Progressive Multifocal Leukoencephalopathy: A rare infectious complication following allogeneic hematopoietic cell transplantation (HCT)

European Journal of Haematology

Volumn 92, Issue 1, 2014, Pages 83-87

  Kaufman, Gregory P ^a   Aksamit, Allen J ^a   Klein, Christopher J ^a   Yi, Eunhee S ^a   Delone, David R ^a   Litzow, Mark R ^a  

^a MAYO CLINIC   (United States)

Author keywords

Allogeneic bone marrow transplantation; Encephalitis; Hematopoietic cell transplantation; Immunocompromised host; Progressive multifocal leukoencephalopathy

Indexed keywords

CIDOFOVIR; CITALOPRAM; CYTARABINE; FLUDARABINE; GANCICLOVIR; INTERLEUKIN 2; MEFLOQUINE; MELPHALAN; MIRTAZAPINE; PREDNISONE; RISPERIDONE;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BONE MARROW BIOPSY; DONOR LYMPHOCYTE INFUSION; DRUG WITHDRAWAL; ENGRAFTMENT; ENTEROCOCCUS FAECALIS; GLIOSIS; GRAFT VERSUS HOST REACTION; HUMAN; IN SITU HYBRIDIZATION; INFECTIOUS COMPLICATION; LEUKEMIA; LUMBAR DISK; MICROSCOPY; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGODENDROGLIA; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; SPASTICITY; WHITE MATTER;

ALLOGENEIC BONE MARROW TRANSPLANTATION; ENCEPHALITIS; HEMATOPOIETIC CELL TRANSPLANTATION; IMMUNOCOMPROMISED HOST; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY;

AGED; BIOPSY; BRAIN; FATAL OUTCOME; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MAGNETIC RESONANCE IMAGING; MALE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TRANSPLANTATION, HOMOLOGOUS;

EID: 84890209620     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12208     Document Type: Article

References (24)

1. Mesquita R, Parravicini C, Bjorkhom M, Ekman M, Biberfield P. Macrophage association of polyomavirus in progressive multifocal leukoencephalopathy: an immunohistochemical and ultrastructural study. APMIS 1992;11:993-1000.
2. Schmidt-Hieber M, Schwender J, Heinz WJ, et al. Viral encephalitis after allogeneic stem cell transplantation: a rare complication with distinct characteristics of different causative agents. Haematologica 2011;96:142-9.
3. Mateen FJ, Muralidharan R, Carone M, van de Beek D, Harrison DM, Aksamit AJ, Gould MS, Clifford DB, Nath A. Progressive multifocal leukoencephalopathy in transplant recipients. Ann Neurol 2011;70:305-22.
4. Amend KL, Turnbull B, Foskett N, Napalkov P, Kurth T, Seeger J. Incidence of progressive multifocal leukoencephalopathy in patients without HIV. Neurology 2010;75:1326-32.
5. Steurer M, Clausen J, Gotwald T, Gunsilius E, Stockhammer G, Gastl G, Nachbaur D. Progressive multifocal leukoencephalopathy after allogeneic stem cell transplantation and posttransplantation rituximab. Transplantation 2003;76:435-6.
6. Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A. PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section. Neurology 2013 Apr 9;80:1430-8.
7. Fong IW, Britton CB, Luinstra KE, Toma E, Mahony JB. Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. J Clin Microbiol 1995;33:484-6.
8. Shah R, Bag AK, Chapman PR, Curé JK. Imaging manifestations of progressive multifocal leukoencephalopathy. Clin Radiol 2010;65:431-9.
9. Yuh W, Nguyen H, Gao F, Turgut Tali E, Fisher DJ, Mayr NA, Mueller DP, Sato Y, Trigg ME, Gingrich R. Brain parenchymal infection in bone marrow transplantation patients: CT and MR findings. Am J Roentgenol 1994;162:425-30.
10. Balduzzi A, Lucchini G, Hirsch HH, et al. Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient. Bone Marrow Transplant 2011;46:987-92.
11. Elphick G, Querbes W, Jordan J, et al. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science 2004;306:1380-3.
12. Owen RG, Patmore RD, Smith GM, Barnard DL. Cytomegalovirus-induced T-cell proliferation and development of progressive multifocal leucoencephalopathy following bone marrow transplantation. Br J Haematol 1995;89:196-8.
13. Seong D, Bruner JM, Hyung Lee K, et al. Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation in a patient with chronic myelogenous leukemia. Clin Infect Dis 1996;23:402-3.
14. Przepiorka D, Jaeckle KA, Birdwell RR, Fuller GN, Kumar AJ, Huh YO, McCutcheon I. Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2. Bone Marrow Transplant 1997;20:983-7.
15. Coppo P, Laporte JPh, Aoudjhane M, Lebon P, Isnard F, Lesage S, Gorin NC, Najman A. Progressive multifocal leucoencephalopathy with peripheral demyelinating neuropathy after autologous bone marrow transplantation for acute myeloblastic leukemia (FAB5). Bone Marrow Transplant 1999;23:401-3.
16. Re D, Bamborschke S, Feiden W, Schröder R, Lehrke R, Diehl V, Tesch H. Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. Bone Marrow Transplant 1999;23:295-8.
17. Buckanovich RJ, Liu G, Stricker C, Luger SM, Stadtmauer EA, Shuster SJ, Duffy K, Tsai D, Pruitt A, Porter DL. Nonmyeloablative allogeneic stem cell transplantation for refractory Hodgkin's lymphoma complicated by interleukin-2 responsive progressive multifocal leukoencephalopathy. Ann Hematol 2002;81:410-3.
18. Goldberg SL, Pecora AL, Alter RS, Kroll MS, Rowley SD, Waintraub SE, Imrit K, Preti RA. Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell rescue and peritransplantation rituximab. Blood 2002;99:1486-8.
19. Osorio S, Cámara R, Golbano N, Marti E, Fedele CG, Nieto S, Manzanares R, Fernández-Ranada JM. Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir. Bone Marrow Transplant 2002;30:963-6.
20. Kharfan-Dabaja MA, Ayala E, Greene J, Rojiani A, Murtagh FR, Anasetti C. Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature. Bone Marrow Transplant 2007;39:101-7.
21. Pelosini M, Focosi D, Rita F, Galimberti S, Caracciolo F, Benedetti E, Papineschi F, Petrini M. Progressive multifocal leukoencephalopathy: report of three cases in HIV-negative hematological patients and review of literature. Ann Hematol 2008;87:405-12.
22. Fianchi L, Colosimo C, De Luca A, Popucci A, Cattani P, Voso MT, LaRocca LM, Leone G, Pagano L. Atypical presentation of progressive multifocal leukoencephalopathy in a multiple myeloma patient after auto-SCT successfully treated with combination therapy. Bone Marrow Transplant 2010;45:1668-70.
23. Kishida S, Tanaka K. Mefloquine treatment in a patient suffering from progressive multifocal leukoencephalopathy after umbilical cord blood transplant. Intern Med 2010;49:2509-13.
24. Ripellino P, Comi C, Mula M, et al. Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation. a treatment option. BMJ Case Rep 2011; pii: bcr1120103549.