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Volumn 11, Issue 6, 2016, Pages 783-798

Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines

Author keywords

[No Author keywords available]

Indexed keywords

4SC 202; ALPHA TUBULIN; CASPASE 3; CASPASE 7; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; VORINOSTAT; IMMUNOGLOBULIN CLASS;

EID: 84976618956     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-016-0444-7     Document Type: Article
Times cited : (56)

References (53)
  • 1
    • 84855583390 scopus 로고    scopus 로고
    • Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986
    • PID: 22162575
    • De Santis M, Bellmunt J, Mead G, Kerst JM, Leahy M, Maroto P, et al. Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986. J Clin Oncol. 2012;30(2):191–9.
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 191-199
    • De Santis, M.1    Bellmunt, J.2    Mead, G.3    Kerst, J.M.4    Leahy, M.5    Maroto, P.6
  • 2
    • 0035873915 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no. 30924
    • COI: 1:CAS:528:DC%2BD3MXkt1Omu78%3D, PID: 11352955
    • Sternberg CN, de Mulder PH, Schornagel JH, Theodore C, Fossa SD, van Oosterom AT, et al. Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no. 30924. J Clin Oncol. 2001;19(10):2638–46.
    • (2001) J Clin Oncol , vol.19 , Issue.10 , pp. 2638-2646
    • Sternberg, C.N.1    de Mulder, P.H.2    Schornagel, J.H.3    Theodore, C.4    Fossa, S.D.5    van Oosterom, A.T.6
  • 3
    • 23044501890 scopus 로고    scopus 로고
    • Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer
    • PID: 16034041
    • von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, et al. Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol. 2005;23(21):4602–8.
    • (2005) J Clin Oncol , vol.23 , Issue.21 , pp. 4602-4608
    • von der Maase, H.1    Sengelov, L.2    Roberts, J.T.3    Ricci, S.4    Dogliotti, L.5    Oliver, T.6
  • 4
    • 33749052312 scopus 로고    scopus 로고
    • Phase III, study of sunitinib malate (SU11248) versus interferon-alpha as first-line treatment in patients with metastatic renal cell carcinoma
    • PID: 16859575
    • Reddy K. Phase III, study of sunitinib malate (SU11248) versus interferon-alpha as first-line treatment in patients with metastatic renal cell carcinoma. Clin Genitourin Cancer. 2006;5(1):23–5.
    • (2006) Clin Genitourin Cancer , vol.5 , Issue.1 , pp. 23-25
    • Reddy, K.1
  • 5
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • COI: 1:CAS:528:DC%2BD1MXpvFejt7w%3D
    • Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol: Off J Am Soc Clin Oncol. 2009;27(20):3312–8. doi:10.1200/JCO.2008.19.5511.
    • (2009) J Clin Oncol: Off J Am Soc Clin Oncol , vol.27 , Issue.20 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 6
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
    • COI: 1:CAS:528:DC%2BD1cXps1GmsLY%3D, PID: 18653228
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008;372(9637):449–56. doi:10.1016/S0140-6736(08)61039-9.
    • (2008) Lancet , vol.372 , Issue.9637 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 7
    • 84899485656 scopus 로고    scopus 로고
    • Targeted therapies in urothelial carcinoma
    • COI: 1:CAS:528:DC%2BC2cXmtVOiurc%3D, PID: 24685646
    • Ghosh M, Brancato SJ, Agarwal PK, Apolo AB. Targeted therapies in urothelial carcinoma. Curr Opin Oncol. 2014;26(3):305–20. doi:10.1097/CCO.0000000000000064.
    • (2014) Curr Opin Oncol , vol.26 , Issue.3 , pp. 305-320
    • Ghosh, M.1    Brancato, S.J.2    Agarwal, P.K.3    Apolo, A.B.4
  • 8
    • 84870062218 scopus 로고    scopus 로고
    • Chemotherapy for urothelial cancer of the bladder—update 2012
    • COI: 1:STN:280:DC%2BC3s7nslWgsg%3D%3D, PID: 23196781
    • Niegisch G, Lorch A, Albers P. Chemotherapy for urothelial cancer of the bladder—update 2012. Aktuelle Urol. 2012;43(6):412–9. doi:10.1055/s-0032-1327699.
    • (2012) Aktuelle Urol , vol.43 , Issue.6 , pp. 412-419
    • Niegisch, G.1    Lorch, A.2    Albers, P.3
  • 9
    • 84910145396 scopus 로고    scopus 로고
    • Multiple mechanisms mediate resistance to sorafenib in urothelial cancer
    • COI: 1:CAS:528:DC%2BC2MXisFais7Y%3D, PID: 25387078
    • Knievel J, Schulz WA, Greife A, Hader C, Lubke T, Schmitz I, et al. Multiple mechanisms mediate resistance to sorafenib in urothelial cancer. Int J Mol Sci. 2014;15(11):20500–17.
    • (2014) Int J Mol Sci , vol.15 , Issue.11 , pp. 20500-20517
    • Knievel, J.1    Schulz, W.A.2    Greife, A.3    Hader, C.4    Lubke, T.5    Schmitz, I.6
  • 10
    • 0037444803 scopus 로고    scopus 로고
    • Histone deacetylases (HDACs): characterization of the classical HDAC family
    • PID: 12429021
    • de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J. 2003;370(Pt 3):737–49. doi:10.1042/BJ20021321.
    • (2003) Biochem J , vol.370 , pp. 737-749
    • de Ruijter, A.J.1    van Gennip, A.H.2    Caron, H.N.3    Kemp, S.4    van Kuilenburg, A.B.5
  • 11
    • 1842578986 scopus 로고    scopus 로고
    • Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis
    • COI: 1:CAS:528:DC%2BD2cXisFyksro%3D, PID: 15050820
    • Gregoretti IV, Lee YM, Goodson HV. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol. 2004;338(1):17–31. doi:10.1016/j.jmb.2004.02.006.
    • (2004) J Mol Biol , vol.338 , Issue.1 , pp. 17-31
    • Gregoretti, I.V.1    Lee, Y.M.2    Goodson, H.V.3
  • 12
    • 61849144810 scopus 로고    scopus 로고
    • HDAC family: what are the cancer relevant targets?
    • COI: 1:CAS:528:DC%2BD1MXjtFOhsL4%3D, PID: 18824292
    • Witt O, Deubzer HE, Milde T, Oehme I. HDAC family: what are the cancer relevant targets? Cancer Lett. 2009;277(1):8–21. doi:10.1016/j.canlet.2008.08.016.
    • (2009) Cancer Lett , vol.277 , Issue.1 , pp. 8-21
    • Witt, O.1    Deubzer, H.E.2    Milde, T.3    Oehme, I.4
  • 13
    • 38549157208 scopus 로고    scopus 로고
    • Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis
    • COI: 1:CAS:528:DC%2BD1cXhsVOnu7c%3D, PID: 18207460
    • Weichert W, Roske A, Gekeler V, Beckers T, Ebert MP, Pross M, et al. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol. 2008;9(2):139–48. doi:10.1016/S1470-2045(08)70004-4.
    • (2008) Lancet Oncol , vol.9 , Issue.2 , pp. 139-148
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Ebert, M.P.5    Pross, M.6
  • 14
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • COI: 1:CAS:528:DC%2BD1cXhs1Krsbo%3D, PID: 18212746
    • Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer. 2008;98(3):604–10. doi:10.1038/sj.bjc.6604199.
    • (2008) Br J Cancer , vol.98 , Issue.3 , pp. 604-610
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Stephan, C.5    Jung, K.6
  • 15
    • 50949104573 scopus 로고    scopus 로고
    • Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas
    • COI: 1:CAS:528:DC%2BD1cXht1Kgs7fI, PID: 18714364
    • Weichert W, Denkert C, Noske A, Darb-Esfahani S, Dietel M, Kalloger SE, et al. Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas. Neoplasia. 2008;10(9):1021–7.
    • (2008) Neoplasia , vol.10 , Issue.9 , pp. 1021-1027
    • Weichert, W.1    Denkert, C.2    Noske, A.3    Darb-Esfahani, S.4    Dietel, M.5    Kalloger, S.E.6
  • 16
    • 39749127166 scopus 로고    scopus 로고
    • The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
    • COI: 1:CAS:528:DC%2BD1cXitlGnurk%3D, PID: 18292778
    • Yang XJ, Seto E. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol. 2008;9(3):206–18. doi:10.1038/nrm2346.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.3 , pp. 206-218
    • Yang, X.J.1    Seto, E.2
  • 17
    • 0030798245 scopus 로고    scopus 로고
    • Histone acetylation in chromatin structure and transcription
    • COI: 1:CAS:528:DyaK2sXmsVWntLk%3D, PID: 9311776
    • Grunstein M. Histone acetylation in chromatin structure and transcription. Nature. 1997;389(6649):349–52. doi:10.1038/38664.
    • (1997) Nature , vol.389 , Issue.6649 , pp. 349-352
    • Grunstein, M.1
  • 18
    • 84896470334 scopus 로고    scopus 로고
    • Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011–2013)
    • Valente S, Mai A. Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011–2013). Expert Opin Ther Pat. 2014. doi:10.1517/13543776.2014.877446.
    • (2014) Expert Opin Ther Pat
    • Valente, S.1    Mai, A.2
  • 19
    • 84874410182 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents
    • COI: 1:CAS:528:DC%2BC3sXktFCms70%3D
    • Ververis K, Hiong A, Karagiannis TC, Licciardi PV. Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biol: Targets Ther. 2013;7:47–60. doi:10.2147/BTT.S29965.
    • (2013) Biol: Targets Ther , vol.7 , pp. 47-60
    • Ververis, K.1    Hiong, A.2    Karagiannis, T.C.3    Licciardi, P.V.4
  • 20
    • 84886292827 scopus 로고    scopus 로고
    • Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers
    • COI: 1:CAS:528:DC%2BC3sXhs1OrtbbJ, PID: 22944197
    • Niegisch G, Knievel J, Koch A, Hader C, Fischer U, Albers P, et al. Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers. Urol Oncol. 2013;31(8):1770–9. doi:10.1016/j.urolonc.2012.06.015.
    • (2013) Urol Oncol , vol.31 , Issue.8 , pp. 1770-1779
    • Niegisch, G.1    Knievel, J.2    Koch, A.3    Hader, C.4    Fischer, U.5    Albers, P.6
  • 21
    • 80053625740 scopus 로고    scopus 로고
    • HDAC inhibition delays cell cycle progression of human bladder cancer cells in vitro
    • COI: 1:CAS:528:DC%2BC3MXht1Kms7rN, PID: 21822119
    • Vallo S, Xi W, Hudak L, Juengel E, Tsaur I, Wiesner C, et al. HDAC inhibition delays cell cycle progression of human bladder cancer cells in vitro. Anti-Cancer Drugs. 2011;22(10):1002–9. doi:10.1097/CAD.0b013e32834a2c70.
    • (2011) Anti-Cancer Drugs , vol.22 , Issue.10 , pp. 1002-1009
    • Vallo, S.1    Xi, W.2    Hudak, L.3    Juengel, E.4    Tsaur, I.5    Wiesner, C.6
  • 22
    • 58849104486 scopus 로고    scopus 로고
    • Histone deacetylase 8 in neuroblastoma tumorigenesis
    • COI: 1:CAS:528:DC%2BD1MXhs1Cjuw%3D%3D, PID: 19118036
    • Oehme I, Deubzer HE, Wegener D, Pickert D, Linke JP, Hero B, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009;15(1):91–9. doi:10.1158/1078-0432.CCR-08-0684.
    • (2009) Clin Cancer Res , vol.15 , Issue.1 , pp. 91-99
    • Oehme, I.1    Deubzer, H.E.2    Wegener, D.3    Pickert, D.4    Linke, J.P.5    Hero, B.6
  • 23
    • 84904080238 scopus 로고    scopus 로고
    • Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment
    • PID: 25011684
    • Lehmann M, Hoffmann MJ, Koch A, Ulrich SM, Schulz WA, Niegisch G. Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment. J Exp Clin Cancer Res: CR. 2014;33:59. doi:10.1186/s13046-014-0059-8.
    • (2014) J Exp Clin Cancer Res: CR , vol.33 , pp. 59
    • Lehmann, M.1    Hoffmann, M.J.2    Koch, A.3    Ulrich, S.M.4    Schulz, W.A.5    Niegisch, G.6
  • 24
    • 84960325769 scopus 로고    scopus 로고
    • Inhibition of class I histone deacetylases 1 and 2 promotes urothelial carcinoma cell death by various mechanisms
    • COI: 1:CAS:528:DC%2BC28XisVWrs7o%3D, PID: 26772204
    • Pinkerneil M, Hoffmann MJ, Deenen R, Köhrer K, Arent T, Schulz WA, et al. Inhibition of class I histone deacetylases 1 and 2 promotes urothelial carcinoma cell death by various mechanisms. Mol Cancer Ther. 2016;15(2):299–312. doi:10.1158/1535-7163.MCT-15-0618.
    • (2016) Mol Cancer Ther , vol.15 , Issue.2 , pp. 299-312
    • Pinkerneil, M.1    Hoffmann, M.J.2    Deenen, R.3    Köhrer, K.4    Arent, T.5    Schulz, W.A.6
  • 25
    • 85003925843 scopus 로고    scopus 로고
    • Tresckow B, Gundermann S, Eichenauer DA, Aulitzky WE, Göbeler M, Sayehli C et al. First-in-human study of 4SC-202, a novel oral HDAC inhibitor in advanced hematologic malignancies (TOPAS study). Journal of Clinical Oncology. 2014;32(supplement 5):abstr. 8559
    • Tresckow B, Gundermann S, Eichenauer DA, Aulitzky WE, Göbeler M, Sayehli C et al. First-in-human study of 4SC-202, a novel oral HDAC inhibitor in advanced hematologic malignancies (TOPAS study). Journal of Clinical Oncology. 2014;32(supplement 5):abstr. 8559.
  • 26
    • 0037229621 scopus 로고    scopus 로고
    • Activities of MAP-kinase pathways in normal uroepithelial cells and urothelial carcinoma cell lines
    • COI: 1:CAS:528:DC%2BD38XpsFyit7k%3D, PID: 12490193
    • Swiatkowski S, Seifert HH, Steinhoff C, Prior A, Thievessen I, Schliess F, et al. Activities of MAP-kinase pathways in normal uroepithelial cells and urothelial carcinoma cell lines. Exp Cell Res. 2003;282(1):48–57.
    • (2003) Exp Cell Res , vol.282 , Issue.1 , pp. 48-57
    • Swiatkowski, S.1    Seifert, H.H.2    Steinhoff, C.3    Prior, A.4    Thievessen, I.5    Schliess, F.6
  • 27
    • 22344444676 scopus 로고    scopus 로고
    • A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function
    • COI: 1:CAS:528:DC%2BD2MXotFeju7s%3D, PID: 15784840
    • Cross WR, Eardley I, Leese HJ, Southgate J. A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function. Am J Physiol Renal Physiol. 2005;289(2):F459–68. doi:10.1152/ajprenal.00040.2005.
    • (2005) Am J Physiol Renal Physiol , vol.289 , Issue.2 , pp. F459-F468
    • Cross, W.R.1    Eardley, I.2    Leese, H.J.3    Southgate, J.4
  • 28
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • COI: 1:CAS:528:DyaK3MXltlenu7Y%3D, PID: 1710634
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods. 1991;139(2):271–9.
    • (1991) J Immunol Methods , vol.139 , Issue.2 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 29
    • 34250782684 scopus 로고    scopus 로고
    • Extraction, purification and analysis of histones
    • COI: 1:CAS:528:DC%2BD2sXhtFagsLnL, PID: 17545981
    • Shechter D, Dormann HL, Allis CD, Hake SB. Extraction, purification and analysis of histones. Nat Protoc. 2007;2(6):1445–57. doi:10.1038/nprot.2007.202.
    • (2007) Nat Protoc , vol.2 , Issue.6 , pp. 1445-1457
    • Shechter, D.1    Dormann, H.L.2    Allis, C.D.3    Hake, S.B.4
  • 32
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • COI: 1:CAS:528:DyaK1cXhsleiu7g%3D, PID: 9488723
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 1998;273(10):5858–68.
    • (1998) J Biol Chem , vol.273 , Issue.10 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 33
    • 84901309171 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing
    • PID: 24722454
    • Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, et al. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog. 2014;10(4), e1004071. doi:10.1371/journal.ppat.1004071.
    • (2014) PLoS Pathog , vol.10 , Issue.4
    • Wei, D.G.1    Chiang, V.2    Fyne, E.3    Balakrishnan, M.4    Barnes, T.5    Graupe, M.6
  • 34
    • 84926614325 scopus 로고    scopus 로고
    • Acetylation site specificities of lysine deacetylase inhibitors in human cells
    • COI: 1:CAS:528:DC%2BC2MXjvFOgtbw%3D, PID: 25751058
    • Scholz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, et al. Acetylation site specificities of lysine deacetylase inhibitors in human cells. Nat Biotechnol. 2015;33(4):415–23. doi:10.1038/nbt.3130.
    • (2015) Nat Biotechnol , vol.33 , Issue.4 , pp. 415-423
    • Scholz, C.1    Weinert, B.T.2    Wagner, S.A.3    Beli, P.4    Miyake, Y.5    Qi, J.6
  • 35
    • 79952396960 scopus 로고    scopus 로고
    • Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
    • COI: 1:CAS:528:DC%2BC3MXps1ahug%3D%3D, PID: 21258344
    • Bantscheff M, Hopf C, Savitski MM, Dittmann A, Grandi P, Michon AM, et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011;29(3):255–65. doi:10.1038/nbt.1759.
    • (2011) Nat Biotechnol , vol.29 , Issue.3 , pp. 255-265
    • Bantscheff, M.1    Hopf, C.2    Savitski, M.M.3    Dittmann, A.4    Grandi, P.5    Michon, A.M.6
  • 36
    • 84941884474 scopus 로고    scopus 로고
    • Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response
    • PID: 26380582
    • Halsall JA, Turan N, Wiersma M, Turner BM. Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response. Epigenetics Chromatin. 2015;8:29. doi:10.1186/s13072-015-0021-9.
    • (2015) Epigenetics Chromatin , vol.8 , pp. 29
    • Halsall, J.A.1    Turan, N.2    Wiersma, M.3    Turner, B.M.4
  • 37
    • 77957091318 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair
    • COI: 1:CAS:528:DC%2BC3cXhtVOgsb%2FN, PID: 20679231
    • Lee JH, Choy ML, Ngo L, Foster SS, Marks PA. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci U S A. 2010;107(33):14639–44. doi:10.1073/pnas.1008522107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.33 , pp. 14639-14644
    • Lee, J.H.1    Choy, M.L.2    Ngo, L.3    Foster, S.S.4    Marks, P.A.5
  • 38
  • 39
    • 84865712964 scopus 로고    scopus 로고
    • Hedgehog signaling regulates bladder cancer growth and tumorigenicity
    • COI: 1:CAS:528:DC%2BC38Xht1ygurrN, PID: 22815529
    • Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, et al. Hedgehog signaling regulates bladder cancer growth and tumorigenicity. Cancer Res. 2012;72(17):4449–58. doi:10.1158/0008-5472.CAN-11-4123.
    • (2012) Cancer Res , vol.72 , Issue.17 , pp. 4449-4458
    • Fei, D.L.1    Sanchez-Mejias, A.2    Wang, Z.3    Flaveny, C.4    Long, J.5    Singh, S.6
  • 40
    • 84856786306 scopus 로고    scopus 로고
    • Wnt signaling pathways in urological cancers: past decades and still growing
    • COI: 1:CAS:528:DC%2BC38XkvVOqur0%3D, PID: 22325146
    • Majid S, Saini S, Dahiya R. Wnt signaling pathways in urological cancers: past decades and still growing. Mol Cancer. 2012;11:7. doi:10.1186/1476-4598-11-7.
    • (2012) Mol Cancer , vol.11 , pp. 7
    • Majid, S.1    Saini, S.2    Dahiya, R.3
  • 41
    • 80052743686 scopus 로고    scopus 로고
    • Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors
    • COI: 1:CAS:528:DC%2BC3MXhtFGjtLrO, PID: 21653597
    • Singh MM, Manton CA, Bhat KP, Tsai WW, Aldape K, Barton MC, et al. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol. 2011;13(8):894–903. doi:10.1093/neuonc/nor049.
    • (2011) Neuro Oncol , vol.13 , Issue.8 , pp. 894-903
    • Singh, M.M.1    Manton, C.A.2    Bhat, K.P.3    Tsai, W.W.4    Aldape, K.5    Barton, M.C.6
  • 42
    • 84905238187 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights
    • COI: 1:CAS:528:DC%2BC2cXnslGnt7o%3D, PID: 24769080
    • Bose P, Dai Y, Grant S. Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights. Pharmacol Ther. 2014;143(3):323–36. doi:10.1016/j.pharmthera.2014.04.004.
    • (2014) Pharmacol Ther , vol.143 , Issue.3 , pp. 323-336
    • Bose, P.1    Dai, Y.2    Grant, S.3
  • 43
    • 67349285731 scopus 로고    scopus 로고
    • Enhancing the apoptotic and therapeutic effects of HDAC inhibitors
    • COI: 1:CAS:528:DC%2BD1MXmsF2jtrY%3D, PID: 19359091
    • Frew AJ, Johnstone RW, Bolden JE. Enhancing the apoptotic and therapeutic effects of HDAC inhibitors. Cancer Lett. 2009;280(2):125–33. doi:10.1016/j.canlet.2009.02.042.
    • (2009) Cancer Lett , vol.280 , Issue.2 , pp. 125-133
    • Frew, A.J.1    Johnstone, R.W.2    Bolden, J.E.3
  • 44
    • 84908265816 scopus 로고    scopus 로고
    • Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
    • COI: 1:CAS:528:DC%2BC2cXhtlKrtLjI, PID: 25131830
    • Falkenberg KJ, Johnstone RW. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov. 2014;13(9):673–91. doi:10.1038/nrd4360.
    • (2014) Nat Rev Drug Discov , vol.13 , Issue.9 , pp. 673-691
    • Falkenberg, K.J.1    Johnstone, R.W.2
  • 45
    • 84879668461 scopus 로고    scopus 로고
    • Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3
    • COI: 1:CAS:528:DC%2BC3sXhtVyktbnM, PID: 23744355
    • Lai F, Guo ST, Jin L, Jiang CC, Wang CY, Croft A, et al. Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3. Cell Death Dis. 2013;4:e655. doi:10.1038/cddis.2013.192.
    • (2013) Cell Death Dis , vol.4
    • Lai, F.1    Guo, S.T.2    Jin, L.3    Jiang, C.C.4    Wang, C.Y.5    Croft, A.6
  • 46
    • 41849120477 scopus 로고    scopus 로고
    • Chromosomal instability in bladder cancer
    • COI: 1:CAS:528:DC%2BD1cXktVegs7o%3D, PID: 18253719
    • Florl AR, Schulz WA. Chromosomal instability in bladder cancer. Arch Toxicol. 2008;82(3):173–82. doi:10.1007/s00204-008-0280-3.
    • (2008) Arch Toxicol , vol.82 , Issue.3 , pp. 173-182
    • Florl, A.R.1    Schulz, W.A.2
  • 47
    • 84983672067 scopus 로고    scopus 로고
    • Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells
    • Zhijun H, Shusheng W, Han M, Jianping L, Li-Sen Q, Dechun L. Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells. Tumour Biol. 2016. doi:10.1007/s13277-016-4868-6.
    • (2016) Tumour Biol
    • Zhijun, H.1    Shusheng, W.2    Han, M.3    Jianping, L.4    Li-Sen, Q.5    Dechun, L.6
  • 48
    • 84959473701 scopus 로고    scopus 로고
    • 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells
    • COI: 1:CAS:528:DC%2BC28XislSrsLs%3D, PID: 26773495
    • Fu M, Wan F, Li Z, Zhang F. 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2016;471(2):267–73. doi:10.1016/j.bbrc.2016.01.030.
    • (2016) Biochem Biophys Res Commun , vol.471 , Issue.2 , pp. 267-273
    • Fu, M.1    Wan, F.2    Li, Z.3    Zhang, F.4
  • 49
    • 30044436439 scopus 로고    scopus 로고
    • Role of histone modifications in marking and activating genes through mitosis
    • COI: 1:CAS:528:DC%2BD2MXhtlCmsLjP, PID: 16199528
    • Valls E, Sanchez-Molina S, Martinez-Balbas MA. Role of histone modifications in marking and activating genes through mitosis. J Biol Chem. 2005;280(52):42592–600. doi:10.1074/jbc.M507407200.
    • (2005) J Biol Chem , vol.280 , Issue.52 , pp. 42592-42600
    • Valls, E.1    Sanchez-Molina, S.2    Martinez-Balbas, M.A.3
  • 50
    • 77956315751 scopus 로고    scopus 로고
    • Acetylation of RNA processing proteins and cell cycle proteins in mitosis
    • COI: 1:CAS:528:DC%2BC3cXptFGguro%3D, PID: 20812760
    • Chuang C, Lin SH, Huang F, Pan J, Josic D, Yu-Lee LY. Acetylation of RNA processing proteins and cell cycle proteins in mitosis. J Proteome Res. 2010;9(9):4554–64. doi:10.1021/pr100281h.
    • (2010) J Proteome Res , vol.9 , Issue.9 , pp. 4554-4564
    • Chuang, C.1    Lin, S.H.2    Huang, F.3    Pan, J.4    Josic, D.5    Yu-Lee, L.Y.6
  • 51
    • 84880842769 scopus 로고    scopus 로고
    • Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells
    • COI: 1:CAS:528:DC%2BC3sXhtFGmsrrJ, PID: 23624524
    • Kuffer C, Kuznetsova AY, Storchova Z. Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells. Chromosoma. 2013;122(4):305–18. doi:10.1007/s00412-013-0414-0.
    • (2013) Chromosoma , vol.122 , Issue.4 , pp. 305-318
    • Kuffer, C.1    Kuznetsova, A.Y.2    Storchova, Z.3
  • 52
    • 84925545335 scopus 로고    scopus 로고
    • Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
    • COI: 1:CAS:528:DC%2BC2cXitFKltbzF, PID: 25533674
    • Knowles MA, Hurst CD. Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nat Rev Cancer. 2015;15(1):25–41. doi:10.1038/nrc3817.
    • (2015) Nat Rev Cancer , vol.15 , Issue.1 , pp. 25-41
    • Knowles, M.A.1    Hurst, C.D.2
  • 53
    • 84935895322 scopus 로고    scopus 로고
    • The UBC-40 urothelial bladder cancer cell line index: a genomic resource for functional studies
    • PID: 25997541
    • Earl J, Rico D, Carrillo-de-Santa-Pau E, Rodriguez-Santiago B, Mendez-Pertuz M, Auer H, et al. The UBC-40 urothelial bladder cancer cell line index: a genomic resource for functional studies. BMC Genomics. 2015;16:403. doi:10.1186/s12864-015-1450-3.
    • (2015) BMC Genomics , vol.16 , pp. 403
    • Earl, J.1    Rico, D.2    Carrillo-de-Santa-Pau, E.3    Rodriguez-Santiago, B.4    Mendez-Pertuz, M.5    Auer, H.6


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