Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library

Journal of Antibiotics

Volumn 69, Issue 6, 2016, Pages 456-458

  Lim, Chung Liang ^a,b   Nogawa, Toshihiko ^a   Okano, Akiko ^a   Futamura, Yushi ^a   Kawatani, Makoto ^a   Takahashi, Shunji ^a   Ibrahim, Darah ^b   Osada, Hiroyuki ^a  

^a Elements Chemistry Laboratory   (Japan)

^b SCHOOL OF PHYSICS   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBENZOIC ACID; ACETONITRILE; AGRICULTURAL CHEMICAL; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BENZENE; DRUG METABOLITE; FUNCTIONAL GROUP; METHYL GROUP; NATURAL PRODUCT; QUINOMYCIN; UNANTIMYCIN A; UNCLASSIFIED DRUG; WATER; MACROCYCLIC COMPOUND;

ANTIMALARIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIUM CULTURE; BIOLOGICAL ACTIVITY; BIOLOGICAL FUNCTIONS; CANCER CELL LINE; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH RESOLUTION MELTING ANALYSIS; HUMAN; HUMAN CELL; INFRARED SPECTROMETRY; LIQUID CHROMATOGRAPHY; MAGNAPORTHE ORYZAE; MASS SPECTROMETRY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STREPTOMYCES; CHEMICAL STRUCTURE; CHEMISTRY; CHROMATOGRAPHY; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CHROMATOGRAPHY; MACROCYCLIC COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; STREPTOMYCES;

EID: 84976616391     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2015.124     Document Type: Article

References (15)

1. Osada, H. An overview on the diversity of actinomycete metabolites. Actinomycetol 15, 11-14 (2001).
2. Newman, D. J. & Cragg, G. M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 75, 311-335 (2012).
3. Dobson, C. M. Chemical space and biology. Nature 432, 824-828 (2004).
4. Osada, H. inBioprobes (ed. Osada, H.) 1-14 (Springer, Berlin, 2000).
5. Osada, H. Chemical biology based on small molecule-protein interaction. in Protein targeting with small molecules. Chemical biology techniques and applications (ed. Osada H.) 1-10 (Wiley, New Jersey, 2009).
6. Osada, H. & Nogawa, T. Systematic isolation of microbial metabolites for natural products depository (NPDepo). Pure Appl. Chem. 81, 1407-1420 (2012).
7. Kato, N., Takahashi, S., Nogawa, T., Saito, T. & Osada, H. Construction of a microbial natural product library for chemical biology studies. Curr. Opin. Chem. Biol. 16, 101-108 (2012).
8. Nogawa, T. et al. Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library. Org. Lett. 12, 4564-4567 (2010).
9. Nogawa, T. et al. Spirotoamides A and B, novel 6, 6-spitoaccetal polyketides isolated from a microbial metabolite fraction library. J. Antibiot. 65, 123-128 (2012).
10. Nogawa, T. et al. Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus. J. Antibiot. 66, 621-623 (2013).
11. Lim, C. L. et al. RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening. J. Antibiot. 67, 323-329 (2014).
12. Takahashi, K., Tsuda, E. & Kurosawa, K. SW-163A and B, novel immunosuppressants produced by Streptomyces sp. J. Antibiot. 54, 867-873 (2001).
13. Izumikawa, M. et al. Novel GRP78 molecular chaperone expression down-regulators JBIR-04 and-05 isolated from Streptomyces violaceoniger. J. Antibiot. 60, 640-644 (2007).
14. Umeda, Y. et al. Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator. Org. Lett. 9, 4239-4242 (2007).
15. Yamakoshi, S. & Kawanishi, E. First total synthesis of prunustatin A. Tetrahedron Lett. 55, 1175-1177 (2014).