Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells

Cell Cycle

Volumn 15, Issue 12, 2016, Pages 1531-1537

  Colak, S ^a   Medema, J P ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Cancer Genomics Center   (Netherlands)

Author keywords

ABT 737; apoptosis; BCLXL; cancer stem cell; chemotherapy; colorectal cancer; fibroblast; microenvironment; resistance

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BH3 PROTEIN; OXALIPLATIN; PROTEIN BCL XL; ABT-737; ANTINEOPLASTIC AGENT; BCL2L1 PROTEIN, HUMAN; BIOLOGICAL FACTOR; BIOLOGICAL MARKER; BIPHENYL DERIVATIVE; CD133 ANTIGEN; CONDITIONED MEDIUM; CYTOKERATIN 20; G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; KRT20 PROTEIN, HUMAN; LGR5 PROTEIN, HUMAN; MUC2 PROTEIN, HUMAN; MUCIN 2; NITROPHENOL; PIPERAZINE DERIVATIVE; PROM1 PROTEIN, HUMAN; PROTEIN BCL X; SULFONAMIDE;

CANCER RESISTANCE; CANCER STEM CELL; CELL DEDIFFERENTIATION; COLORECTAL CANCER; CONDITIONED MEDIUM; CONTROLLED STUDY; HUMAN; HUMAN CELL; MYOFIBROBLAST; NOTE; PROTEIN EXPRESSION; REGULATORY MECHANISM; TUMOR CELL; TUMOR MICROENVIRONMENT; CELL COMMUNICATION; CELL DEATH; CELL DIFFERENTIATION; CHEMISTRY; COLON TUMOR; DRUG EFFECTS; DRUG RESISTANCE; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PHARMACOLOGY; PRIMARY CELL CULTURE; REPORTER GENE; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

AC133 ANTIGEN; ANTINEOPLASTIC AGENTS; BCL-X PROTEIN; BIOLOGICAL FACTORS; BIOMARKERS; BIPHENYL COMPOUNDS; CELL COMMUNICATION; CELL DEATH; CELL DIFFERENTIATION; COLONIC NEOPLASMS; CULTURE MEDIA, CONDITIONED; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; KERATIN-20; MUCIN-2; NEOPLASTIC STEM CELLS; NITROPHENOLS; PIPERAZINES; PRIMARY CELL CULTURE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; SULFONAMIDES;

EID: 84976299740     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/15384101.2014.973321     Document Type: Note

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