Antiphospholipid antibodies in a large population-based cohort: Genome-wide associations and effects on monocyte gene expression

Thrombosis and Haemostasis

Volumn 116, Issue 1, 2016, Pages 115-123

  Müller Calleja, Nadine ^a   Rossmann, Heidi ^a   Müller, Christian ^b,c   Wild, Philipp ^a,c   Blankenberg, Stefan ^b,c   Pfeiffer, Norbert ^a   Binder, Harald ^a   Beutel, Manfred E ^a   Manukyan, Davit ^a   Zeller, Tanja ^b,c   Lackner, Karl J ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY HEART CENTER HAMBURG   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Antiphospholipid antibodies; Cohort study; Gene expression; Genome wide association study; Monocytes

Indexed keywords

BETA2 GLYCOPROTEIN 1; CARDIOLIPIN; CRYOPYRIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MONOCLONAL ANTIBODY; PHOSPHOLIPID ANTIBODY; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA; MEMBRANE PROTEIN; NAV3 PROTEIN, HUMAN; NERVE PROTEIN; RNA;

ADULT; AGED; ANTIPHOSPHOLIPID SYNDROME; APOH GENE; ARTICLE; CHROMOSOME 17; CHROMOSOME 20; COHORT ANALYSIS; CONTROLLED STUDY; DNA EXTRACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENOTYPING TECHNIQUE; HUMAN; HUMAN CELL; MACROD2 GENE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MONOCYTE; NEURON NAVIGATOR 3 GENE; OBSERVATIONAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE TRAIT LOCUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SINGLE NUCLEOTIDE POLYMORPHISM; UMBILICAL VEIN ENDOTHELIAL CELL; BLOOD; GENETICS; GENOME-WIDE ASSOCIATION STUDY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PREGNANCY;

ADULT; AGED; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; COHORT STUDIES; FEMALE; GENE EXPRESSION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MONOCYTES; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PROSPECTIVE STUDIES; RNA;

EID: 84977534305     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-12-0947     Document Type: Article

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