메뉴 건너뛰기




Volumn 214, Issue 2, 2016, Pages 216-225

T-Cell Activation Independently Associates with Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

(87)  Jimnez, Viviana Cobos a,c   Wit, Ferdinand W N M a,b,c   Joerink, Maaike a,c   Maurer, Irma a   Harskamp, Agnes M a   Schouten, Judith a,b,c   Prins, Maria e   Van Leeuwen, Ester M M a   Booiman, Thijs a,c   Deeks, Steven G f   Reiss, Peter a,b,c,d   Kootstra, Neeltje A a   Reiss, P a   Wit, F W N M a   Van Der Valk, M a   Schouten, J a   Kooij, K W a   Van Zoest, R A a   Elsenga, B C a   Prins, M a   more..


Author keywords

ART; HIV; Immune activation; Senescence; Telomeres; Thymic output

Indexed keywords

ANTIVIRUS AGENT; CD14 ANTIGEN; CD27 ANTIGEN; CD28 ANTIGEN; CD31 ANTIGEN; CD38 ANTIGEN; CD57 ANTIGEN; CYTOMEGALOVIRUS ANTIBODY; HLA DR ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; ANTIRETROVIRUS AGENT; PDCD1 PROTEIN, HUMAN;

EID: 84977080475     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw146     Document Type: Article
Times cited : (96)

References (49)
  • 1
    • 0242301662 scopus 로고    scopus 로고
    • Mortality and progression to AIDS after starting highly active antiretroviral therapy
    • van Sighem AI, van de Wiel MA, Ghani AC, et al. Mortality and progression to AIDS after starting highly active antiretroviral therapy. AIDS 2003; 17:2227-36.
    • (2003) AIDS , vol.17 , pp. 2227-2236
    • Van Sighem, A.I.1    Van De Wiel, M.A.2    Ghani, A.C.3
  • 2
    • 84872232623 scopus 로고    scopus 로고
    • Cause-specific life expectancies after 35 years of age for human immunodeficiency syndromeinfected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008
    • Wada N, Jacobson LP, Cohen M, French A, Phair J, Munoz A. Cause-specific life expectancies after 35 years of age for human immunodeficiency syndromeinfected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008. Am J Epidemiol 2013; 177:116-25.
    • (2013) Am J Epidemiol , vol.177 , pp. 116-125
    • Wada, N.1    Jacobson, L.P.2    Cohen, M.3    French, A.4    Phair, J.5    Munoz, A.6
  • 3
    • 40449103813 scopus 로고    scopus 로고
    • Aging and infectious diseases: Do patterns of comorbidity vary by HIV status, age, and HIV severity?
    • Goulet JL, Fultz SL, Rimland D, et al. Aging and infectious diseases: do patterns of comorbidity vary by HIV status, age, and HIV severity? Clin Infect Dis 2007; 45:1593-601.
    • (2007) Clin Infect Dis , vol.45 , pp. 1593-1601
    • Goulet, J.L.1    Fultz, S.L.2    Rimland, D.3
  • 4
    • 80755123417 scopus 로고    scopus 로고
    • Premature age-related comorbidities among HIV-infected persons compared with the general population
    • Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis 2011; 53:1120-6.
    • (2011) Clin Infect Dis , vol.53 , pp. 1120-1126
    • Guaraldi, G.1    Orlando, G.2    Zona, S.3
  • 5
    • 84924971538 scopus 로고    scopus 로고
    • Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: The AGEhIV cohort study
    • Schouten J, Wit FW, Stolte IG, et al. Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study. Clin Infect Dis 2014; 59:1787-97.
    • (2014) Clin Infect Dis , vol.59 , pp. 1787-1797
    • Schouten, J.1    Wit, F.W.2    Stolte, I.G.3
  • 6
    • 79551614790 scopus 로고    scopus 로고
    • HIV infection, inflammation, immunosenescence, and aging
    • Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med 2011; 62:141-55.
    • (2011) Annu Rev Med , vol.62 , pp. 141-155
    • Deeks, S.G.1
  • 7
    • 84885753789 scopus 로고    scopus 로고
    • Systemic effects of inflammation on health during chronic HIV infection
    • Deeks SG, Tracy R, Douek DC. Systemic effects of inflammation on health during chronic HIV infection. Immunity 2013; 39:633-45.
    • (2013) Immunity , vol.39 , pp. 633-645
    • Deeks, S.G.1    Tracy, R.2    Douek, D.C.3
  • 8
    • 79955973916 scopus 로고    scopus 로고
    • Inflammatory markers in population studies of aging
    • Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev 2011; 10:319-29.
    • (2011) Ageing Res Rev , vol.10 , pp. 319-329
    • Singh, T.1    Newman, A.B.2
  • 9
    • 80052918982 scopus 로고    scopus 로고
    • Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
    • Appay V, Fastenackels S, Katlama C, et al. Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients. AIDS 2011; 25:1813-22.
    • (2011) AIDS , vol.25 , pp. 1813-1822
    • Appay, V.1    Fastenackels, S.2    Katlama, C.3
  • 10
    • 77952507646 scopus 로고    scopus 로고
    • Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease
    • Naeger DM, Martin JN, Sinclair E, et al. Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease. PLoS One 2010; 5:e8886.
    • (2010) PLoS One , vol.5 , pp. e8886
    • Naeger, D.M.1    Martin, J.N.2    Sinclair, E.3
  • 11
    • 84864017351 scopus 로고    scopus 로고
    • Role of CD8T cell replicative senescence in human aging and in HIV-mediated immunosenescence
    • Dock JN, Effros RB. Role of CD8T cell replicative senescence in human aging and in HIV-mediated immunosenescence. Aging Dis 2011; 2:382-97.
    • (2011) Aging Dis , vol.2 , pp. 382-397
    • Dock, J.N.1    Effros, R.B.2
  • 12
    • 77249105912 scopus 로고    scopus 로고
    • Early immune senescence in HIV disease
    • Desai S, Landay A. Early immune senescence in HIV disease. Curr HIV/AIDS Rep 2010; 7:4-10.
    • (2010) Curr HIV/AIDS Rep , vol.7 , pp. 4-10
    • Desai, S.1    Landay, A.2
  • 13
    • 0037561928 scopus 로고    scopus 로고
    • Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    • Brenchley JM, Karandikar NJ, Betts MR, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003; 101:2711-20.
    • (2003) Blood , vol.101 , pp. 2711-2720
    • Brenchley, J.M.1    Karandikar, N.J.2    Betts, M.R.3
  • 14
    • 34347232370 scopus 로고    scopus 로고
    • Intracellular cytokine optimization and standard operating procedure
    • Lamoreaux L, Roederer M, Koup R. Intracellular cytokine optimization and standard operating procedure. Nat Protoc 2006; 1:1507-16.
    • (2006) Nat Protoc , vol.1 , pp. 1507-1516
    • Lamoreaux, L.1    Roederer, M.2    Koup, R.3
  • 15
    • 0034093051 scopus 로고    scopus 로고
    • Analysis of CD8T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides
    • Kern F, Faulhaber N, Frommel C, et al. Analysis of CD8T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides. Eur J Immunol 2000; 30:1676-82.
    • (2000) Eur J Immunol , vol.30 , pp. 1676-1682
    • Kern, F.1    Faulhaber, N.2    Frommel, C.3
  • 16
    • 63349111567 scopus 로고    scopus 로고
    • Telomere length measurement by a novel monochrome multiplex quantitative PCR method
    • Cawthon RM. Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 2009; 37:e21.
    • (2009) Nucleic Acids Res , vol.37 , pp. e21
    • Cawthon, R.M.1
  • 17
    • 71749119317 scopus 로고    scopus 로고
    • A reliable and simplified sj/beta-TREC ratio quantification method for human thymic output measurement
    • Ferrando-Martinez S, Franco JM, Ruiz-Mateos E, et al. A reliable and simplified sj/beta-TREC ratio quantification method for human thymic output measurement. J Immunol Methods 2010; 352:111-7.
    • (2010) J Immunol Methods , vol.352 , pp. 111-117
    • Ferrando-Martinez, S.1    Franco, J.M.2    Ruiz-Mateos, E.3
  • 18
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345:458-60.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 19
    • 0036197236 scopus 로고    scopus 로고
    • The effects of aging on lymphocyte development and function: Introduction
    • Hodes RJ. The effects of aging on lymphocyte development and function: introduction. Springer Semin Immunopathol 2002; 24:1-5.
    • (2002) Springer Semin Immunopathol , vol.24 , pp. 1-5
    • Hodes, R.J.1
  • 20
    • 19344370239 scopus 로고    scopus 로고
    • Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    • Papagno L, Spina CA, Marchant A, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol 2004; 2:E20.
    • (2004) PLoS Biol , vol.2 , pp. E20
    • Papagno, L.1    Spina, C.A.2    Marchant, A.3
  • 21
    • 84896348458 scopus 로고    scopus 로고
    • Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging
    • Lee SA, Sinclair E, Hatano H, et al. Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. PLoS One 2014; 9:e89444.
    • (2014) PLoS One , vol.9 , pp. e89444
    • Lee, S.A.1    Sinclair, E.2    Hatano, H.3
  • 22
    • 84902284706 scopus 로고    scopus 로고
    • Low proportions of CD28-CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection
    • Lee SA, Sinclair E, Jain V, et al. Low proportions of CD28-CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis 2014; 210:374-82.
    • (2014) J Infect Dis , vol.210 , pp. 374-382
    • Lee, S.A.1    Sinclair, E.2    Jain, V.3
  • 23
    • 33644548654 scopus 로고    scopus 로고
    • Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells
    • Raimondi G, Shufesky WJ, Tokita D, Morelli AE, Thomson AW. Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. J Immunol 2006; 176:2808-16.
    • (2006) J Immunol , vol.176 , pp. 2808-2816
    • Raimondi, G.1    Shufesky, W.J.2    Tokita, D.3    Morelli, A.E.4    Thomson, A.W.5
  • 24
    • 35948988938 scopus 로고    scopus 로고
    • Cytomegalovirus infection: A driving force in human T cell immunosenescence
    • Koch S, Larbi A, Ozcelik D, et al. Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci 2007; 1114:23-35.
    • (2007) Ann N y Acad Sci , vol.1114 , pp. 23-35
    • Koch, S.1    Larbi, A.2    Ozcelik, D.3
  • 25
    • 80755136930 scopus 로고    scopus 로고
    • Morbidity and aging in HIV-infected persons: The Swiss HIV cohort study
    • Hasse B, Ledergerber B, Furrer H, et al. Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis 2011; 53:1130-9.
    • (2011) Clin Infect Dis , vol.53 , pp. 1130-1139
    • Hasse, B.1    Ledergerber, B.2    Furrer, H.3
  • 26
    • 10744227881 scopus 로고    scopus 로고
    • CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: The Swiss HIV Cohort Study
    • Kaufmann GR, Perrin L, Pantaleo G, et al. CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study. Arch Intern Med 2003; 163:2187-95.
    • (2003) Arch Intern Med , vol.163 , pp. 2187-2195
    • Kaufmann, G.R.1    Perrin, L.2    Pantaleo, G.3
  • 27
    • 84901686066 scopus 로고    scopus 로고
    • HIV-infected individuals with low CD4/ CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality
    • Serrano-Villar S, Sainz T, Lee SA, et al. HIV-infected individuals with low CD4/ CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog 2014; 10:e1004078.
    • (2014) PLoS Pathog , vol.10 , pp. e1004078
    • Serrano-Villar, S.1    Sainz, T.2    Lee, S.A.3
  • 28
    • 0032741277 scopus 로고    scopus 로고
    • Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues
    • Bucy RP, Hockett RD, Derdeyn CA, et al. Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest 1999; 103:1391-8.
    • (1999) J Clin Invest , vol.103 , pp. 1391-1398
    • Bucy, R.P.1    Hockett, R.D.2    Derdeyn, C.A.3
  • 29
    • 0031849216 scopus 로고    scopus 로고
    • Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults
    • Walker RE, Carter CS, Muul L, et al. Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults. Nat Med 1998; 4:852-6.
    • (1998) Nat Med , vol.4 , pp. 852-856
    • Walker, R.E.1    Carter, C.S.2    Muul, L.3
  • 30
    • 17444372347 scopus 로고    scopus 로고
    • Changes in thymic function with age and during the treatment of HIV infection
    • Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998; 396:690-5.
    • (1998) Nature , vol.396 , pp. 690-695
    • Douek, D.C.1    McFarland, R.D.2    Keiser, P.H.3
  • 31
    • 0037093057 scopus 로고    scopus 로고
    • T-cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy
    • Franco JM, Rubio A, Martinez-Moya M, et al. T-cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy. Blood 2002; 99:3702-6.
    • (2002) Blood , vol.99 , pp. 3702-3706
    • Franco, J.M.1    Rubio, A.2    Martinez-Moya, M.3
  • 32
    • 0035964691 scopus 로고    scopus 로고
    • Poor CD4T cell restoration after suppression of HIV-1 replication may reflect lower thymic function
    • Teixeira L, Valdez H, McCune JM, et al. Poor CD4T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 2001; 15:1749-56.
    • (2001) AIDS , vol.15 , pp. 1749-1756
    • Teixeira, L.1    Valdez, H.2    McCune, J.M.3
  • 33
    • 0032104145 scopus 로고    scopus 로고
    • High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
    • McCune JM, Loftus R, Schmidt DK, et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest 1998; 101:2301-8.
    • (1998) J Clin Invest , vol.101 , pp. 2301-2308
    • McCune, J.M.1    Loftus, R.2    Schmidt, D.K.3
  • 34
    • 84908448373 scopus 로고    scopus 로고
    • CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells
    • Cockerham LR, Siliciano JD, Sinclair E, et al. CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One 2014; 9:e110731.
    • (2014) PLoS One , vol.9 , pp. e110731
    • Cockerham, L.R.1    Siliciano, J.D.2    Sinclair, E.3
  • 35
    • 84879520476 scopus 로고    scopus 로고
    • The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation
    • Chevalier MF, Petitjean G, Dunyach-Remy C, et al. The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation. PLoS Pathog 2013; 9:e1003453.
    • (2013) PLoS Pathog , vol.9 , pp. e1003453
    • Chevalier, M.F.1    Petitjean, G.2    Dunyach-Remy, C.3
  • 36
    • 79955942152 scopus 로고    scopus 로고
    • Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study
    • O'Donovan A, Pantell MS, Puterman E, et al. Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One 2011; 6:e19687.
    • (2011) PLoS One , vol.6 , pp. e19687
    • O'Donovan, A.1    Pantell, M.S.2    Puterman, E.3
  • 37
    • 84922479734 scopus 로고    scopus 로고
    • Soluble CD163 is associated with shortened telomere length in HIV-infected patients
    • Srinivasa S, Fitch KV, Petrow E, et al. Soluble CD163 is associated with shortened telomere length in HIV-infected patients. J Acquir Immune Defic Syndr 2014; 67:414-8.
    • (2014) J Acquir Immune Defic Syndr , vol.67 , pp. 414-418
    • Srinivasa, S.1    Fitch, K.V.2    Petrow, E.3
  • 38
    • 84900317782 scopus 로고    scopus 로고
    • The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study
    • Wong JY, De Vivo I, Lin X, Fang SC, Christiani DC. The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study. PLoS One 2014; 9:e87348.
    • (2014) PLoS One , vol.9 , pp. e87348
    • Wong, J.Y.1    De Vivo, I.2    Lin, X.3    Fang, S.C.4    Christiani, D.C.5
  • 40
    • 84861553601 scopus 로고    scopus 로고
    • Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women
    • Parrinello CM, Sinclair E, Landay AL, et al. Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women. J Infect Dis 2012; 205:1788-96.
    • (2012) J Infect Dis , vol.205 , pp. 1788-1796
    • Parrinello, C.M.1    Sinclair, E.2    Landay, A.L.3
  • 41
    • 84916224374 scopus 로고    scopus 로고
    • The use of humoral responses as a marker of CMV burden in HIV patients on ART requires consideration of T-cell recovery and persistent B-cell activation
    • Brunt SJ, Lee S, D'Orsogna L, Bundell C, Burrows S, Price P. The use of humoral responses as a marker of CMV burden in HIV patients on ART requires consideration of T-cell recovery and persistent B-cell activation. Dis Markers 2014; 2014:947432.
    • (2014) Dis Markers , vol.2014 , pp. 947432
    • Brunt, S.J.1    Lee, S.2    D'Orsogna, L.3    Bundell, C.4    Burrows, S.5    Price, P.6
  • 42
    • 34748873441 scopus 로고    scopus 로고
    • Regulatory T cells and infection: A dangerous necessity
    • Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol 2007; 7:875-88.
    • (2007) Nat Rev Immunol , vol.7 , pp. 875-888
    • Belkaid, Y.1
  • 43
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009; 30:636-45.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 44
    • 34447578626 scopus 로고    scopus 로고
    • Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy
    • Lim A, Tan D, Price P, et al. Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy. AIDS 2007; 21:1525-34.
    • (2007) AIDS , vol.21 , pp. 1525-1534
    • Lim, A.1    Tan, D.2    Price, P.3
  • 45
    • 77955432632 scopus 로고    scopus 로고
    • Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy
    • Piconi S, Trabattoni D, Gori A, et al. Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy. AIDS 2010; 24:1991-2000.
    • (2010) AIDS , vol.24 , pp. 1991-2000
    • Piconi, S.1    Trabattoni, D.2    Gori, A.3
  • 46
    • 77955351656 scopus 로고    scopus 로고
    • Relationship between regulatory T cells and immune activation in human immunodeficiency virus-infected patients interrupting antiretroviral therapy
    • Weiss L, Piketty C, Assoumou L, et al. Relationship between regulatory T cells and immune activation in human immunodeficiency virus-infected patients interrupting antiretroviral therapy. PLoS One 2010; 5:e11659.
    • (2010) PLoS One , vol.5 , pp. e11659
    • Weiss, L.1    Piketty, C.2    Assoumou, L.3
  • 47
    • 84863993864 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4T cell responses by upregulating interleukin-10 production in monocytes
    • Kwon DS, Angin M, Hongo T, et al. CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4T cell responses by upregulating interleukin-10 production in monocytes. J Virol 2012; 86:6586-94.
    • (2012) J Virol , vol.86 , pp. 6586-6594
    • Kwon, D.S.1    Angin, M.2    Hongo, T.3
  • 48
    • 77950525439 scopus 로고    scopus 로고
    • Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    • Said EA, Dupuy FP, Trautmann L, et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med 2010; 16:452-9.
    • (2010) Nat Med , vol.16 , pp. 452-459
    • Said, E.A.1    Dupuy, F.P.2    Trautmann, L.3
  • 49
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity 2013; 39:1-10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.