Complement Activation in Trauma Patients Alters Platelet Function

Shock

Volumn 46, Issue 3S, 2016, Pages 83-88

  Atefi, Gelareh ^a   Aisiku, Omozuanvbo ^a   Shapiro, Nathan ^a   Hauser, Carl ^a   Dalle Lucca, Jurandir ^b   Flaumenhaft, Robert ^a   Tsokos, George C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

Aggregation; calcium flux; coagulopathy; complement; platelets; trauma

Indexed keywords

CALCIUM; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C4D; THROMBIN RECEPTOR ACTIVATING PEPTIDE; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; PEPTIDE FRAGMENT;

AGED; ARTICLE; CALCIUM TRANSPORT; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INJURY; MALE; PROSPECTIVE STUDY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; BLOOD; BLOOD CLOTTING PARAMETERS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; THROMBOCYTE;

AGED; BLOOD PLATELETS; CALCIUM; COMPLEMENT C3A; COMPLEMENT C4B; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; PROSPECTIVE STUDIES; WOUNDS AND INJURIES;

EID: 84976363302     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000675     Document Type: Article

References (27)

1. U.S. Census Bureau. Statistical Abstract of the United States: 2012 (131th edition). Washington, DC: U.S. Department of Commerce; 2012.
2. Hoyert DL, Xu J: Deaths: preliminary data for 2011. Natl Vital Stat Rep 61:1-51, 2012.
3. Rhee P, Joseph B, Pandit V, Aziz H, Vercruysse G, Kulvatunyou N, Friese RS: Increasing trauma deaths in the United States. Ann Surg 260(1):13-21, 2014.
4. White NJ: Mechanisms of trauma-induced coagulopathy. Hematology Am Soc Hematol Educ Program 2013:660-663, 2013.
5. Neher MD, Weckbach S, Flierl MA: Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the ''bad guy''? J Biomed Sci 18:90, 2011.
6. Ramsey MT, Fabian TC, Shahan CP, Sharpe JP, Mabry SE, Weinberg JA, Croce MA, Jennings LK: A prospective study of platelet function in trauma patients. J Trauma Acute Care Surg 80(5):726-733, 2016.
7. Lood C, Eriksson S, Gullstrand B, Jönsen A, Sturfelt G, Truedsson L, Bengtsson AA: Increased C1q, C4 and C3 deposition on platelets in patients with systemic lupus erythematosus-a possible link to venous thrombosis? Lupus 21(13):1423-1432, 2012.
8. Navratil JS, Manzi S, Kao AH, Krishnaswami S, Liu CC, Ruffing MJ, Shaw PS, Nilson AC, Dryden ER, Johnson JJ, et al.: Platelet C4d is highly specific for systemic lupus erythematosus. Arthritis Rheum 54:670-674, 2006.
9. Mehta N, Uchino K, Fakhran S, Sattar MA, Branstetter BF 4th, Au K, Navratil JS, Paul B, Lee M, Gallagher KM, et al.: Platelet C4d is associated with acute ischemic stroke and stroke severity. Stroke 39(12):3236-3241, 2008.
10. Graham GJ, Ren Q, Dilks JR: VAMP-8-dependent dense granule release mediates thrombus formation in vivo. Blood 114(5):1083-1090, 2009.
11. Dowal L, Sim DS, Dilks JR: Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1. Proc Natl Acad Sci U S A 108(7):2951-2956, 2011.
12. Grynkiewicz G, Poenie M, Tsien RY: A new generation of Ca2 indicators with greatly improved fluorescence properties. J Biol Chem 260(6):3440-3450, 1985.
13. Solomon C1, Traintinger S, Ziegler B, Hanke A, Rahe-Meyer N, Voelckel W, Schöchl H: Platelet function following trauma. A multiple electrode aggregometry study. Thromb Haemost 106(2):322-330, 2011.
14. Ganter MT, Brohi K, Cohen MJ: Role of the alternative pathway in the early complement activation following major trauma. Shock 28:29-34, 2007.
15. Torzewski J, Bowyer DE, Waltenberger J, Fitzsimmons C: Processes in atherogenesis: complement activation. Atherosclerosis 132:131-138, 1997.
16. Petri M: Epidemiology of the antiphospholipid antibody syndrome. J Autoimmun 15:145-151, 2000.
17. Davis WD, Brey RL: Antiphospholipid antibodies and complement activation in patients with cerebral ischemia. Clin Exp Immunol 10:445-446, 1992.
18. Leinhase I, Rozanski M, Harhausen D, Thurman JM, Schmidt OI, Hossini AM, Taha ME, Rittirsch D, Ward PA, Holers VM, et al.: Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. J Neuroinflammation 4:13, 2007.
19. Wiedmer T, Esmon CT, Sims PJ: Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase. Blood 68:875-880, 1986.
20. Muroya T, Kannan L, Ghiran IC, Shevkoplyas SS, Paz Z, Tsokos M, Dalle Lucca JJ, Shapiro NI, Tsokos GC: C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med 42(5):364-372, 2014.
21. Hecke F, Schmidt U, Kola A, Bautsch W, Klos A, Köhl J: Circulating complement proteins in multiple trauma patients-correlation with injury severity, development of sepsis, and outcome. Crit Care Med 25(12): 2015-2024, 1997.
22. Baldwin WM 3rd, Kasper EK, Zachary AA: Beyond C4d: other complementrelated diagnostic approaches to antibody-mediated rejection. Am J Transplant 4:311-318, 2004.
23. Fleming SD, Phillips LM, Lambris JD: Complement component C5a mediates hemorrhage-induced intestinal damage. J Surg Res 150:196-220, 2008.
24. Jacoby RC, Owings JT, Holmes J, Battistella FD, Gosselin RC, Paglieroni TG: Platelet activation and function after trauma. J Trauma 51:639-647, 2001.
25. Del Conde I, Cruz MA, Zhang H, Lopez JA, Afshar-Kharghan V: Platelet activation leads to activation and propagation of the complement system. J Exp Med 201:871-879, 2005.
26. Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC: Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum 63(2):503-512, 2011.
27. Lapchak PH, Kannan L, Ioannou A, Rani P, Karian P, Dalle Lucca JJ, Tsokos GC: Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 302:G888-G897, 2012.