IgG and IgG4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort

Journal of Allergy and Clinical Immunology

Volumn 138, Issue 5, 2016, Pages 1426-1433.e12

  Schwarz, Alina ^a   Panetta, Valentina ^b   Cappella, Antonio ^c   Hofmaier, Stephanie ^a   Hatzler, Laura ^a   Rohrbach, Alexander ^a   Tsilochristou, Olympia ^a   Bauer, Carl Peter ^d   Hoffmann, Ute ^d   Forster, Johannes ^e   Zepp, Fred ^f   Schuster, Antje ^g   D'Amelio, Raffaele ^c   Wahn, Ulrich ^a   Keil, Thomas ^a,h   Lau, Susanne ^a   Matricardi, Paolo Maria ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b L'altrastatistica srl Consultancy and Training Biostatistics Office   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e St Josefs Hospital   (Germany)

^f UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^g HEINRICH HEINE UNIVERSITY   (Germany)

^h UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Allergenic molecules; birth cohort; childhood; IgE; IgE sensitization; IgG; IgG4; microarray; prediction

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G;

ALLERGY RAPID TEST; ALLERGY TEST; ANIMAL FOOD; ANTIBODY TITER; ARTICLE; BIRCH; CAT; CHILD; CHILDHOOD; COHORT ANALYSIS; CONTROLLED STUDY; DERMATOPHAGOIDES; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE PREDISPOSITION; DOG; EGG; EGG ALLERGY; EXPOSURE; FEMALE; FOOD ALLERGY; GEOMETRY; GRASS; HOUSE DUST ALLERGY; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; MILK; MILK ALLERGY; MOLECULE; MULTICENTER STUDY; OBSERVATIONAL STUDY; POLLEN ALLERGY; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; SENSITIZATION; SEROPREVALENCE; SERUM; SOY FOOD; VEGETABLE; WHEAT ALLERGY; BLOOD; CLINICAL TRIAL; GERMANY; HYPERSENSITIVITY; IMMUNOLOGY;

ALLERGENS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GERMANY; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MALE;

EID: 84976508522     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.01.057     Document Type: Article

References (38)

1. 1 Johansson, S.G., IgE in allergic diseases. Proc R Soc Med 62 (1969), 975–976.
2. 2 Orgel, H.A., Hamburger, R.N., Bazaral, M., Gorrin, H., Groshong, T., Lenoir, M., et al. Development of IgE and allergy in infancy. J Allergy Clin Immunol 56 (1975), 296–307.
3. 3 Hesselmar, B., Aberg, B., Eriksson, B., Björksten, B., Aberg, N., High-dose exposure to cat is associated with clinical tolerance—a modified Th2 immune response?. Clin Exp Allergy 33 (2003), 1681–1685.
4. 4 Platts-Mills, T.A., Vaughan, J.W., Blumenthal, K., Pollart Squillace S, Sporik RB. Serum IgG and IgG4 antibodies to Fel d 1 among children exposed to 20 microg Fel d 1 at home: relevance of a nonallergic modified Th2 response. Int Arch Allergy Immunol 124 (2001), 126–129.
5. 5 Wachholz, P.A., Soni, N.K., Till, S.J., Durham, S.R., Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy. J Allergy Clin Immunol 112 (2003), 915–922.
6. 6 Flicker, S., Valenta, R., Renaissance of the blocking antibody concept in type I allergy. Int Arch Allergy Immunol 132 (2003), 13–24.
7. 7 Jönsson, F., Mancardi, D.A., Zhao, W., Kita, Y., Iannascoli, B., Khun, H., et al. Human FcγRIIA induces anaphylactic and allergic reactions. Blood 119 (2012), 2533–2544.
8. 8 Hofmaier, S., Hatzler, L., Rohrbach, A., Panetta, V., Hakimeh, D., Bauer, C.P., et al. “Default” versus “pre-atopic” IgG responses to foodborne and airborne pathogenesis-related group 10 protein molecules in birch-sensitized and nonatopic children. J Allergy Clin Immunol 135 (2015), 1367–1374.e8.
9. 9 Aalberse, R.C., Specific IgE and IgG responses in atopic versus nonatopic subjects. Am J Respir Crit Care Med 162:suppl (2000), S124–S127.
10. 10 Aalberse, R.C., Van Milligen, F., Tan, K.Y., Stapel, S.O., Allergen-specific IgG4 in atopic disease. Allergy 48 (1993), 559–569.
11. 11 Shamji, M.H., Durham, S.R., Mechanisms of immunotherapy to aeroallergens. Clin Exp Allergy 41 (2011), 1235–1246.
12. 12 Rowntree, S., Cogswell, J.J., Platts-Mills, T.A., Mitchell, E.B., Development of IgE and IgG antibodies to food and inhalant allergens in children at risk of allergic disease. Arch Dis Child 60 (1985), 727–735.
13. 13 Chapman, M.D., Platts-Mills, T.A., Measurement of IgG, IgA and IgE antibodies to Dermatophagoides pteronyssinus by antigen-binding assay, using a partially purified fraction of mite extract (F4P1). Clin Exp Immunol 34 (1978), 126–136.
14. 14 Platts-Mills, T.A., Local production of IgG, IgA and IgE antibodies in grass pollen hay fever. J Immunol 122 (1979), 2218–2225.
15. 15 Curin, M., Swoboda, I., Wollmann, E., Lupinek, C., Spitzauer, S., van Hage, M., et al. Microarrayed dog, cat, and horse allergens show weak correlation between allergen-specific IgE and IgG responses. J Allergy Clin Immunol 133 (2014), 918–921.e6.
16. 16 Kolopp-Sarda, M.N., Moneret-Vautrin, D.A., Gobert, B., Kanny, G., Brodschii, M., Bene, M.C., et al. Specific humoral immune responses in 12 cases of food sensitization to sesame seed. Clin Exp Allergy 27 (1997), 1285–1291.
17. 17 Sverremark-Ekström, E., Hultgren, E.H., Borres, M.P., Nilsson, C., Peanut sensitization during the first 5 yr of life is associated with elevated levels of peanut-specific IgG. Pediatr Allergy Immunol 23 (2012), 224–229.
18. 18 Kukkonen, A.K., Savilahti, E.M., Haahtela, T., Savilahti, E., Kuitunen, M., Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders. Clin Exp Allergy 41 (2011), 1414–1421.
19. 19 Eysink, P.E., De Jong, M.H., Bindels, P.J., Scharp-Van Der Linden, V.T., De Groot, C.J., Stapel, S.O., et al. Relation between IgG antibodies to foods and IgE antibodies to milk, egg, cat, dog and/or mite in a cross-sectional study. Clin Exp Allergy 29 (1999), 604–610.
20. 20 Orivuori, L., Mustonen, K., Roduit, C., Braun-Fahrländer, C., Dalphin, J.C., Genuneit, J., et al. Immunoglobulin A and immunoglobulin G antibodies against β-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6. Pediatr Allergy Immunol 25 (2014), 329–337.
21. 21 Eysink, P.E., Bindels, P.J., Stapel, S.O., Bottema, B.J., Van Der Zee, J.S., Aalberse, R.C., Do levels of immunoglobulin G antibodies to foods predict the development of immunoglobulin E antibodies to cat, dog and/or mite?. Clin Exp Allergy 32 (2002), 556–562.
22. 22 Hatzler, L., Panetta, V., Lau, S., Wagner, P., Bergmann, R.L., Illi, S., et al. Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 130 (2012), 894–901.e5.
23. 23 Bergmann, R.L., Bergmann, K.E., Lau-Schadendorf, S., Luck, W., Dannemann, A., Bauer, C.P., et al. Atopic diseases in infancy. The German multicenter atopy study (MAS-90). Pediatr Allergy Immunol 5 (1994), 19–25.
24. 24 Matricardi, P.M., Illi, S., Grueber, C., Keil, T., Nickel, R., Wahn, U., et al. Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence. Eur Respir J 32 (2008), 585–592.
25. 25 Härfast, B., van Hage-Hamsten, M., Lilja, G., IgG subclass antibody responses to birch pollen in sibling pairs discordant for atopy. Pediatr Allergy Immunol 9 (1998), 208–214.
26. 26 Lindmark-Månsson, H., Fondén, R., Pettersson, H.-E., Composition of Swedish dairy milk. Int Dairy J 13 (2003), 409–425.
27. 27 Thorisdottir, B., Gunnarsdottir, I., Palsson, G.I., Halldorsson, T.I., Thorsdottir, I., Animal protein intake at 12 months is associated with growth factors at the age of six. Acta Paediatr 103 (2014), 512–517.
28. 28 HIALINE working group, Buters, J., Prank, M., Sofiev, M., Pusch, G., Albertini, R., Annesi-Maesano, I., et al. Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season. J Allergy Clin Immunol 136 (2015), 87–95.e6.
29. 29 Jenmalm, M.C., Björkstén, B., Development of immunoglobulin G subclass antibodies to ovalbumin, birch and cat during the first eight years of life in atopic and non-atopic children. Pediatr Allergy Immunol 10 (1999), 112–121.
30. 30 Husby, S., Larsen, F.S., Petersen, P.H., Svehag, S.E., Humoral immunity to dietary antigens in atopic dermatitis. I. Biotin-avidin amplified ELISA-analysis for serum IgG antibodies. Allergy 41 (1986), 379–385.
31. 31 Pomponi, D., Di Zenzo, G., Zennaro, D., Calabresi, V., Eming, R., Zuzzi, S., et al. Detection of IgG and IgE reactivity to BP180 using the ISAC® microarray system. Br J Dermatol 168 (2013), 1205–1214.
32. 32 Matricardi, P.M., Bockelbrink, A., Keil, T., Grüber, C., Niggemann, B., Hamelmann, E., et al. Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort. Clin Exp Allergy 39 (2009), 1551–1557.
33. 33 Asarnoj, A., Ostblom, E., Kull, I., Lilja, G., Pershagen, G., Hedlin, G., et al. Sensitization to inhalant allergens between 4 and 8 years of age is a dynamic process: results from the BAMSE birth cohort. Clin Exp Allergy 38 (2008), 1507–1513.
34. 34 Holt, P.G., Postnatal maturation of immune competence during infancy and childhood. Pediatr Allergy Immunol 6 (1995), 59–70.
35. 35 Yabuhara, A., Macaubas, C., Prescott, S.L., Venaille, T.J., Holt, B.J., Habre, W., et al. TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin Exp Allergy 27 (1997), 1261–1269.
36. 36 Rowe, J., Kusel, M., Holt, B.J., Suriyaarachchi, D., Serralha, M., Hollams, E., et al. Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort. J Allergy Clin Immunol 119 (2007), 1164–1173.
37. 37 Hollams, E.M., Deverell, M., Serralha, M., Suriyaarachchi, D., Parsons, F., Zhang, G., et al. Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling. J Allergy Clin Immunol 124 (2009), 463–470 e1-16.
38. 38 Calkhoven, P.G., Aalbers, M., Koshte, V.L., Schilte, P.P., Yntema, J.L., Griffioen, R.W., et al. Relationship between IgG1 and IgG4 antibodies to foods and the development of IgE antibodies to inhalant allergens. II. Increased levels of IgG antibodies to foods in children who subsequently develop IgE antibodies to inhalant allergens. Clin Exp Allergy 21 (1991), 99–107.