Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism

Translational Psychiatry

Volumn 5, Issue 9, 2015, Pages

  Wiers, C E ^a   Shumay, E ^a   Volkow, N D ^a,b   Frieling, H ^c   Kotsiari, A ^c   Lindenmeyer, J ^d   Walter, H ^e,f   Bermpohl, F ^e,f  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d Salus Clinic   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; DOPAMINE TRANSPORTER;

ADULT; ALCOHOLISM; AMYGDALA; ARTICLE; BECK DEPRESSION INVENTORY; BLOOD OXYGENATION; CLINICAL ARTICLE; CONTROLLED STUDY; CRAVING; DEPRESSION; DISEASE SEVERITY; DOPAMINE TRANSPORTER GENE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE; HUMAN; MALE; METHYLATION; NUCLEUS ACCUMBENS; PERCEPTION; PROMOTER REGION; RELAPSE; ASSOCIATION; COMPLICATION; FEMALE; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; PROTECTION; PSYCHOLOGICAL RATING SCALE; SECONDARY PREVENTION; STATISTICS; WITHDRAWAL SYNDROME;

ADULT; ALCOHOLISM; AMYGDALA; CRAVING; CUES; DEPRESSION; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ETHANOL; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; METHYLATION; MIDDLE AGED; NUCLEUS ACCUMBENS; PROTECTIVE FACTORS; PSYCHIATRIC STATUS RATING SCALES; SECONDARY PREVENTION; STATISTICS AS TOPIC;

EID: 84977764346     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2015.141     Document Type: Article

References (50)

1. Boileau I, Assaad JM, Pihl RO, Benkelfat C, Leyton M, Diksic M et al. Alcohol promotes dopamine release in the human nucleus accumbens. Synapse 2003; 49: 226-231.
2. Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F. Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci USA 2011; 108: 15037-15042.
3. Robinson TE, Berridge KC. Addiction. Annu Rev Psychol 2003; 54: 25-53.
4. Heinz A, Beck A, Grusser SM, Grace AA, Wrase J. Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol 2009; 14: 108-118.
5. Wiers CE, Stelzel C, Gladwin TE, Park SQ, Pawelczack S, Gawron CK et al. Effects of cognitive bias modification training on neural alcohol cue reactivity in alcohol dependence. Am J Psychiatry 2015; 172: 335-343.
6. Beck A, Wustenberg T, Genauck A, Wrase J, Schlagenhauf F, Smolka MN et al. Effect of brain structure, brain function, and brain connectivity on relapse in alcohol-dependent patients. Arch Gen Psychiatry 2012; 69: 842-852.
7. Jorde A, Bach P, Witt SH, Becker K, Reinhard I, Vollstadt-Klein S et al. Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence. Biol Psychiatry 2013; 75: 790-797.
8. Volkow ND, Baler RD. Brain imaging biomarkers to predict relapse in alcohol addiction. JAMA Psychiatry 2013; 70: 661-663.
9. Koob GF, Le Moal M. Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philos Trans R Soc Lond B Biol Sci 2008; 363: 3113-3123.
10. Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology 2010; 35: 217-238.
11. Volkow ND The reality of comorbidity: depression and drug abuse. Biol Psychiatry 2004; 56: 714-717.
12. Markou A, Kosten TR, Koob GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 1998; 18: 135-174.
13. Hagele C, Schlagenhauf F, Rapp M, Sterzer P, Beck A, Bermpohl F et al. Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders. Psychopharmacology 2015; 232: 331-341.
14. Stoy M, Schlagenhauf F, Sterzer P, Bermpohl F, Hagele C, Suchotzki K et al. Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram. J Psycho-pharmacol 2012; 26: 677-688.
15. Schacht JP, Anton RF, Voronin KE, Randall PK, Li X, Henderson S et al. Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues. Neuropsychopharmacology 2013; 38: 414-422.
16. Heinz A, Goldman D, Gallinat J, Schumann G, Puls I. Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. Psychopharmacology 2004; 174: 561-570.
17. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J 2001; 1: 152-156.
18. Meyer JH, Kruger S, Wilson AA, Christensen BK, Goulding VS, Schaffer A et al. Lower dopamine transporter binding potential in striatum during depression. Neuroreport 2001; 12: 4121-4125.
19. Camardese G, De Risio L, Di Nicola M, Pucci L, Cocciolillo F, Bria P et al. Changes of dopamine transporter availability in depressed patients with and without anhedonia: a 123I-N-omega-fluoropropyl-carbomethoxy-3beta-(4-iodophenyl)tropane SPECT Study. Neuropsychobiology 2014; 70: 235-243.
20. Kim P, Choi CS, Park JH, Joo SH, Kim SY, Ko HM et al. Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring. J Neurosci Res 2014; 92: 658-670.
21. Hillemacher T, Frieling H, Hartl T, Wilhelm J, Kornhuber J, Bleich S. Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. J Psychiatr Res 2009; 43: 388-392.
22. Nieratschker V, Grosshans M, Frank J, Strohmaier J, von der Goltz C, El-Maarri O et al. Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age. Addict Biol 2014; 19: 305-311.
23. Kaufman AS, Lichtenberger E. Assessing Adolescent and Adult Intelligence, 3rd edn. Wiley: Hoboken, NJ, USA, 2005.
24. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59: 22-33.
25. Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II. Addiction 1993; 88: 791-804.
26. Skinner HA, Sheu WJ. Reliability of alcohol use indices. The Lifetime Drinking History and the MAST. J Stud Alcohol 1982; 43: 1157-1170.
27. Skinner HA, Allen BA. Alcohol dependence syndrome: measurement and validation. J Abnorm Psychol 1982; 91: 199-209.
28. Love A, James D, Willner P. A comparison of two alcohol craving questionnaires. Addiction 1998; 93: 1091-1102.
29. Beck AT, Steer RA, Garbin MG. Psychometric properties of the Beck Depression Inventory-25 years of evaluation. Clin Psychol Rev 1988; 8: 77-100.
30. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 2003; 19: 1233-1239.
31. Wiers CE, Stelzel C, Park SQ, Gawron CK, Ludwig VU, Gutwinski S et al. Neural correlates of alcohol-approach bias in alcohol addiction: the spirit is willing but the flesh is weak for spirits. Neuropsychopharmacology 2014; 39: 688-697.
32. Gladwin TE, Rinck M, Eberl C, Becker ES, Lindenmeyer J, Wiers RW. Mediation of cognitive bias modification for alcohol addiction via stimulus-specific alcohol avoidance association. Alcohol Clin Exp Res 2015; 39: 101-107.
33. Wiers RW, Eberl C, Rinck M, Becker ES, Lindenmeyer J. Retraining automatic action tendencies changes alcoholic patients' approach bias for alcohol and improves treatment outcome. Psychol Sci 2011; 22: 490-497.
34. Heilig M, Egli M, Crabbe JC, Becker HC. Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addict Biol 2010; 15: 169-184.
35. Anton RF, Moak DH, Latham PK. The obsessive compulsive drinking scale: a new method of assessing outcome in alcoholism treatment studies. Arch Gen Psychiatry 1996; 53: 225-231.
36. Volkow ND, Koob GF, Baler RD. Biomarkers in substance use disorders. ACS Chem Neurosci 2015; 6: 522-525.
37. Volkow ND, Wang GJ, Fowler JS, Logan J, Hitzemann R, Ding YS et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res 1996; 20: 1594-1598.
38. Bergman O, Ahs F, Furmark T, Appel L, Linnman C, Faria V et al. Association between amygdala reactivity and a dopamine transporter gene polymorphism. Transl Psychiatry 2014; 4: e420.
39. Jiao X, Pare WP, Tejani-Butt SM. Alcohol consumption alters dopamine transporter sites in Wistar-Kyoto rat brain. Brain Res 2006; 1073-1074: 175-182.
40. Eshel N, Roiser JP. Reward and punishment processing in depression. Biol Psychiatry 2010; 68: 118-124.
41. Sjoerds Z, van den Brink W, Beekman AT, Penninx BW, Veltman DJ. Cue reactivity is associated with duration and severity of alcohol dependence: an FMRI study. PLoS One 2014; 9: e84560.
42. Tylee DS, Kawaguchi DM, Glatt SJ. On the outside, looking in: a review and evaluation of the comparability of blood and brain '-omes". Am J Med Genet B Neuropsychiatr Genet 2013; 162b: 595-603.
43. Horvath S, Zhang Y, Langfelder P, Kahn RS, Boks MP, van Eijk K et al. Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol 2012; 13: R97.
44. Farre P, Jones MJ, Meaney MJ, Emberly E, Turecki G, Kobor MS. Concordant and discordant DNA methylation signatures of aging in human blood and brain. Epigenetics Chromatin 2015; 8: 19.
45. Walton E, Hass J, Liu J, Roffman JL, Bernardoni F, Roessner V et al. Correspondence of DNA methylation between blood and brain tissue and its application to schizophrenia research. Schizophr Bull; advance online publication, 8 June 2015.
46. Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol 2012; 13: R43.
47. Nikolova YS, Hariri AR. Can we observe epigenetic effects on human brain function? Trends Cogn Sci 2015; 19: 366-373.
48. Smith AK, Kilaru V, Klengel T, Mercer KB, Bradley B, Conneely KN et al. DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain. Am J Med Genet B Neuropsychiatr Genet 2015; 168b: 36-44.
49. Shumay E, Logan J, Volkow ND, Fowler JS. Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. Epigenetics 2012; 7: 1151-1160.
50. Wiers CE Methylation and the human brain: towards a new discipline of imaging epigenetics. Eur Arch Psychiatry Clin Neurosci 2012; 262: 271-273.