Early Life Metabolism of Bisphenol A: A Systematic Review of the Literature

Current environmental health reports

Volumn 1, Issue 1, 2014, Pages 90-100

  Nachman, Rebecca M ^a   Hartle, Jennifer C ^b   Lees, Peter S J ^a   Groopman, John D ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bisphenol A; BPA; Chemicals; Early life; Exposure; Metabolism; Toxicity; Toxicokinetics

Indexed keywords

EID: 84976448774     PISSN: None     EISSN: 21965412     Source Type: Journal    
DOI: 10.1007/s40572-013-0003-7     Document Type: Review

References (53)

1. National Toxicology Program (Center for the Evaluation of Risks to Human Reproduction). NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. 2008; NIH Publication No. 08 – 5994.
2. European Commission Joint Research Center (Institute for Health and Consumer Protection). European Union risk assessment report: bisphenol-A. Luxembourg: Office for Official Publications of the European Communities; 2003; EUR 20843 EN.
3. Liao C, Kannan K. Widespread occurrence of bisphenol A in paper and paper products: implications for human exposure. Environ Sci Technol. 2011;45:9372–9.
4. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect. 2008;116:39–44.
5. Bushnik T, Haines D, Levallois P, Levesque J, Van Oostdam J, Viau C. Lead and bisphenol A concentrations in the Canadian population. Health Rep. 2010;21:7–18.
6. Koch HM, Kolossa-Gehring M, Schroter-Kermani C, Angerer J, Bruning T. Bisphenol A in 24h urine and plasma samples of the German environmental specimen bank from 1995 to 2009: a retrospective exposure evaluation. J Expo Sci Environ Epidemiol. 2012;22:610–6.
7. Zhang Z, Alomirah H, Cho HS, et al. Urinary bisphenol A concentrations and their implications for human exposure in several Asian countries. Environ Sci Technol. 2011;45:7044–50.
8. Lang IA, Galloway TS, Scarlett A, et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA. 2008;300:1303–10.
9. Braun JM, Kalkbrenner AE, Calafat AM, et al. Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics. 2011;128:873–82. This paper presents results of an epidemiologic study in which maternal urinary BPA concentrations during pregnancy were associated with behavior changes in 3 year old children.
10. Trasande L, Attina TM, Blustein J. Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA. 2012;308:1113–21.
11. Acevedo N, Davis B, Schaeberle CM, Sonnenschein C, Soto AM. Perinatally administered bisphenol A acts as a mammary gland carcinogen in rats. Environ Health Perspect. 2013
12. Selevan SG, Kimmel CA, Mendola P. Identifying critical windows of exposure for children's health. Environ Health Perspect. 2000;108 Suppl 3:451–5.
13. Hajszan T, Leranth C. Bisphenol A interferes with synaptic remodeling. Front Neuroendocrinol. 2010;31:519–30.
14. Lakind JS, Naiman DQ. Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003–2004 NHANES urinary BPA data. J Expo Sci Environ Epidemiol. 2008;18:608–15.
15. European Commission Joint Research Center (Institute for Health and Consumer Protection). European Union risk assessment report: 4-4' isopropylidenediphenol (Bisphenol A), Part 2 Human Health. Luxembourg: Publications Office of the European Union; 2008;EINECS No. 201-245-8.
16. Wilson NK, Chuang JC, Morgan MK, Lordo RA, Sheldon LS. An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare. Environ Res. 2007;103:9–20.
17. Volkel W, Colnot T, Csanady GA, Filser JG, Dekant W. Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem Res Toxicol. 2002;15:1281–7.
18. McCarver DG, Hines RN. The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms. J Pharmacol Exp Ther. 2002;300:361–6.
19. Alcorn J, McNamara PJ. Pharmacokinetics in the newborn. Adv Drug Deliv Rev. 2003;55:667–86.
20. Dekant W, Volkel W. Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. Toxicol Appl Pharmacol. 2008;228:114–34.
21. Ye X, Zhou X, Wong LY, Calafat AM. Concentrations of bisphenol A and seven other phenols in pooled sera from 3–11 year old children: 2001–2002 National Health and Nutrition Examination Survey. Environ Sci Technol. 2012;46:12664–71. This paper demonstrates that urine, not blood, is the appropriate matrix for BPA biomonitoring in the general population.
22. Perera F, Vishnevetsky J, Herbstman JB, et al. Prenatal bisphenol a exposure and child behavior in an inner-city cohort. Environ Health Perspect. 2012;120:1190–4.
23. Morgan MK, Jones PA, Calafat AM, et al. Assessing the quantitative relationships between preschool children's exposures to bisphenol A by route and urinary biomonitoring. Environ Sci Technol. 2011;45:5309–16.
24. Sathyanarayana S, Alcedo G, Saelens BE, et al. Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures. J Expo Sci Environ Epidemiol. 2013;23:378–84.
25. Casas M, Valvi D, Luque N, et al. Dietary and sociodemographic determinants of bisphenol A urine concentrations in pregnant women and children. Environ Int. 2013;56:10–8.
26. Hoepner LA, Whyatt RM, Just AC, Calafat AM, Perera FP, Rundle AG. Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years. Environ Res. 2013;122:38–44.
27. Harley KG, Aguilar Schall R, Chevrier J, et al. Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort. Environ Health Perspect. 2013;121:514–20.
28. Harley KG, Gunier RB, Kogut K, et al. Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Environ Res. 2013;126:43–50.
29. Health Canada. Second Report on Human Biomonitoring of Environmental Chemicals in Canada. 2013. This report includes biomonitoring data for environmental chemicals (including BPA) for children as young as age 3 years from a nationally representative sample of Canadians; the previous report and the analysis report for the U.S. population includes children aged 6 and up.
30. Becker K, Göen T, Seiwert M, Conrad A, Pick-Fuss H, Müller J, Wittassek M, Schulz C, Kolossa-Gehring M. GerES IV: phthalate metabolites and bisphenol A in urine of German children. Int J Hyg Environ Health. 2009;212(6):685–92.
31. Calafat AM, Weuve J, Ye X, et al. Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect. 2009;117:639–44. This paper presents the first BPA biomonitoring data in infants and demonstrates that medical equipment in a NICU is an important potential source of BPA exposure.
32. Centers for Disease Control and Prevention. Fourth national report on human exposure to environmental chemicals, updated tables, February 2012. 2012.
33. Li D, Zhou Z, Qing D, et al. Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum Reprod. 2010;25:519–27.
34. Volkel W, Kiranoglu M, Fromme H. Determination of free and total bisphenol A in urine of infants. Environ Res. 2011;111:143–8.
35. Mendonca K, Hauser R, Calafat AM, Arbuckle TE, Duty SM. Bisphenol A concentrations in maternal breast milk and infant urine. Int Arch Occup Environ Health. 2012
36. Nachman RM, Fox SD, Golden WC, et al. Urinary free bisphenol A and bisphenol A-glucuronide concentrations in newborns. J Pediatr. 2013;162:870–2.
37. Prins GS, Ye SH, Birch L, Ho SM, Kannan K. Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats. Reprod Toxicol. 2011;31(1):1–9.
38. Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague–Dawley rats and rhesus monkeys. Toxicol Lett. 2011;207:298–305.
39. Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Pharmacokinetics of bisphenol A in neonatal and adult Sprague–Dawley rats. Toxicol Appl Pharmacol. 2010;247:158–65.
40. Doerge DR, Twaddle NC, Woodling KA, Fisher JW. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Toxicol Appl Pharmacol. 2010;248:1–11.
41. U.S. Environmental Protection Agency. IRIS database.
42. Mielke H, Gundert-Remy U. Bisphenol A levels in blood depend on age and exposure. Toxicol Lett. 2009;190:32–40.
43. European Food Safety Authority. Opinion of the scientific panel on food additives, flavourings, food processing aids, and materials in contact with food (AFC). EFSA J. 2006;759:1–10.
44. European Commission. Updated Risk Assessment of 4, 4’-isopropylidenediphenol (Bisphenol-A) (CAS Number: 80-05-7, EINECS Number: 201-245-8). Accessed September 3, 2013. Available at http://publications.jrc.ec.europa.eu/repository/bitstream/111111111/15069/1/lbna24589enn.pdf.
45. Kuester RK, Sipes IG. Prediction of metabolic clearance of bisphenol A (4,4'-dihydroxy-2,2-diphenylpropane) using cryopreserved human hepatocytes. Drug Metab Dispos. 2007;35:1910–5.
46. Edginton AN, Ritter L. Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic model. Environ Health Perspect. 2009;117:645–52.
47. Ye X, Bishop AM, Needham LL, Calafat AM. Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. Anal Chim Acta. 2008;622:150–6.
48. Hanioka N, Naito T, Narimatsu S. Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation. Chemosphere. 2008;74:33–6.
49. Matsumoto J, Yokota H, Yuasa A. Developmental increases in rat hepatic microsomal UDP-glucuronosyltransferase activities toward xenoestrogens and decreases during pregnancy. Environ Health Perspect. 2002;110:193–6.
50. Domoradzki JY, Thornton CM, Pottenger LH, et al. Age and dose dependency of the pharmacokinetics and metabolism of bisphenol A in neonatal Sprague–Dawley rats following oral administration. Toxicol Sci. 2004;77:230–42.
51. Ye X, Zhou X, Hennings R, Kramer J, Calafat AM. Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge. Environ Health Perspect. 2013;121:283–6.
52. Edginton AN, Schmitt W, Voith B, Willmann S. A mechanistic approach for the scaling of clearance in children. Clin Pharmacokinet. 2006;45:683–704.
53. Wells J, Koontz. Decline in urinary bisphenol A concentrations in the U.S. Epidemiology