PPAR-α Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial Fibroblasts via NF-kB Pathway

Journal of Molecular Neuroscience

Volumn 59, Issue 4, 2016, Pages 544-553

  Huang, Degang ^a   Zhao, Quanlai ^a   Liu, Hongfei ^a   Guo, Yongjie ^a   Xu, Hongguang ^a  

^a WANNAN MEDICAL COLLEGE   (China)

Author keywords

Inflammation; NF kB; Osteoarthritis; Synovial fibroblasts; WY 14643

Indexed keywords

ENDOTHELIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PIRINIXIC ACID; PROSTAGLANDIN E2; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; ANTIINFLAMMATORY AGENT; CCL2 PROTEIN, HUMAN; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PPARGC1A PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; FIBROBLAST; HUMAN; HUMAN TISSUE; INFLAMMATION; INVESTIGATIVE PROCEDURES; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SYNOVIAL FLUID; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; JOINT CAPSULE; METABOLISM; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CHEMOKINE CCL2; DINOPROSTONE; ENDOTHELIN-1; FIBROBLASTS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; JOINT CAPSULE; LIPOPOLYSACCHARIDES; NF-KAPPA B; NITRIC OXIDE; OSTEOARTHRITIS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PYRIMIDINES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84976292332     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-016-0775-y     Document Type: Article

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