • (2011) Circulation , vol.123 , pp. 474-482
    • Simon, T.1    Steg, P.G.2    Gilard, M.3
  • 58
    • 84881112989 scopus 로고    scopus 로고
    • The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: The PARADOX study
    • PA Gurbel, KP Bliden, DK Logan et al. The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study J Am Coll Cardiol 62 2013 505 512
    • (2013) J Am Coll Cardiol , vol.62 , pp. 505-512
    • Gurbel, P.A.1    Bliden, K.P.2    Logan, D.K.3
  • 59
    • 84903130512 scopus 로고    scopus 로고
    • Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. Clopidogrel in patients with acute coronary syndromes managed without revascularization: Insights from the TRILOGY ACS trial
    • JH Cornel, EM Ohman, B Neely et al. Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. clopidogrel in patients with acute coronary syndromes managed without revascularization: insights from the TRILOGY ACS trial Am Heart J 168 2014 76 87
    • (2014) Am Heart J , vol.168 , pp. 76-87
    • Cornel, J.H.1    Ohman, E.M.2    Neely, B.3
  • 61
    • 34047096264 scopus 로고    scopus 로고
    • Variability in individual responsiveness to clopidogrel: Clinical implications, management, and future perspectives
    • DJ Angiolillo, A Fernandez-Ortiz, E Bernardo et al. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives J Am Coll Cardiol 49 2007 1505 1516
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1505-1516
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 62
    • 84882248344 scopus 로고    scopus 로고
    • Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): A prospective multicentre registry study
    • GW Stone, B Witzenbichler, G Weisz the ADAPT-DES Investigators Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study Lancet 382 2013 614 623
    • (2013) Lancet , vol.382 , pp. 614-623
    • Stone, G.W.1    Witzenbichler, B.2    Weisz, G.3
  • 63
    • 80053080512 scopus 로고    scopus 로고
    • High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI
    • G Parodi, R Marcucci, R Valenti et al. High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI JAMA 306 2011 1215 1223
    • (2011) JAMA , vol.306 , pp. 1215-1223
    • Parodi, G.1    Marcucci, R.2    Valenti, R.3
  • 64
    • 84866861394 scopus 로고    scopus 로고
    • Relationship between post-treatment platelet reactivity and ischemic and bleeding events at 1-year follow-up in patients receiving prasugrel
    • L Bonello, J Mancini, M Pansieri et al. Relationship between post-treatment platelet reactivity and ischemic and bleeding events at 1-year follow-up in patients receiving prasugrel J Thromb Haemost 10 2012 1999 2005
    • (2012) J Thromb Haemost , vol.10 , pp. 1999-2005
    • Bonello, L.1    Mancini, J.2    Pansieri, M.3
  • 65
    • 84868568462 scopus 로고    scopus 로고
    • Reduction in platelet reactivity with prasugrel 5 mg in low-body-weight patients is noninferior to prasugrel 10 mg in higher-body-weight patients: Results from the FEATHER trial
    • D Erlinge, J Ten Berg, D Foley et al. Reduction in platelet reactivity with prasugrel 5 mg in low-body-weight patients is noninferior to prasugrel 10 mg in higher-body-weight patients: results from the FEATHER trial J Am Coll Cardiol 60 2012 2032 2040
    • (2012) J Am Coll Cardiol , vol.60 , pp. 2032-2040
    • Erlinge, D.1    Ten Berg, J.2    Foley, D.3
  • 66
    • 84881362012 scopus 로고    scopus 로고
    • Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: The GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients
    • D Erlinge, PA Gurbel, S James et al. Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients J Am Coll Cardiol 62 2013 577 583
    • (2013) J Am Coll Cardiol , vol.62 , pp. 577-583
    • Erlinge, D.1    Gurbel, P.A.2    James, S.3
  • 67
    • 79952598836 scopus 로고    scopus 로고
    • Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: The GRAVITAS randomized trial
    • MJ Price, PB Berger, PS Teirstein the GRAVITAS Investigators Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial JAMA 305 2011 1097 1105
    • (2011) JAMA , vol.305 , pp. 1097-1105
    • Price, M.J.1    Berger, P.B.2    Teirstein, P.S.3
  • 68
    • 84870032410 scopus 로고    scopus 로고
    • Bedside monitoring to adjust antiplatelet therapy for coronary stenting
    • JP Collet, T Cuisset, G Rangé the ARCTIC Investigators Bedside monitoring to adjust antiplatelet therapy for coronary stenting N Engl J Med 367 2012 2100 2109
    • (2012) N Engl J Med , vol.367 , pp. 2100-2109
    • Collet, J.P.1    Cuisset, T.2    Rangé, G.3
  • 69
    • 84861857758 scopus 로고    scopus 로고
    • A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: Results of the TRIGGER-PCI (Testing Platelet Reactivity in Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy with Prasugrel) study
    • D Trenk, GW Stone, M Gawaz et al. A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: results of the TRIGGER-PCI (Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel) study J Am Coll Cardiol 59 2012 2159 2164
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2159-2164
    • Trenk, D.1    Stone, G.W.2    Gawaz, M.3
  • 70
    • 84858767790 scopus 로고    scopus 로고
    • A therapeutic window for platelet reactivity for patients undergoing elective percutaneous coronary intervention: Results of the ARMYDA-PROVE (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity for Outcome Validation Effort) study
    • F Mangiacapra, G Patti, E Barbato et al. A therapeutic window for platelet reactivity for patients undergoing elective percutaneous coronary intervention: results of the ARMYDA-PROVE (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity for Outcome Validation Effort) study JACC Cardiovasc Interv 5 2012 281 289
    • (2012) JACC Cardiovasc Interv , vol.5 , pp. 281-289
    • Mangiacapra, F.1    Patti, G.2    Barbato, E.3
  • 71
    • 84890025521 scopus 로고    scopus 로고
    • Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding
    • US Tantry, L Bonello, D Aradi the Working Group on On-Treatment Platelet Reactivity Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding J Am Coll Cardiol 62 2013 2261 2273
    • (2013) J Am Coll Cardiol , vol.62 , pp. 2261-2273
    • Tantry, U.S.1    Bonello, L.2    Aradi, D.3
  • 72
    • 84925351860 scopus 로고    scopus 로고
    • Platelet function testing in acute cardiac care - Is there a role for prediction or prevention of stent thrombosis and bleeding?
    • D Aradi, JP Collet, J Mair the Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association of the European Society of Cardiology and the Working Group on Thrombosis of the European Society of Cardiology Platelet function testing in acute cardiac care - is there a role for prediction or prevention of stent thrombosis and bleeding? Thromb Haemost 113 2015 221 230
    • (2015) Thromb Haemost , vol.113 , pp. 221-230
    • Aradi, D.1    Collet, J.P.2    Mair, J.3
  • 75
    • 70449484408 scopus 로고    scopus 로고
    • Ticagrelor: The first reversibly binding oral P2Y12 receptor antagonist
    • S Husted, JJ van Giezen Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist Cardiovasc Ther 27 2009 259 274
    • (2009) Cardiovasc Ther , vol.27 , pp. 259-274
    • Husted, S.1    Van Giezen, J.J.2
  • 76
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study
    • PA Gurbel, KP Bliden, K Butler et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study Circulation 120 2009 2577 2585
    • (2009) Circulation , vol.120 , pp. 2577-2585
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3
  • 77
    • 84875997213 scopus 로고    scopus 로고
    • Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) primary PCI study
    • G Parodi, R Valenti, B Bellandi et al. Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) primary PCI study J Am Coll Cardiol 61 2013 1601 1606
    • (2013) J Am Coll Cardiol , vol.61 , pp. 1601-1606
    • Parodi, G.1    Valenti, R.2    Bellandi, B.3
  • 78
    • 33845540851 scopus 로고    scopus 로고
    • Normalization of platelet reactivity in clopidogrel-treated subjects
    • G Vilahur, BG Choi, MU Zafar et al. Normalization of platelet reactivity in clopidogrel-treated subjects J Thromb Haemost 5 2007 82 90
    • (2007) J Thromb Haemost , vol.5 , pp. 82-90
    • Vilahur, G.1    Choi, B.G.2    Zafar, M.U.3
  • 79
    • 84876228087 scopus 로고    scopus 로고
    • A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats
    • A Sugidachi, K Ohno, T Ogawa, J Jakubowski, M Hashimoto, A Tomizawa A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats Br J Pharmacol 169 2013 82 89
    • (2013) Br J Pharmacol , vol.169 , pp. 82-89
    • Sugidachi, A.1    Ohno, K.2    Ogawa, T.3    Jakubowski, J.4    Hashimoto, M.5    Tomizawa, A.6
  • 80
    • 84920585324 scopus 로고    scopus 로고
    • Inefficacy of platelet transfusion to reverse ticagrelor
    • A Godier, G Taylor, P Gaussem Inefficacy of platelet transfusion to reverse ticagrelor N Engl J Med 372 2015 196 197
    • (2015) N Engl J Med , vol.372 , pp. 196-197
    • Godier, A.1    Taylor, G.2    Gaussem, P.3
  • 81
    • 84878117557 scopus 로고    scopus 로고
    • Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects
    • MT Holmberg, A Tornio, L Joutsi-Korhonen et al. Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects Br J Clin Pharmacol 75 2013 1488 1496
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 1488-1496
    • Holmberg, M.T.1    Tornio, A.2    Joutsi-Korhonen, L.3
  • 82
    • 84902214445 scopus 로고    scopus 로고
    • Adenosine-mediated effects of ticagrelor: Evidence and potential clinical relevance
    • M Cattaneo, R Schulz, S Nylander Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance J Am Coll Cardiol 63 2014 2503 2509
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2503-2509
    • Cattaneo, M.1    Schulz, R.2    Nylander, S.3
  • 83
    • 73949157474 scopus 로고    scopus 로고
    • Platelet thrombin receptor antagonism and atherothrombosis
    • DJ Angiolillo, D Capodanno, S Goto Platelet thrombin receptor antagonism and atherothrombosis Eur Heart J 31 2010 17 28
    • (2010) Eur Heart J , vol.31 , pp. 17-28
    • Angiolillo, D.J.1    Capodanno, D.2    Goto, S.3
  • 84
    • 84859555815 scopus 로고    scopus 로고
    • Vorapaxar in the secondary prevention of atherothrombotic events
    • DA Morrow, E Braunwald, MP Bonaca the TRA 2P-TIMI 50 Steering Committee and Investigators Vorapaxar in the secondary prevention of atherothrombotic events N Engl J Med 366 2012 1404 1413
    • (2012) N Engl J Med , vol.366 , pp. 1404-1413
    • Morrow, D.A.1    Braunwald, E.2    Bonaca, M.P.3
  • 85
    • 84893604297 scopus 로고    scopus 로고
    • Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation
    • V Capra, M Bäck, DJ Angiolillo, M Cattaneo, KS Sakariassen Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation J Thromb Haemost 12 2014 126 137
    • (2014) J Thromb Haemost , vol.12 , pp. 126-137
    • Capra, V.1    Bäck, M.2    Angiolillo, D.J.3    Cattaneo, M.4    Sakariassen, K.S.5
  • 86
    • 37049242417 scopus 로고
    • Waterfall Sequence for Intrinsic Blood Clotting
    • EW Davie, OD Ratnoff Waterfall Sequence for Intrinsic Blood Clotting Science 145 1964 1310 1312
    • (1964) Science , vol.145 , pp. 1310-1312
    • Davie, E.W.1    Ratnoff, O.D.2
  • 87
    • 0002602296 scopus 로고    scopus 로고
    • Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease
    • D. Mann D.P. Zipes P. Libby R.O. Bonow E. Braunwald 10th edn. Elsevier Saunders Philadelphia, PA
    • JI Weitz Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease D Mann DP Zipes P Libby RO Bonow E Braunwald Braunwald's Heart Disease 10th edn. 2014 Elsevier Saunders Philadelphia, PA 1809 1833
    • (2014) Braunwald's Heart Disease , pp. 1809-1833
    • Weitz, J.I.1
  • 88
    • 0002530154 scopus 로고
    • The discovery of dicumarol and its sequels
    • KP Link The discovery of dicumarol and its sequels Circulation 19 1959 97 107
    • (1959) Circulation , vol.19 , pp. 97-107
    • Link, K.P.1
  • 89
    • 84903040567 scopus 로고    scopus 로고
    • Pharmacogenetics
    • E.M. Antman M.S. Sabatine Elsevier Saunders Philadelphia, PA
    • JY Chyou, JL Mega, MS Sabatine Pharmacogenetics EM Antman MS Sabatine Cardiovascular therapeutics 2013 Elsevier Saunders Philadelphia, PA 53 66
    • (2013) Cardiovascular Therapeutics , pp. 53-66
    • Chyou, J.Y.1    Mega, J.L.2    Sabatine, M.S.3
  • 90
    • 0034605685 scopus 로고    scopus 로고
    • Treatment of warfarin-associated coagulopathy with oral Vitamin K: A randomised controlled trial
    • MA Crowther, J Julian, D McCarty et al. Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial Lancet 356 2000 1551 1553
    • (2000) Lancet , vol.356 , pp. 1551-1553
    • Crowther, M.A.1    Julian, J.2    McCarty, D.3
  • 92
    • 34447306023 scopus 로고    scopus 로고
    • Bleeding complications with warfarin use: A prevalent adverse effect resulting in regulatory action
    • DK Wysowski, P Nourjah, L Swartz Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action Arch Intern Med 167 2007 1414 1419
    • (2007) Arch Intern Med , vol.167 , pp. 1414-1419
    • Wysowski, D.K.1    Nourjah, P.2    Swartz, L.3
  • 93
    • 0026575955 scopus 로고
    • The mechanism of the interaction between amiodarone and warfarin in humans
    • LD Heimark, L Wienkers, K Kunze et al. The mechanism of the interaction between amiodarone and warfarin in humans Clin Pharmacol Ther 51 1992 398 407
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 398-407
    • Heimark, L.D.1    Wienkers, L.2    Kunze, K.3
  • 94
    • 80052962391 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing
    • JA Johnson, L Gong, M Whirl-Carrillo the Clinical Pharmacogenetics Implementation Consortium Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing Clin Pharmacol Ther 90 2011 625 629
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 625-629
    • Johnson, J.A.1    Gong, L.2    Whirl-Carrillo, M.3
  • 95
    • 84862777241 scopus 로고    scopus 로고
    • A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II)
    • JL Anderson, BD Horne, SM Stevens et al. A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II) Circulation 125 2012 1997 2005
    • (2012) Circulation , vol.125 , pp. 1997-2005
    • Anderson, J.L.1    Horne, B.D.2    Stevens, S.M.3
  • 96
    • 84889873119 scopus 로고    scopus 로고
    • A randomized trial of genotype-guided dosing of warfarin
    • M Pirmohamed, G Burnside, N Eriksson the EU-PACT Group A randomized trial of genotype-guided dosing of warfarin N Engl J Med 369 2013 2294 2303
    • (2013) N Engl J Med , vol.369 , pp. 2294-2303
    • Pirmohamed, M.1    Burnside, G.2    Eriksson, N.3
  • 97
    • 84889778153 scopus 로고    scopus 로고
    • A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon
    • TI Verhoef, G Ragia, A de Boer the EU-PACT Group A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon N Engl J Med 369 2013 2304 2312
    • (2013) N Engl J Med , vol.369 , pp. 2304-2312
    • Verhoef, T.I.1    Ragia, G.2    De Boer, A.3
  • 98
    • 84889824971 scopus 로고    scopus 로고
    • A pharmacogenetic versus a clinical algorithm for warfarin dosing
    • SE Kimmel, B French, SE Kasner the COAG Investigators A pharmacogenetic versus a clinical algorithm for warfarin dosing N Engl J Med 369 2013 2283 2293
    • (2013) N Engl J Med , vol.369 , pp. 2283-2293
    • Kimmel, S.E.1    French, B.2    Kasner, S.E.3
  • 99
    • 84889762983 scopus 로고    scopus 로고
    • Pharmacogenetics and coumarin dosing - Recalibrating expectations
    • I Zineh, M Pacanowski, J Woodcock Pharmacogenetics and coumarin dosing - recalibrating expectations N Engl J Med 369 2013 2273 2275
    • (2013) N Engl J Med , vol.369 , pp. 2273-2275
    • Zineh, I.1    Pacanowski, M.2    Woodcock, J.3
  • 100
    • 84877301336 scopus 로고    scopus 로고
    • European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
    • H Heidbuchel, P Verhamme, M Alings on behalf of European Heart Rhythm Association European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation Europace 15 2013 625 651
    • (2013) Europace , vol.15 , pp. 625-651
    • Heidbuchel, H.1    Verhamme, P.2    Alings, M.3
  • 101
    • 84879313636 scopus 로고    scopus 로고
    • New oral antithrombotic strategies: 2013 update on atrial fibrillation
    • LT Grip, RP Giugliano, CT Ruff New oral antithrombotic strategies: 2013 update on atrial fibrillation Hot Topics Cardiol 31 2013 7 18
    • (2013) Hot Topics Cardiol , vol.31 , pp. 7-18
    • Grip, L.T.1    Giugliano, R.P.2    Ruff, C.T.3
  • 102
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • S Blech, T Ebner, E Ludwig-Schwellinger, J Stangier, W Roth The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans Drug Metab Dispos 36 2008 386 399
    • (2008) Drug Metab Dispos , vol.36 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3    Stangier, J.4    Roth, W.5
  • 103
    • 84896117299 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomised trials
    • CT Ruff, RP Giugliano, E Braunwald et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials Lancet 383 2014 955 962
    • (2014) Lancet , vol.383 , pp. 955-962
    • Ruff, C.T.1    Giugliano, R.P.2    Braunwald, E.3
  • 104
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • SJ Connolly, MD Ezekowitz, S Yusuf the RE-LY Steering Committee and Investigators Dabigatran versus warfarin in patients with atrial fibrillation N Engl J Med 361 2009 1139 1151
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 105
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • MR Patel, KW Mahaffey, J Garg the ROCKET AF Investigators Rivaroxaban versus warfarin in nonvalvular atrial fibrillation N Engl J Med 365 2011 883 891
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 106
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • CB Granger, JH Alexander, JJ McMurray the ARISTOTLE Committees and Investigators Apixaban versus warfarin in patients with atrial fibrillation N Engl J Med 365 2011 981 992
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 107
    • 84888362796 scopus 로고    scopus 로고
    • Edoxaban versus warfarin in patients with atrial fibrillation
    • RP Giugliano, CT Ruff, E Braunwald the ENGAGE AF-TIMI 48 Investigators Edoxaban versus warfarin in patients with atrial fibrillation N Engl J Med 369 2013 2093 2104
    • (2013) N Engl J Med , vol.369 , pp. 2093-2104
    • Giugliano, R.P.1    Ruff, C.T.2    Braunwald, E.3
  • 108
    • 84880785759 scopus 로고    scopus 로고
    • Gastrointestinal bleeding with the new oral anticoagulants - Defining the issues and the management strategies
    • J Desai, JM Kolb, JI Weitz, J Aisenberg Gastrointestinal bleeding with the new oral anticoagulants - defining the issues and the management strategies Thromb Haemost 110 2013 205 212
    • (2013) Thromb Haemost , vol.110 , pp. 205-212
    • Desai, J.1    Kolb, J.M.2    Weitz, J.I.3    Aisenberg, J.4
  • 109
    • 67649562905 scopus 로고    scopus 로고
    • Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): A randomised, double-blind, phase II trial
    • JL Mega, E Braunwald, S Mohanavelu the ATLAS ACS-TIMI 46 study group Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial Lancet 374 2009 29 38
    • (2009) Lancet , vol.374 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 110
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: Results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial
    • JH Alexander, RC Becker, DL Bhatt the APPRAISE Steering Committee and Investigators Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial Circulation 119 2009 2877 2885
    • (2009) Circulation , vol.119 , pp. 2877-2885
    • Alexander, J.H.1    Becker, R.C.2    Bhatt, D.L.3
  • 111
    • 80052232522 scopus 로고    scopus 로고
    • Dabigatran vs. Placebo in patients with acute coronary syndromes on dual antiplatelet therapy: A randomized, double-blind, phase II trial
    • J Oldgren, A Budaj, CB Granger the RE-DEEM Investigators Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial Eur Heart J 32 2011 2781 2789
    • (2011) Eur Heart J , vol.32 , pp. 2781-2789
    • Oldgren, J.1    Budaj, A.2    Granger, C.B.3
  • 112
    • 84881190857 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of two rivaroxaban doses in acute coronary syndrome (from ATLAS ACS 2-TIMI 51)
    • JL Mega, E Braunwald, SD Wiviott et al. Comparison of the efficacy and safety of two rivaroxaban doses in acute coronary syndrome (from ATLAS ACS 2-TIMI 51) Am J Cardiol 112 2013 472 478
    • (2013) Am J Cardiol , vol.112 , pp. 472-478
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 113
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • JH Alexander, RD Lopes, S James the APPRAISE-2 Investigators Apixaban with antiplatelet therapy after acute coronary syndrome N Engl J Med 365 2011 699 708
    • (2011) N Engl J Med , vol.365 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 114
    • 84922394366 scopus 로고    scopus 로고
    • Laboratory measurement of the anticoagulant activity of the non-Vitamin K oral anticoagulants
    • A Cuker, DM Siegal, MA Crowther, DA Garcia Laboratory measurement of the anticoagulant activity of the non-vitamin K oral anticoagulants J Am Coll Cardiol 64 2014 1128 1139
    • (2014) J Am Coll Cardiol , vol.64 , pp. 1128-1139
    • Cuker, A.1    Siegal, D.M.2    Crowther, M.A.3    Garcia, D.A.4
  • 117
    • 84880141189 scopus 로고    scopus 로고
    • Cost-effectiveness of apixaban, dabigatran, rivaroxaban, and warfarin for stroke prevention in atrial fibrillation
    • AR Harrington, EP Armstrong, PE Nolan Jr, DC Malone Cost-effectiveness of apixaban, dabigatran, rivaroxaban, and warfarin for stroke prevention in atrial fibrillation Stroke 44 2013 1676 1681
    • (2013) Stroke , vol.44 , pp. 1676-1681
    • Harrington, A.R.1    Armstrong, E.P.2    Nolan, Jr.P.E.3    Malone, D.C.4
  • 118
    • 84896812253 scopus 로고    scopus 로고
    • Novel oral anticoagulants versus warfarin therapy at various levels of anticoagulation control in atrial fibrillation - A cost-effectiveness analysis
    • JH You Novel oral anticoagulants versus warfarin therapy at various levels of anticoagulation control in atrial fibrillation - a cost-effectiveness analysis J Gen Intern Med 29 2014 438 446
    • (2014) J Gen Intern Med , vol.29 , pp. 438-446
    • You, J.H.1
  • 119
    • 0015237275 scopus 로고
    • Aspirin selectively inhibits prostaglandin production in human platelets
    • JB Smith, AL Willis Aspirin selectively inhibits prostaglandin production in human platelets Nat New Biol 231 1971 235 237
    • (1971) Nat New Biol , vol.231 , pp. 235-237
    • Smith, J.B.1    Willis, A.L.2


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