Pycnogenol® and its fractions influence the function of isolated heart in rats with experimental diabetes mellitus

Pathology Research and Practice

Volumn 211, Issue 2, 2015, Pages 156-161

  Kralova, Eva ^a   Jankyova, Stanislava ^a   Mucaji, Pavel ^a   Gresakova, Eva ^a   Stankovicova, Tatiana ^a  

^a Physics and Informatics   (Slovakia)

Author keywords

Antioxidant activity; Diabetic rats; Fractions; Isolated heart; Pycnogenol

Indexed keywords

ACETIC ACID ETHYL ESTER; PYCNOGENOL; STREPTOZOCIN; WATER; ANTIOXIDANT; CARDIOTONIC AGENT; FLAVONOID; PYCNOGENOLS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG DOSAGE FORM COMPARISON; HEART CONTRACTION; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HEART LEFT VENTRICLE WALL; IN VITRO STUDY; MALE; NONHUMAN; QT PROLONGATION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SYSTOLIC BLOOD PRESSURE; ANIMAL; DRUG EFFECTS; EVALUATION STUDY; EXPERIMENTAL DIABETES MELLITUS; HEART; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CARDIOTONIC AGENTS; DIABETES MELLITUS, EXPERIMENTAL; FLAVONOIDS; HEART; IN VITRO TECHNIQUES; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 84977814227     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2014.11.011     Document Type: Article

References (34)

1. Abe T., Ohga Y., Tabayashi N., Kobayashi S., Sakata S., Misawa H., Tsuji T., Kohzuki H., Suga H., Taniguchi S., Takaki M. Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats. Am. J. Physiol. Heart. Circ. Physiol. 2002, 282:138-148.
2. Akula A., Kota M.K., Gopisetty S.G., Chitrapu R.V., Kalagara M., Kalagara S., Veeravalli K.K., Gomedhikam J.P. Biochemical, histological and echocardiographic changes during experimental cardiomyopathy in STZ-induced diabetic rats. Pharmacol. Res. 2003, 48:429-435.
3. Bauters Ch., Lamblin N., Mc Fadden E.P., Van Belle E., Millaire A., de Groote P. Influence of diabetes mellitus on heart failure risk and outcome. Cardiovas. Diabetol. 2003, 2:1.
4. Bhandary B., Piao C.H.S., Kim D.S., Lee G.H., Chae S.W., Kim H.R., Chae H.J. The protective effect of rutin against ischemia/reperfusion-associated hemodynamic alteration through antioxidant activity. Arch. Pharm. Res. 2012, 35:1091-1097.
5. Blazso G., Gaspar R., Gabor M., Ruve H.J., Rohdewald P. ACE inhibition and hypotensive effect of procyanidinscontaining extract from the bark of Pinus pinaster sol. Pharm. Pharmacol. Lett. 1996, 6:8-11.
6. Blaskovic D., Zizkova P., Drzik F., Viskupicova J., Veverka M., Horakova L. Modulation of rabbit muscle sarcoplasmic reticulum Ca2+-ATPase activity by novel quercetin derivatives. Interdiscip. Toxicol. 2013, 6:3-8.
7. Borges G.R., de Oliveira M., Salgado H.C., Fazan R. Myocardial performance in conscious streptozotocin diabetic rats. Cardiovas. Diabetol. 2006, 5:26.
8. Deng W., Jiang D., Fang Y., Zhou Y., Cheng Z., Lin Y., Zhang R., Zhang J., Pu P., Liu Y., Bian Z., Tang Q. Hesperetin protects against cardiac remodelling induced by pressure overload in mice. J. Mol. Hist. 2013, 44:575-585.
9. Han J.J., Hao J., Kim C.H., Hong J.S., Ahn H.Y., Lee Y.S. Quercetin prevents cardiac hypertrophy induced by pressure overload in rats. J. Vet. Med. Sci. 2009, 71:737-743.
10. Howarth F.C., Jacobson M., Naseer O., Adeghate E. Shortterm effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats. Exp. Physiol. 2005, 90:237-245.
11. Choi K.M., Zhong Y., Hoit B.D., Grupp I.L., Hahn H., Dilly K.W., Guatimosim S., Lederer W.J., Matlib M.A. Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats. Am. J. Physiol. Heart. Circ. Physiol. 2002, 283:1398-1408.
12. Jankyova S., Kucera P., Goldenberg Z., Yaghi D., Navarova J., Kyselova Z., Stolc J., Klimas J., Racanska E., Matyas S. Pycnogenol efficiency on glycaemia, motor nerve conduction velocity and markers of oxidative stress in mild type diabetes in rats. Phytother. Res. 2009, 23:1169-1174.
13. Jankyova S., Kmecova J., Cernecka H., Mesarosova L., Musil P., Brnoliakova Z., Kyselovic J., Babal P., Klimas J. Glucose and blood pressure lowering effects of diabetic cardiomyopathy. Pathol. Res. Pract. 2012, 208:452-457.
14. ® fractions on endothelial dysfunction. Acta. Fac. Pharm. Univ. Comen. 2013, LX:7-14.
15. Joffe I.I., Travers K.E., Perreault-Micali C.L., Hampton T., Katz S.E., Morgan J.P., Douglas P.S. Abnormal cardiac function in the streptozotocin- induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. J. Am. Coll. Cardiol. 1999, 34:2111-2119.
16. Jung M., Park M., Lee H.C., Kang Y.H., Kang E.S., Kim S.K. Antidiabetic agents from medicinal plants. Curr. Med. Chem. 2006, 10:1203-1218.
17. Kim S.H., Hyun S.H., Choung S.Y. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J. Ethnopharmacol. 2006, 104:119-123.
18. Kinsel J.F., Straus S.E. Complementary and alternative therpaeutics: rigorous research is needed to support claims. Annu. Rev. Pharmacol. Toxicol. 2003, 43:463-484.
19. Kitabchi A.E., Wall B.M. Diabetic ketoacidosis. Med. Clin. North Am. 1995, 79:9-37.
20. Klimas J., Kmecova J., Jankyova S., Yaghi D., Priesolova E., Kyselova Z., Musil P., Ochodnicky P., Krenek P., Kyselovic J., Matyas S. Pycnogenol improves left ventricular function in streptozotocin-induced diabetic cardiomyopathy in rats. Phytother. Res. 2010, 24:969-974.
21. Kmecova J., Klimas J. Heart rate correction of the QT duration in rats. Eur. J. Pharmacol. 2010, 641:187-192.
22. Kuyvenhoven J.P., Meinders A.E. Oxidative stress and diabetes mellitus pathogenesis of long-term complications. Eur. J. Intern. Med. 1999, 10:9-19.
23. Oubre A.Y., Carlson T.J., King S.R., Reaven G.M. From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia 1997, 5:614-617.
24. Packer L., Rimbach G., Virgilli F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free. Radic. Biol. Med. 1999, 27:704-724.
25. ® on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats. Chem. Biol. Interact. 2010, 186:219-222.
26. Rackova L., Majekova M., Kostalova D., Stefek M. Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects. Bioorg. Med. Chem. 2004, 12:4709-4715.
27. Shafrir E. Diabetes in animals: contribution to the understanding of diabetes by study of its etiopathology in animal models. Diabetes Mellitus 2003, 362. McGraw-Hill, NewYork. D. Porte, R.S. Sherwin, A. Baron (Eds.).
28. Vasan S., Foiles P., Founds H. Therapeutic potential of breakers of advanced glycation end product-protein crosslinks. Arch. Biochem. Biophys. 2003, 419:89-96.
29. Veglio M., Chinaglia A., Cavallo-Perin P. QT interval, cardiovascular risk factors and risk of death in diabetes. J. Endocrinol. Invest. 2004, 27:175-181.
30. Virgili F., Packer L., Kobuchi H. Procyanidins extracted from Pinus maritima (Pycnogenol): scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine RAW 264.7 macrophages. Free. Radic. Biol. Med. 1998, 24:1120-1129.
31. Wichi R., Malfitano C.H., Rosa K., De Souza S., Salemi V., Mostarda C., De Angelis K., Irigoyen M.C. Noninvasive and invasive evaluation of cardiac dysfunction in experimental diabetes in rodents. Cardiovas. Diabetol. 2007, 6:14.
32. Yu X., Tesiram Y.A., Towner R.A., Abbott A., Patterson E., Huang S., Garrett M.W., Chandrasekaran S., Matsuzaki S., Szweda L.I., Gordon B.E., Kem D.C. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovas. Diabetol. 2007, 6:6.
33. Zibadia S., Rohdewald P.J., Parkc D., Watson R.R. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nut. Res. 2008, 28:315-320.
34. ® Ginkgo biloba extract: effect on peroxynitrite-oxidized sarcoplasmic reticulum Ca2+-ATPase. Interdis. Toxicol. 2010, 3:132-136.