Synthetic evolutionary origin of a proofreading reverse transcriptase

Science

Volumn 352, Issue 6293, 2016, Pages 1590-1593

  Ellefson, Jared W ^a   Gollihar, Jimmy ^a   Shroff, Raghav ^a   Shivram, Haridha ^a   Iyer, Vishwanath R ^a   Ellington, Andrew D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA POLYMERASE; REVERSE TRANSCRIPTION XENOPOLYMERASE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; EXONUCLEASE; RNA;

DNA; ENZYME; ENZYME ACTIVITY; EVOLUTIONARY THEORY; PROTEIN; RNA;

ARTICLE; CONTROLLED STUDY; DNA ISOLATION; DNA STRUCTURE; DNA TEMPLATE; ENZYME ACTIVITY; GENE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PYROCOCCUS FURIOSUS; REVERSE TRANSCRIPTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; THERMOCOCCUS KODAKARENSIS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DIRECTED MOLECULAR EVOLUTION; DNA MUTATIONAL ANALYSIS; ENZYMOLOGY; GENETICS; MISMATCH REPAIR; MOLECULAR EVOLUTION; PHYLOGENY; PROTEIN TERTIARY STRUCTURE; THERMOCOCCUS;

DIRECTED MOLECULAR EVOLUTION; DNA MISMATCH REPAIR; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; EXONUCLEASES; MODELS, MOLECULAR; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; PYROCOCCUS FURIOSUS; RNA; RNA-DIRECTED DNA POLYMERASE; TEMPLATES, GENETIC; THERMOCOCCUS;

EID: 84976337073     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf5409     Document Type: Article

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