Monocyte trafficking, engraftment, and delivery of nanoparticles and an exogenous gene into the acutely inflamed brain tissue - Evaluations on monocyte-based delivery system for the central nervous system

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Tong, Hsin I ^a,b   Kang, Wen ^a,d   Davy, Philip M C ^c   Shi, Yingli ^a,e   Sun, Si ^a   Allsopp, Richard C ^c   Lu, Yuanan ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c UNIVERSITY OF HAWAII   (United States)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^e INSTITUTE OF OCEANOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; COLONY STIMULATING FACTOR 1; GENOMIC DNA; GREEN FLUORESCENT PROTEIN; LIPOPOLYSACCHARIDE; MANNITOL; SEROTONIN; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; CYTOKINE; MESSENGER RNA; NANOPARTICLE;

ACUTE NEUROINFLAMMATION; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL DIFFERENTIATION; CELL HOMING; CELL MIGRATION; CELL TRANSMIGRATION EFFICIENCY; CELLULAR PARAMETERS; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENGRAFTMENT; FEMALE; GENE DELIVERY SYSTEM; GENE IDENTIFICATION; GENETIC TRANSFECTION; GFP GENE; IN VITRO STUDY; MACROPHAGE; MALE; MEMBRANE PERMEABILITY; MICROGLIA; MONOCYTE DERIVED MACROPHAGE; MONOCYTE TRAFFICKING; MOUSE; NERVOUS SYSTEM INFLAMMATION; NON INVASIVE INTRAVENOUS CELL ADOPTIVE TRANSFER; NONHUMAN; PARTICLE SIZE; PROCESS OPTIMIZATION; VALIDATION PROCESS; VIRAL GENE DELIVERY SYSTEM; ANIMAL; C57BL MOUSE; CYTOLOGY; ENCEPHALITIS; GENETICS; MONOCYTE; PATHOLOGY;

ADOPTIVE TRANSFER; ANIMALS; BLOOD-BRAIN BARRIER; CELL DIFFERENTIATION; CYTOKINES; ENCEPHALITIS; FEMALE; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; NANOPARTICLES; RNA, MESSENGER; TRANSFECTION;

EID: 84977557547     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154022     Document Type: Article

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