Efficacy of recombinant human interleukin 7 in a patient with severe lymphopenia-related progressive multifocal leukoencephalopathy

Open Forum Infectious Diseases

Volumn 1, Issue 2, 2014, Pages

  Gasnault, Jacques ^a,b   de Herve, Marie Ghislaine de Goër ^b   Michot, Jean Marie ^a,c   Hendel Chavez, Houria ^b   Seta, Vannina ^a   Mazet, Anne Aurélie ^d   Croughs, Thérèse ^b   Stankoff, Bruno ^e   Bourhis, Jean Henri ^c   Lambotte, Olivier ^a,b   Delfraissy, Jean François ^a,b   Taoufik, Yassine ^b  

^a BICÊTRE HOSPITAL   (France)

^b INSERM   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d HÔPITAL PAUL BROUSSE   (France)

^e HÔPITAL TENON   (France)

Author keywords

Bone marrow transplantation; JC virus; Progressive multifocal leukoencephalopathy; Recombinant interleukin 7; T cell lymphopenia

Indexed keywords

ACICLOVIR; ATOVAQUONE; BUSULFAN; CORTICOSTEROID; CYCLOSPORIN; ETIRACETAM; FLUDARABINE; HEMOGLOBIN; HYDROXYUREA; JANUS KINASE 2; MERCAPTOPURINE; METHOTREXATE; PENICILLIN V; PENTAMIDINE; PIPOBROMAN; PYRIMETHAMINE PLUS SULFADOXINE; RECOMBINANT INTERLEUKIN 7; THYMOCYTE ANTIBODY;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BRAIN DAMAGE; CASE REPORT; CD4 CD8 RATIO; CELL PROLIFERATION; CEREBROSPINAL FLUID; DYSARTHRIA; DYSPHAGIA; FEMALE; GENE MUTATION; GRAFT VERSUS HOST REACTION; HEMIPARESIS; HUMAN; JC VIRUS; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MIDDLE AGED; MYELOFIBROSIS; NEUTROPHIL COUNT; PANCYTOPENIA; PARESTHESIA; PERCEPTION DEAFNESS; PNEUMOCYSTOSIS; POLYCYTHEMIA; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; SPLENOMEGALY; T LYMPHOCYTE; THROMBOCYTE COUNT; VIRAL CLEARANCE;

EID: 84978014375     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofu074     Document Type: Article

References (13)

1. Brew BJ, Davies NW, Cinque P, et al. Progressive multifocal leukoencephalopathy and other forms of JC virus disease. Nat Rev Neurol 2010; 6:667-79.
2. Gasnault J, Taoufik Y. New trends in progressive multifocal leukoencephalopathy. Rev Neurol (Paris) 2006; 162:43-56.
3. Gosert R, Rinaldo CH, Wernli M, et al. CMX001 (1-O-hexadecyloxypropyl- cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes. Antimicrob Agents Chemother 2011; 55:2129-36.
4. Patel A, Patel J, Ikwuagwu J. A case of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia. J Antimicrob Chemother 2010; 65:2697-8.
5. Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 2011; 11:330-42.
6. Levy Y, Lacabaratz C,Weiss L, et al. Enhanced T cell recovery in HIV-1- infected adults through IL-7 treatment. J Clin Invest 2009; 119:997-1007.
7. Kharfan-Dabaja MA, Ayala E, Greene J, et al. Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature. Bone Marrow Transplant 2007; 39:101-7.
8. Kaufman GP, Aksamit AJ, Klein CJ, et al. Progressive multifocal leukoencephalopathy: a rare infectious complication following allogeneic hematopoietic cell transplantation (HCT). Eur J Haematol 2014; 92:83-7.
9. Gasnault J, Costagliola D, Hendel-Chavez H, et al. Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapy. PloS One 2011; 6:e20967.
10. Gasnault J, Kahraman M, de Goër de Herve MG, et al. Critical role of JC virus-specific CD4 T-cell responses in preventing progressive multifocal leukoencephalopathy. AIDS Lond Engl 2003; 17:1443-9.
11. Hendel-Chavez H, de Goër de Herve MG, Giannesini C, et al. Immunological hallmarks of JC virus replication in multiple sclerosis patients on long-term natalizumab therapy. J Virol 2013; 87:6055-9.
12. Cimbro R, Vassena L, Arthos J, et al. IL-7 induces expression and activation of integrin a4ß7 promoting naive T-cell homing to the intestinal mucosa. Blood 2012; 120:2610-9.
13. Beq S, Rozlan S, Gautier D, et al. Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques. Blood 2009; 114:816-25.